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Personal profile

Research Interests

Our laboratory utilizes DNA sequencing, gene expression profiling, proteomic analyses, flow cytometric methodology and many other basic techniques to pursue goals that are ultimately translatable for improving health and overall survival in patients with brain cancer. Although our research is primarily focused on malignant glioma, with a special emphasis on glioblastoma, we are also interested in pursuing incurable pediatric brain tumors, as well as metastatic tumors that invade the brain/spinal cord. It is our sincere hope that, the basic mechanistic investigations that we carry out, uncover important and meaningful discoveries that translate into highly effective immunotherapeutic modalities for the benefit of patients with incurable cancer in the brain.

The primary goal of our research is to analyze the immune response in human brain tumors, as well as syngeneic and humanized mouse brain tumor models, with the intent to develop and evaluate novel immunotherapeutic strategies for malignant brain cancer. We aim to: 1) discover new targets that increase immunosuppression, 2) develop new drugs that inhibit immunosuppression, 3) and test novel treatment strategies for clinical translation into human patients with malignant glioma. Current Projects -Dissect the multiple roles of immunosuppressive indoleamine 2,3 dioxygenase 1 (IDO) in glioblastoma (GBM) -Determine how advanced age suppresses the effectiveness of immunotherapy for treatment of GBM -Investigate the psychosocial aspects of stress, anxiety and/or depression on the suppression of immunotherapeutic efficacy for GBM. -Characterize the gut microbiota of GBM patients, before and after treatment with immunotherapy

Training Experience

2013Postdoctoral Fellowship, University of Chicago

Education/Academic qualification

PhD, Loyola University-Chicago

… → 2009

MS, Loyola University-Chicago

… → 2004

Research interests

  • Aging
  • Biologic Therapies
  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Immune Regulation
  • Immunology
  • Metabolism
  • Neuro-Oncology
  • Neurobiology
  • Neuroinflammation
  • Neuroscience
  • Psychology

Fingerprint Dive into the research topics where Derek Alan Wainwright is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 17 Similar Profiles
Glioblastoma Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Indoleamine-Pyrrole 2,3,-Dioxygenase Medicine & Life Sciences
Glioma Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Survival Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2023

Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Survival

Research Output 2008 2019

CD73: An emerging checkpoint for cancer immunotherapy

Chen, S., Wainwright, D. A., Wu, J. D., Wan, Y., Matei, D. E., Zhang, Y. & Zhang, B., Jan 1 2019, In : Immunotherapy. 11, 11, p. 983-997 15 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
Adenosine
Immunity
Carcinogenesis

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

Zhai, L., Ladomersky, E., Lauing, K. L., Wu, M., Scholtens, D. M., Savoor, R., Zhang, B., Wu, J. D., Horbinski, C. M., Lukas, R. V., Binder, D. C. & Wainwright, D. A., Mar 4 2019, In : OncoImmunology. 8, 3, 1548242.

Research output: Contribution to journalComment/debate

Glioblastoma
Biomarkers
Computational Biology
Gene Expression
2 Citations (Scopus)

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod

Lukas, R. V., Juhász, C., Wainwright, D. A., James, C. D., Kennedy, E., Stupp, R. & Lesniak, M. S., Jan 15 2019, In : Journal of Neuro-Oncology. 141, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Glioblastoma
Tryptophan
Positron-Emission Tomography
temozolomide

Newly diagnosed glioblastoma: A review on clinical management

Lukas, R. V., Wainwright, D. A., Ladomersky, E., Sachdev, S., Sonabend Worthalter, A. M. & Stupp, R., Jan 1 2019, In : ONCOLOGY (United States). 33, 3, p. 91-100 10 p.

Research output: Contribution to journalReview article

Glioblastoma
Central Nervous System Neoplasms
Standard of Care
Cations
Radiotherapy

Quantification of IDO1 enzyme activity in normal and malignant tissues

Zhai, L., Ladomersky, E., Bell, A., Dussold, C., Cardoza, K., Qian, J., Lauing, K. L. & Wainwright, D. A., Jan 1 2019, Methods in Enzymology. Academic Press Inc, (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Enzyme activity
Tryptophan
Tissue