• 19302 Citations
1993 …2022
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Research Output 1993 2020

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2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature Neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Electron Transport
Dopamine
Mitochondrial Membranes
Hydrogen Peroxide
2019
2 Citations (Scopus)
Glucosylceramidase
Parkinson Disease
Phenotype
Mutation
Synucleins
3 Citations (Scopus)

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship

Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes

Trajkovic, K., Valdez, C., Ysselstein, D. & Krainc, D., Feb 2019, In : PloS one. 14, 2, e0211727.

Research output: Contribution to journalArticle

Cell Count
Cells
Focal Adhesion Protein-Tyrosine Kinases
Proteins
Cell culture
6 Citations (Scopus)

Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity

Tsunemi, T., Perez-Rosello, T., Ishiguro, Y., Yoroisaka, A., Jeon, S., Hamada, K., Rammonhan, M., Wong, Y. C., Xie, Z., Akamatsu, W., Mazzulli, J., Surmeier Jr, D. J., Hattori, N. & Krainc, D., Jul 17 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 29, p. 5760-5772 13 p.

Research output: Contribution to journalArticle

Synucleins
Dopaminergic Neurons
Exocytosis
Parkinson Disease
Neurons
3 Citations (Scopus)

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Ysselstein, D., Nguyen, M., Young, T. J., Severino, A., Schwake, M., Merchant, K. & Krainc, D., Dec 1 2019, In : Nature communications. 10, 1, 5570.

Research output: Contribution to journalArticle

Open Access
Glucosylceramidase
Parkinson disease
neurons
Neurons
Parkinson Disease
2 Citations (Scopus)

Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2

Wong, Y. C., Peng, W. & Krainc, D., Aug 5 2019, In : Developmental Cell. 50, 3, p. 339-354.e4

Research output: Contribution to journalArticle

Guanosine Triphosphate
Tooth
Mitochondria
Hydrolysis
Mitochondrial Dynamics
2018
14 Citations (Scopus)

Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function

Kim, M. J., Jeon, S., Burbulla, L. F. & Krainc, D., Jun 1 2018, In : Human molecular genetics. 27, 11, p. 1972-1988 17 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Synucleins
Ceramides
Glucosylceramidase
Parkinson Disease
3 Citations (Scopus)

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

Causevic, M., Dominko, K., Malnar, M., Vidatic, L., Cermak, S., Pigoni, M., Kuhn, P. H., Colombo, A., Havas, D., Flunkert, S., McDonald, J., Gunnersen, J. M., Hutter-Paier, B., Tahirovic, S., Windisch, M., Krainc, D., Lichtenthaler, S. F. & Hecimovic, S., Jul 2018, In : PloS one. 13, 7, e0200344.

Research output: Contribution to journalArticle

Type C Niemann-Pick Disease
seizures
Brain
Seizures
brain
6 Citations (Scopus)

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Münchau, A., Krainc, D. & Klein, C., Oct 1 2018, In : Brain. 141, 10, p. 3052-3064 13 p.

Research output: Contribution to journalArticle

Iron Overload
Iron
Autophagy
Oxidative Stress
Induced Pluripotent Stem Cells
22 Citations (Scopus)
Auxilins
Dopaminergic Neurons
Leucine
Parkinson Disease
Synaptic Vesicles
105 Citations (Scopus)

Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

Wong, Y. C., Ysselstein, D. & Krainc, D., Feb 15 2018, In : Nature. 554, 7692, p. 382-386 5 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Guanosine Triphosphate
Lysosomes
Mitochondria
Hydrolysis
13 Citations (Scopus)

Recessive mutations in >VPS13D cause childhood onset movement disorders

Gauthier, J., Meijer, I. A., Lessel, D., Mencacci, N. E., Krainc, D., Hempel, M., Tsiakas, K., Prokisch, H., Rossignol, E., Helm, M. H., Rodan, L. H., Karamchandani, J., Carecchio, M., Lubbe, S. J., Telegrafi, A., Henderson, L. B., Lorenzo, K., Wallace, S. E., Glass, I. A., Hamdan, F. F. & 3 others, Michaud, J. L., Rouleau, G. A. & Campeau, P. M., Jun 2018, In : Annals of neurology. 83, 6, p. 1089-1095 7 p.

Research output: Contribution to journalArticle

Movement Disorders
Neuroacanthocytosis
Leigh Disease
Spastic Paraparesis
Lipidoses
7 Citations (Scopus)

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

Zheng, J., Chen, L., Skinner, O. S., Ysselstein, D., Remis, J., Lansbury, P., Skerlj, R., Mrosek, M., Heunisch, U., Krapp, S., Charrow, J., Schwake, M., Kelleher, N. L., Silverman, R. B. & Krainc, D., May 9 2018, In : Journal of the American Chemical Society. 140, 18, p. 5914-5924 11 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Allosteric Site
Dimerization
Binding sites
Modulators
2017
17 Citations (Scopus)

Analysis of blood-based gene expression in idiopathic Parkinson disease

Shamir, R., Klein, C., Amar, D., Vollstedt, E. J., Bonin, M., Usenovic, M., Wong, Y. C., Maver, A., Poths, S., Safer, H., Corvol, J. C., Lesage, S., Lavi, O., Deuschl, G., Kuhlenbaeumer, G., Pawlack, H., Ulitsky, I., Kasten, M., Riess, O., Brice, A. & 2 others, Peterlin, B. & Krainc, D., Oct 17 2017, In : Neurology. 89, 16, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Gene Expression
Genes
Area Under Curve
Down-Regulation

Dopamine oxidation mediates a human-specific cascade of mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C., Strojny, C., Savas, J., Kiskinis, E., Zhuang, X., Kruger, R., Surmeier, J. D. & Krainc, D., 2017, In : Science.

Research output: Contribution to journalArticle

159 Citations (Scopus)

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L., Song, P., Mazzulli, J., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier Jr, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Dopamine
Synucleins
Neurons
Glucosylceramidase
3 Citations (Scopus)

Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies

Völker, J. M., Dergai, M., Abriata, L. A., Mingard, Y., Ysselstein, D., Krainc, D., Peraro, M. D., Von Mollard, G. F., Fasshauer, D., Koliwer, J. & Schwake, M., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1391-1398 8 p.

Research output: Contribution to journalArticle

Progressive Myoclonic Epilepsy
SNARE Proteins
Virulence
Assays
Mutation
11 Citations (Scopus)

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

Al-Ramahi, I., Giridharan, S. S. P., Chen, Y. C., Patnaik, S., Safren, N., Hasegawa, J., de Haro, M., Gee, A. K. W., Titus, S. A., Jeong, H., Clarke, J., Krainc, D., Zheng, W., Irvine, R. F., Barmada, S., Ferrer, M., Southall, N., Weisman, L. S., Botas, J. & Marugan, J. J., Dec 26 2017, In : eLife. 6, e29123.

Research output: Contribution to journalArticle

Huntington Disease
Mutant Proteins
Autophagy
Proteins
Pharmacology
8 Citations (Scopus)

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

Conrad, K. S., Cheng, T. W., Ysselstein, D., Heybrock, S., Hoth, L. R., Chrunyk, B. A., Am Ende, C. W., Krainc, D., Schwake, M., Saftig, P., Liu, S., Qiu, X. & Ehlers, M. D., Dec 1 2017, In : Nature communications. 8, 1, 1908.

Research output: Contribution to journalArticle

Lysosome-Associated Membrane Glycoproteins
Glucosylceramidase
Phosphatidylserines
Phosphatidylcholines
Phospholipids
15 Citations (Scopus)

Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway

Trajkovic, K., Jeong, H. & Krainc, D., Jan 1 2017, In : Journal of Neuroscience. 37, 37, p. 9000-9012 13 p.

