• 911 Citations
20042019

Research output per year

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Personal profile

Research Interests

The broad area of my research interest is in the cytoskeleton and intracellular motility. The cytoskeletal polymer that I am most interested in is the microtubules and the cytoskeletal process that I am most excited about is the accurate segregation of chromosomes during mitosis. A dividing cell assembles mitotic kinetochores and a mitotic spindle at the onset of mitosis. The kinetochores serve as sites where the microtubules of the mitotic spindle comes in physical contact with the chromosomes, and are hence extremely important for accurate chromosome segregation. Improper kinetochore microtubule (kMT) attachments lead to erroneous chromosome segregation, chromosome loss and aneuploidy in turn, which is the leading cause of cancer in tissue cells and of birth defects and miscarriages during human embryonic development. Over a decade of research had identified the kinetochore-bound Ndc80 complex as the key requirement for the direct physical contact with microtubules of the spindle. But what is still not understood well is how the kinetochores and the Ndc80 complex remains stably attached to the highly dynamic microtubule plus-ends during mitotic metaphase and subsequent chromosome segregation in anaphase. Work is yeast model system had provided us with important insights into the possible mechanism governing this process, but we still do not have a clear mechanistic picture in vertebrate systems. Work in my lab focusses on understanding the molecular mechanisms that are involved the controlling and regulating kinetochore microtubule attachments in vertebrate cells. We are also very interested to delineate the intricate mechanism that link this event with the activation and silencing of the spindle assembly checkpoint which is also absolutely critical for accurate chromosome segregation.

Training Experience

2014Postdoctoral Fellowship, University of North Carolina

Education/Academic qualification

PhD, Columbia College of Physicians and Surgeons

… → 2008

Research interests

  • Biochemistry: Proteins
  • Cancer Biology
  • Cell Biology
  • Cell Division
  • Cell Imaging
  • Chromosome Segregation
  • Cytoskeleton
  • Microscopy

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Grants

  • Research Output

    • 911 Citations
    • 14 Article
    • 5 Review article
    • 2 Comment/debate
    • 2 Short survey

    Computational model demonstrates that Ndc80-associated proteins strengthen kinetochore-microtubule attachments in metaphase

    Campbell, S., Amin, M. A., Varma, D. & Bidone, T. C., Nov 1 2019, In : Cytoskeleton. 76, 11-12, p. 549-561 13 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Mapping the kinetochore MAP functions required for stabilizing microtubule attachments to chromosomes during metaphase

    Amin, M. A., Agarwal, S. & Varma, D., Jun 1 2019, In : Cytoskeleton. 76, 6, p. 398-412 15 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis

    Amin, M. A., McKenney, R. J. & Varma, D., Jan 1 2018, In : Journal of Biological Chemistry. 293, 16, p. 5755-5765 11 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism

    Agarwal, S., Smith, K. P., Zhou, Y., Suzuki, A., McKenney, R. J. & Varma, D., Oct 1 2018, In : Journal of Cell Biology. 217, 10, p. 3446-3463 18 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Cell Division: The Unattached Kinetochore Wears an Expansive RZZ Coat

    Suzuki, A. & Varma, D., Nov 5 2018, In : Current Biology. 28, 21, p. R1250-R1252

    Research output: Contribution to journalShort survey

  • 1 Scopus citations