Grants per year
Personal profile
Research Interests
Dr. Denise Scholtens is interested in statistical problems arising from high-throughput omics data. She is Chief of the Division of Biostatistics and Associate Director for Biostatistics in the Robert H. Lurie Comprehensive Cancer Center Quantitative Data Sciences Core where she collaborates on a variety of basic science and clinical cancer studies. She also directs the Data Coordinating Center for the international, observational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-Up Study and serves as the primary statistician for the HAPO Metabolomics and Integrated Omics Studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biostatistics, Harvard University
… → 2004
Research interests keywords
- Bioinformatics
- Biostatistics
- Computational Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Multi-Institutional Phase 2/3 Trial of Valproic Acid in Patients with Moderate to Severe Traumatic Brain Injury
Alam, H. B. (PD/PI), Hill, V. B. (Co-Investigator), Katsaggelos, A. K. (Co-Investigator), Parrish, T. B. (Co-Investigator), Scholtens, D. M. (Co-Investigator) & Tatebe, L. C. (Co-Investigator)
U.S. Army Medical Research and Materiel Command
5/1/24 → 4/30/29
Project: Research project
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The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases
Fourati, S. (Co-Investigator), Luo, Y. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Wunderink, R. G. (Co-Investigator) & Walunas, T. L. (Other)
National Institute of Allergy and Infectious Diseases
4/1/24 → 3/31/29
Project: Research project
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Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial
Bonner, L. B. (PD/PI), Bonner, L. B. (PD/PI), Dulai, P. S. (PD/PI), Dulai, P. S. (PD/PI), Hanauer, S. B. (Co-Investigator), Hanauer, S. B. (Co-Investigator), Hanauer, S. B. (Co-Investigator), Hirano, I. (Co-Investigator), Hirano, I. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Sumagin, R. (Co-Investigator), Sumagin, R. (Co-Investigator), Sumagin, R. (Co-Investigator), Yang, G.-Y. (Co-Investigator), Yang, G.-Y. (Co-Investigator) & Yang, G.-Y. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/23 → 2/29/28
Project: Research project
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Hyperglycemia and Adverse Pregnancy Outcome Study-
Lloyd-Jones, D. M. (PD/PI), Allen, N. B. (Co-Investigator), Bonner, L. B. (Co-Investigator), Lowe Jr, W. L. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Wilkins, J. T. (Co-Investigator), Lowe Jr, W. L. (Other) & Metzger, B. E. (Other)
Ann & Robert H. Lurie Children's Hospital of Chicago, National Heart, Lung, and Blood Institute
3/1/23 → 2/29/28
Project: Research project
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Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Wunderink, R. G. (PD/PI), Wunderink, R. G. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Abdala-Valencia, H. (Co-Investigator), Budinger, G. S. (Co-Investigator), Budinger, G. S. (Co-Investigator), Etemadi, M. (Co-Investigator), Etemadi, M. (Co-Investigator), Hartmann, E. M. (Co-Investigator), Hartmann, E. M. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Luo, Y. (Co-Investigator), Luo, Y. (Co-Investigator), Misharin, A. (Co-Investigator), Misharin, A. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Ozer, E. A. (Co-Investigator), Ozer, E. A. (Co-Investigator), Pickens, C. I. (Co-Investigator), Pickens, C. I. (Co-Investigator), Qi, C. (Co-Investigator), Qi, C. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Singer, B. (Co-Investigator), Singer, B. (Co-Investigator), Stoeger, T. (Co-Investigator), Stoeger, T. (Co-Investigator), Swaminathan, S. (Co-Investigator), Swaminathan, S. (Co-Investigator), Walter, J. M. (Co-Investigator), Walter, J. M. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Amaral, L. A. N. (Other), Amaral, L. A. N. (Other), Budinger, G. S. (Other), Budinger, G. S. (Other), Hartmann, E. M. (Other), Hartmann, E. M. (Other), Hauser, A. R. (Other), Hauser, A. R. (Other), Misharin, A. (Other), Misharin, A. (Other), Ozer, E. A. (Other), Ozer, E. A. (Other), Pickens, C. I. (Other), Pickens, C. I. (Other), Qi, C. (Other), Qi, C. (Other), Singer, B. (Other), Singer, B. (Other), Starren, J. (Other), Stoeger, T. (Other), Walter, J. M. (Other), Walter, J. M. (Other), Wunderink, R. G. (Other) & Wunderink, R. G. (Other)