Research output: Contribution to journalArticle

Secretory Pathway
Endosomes
Lysosomes
Synaptotagmins
Phosphatidylinositol 3-Kinase
17 Citations (Scopus)

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G., Wszolek, Z. K. & Krainc, D., Dec 1 2017, In : Human molecular genetics. 26, 24, p. 4861-4872 12 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Frontotemporal Dementia
Cathepsin D
Phenotype
Neurons
18 Citations (Scopus)
Secretory Vesicles
Parkinson Disease
Autophagy
Proteins
Genes
2016
81 Citations (Scopus)

Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson’s patient midbrain neurons

Mazzulli, J. R., Zunke, F., Tsunemi, T., Toker, N. J., Jeon, S., Burbulla, L. F., Patnaik, S., Sidransky, E., Marugan, J. J., Sue, C. M. & Krainc, D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7693-7706 14 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Mesencephalon
Neurons
Parkinson Disease
6 Citations (Scopus)

Challenges to neurology residency education in today's health care environment

Bega, D. & Krainc, D., Sep 1 2016, In : Annals of neurology. 80, 3, p. 315-320 6 p.

Research output: Contribution to journalArticle

Neurology
Internship and Residency
Delivery of Health Care
Education
Teaching
20 Citations (Scopus)

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Zunke, F., Andresen, L., Wesseler, S., Groth, J., Arnold, P., Rothaug, M., Mazzulli, J. R., Krainc, D., Blanz, J., Saftig, P. & Schwake, M., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3791-3796 6 p.

Research output: Contribution to journalArticle

Lysosome-Associated Membrane Glycoproteins
Glucosylceramidase
Gaucher Disease
Parkinson Disease
Peptides
5 Citations (Scopus)

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

Zheng, J., Chen, L., Schwake, M., Silverman, R. B. & Krainc, D., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8508-8520 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Gaucher Disease
Parkinson Disease
Lewy Body Disease
15 Citations (Scopus)

Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence

Mazzulli, J. R., Burbulla, L. F., Krainc, D. & Ischiropoulos, H., Feb 16 2016, In : Analytical Chemistry. 88, 4, p. 2399-2405 7 p.

Research output: Contribution to journalArticle

Quinones
Dopamine
Fluorescence
Infrared radiation
Proteins
16 Citations (Scopus)

Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism

Domingo, A., Amar, D., Grütz, K., Lee, L. V., Rosales, R., Brüggemann, N., Jamora, R. D., Cutiongco-dela Paz, E., Rolfs, A., Dressler, D., Walter, U., Krainc, D., Lohmann, K., Shamir, R., Klein, C. & Westenberger, A., Aug 1 2016, In : Cellular and Molecular Life Sciences. 73, 16, p. 3205-3215 11 p.

Research output: Contribution to journalArticle

TATA-Binding Protein Associated Factors
TATA-Box Binding Protein
Genes
Gene Expression
Gene Ontology
111 Citations (Scopus)

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease

Hsieh, C. H., Shaltouki, A., Gonzalez, A. E., Bettencourt da Cruz, A., Burbulla, L. F., St. Lawrence, E., Schüle, B., Krainc, D., Palmer, T. D. & Wang, X., Dec 1 2016, In : Cell Stem Cell. 19, 6, p. 709-724 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Parkinson Disease
Mitochondria
Neurons
Induced Pluripotent Stem Cells
88 Citations (Scopus)

