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Dimitri Krainc

  • 20793 Citations
1993 …2020

Research output per year

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Personal profile

Research Interests

The overarching goal of our scientific work has been to define key molecular pathways in the pathogenesis of neurodegeneration and to uncover novel targets for therapeutic development. We have focused on pathogenic mechanisms that are commonly altered in neurodegenerative disorders such as deficient degradation of aggregation-prone proteins and mitochondrial dysfunction. As a general strategy, we study rare genetic diseases with mutations in genes that play a role in these key mechanisms and pathways. Models of Huntington’s, Parkinson’s and Gaucher’s disease have been utilized to examine if activation of cellular degradation pathways can lead to neuroprotection. To validate and study these findings in human neurons, we utilize induced pluripotent stem cells (iPS) generated by reprogramming of patient-specific skin fibroblasts. These iPS cells are differentiated into specific neuronal subtypes in order to characterize the interplay of genetic, epigenetic and environmental factors in disease pathogenesis. The ultimate goal of these studies is to develop targeted therapies for Parkinson’s and related neurodegenerative disorders.

Certifications and Licenses

Neurology

Training Experience

2000Residency, Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School
2002Fellowship, Massachusetts General Hospital, Harvard Medical School

Education/Academic qualification

MD, University of Zagreb

… → 1992

Research interests

  • Aging
  • Alzheimer's Disease
  • Gene Regulation
  • Movement Disorders
  • Neurogenetics
  • Neurology
  • Neuroscience
  • Parkinson’s Disease

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Grants

2019 and 2020 – Parkinson's Foundation Institutional MDS Training Award

Krainc, D., Mencacci, N. E., Simuni, T. & Zadikoff, C.

Parkinson's Foundation, Inc.

7/1/19 → 6/30/21

Project: Research project

    • Convergence of LRRK2 and GBA1 in the pathogenesis of Parkinson' Disease

    Krainc, D.

    The Michael J Fox Foundation for Parkinson's Research

    6/10/19 → 6/9/21

    Project: Research project

    • Neuronal Regulation of Mitochondria-Lysosome Contact Sites

    Krainc, D.

    Warren Alpert Foundation

    4/1/19 → 3/31/21

    Project: Research project

    • Molecular mechanisms underlying mitochondria-lysosome membrane contact sites in neuronal function and neurodegeneration

    Krainc, D.

    National Institute of Neurological Disorders and Stroke

    9/30/18 → 8/31/20

    Project: Research project

    • Genotype-phenotype analysis and therapeutic development for Parkinson’s disease

    Krainc, D.

    Wanxiang America Corporation

    2/1/18 → 2/1/21

    Project: Research project

    • Research Output

    Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (Nature Neuroscience, (2020), 23, 1, (15-20), 10.1038/s41593-019-0556-3)

    Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Feb 1 2020, In : Nature Neuroscience. 23, 2, 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access

    • Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

    Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature neuroscience. 23, 1, p. 15-20 6 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture

    Godbe, J. M., Freeman, R., Burbulla, L. F., Lewis, J., Krainc, D. & Stupp, S. I., Feb 10 2020, In : ACS Biomaterials Science and Engineering. 6, 2, p. 1196-1207 12 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery

    Marotta, N., Kim, S. & Krainc, D., Apr 2 2020, In : Expert Opinion on Drug Discovery. 15, 4, p. 427-441 15 p.

    Research output: Contribution to journal › Review article

    • 3 Scopus citations

    Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity

    Valdez, C., Ysselstein, D., Young, T. J., Zheng, J. & Krainc, D., Mar 27 2020, In : Human molecular genetics. 29, 5, p. 716-726 11 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations