Grants per year
Personal profile
Research Interests
The overarching goal of our scientific work has been to define key molecular pathways in the pathogenesis of neurodegeneration and to uncover novel targets for therapeutic development. We have focused on pathogenic mechanisms that are commonly altered in neurodegenerative disorders such as deficient degradation of aggregation-prone proteins and mitochondrial dysfunction. As a general strategy, we study rare genetic diseases with mutations in genes that play a role in these key mechanisms and pathways. Models of Huntington’s, Parkinson’s and Gaucher’s disease have been utilized to examine if activation of cellular degradation pathways can lead to neuroprotection. To validate and study these findings in human neurons, we utilize induced pluripotent stem cells (iPS) generated by reprogramming of patient-specific skin fibroblasts. These iPS cells are differentiated into specific neuronal subtypes in order to characterize the interplay of genetic, epigenetic and environmental factors in disease pathogenesis. The ultimate goal of these studies is to develop targeted therapies for Parkinson’s and related neurodegenerative disorders.
Certifications and Licenses
| Neurology |
Training Experience
| 2000 | Residency, Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School |
| 2002 | Fellowship, Massachusetts General Hospital, Harvard Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Zagreb
… → 1992
Research interests keywords
- Aging
- Alzheimer's Disease
- Gene Regulation
- Movement Disorders
- Neurogenetics
- Neurology
- Neuroscience
- Parkinson’s Disease
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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The Edmond J. Safra Fellowship in Movement Disorders - Class of 2025
Simuni, T. (PD/PI), Bega, D. (Other), Goldman, J. G. (Other), Krainc, D. (Other) & Wu, A. D. (Other)
Michael J. Fox Foundation for Parkinson's Research
4/1/22 → 6/30/25
Project: Research project
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Mechanistic Analysis of Genetic Modifiers in Parkinson's Disease
Krainc, D. (PD/PI) & Krainc, D. (PD/PI)
National Institute of Neurological Disorders and Stroke
5/1/21 → 4/30/29
Project: Research project
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Neuronal roles of Parkinsons Disease Vps13C in regulating autophagy and calcium dynamics
Caraveo Piso, G. (PD/PI), Caraveo Piso, G. (PD/PI), Krainc, D. (PD/PI) & Krainc, D. (PD/PI)
National Institute of Neurological Disorders and Stroke
9/30/20 → 6/30/25
Project: Research project
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Nikon CSU W1 SoRa for the Center for Advanced Microscopy and Nikon Imaging Center at Northwestern University
Arvanitis, C. (PD/PI), Arispe, L. (Other), Chen, H. (Other), Gelfand, V. I. (Other), KIrchenbuechler, D. (Other), Krainc, D. (Other), Muller, W. A. (Other), Penzes, P. (Other), Varma, D. (Other) & Webber, J. L. (Other)
Office of the Director, National Institutes of Health
4/1/23 → 3/31/24
Project: Research project
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A GNAI1 Pathogenic Variant in a Case with GNAO1-Isolated Dystonia: A Modifier of Disease Severity?
Monje, M. H. G., Blackburn, J. S., Kinsley, L., Krainc, D. & Mencacci, N. E., May 2024, In: Movement Disorders. 39, 5, p. 918-920 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease
Gonzalez-Latapi, P., Bustos, B., Dong, S., Lubbe, S., Simuni, T. & Krainc, D., Jun 2024, In: Annals of neurology. 95, 6, p. 1162-1172 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cell biology of Parkinson's disease: Mechanisms of synaptic, lysosomal, and mitochondrial dysfunction
Brooker, S. M., Naylor, G. E. & Krainc, D., Apr 2024, In: Current opinion in neurobiology. 85, 102841.Research output: Contribution to journal › Review article › peer-review
10 Scopus citations -
De novo FRMD5 Missense Variants in Patients with Childhood-Onset Ataxia, Prominent Nystagmus, and Seizures
Keller Sarmiento, I. J., Bustos, B. I., Blackburn, J., Hac, N. E. F., Ruzhnikov, M., Monroe, M., Levy, R. J., Kinsley, L., Li, M., Silani, V., Lubbe, S. J., Krainc, D. & Mencacci, N. E., Jul 2024, In: Movement Disorders. 39, 7, p. 1231-1236 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Diverse Functions of Parkin in Midbrain Dopaminergic Neurons
Song, P. & Krainc, D., Aug 2024, In: Movement Disorders. 39, 8, p. 1282-1288 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy
Charif, M. (Creator), Wong, Y. C. (Creator), Kim, S. (Contributor), Guichet, A. (Creator), Vignal, C. (Creator), Zanlonghi, X. (Creator), Bensaid, P. (Creator), Procaccio, V. (Creator), Bonneau, D. (Creator), Amati-Bonneau, P. (Creator), Reynier, P. (Creator), Krainc, D. (Creator) & Lenaers, G. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5319642, https://springernature.figshare.com/collections/Dominant_mutations_in_MIEF1_affect_mitochondrial_dynamics_and_cause_a_singular_late_onset_optic_neuropathy/5319642
Dataset
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5LVX : Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator
Zheng, J. (Contributor), Chen, L. (Contributor), Skinner, O. S. (Contributor), Lansbury, P. (Contributor), Skerlj, R. (Contributor), Mrosek, M. (Contributor), Heunisch, U. (Contributor), Krapp, S. (Contributor), Charrow, J. (Contributor), Schwake, M. (Contributor), Kelleher, N. L. (Contributor), Silverman, R. B. (Contributor) & Krainc, D. (Contributor), RCSB-PDB, 2017
DOI: 10.2210/pdb5lvx/pdb, https://www.rcsb.org/structure/5LVX
Dataset
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Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator
Zheng, J. (Contributor), Chen, L. (Contributor), Skinner, O. S. (Contributor), Ysselstein, D. (Contributor), Remis, J. (Contributor), Lansbury, P. (Contributor), Skerlj, R. (Contributor), Mrosek, M. (Contributor), Heunisch, U. (Contributor), Krapp, S. (Contributor), Charrow, J. (Contributor), Schwake, M. (Contributor), Kelleher, N. L. (Contributor), Silverman, R. B. (Contributor) & Krainc, D. (Contributor), Protein Data Bank (PDB), Oct 25 2017
DOI: 10.2210/pdb5LVX/pdb, https://www.wwpdb.org/pdb?id=pdb_00005lvx
Dataset
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Lipids bound lysosomal integral membrane protein 2
Conrad, K. S. (Contributor), Cheng, T.-W. (Contributor), Ysselstein, D. (Contributor), Heybrock, S. (Contributor), Hoth, L. R. (Contributor), Chrunyk, B. A. (Contributor), Am Ende, C. W. (Contributor), Krainc, D. (Contributor), Schwake, M. (Contributor), Saftig, P. (Contributor), Liu, S. (Contributor), Qiu, X. (Contributor) & Ehlers, M. D. (Contributor), Protein Data Bank (PDB), Dec 13 2017
DOI: 10.2210/pdb5UPH/pdb, https://www.wwpdb.org/pdb?id=pdb_00005uph
Dataset
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Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson's disease
Arena, G. (Contributor), Landoulsi, Z. (Contributor), Grossmann, D. (Contributor), Vitali, A. (Contributor), Delcambre, S. (Contributor), Baron, A. (Contributor), Antony, P. (Contributor), Boussaad, I. (Contributor), Bobbili, D. R. (Contributor), Kumar Sreelatha, A. A. (Contributor), Pavelka, L. (Contributor), Klein, C. (Contributor), Seibler, P. (Contributor), Glaab, E. (Contributor), Sharma, M. (Contributor), Krüger, R. (Contributor), May, P. (Contributor), Grünewald, A. (Contributor), Hundt, A. (Contributor), Bisdorff, A. (Contributor), Sharify, A. (Contributor), Hanff, A.-M. (Contributor), Rauschenberger, A. (Contributor), Nicolai, B. (Contributor), Mollenhauer, B. (Contributor), Bellora, C. (Contributor), Moreno, C. (Contributor), Mediouni, C. (Contributor), Trefois, C. (Contributor), Pauly, C. (Contributor), Mackay, C. (Contributor), Gomes, C. (Contributor), Berg, D. (Contributor), Esteves, D. (Contributor), McIntyre, D. (Contributor), Reddy Bobbili, D. (Contributor), Rosales, E. (Contributor), Soboleva, E. (Contributor), Gómez De Lope, E. (Contributor), Thiry, E. (Contributor), Henry, E. (Contributor), Sandt, E. (Contributor), Wollscheid-Lengeling, E. (Contributor), Meisch, F. (Contributor), Mühlschlegel, F. (Contributor), Hammot, G. (Contributor), Acharya, G. (Contributor), Zelimkhanov, G. (Contributor), Contesotto, G. (Contributor), Aguayo, G. (Contributor), Marques, G. (Contributor), Berchem, G. (Contributor), Fagherazzi, G. (Contributor), Thien, H. (Contributor), Liepelt, I. (Contributor), Rosety, I. (Contributor), Jaroslaw Lebioda, J. (Contributor), Schweitzer, J.-E. (Contributor), Nicolay, J.-P. (Contributor), Ferrand, J.-Y. (Contributor), Schwamborn, J. (Contributor), Graas, J. (Contributor), Calmes, J. (Contributor), Klucken, J. (Contributor), Trouet, J. (Contributor), Sokolowska, K. (Contributor), Brockmann, K. (Contributor), Marcus, K. (Contributor), Beaumont, K. (Contributor), Rump, K. (Contributor), Longhino, L. (Contributor), Pauly, L. (Contributor), Vilas Boas, L. (Contributor), Hansen, L. (Contributor), Castillo, L. (Contributor), Perquin, M. (Contributor), Vyas, M. (Contributor), Gantenbein, M. (Contributor), Ostaszewski, M. (Contributor), Schmitt, M. (Contributor), Graziano, M. (Contributor), Giraitis, M. (Contributor), Minelli, M. (Contributor), Hansen, M. (Contributor), Valenti, M. (Contributor), Heneka, M. (Contributor), Heymann, M. (Contributor), Mittelbronn, M. (Contributor), Vaillant, M. (Contributor), Bassis, M. (Contributor), Hu, M. (Contributor), Ali, M. (Contributor), Alexandre, M. (Contributor), Menster, M. (Contributor), Jacoby, N. (Contributor), Diederich, N. (Contributor), Tsurkalenko, O. (Contributor), Terwindt, O. (Contributor), Martins Conde, P. (Contributor), Wilmes, P. (Contributor), Lupu, P. C. (Contributor), Lambert, P. (Contributor), Gawron, P. (Contributor), Klopfenstein, Q. (Contributor), Rawal, R. (Contributor), Ting Jiin Loo, R. (Contributor), Becker, R. (Contributor), Schneider, R. (Contributor), Dondelinger, R. (Contributor), Wade-Martins, R. (Contributor), Liszka, R. (Contributor), Nati, R. (Contributor), Ramos Lima, R. (Contributor), Lentz, R. (Contributor), Balling, R. (Contributor), Schmitz, S. (Contributor), Nickels, S. (Contributor), Herzinger, S. (Contributor), Pachchek, S. (Contributor), Ghosh, S. (Contributor), Sapienza, S. (Contributor), Herbrink, S. (Contributor), Marques, T. (Contributor), Gasser, T. (Contributor), Nehrbass, U. (Contributor), Groues, V. (Contributor), Satagopam, V. (Contributor), Lorentz, V. (Contributor), Maetzler, W. (Contributor), Gu, W. (Contributor), Ammerlann, W. (Contributor), Jaroz, Y. (Contributor), Koks, S. (Contributor), Mellick, G. D. (Contributor), Pirker, W. (Contributor), Zimprich, A. (Contributor), Lang, A. E. (Contributor), Rogaeva, E. (Contributor), Taba, P. (Contributor), Brice, A. (Contributor), Chartier-Harlin, M.-C. (Contributor), Corvol, J.-C. (Contributor), Domenighetti, C. (Contributor), Elbaz, A. (Contributor), Lesage, S. (Contributor), Mutez, E. (Contributor), Sugier, P.-E. (Contributor), Grover, S. (Contributor), Brockmann, K. (Contributor), Deutschlander, A. B. (Contributor), Gasser, T. (Contributor), Kruger, J. (Contributor), Lichtner, P. (Contributor), Radivojkov-Blagojevic, M. (Contributor), Schulte, C. (Contributor), Sharma, M. (Contributor), Dardiotis, E. (Contributor), Hadjigeorgiou, G. M. (Contributor), Simitsi, A. M. (Contributor), Stefanis, L. (Contributor), Annesi, G. (Contributor), Brighina, L. (Contributor), Ferrarese, C. (Contributor), Petrucci, S. (Contributor), Pezzoli, G. (Contributor), Quattrone, A. (Contributor), Straniero, L. (Contributor), Gagliardi, M. (Contributor), Valente, E. M. (Contributor), Zecchinelli, A. (Contributor), Hattori, N. (Contributor), Nakayama, A. (Contributor), Matsuo, H. (Contributor), Nishioka, K. (Contributor), Bobbili, D. (Contributor), Bloem, B. R. (Contributor), van de Warrenburg, B. P. C. (Contributor), Aasly, J. (Contributor), Pihlstrom, L. (Contributor), Toft, M. (Contributor), Ferreira, J. J. (Contributor), Correia Guedes, L. (Contributor), Bardien, S. (Contributor), Carr, J. (Contributor), Chung, S. J. (Contributor), Kim, Y. J. (Contributor), Diez-Fairen, M. (Contributor), Ezquerra, M. (Contributor), Pastor, P. (Contributor), Tolosa, E. (Contributor), Belin, A. C. (Contributor), Pedersen, N. L. (Contributor), Puschmann, A. (Contributor), Ran, C. (Contributor), Rodstrom, E. Y. (Contributor), Wirdefeldt, K. (Contributor), Clarke, C. E. (Contributor), Morrison, K. E. (Contributor), Tan, M. (Contributor), Edsall, C. (Contributor), Farrer, M. J. (Contributor), Krainc, D. (Contributor), Singleton, A. B. (Contributor), Burbulla, L. F. (Contributor), Hernandez, D. G. (Contributor) & Consortia, T.N.-P. A.C.-P. (Creator), ZENODO, 2023
DOI: 10.5281/zenodo.7973685, https://zenodo.org/record/7973685
Dataset