National Institute of Allergy and Infectious Diseases
1/1/23 → 12/31/27
Project: Research project
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Blood Pressure in Pregnancy and Hypertension 10-14 Years after Delivery
Venkatesh, K. K., Grobman, W. A., Wu, J., Costantine, M. M., Landon, M. B., Scholtens, D., Lowe, W., Shah, N. S., Cameron, N. A. & Khan, S. S., Feb 1 2025, In: Obstetrics and gynecology. 145, 2, p. 217-219 3 p.Research output: Contribution to journal › Article › peer-review
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Development of a method for qualitative data integration to advance implementation science within research consortia
on behalf of the IMPACT Consortium, Dec 2025, In: Implementation Science Communications. 6, 1, 21.Research output: Contribution to journal › Article › peer-review
Open Access -
Evolution of the umbilical cord blood proteome across gestational development
Mithal, L. B., Lancki, N., Ling-Hu, T., Goo, Y. A., Otero, S., Rhodes, N. J., Cho, B. K., Grobman, W. A., Hultquist, J. F., Scholtens, D., Mestan, K. K. L. & Seed, P. C., Dec 2025, In: Scientific reports. 15, 1, 2233.Research output: Contribution to journal › Article › peer-review
Open Access -
Factorial Clinical Trial Designs
Ciolino, J. D., Scholtens, D. M. & Bonner, L. B., Feb 11 2025, In: JAMA. 333, 6, p. 532-533 2 p.Research output: Contribution to journal › Review article › peer-review
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Hypertensive disorders of pregnancy and gestational diabetes mellitus and predicted risk of maternal cardiovascular disease 10–14 years after delivery: A prospective cohort
Venkatesh, K. K., Grobman, W. A., Wu, J., Shah, N. S., Pencina, M., Costantine, M. M., Landon, M. B., Catalano, P., Lowe Jr, W. L., Scholtens, D. M. & Khan, S. S., May 2025, In: Diabetic Medicine. 42, 5, e15516.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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GC/MS Simulated Data Sets normalized using quantile + ComBat
Scholtens, D. M. (Creator), Harvard Dataverse, Jan 25 2017
DOI: 10.7910/dvn/aetjqs, https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/AETJQS
Dataset
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GC/MS Simulated Data Sets normalized using vsn
Scholtens, D. M. (Creator), Harvard Dataverse, Jan 25 2017
DOI: 10.7910/dvn/qztgfn, https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/QZTGFN
Dataset
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GC/MS Simulated Data Sets normalized using mean centering
Scholtens, D. M. (Creator), Harvard Dataverse, Jan 25 2017
DOI: 10.7910/dvn/uyo4yf, https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/UYO4YF
Dataset
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Path-level interpretation of Gaussian graphical models using the pair-path subscore
Gill, N. P. (Creator), Balasubramanian, R. (Creator), Bain, J. R. (Creator), Muehlbauer, M. J. (Creator), Lowe, W. L. (Contributor) & Scholtens, D. M. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.5780017, https://springernature.figshare.com/collections/Path-level_interpretation_of_Gaussian_graphical_models_using_the_pair-path_subscore/5780017
Dataset
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Additional file 2: Table S1. of Transversions have larger regulatory effects than transitions
Guo, C. (Creator), McDowell, I. C. (Creator), Nodzenski, M. (Creator), Scholtens, D. M. (Creator), Allen, A. S. (Creator), Lowe, W. L. (Creator) & Reddy, T. E. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3784286_d2, https://springernature.figshare.com/articles/dataset/Additional_file_2_Table_S1_of_Transversions_have_larger_regulatory_effects_than_transitions/5027066
Dataset