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Personal profile

Research Interests

The broad area of my research interest is in the cytoskeleton and intracellular motility. The cytoskeletal polymer that I am most interested in is the microtubules and the cytoskeletal process that I am most excited about is the accurate segregation of chromosomes during mitosis. A dividing cell assembles mitotic kinetochores and a mitotic spindle at the onset of mitosis. The kinetochores serve as sites where the microtubules of the mitotic spindle comes in physical contact with the chromosomes, and are hence extremely important for accurate chromosome segregation. Improper kinetochore microtubule (kMT) attachments lead to erroneous chromosome segregation, chromosome loss and aneuploidy in turn, which is the leading cause of cancer in tissue cells and of birth defects and miscarriages during human embryonic development. Over a decade of research had identified the kinetochore-bound Ndc80 complex as the key requirement for the direct physical contact with microtubules of the spindle. But what is still not understood well is how the kinetochores and the Ndc80 complex remains stably attached to the highly dynamic microtubule plus-ends during mitotic metaphase and subsequent chromosome segregation in anaphase. Work is yeast model system had provided us with important insights into the possible mechanism governing this process, but we still do not have a clear mechanistic picture in vertebrate systems. Work in my lab focusses on understanding the molecular mechanisms that are involved the controlling and regulating kinetochore microtubule attachments in vertebrate cells. We are also very interested to delineate the intricate mechanism that link this event with the activation and silencing of the spindle assembly checkpoint which is also absolutely critical for accurate chromosome segregation.

Training Experience

2014Postdoctoral Fellowship, University of North Carolina

Education/Academic qualification

PhD, Columbia College of Physicians and Surgeons

… → 2008

Research interests

  • Biochemistry: Proteins
  • Cancer Biology
  • Cell Biology
  • Cell Division
  • Cell Imaging
  • Chromosome Segregation
  • Cytoskeleton
  • Microscopy

Fingerprint Dive into the research topics where Dileep Varma is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Kinetochores Medicine & Life Sciences
Dyneins Medicine & Life Sciences
Microtubules Medicine & Life Sciences
M Phase Cell Cycle Checkpoints Medicine & Life Sciences
Mitosis Medicine & Life Sciences
Cytoplasmic Dyneins Medicine & Life Sciences
Cells Chemical Compounds
Chromosome Segregation Medicine & Life Sciences

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Grants 2014 2018

Organized Financing
Financial Management
Research
Publications
Neoplasms
Kinetochores
Microtubules
Chromosomes
Mitosis
Chromosomal Instability

Research Output 2004 2018

  • 831 Citations
  • 14 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Short survey
2 Citations (Scopus)

Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis

Amin, M. A., McKenney, R. J. & Varma, D., Jan 1 2018, In : Journal of Biological Chemistry. 293, 16, p. 5755-5765 11 p.

Research output: Contribution to journalArticle

Dyneins
Kinetochores
Mitosis
Microtubules
Chromosomes
1 Citation (Scopus)

Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism

Agarwal, S., Smith, K. P., Zhou, Y., Suzuki, A., McKenney, R. J. & Varma, D., Oct 1 2018, In : The Journal of cell biology. 217, 10, p. 3446-3463 18 p.

Research output: Contribution to journalArticle

Aurora Kinase B
Kinetochores
Microtubules
Chromosome Segregation
Spindle Apparatus

Cell Division: The Unattached Kinetochore Wears an Expansive RZZ Coat

Suzuki, A. & Varma, D., Nov 5 2018, In : Current Biology. 28, 21, p. R1250-R1252

Research output: Contribution to journalShort survey

Kinetochores
kinetochores
Cell Division
cell division
Cells
Cell Cycle Proteins
Confocal microscopy
Mitosis
Confocal Microscopy
Synchronization