Personal profile

Certifications and Licenses

2000Residency, Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School
2002Fellowship, Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School
Neurology

Keywords

  • Gene Regulation
  • Neurology
  • Neuroscience
  • Neurogenetics
  • Alzheimer's Disease
  • Aging
  • Movement Disorders
  • Parkinson’s disease

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Huntington Disease Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Neurons Medicine & Life Sciences
alpha-Synuclein Medicine & Life Sciences
Genes Medicine & Life Sciences
Proteins Medicine & Life Sciences
Supravalvular Aortic Stenosis Chemical Compounds
Neurodegenerative Diseases Medicine & Life Sciences

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Research Output 1993 2017

Dopamine oxidation mediates a human-specific cascade of mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C., Strojny, C., Savas, J., Kiskinis, E., Zhuang, X., Kruger, R., Surmeier, J. D. & Krainc, D. 2017 In : Science.

Research output: Contribution to journalArticle

Lysosomal Proteins as a Therapeutic Target in Neurodegeneration

Mc Donald, J. M. & Krainc, D. Jan 14 2017 In : Annual Review of Medicine. 68, p. 445-458 14 p.

Research output: Contribution to journalReview article

Lysosomal Storage Diseases
Neurodegenerative Diseases
Proteins
Supravalvular Aortic Stenosis
Submandibular Gland
3 Citations
Secretory Vesicles
Parkinson Disease
Proteins
Genes
Autophagy
4 Citations

α-synuclein toxicity in neurodegeneration: Mechanism and therapeutic strategies

Wong, Y. C. & Krainc, D. Feb 7 2017 In : Nature Medicine. 23, 2, p. 1-13 13 p.

Research output: Contribution to journalReview article

alpha-Synuclein
Supravalvular Aortic Stenosis
Parkinson Disease
Acrodermatitis
Multiple System Atrophy
14 Citations

Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson’s patient midbrain neurons

Mazzulli, J. R., Zunke, F., Tsunemi, T., Toker, N. J., Jeon, S., Burbulla, L. F., Patnaik, S., Sidransky, E., Marugan, J. J., Sue, C. M. & Krainc, D. Jul 20 2016 In : Journal of Neuroscience. 36, 29, p. 7693-7706 14 p.

Research output: Contribution to journalArticle

Glucosylceramidase
alpha-Synuclein
Mesencephalon
Neurons
Parkinson Disease