Identification of TMEM230 mutations in familial Parkinson's disease

Deng, H. X., Shi, Y., Yang, Y., Ahmeti, K. B., Miller, N., Huang, C., Cheng, L., Zhai, H., Deng, S., Nuytemans, K., Corbett, N. J., Kim, M. J., Deng, H., Tang, B., Yang, Z., Xu, Y., Chan, P., Huang, B., Gao, X. P., Song, Z. & 14 others, Liu, Z., Fecto, F., Siddique, N., Foroud, T., Jankovic, J., Ghetti, B., Nicholson, D. A., Krainc, D., Melen, O., Vance, J. M., Pericak-Vance, M. A., Ma, Y. C., Rajput, A. H. & Siddique, T., Jul 1 2016, In : Nature Genetics. 48, 7, p. 733-739 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Synaptic Vesicles
Chromosomes, Human, Pair 20
Neurons
24 Citations (Scopus)

Lysosomal trafficking defects link Parkinson’s disease with Gaucher’s disease

Wong, Y. C. & Krainc, D., Nov 1 2016, In : Movement Disorders. 31, 11, p. 1610-1618 9 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Gaucher Disease
Synucleins
Parkinson Disease
Hydrolases
11 Citations (Scopus)
Induced Pluripotent Stem Cells
Stem cells
Neurons
Growth
Pathologic Processes
61 Citations (Scopus)

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Chung, S. Y., Kishinevsky, S., Mazzulli, J. R., Graziotto, J., Mrejeru, A., Mosharov, E. V., Puspita, L., Valiulahi, P., Sulzer, D., Milner, T. A., Taldone, T., Krainc, D., Studer, L. & Shim, J. W., Oct 11 2016, In : Stem cell reports. 7, 4, p. 664-677 14 p.

Research output: Contribution to journalArticle

Synucleins
Induced Pluripotent Stem Cells
Dopaminergic Neurons
Mesencephalon
Stem cells
40 Citations (Scopus)

Parkin modulates endosomal organization and function of the endo-lysosomal pathway

Song, P., Trajkovic, K., Tsunemi, T. & Krainc, D., Feb 24 2016, In : Journal of Neuroscience. 36, 8, p. 2425-2437 13 p.

Research output: Contribution to journalArticle

Exosomes
Sorting Nexins
Mitochondrial Degradation
IGF Type 2 Receptor
Ubiquitin-Protein Ligases
111 Citations (Scopus)
Synucleins
Protein Transport
Mesencephalon
Parkinson Disease
Hydrolases
2014
83 Citations (Scopus)

ATP13A2/PARK9 regulates secretion of exosomes and α-Synuclein

Tsunemi, T., Hamada, K. & Krainc, D., Nov 12 2014, In : Journal of Neuroscience. 34, 46, p. 15281-15287 7 p.

Research output: Contribution to journalArticle

Synucleins
Exosomes
Multivesicular Bodies
Extracellular Space
Parkinsonian Disorders
53 Citations (Scopus)

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Rothaug, M., Zunke, F., Mazzulli, J. R., Schweizer, M., Altmeppen, H., Lüllmann-Rauche, R., Kallemeijn, W. W., Gaspar, P., Aerts, J. M., Glatzel, M., Saftig, P., Krainc, D., Schwake, M. & Blanz, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15573-15578 6 p.

Research output: Contribution to journalArticle

Synucleins
Lysosome-Associated Membrane Glycoproteins
Glucosylceramidase
Gaucher Disease
Dopaminergic Neurons
27 Citations (Scopus)

The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models

Knight, A. L., Yan, X., Hamamichi, S., Ajjuri, R. R., Mazzulli, J., Zhang, M. W., Daigle, J. G., Zhang, S., Borom, A. R., Roberts, L. R., Lee, S. K., DeLeon, S. M., Viollet-Djelassi, C., Krainc, D., O'Donnell, J. M., Caldwell, K. A. & Caldwell, G. A., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 145-157 13 p.

Research output: Contribution to journalArticle

Synucleins
Insulin-Like Growth Factor I
Enzymes
Insulin
Glucose
77 Citations (Scopus)

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

Tsunemi, T. & Krainc, D., 2014, In : Human Molecular Genetics. 23, 11, p. 2791-2801 11 p., ddt572.

Research output: Contribution to journalArticle

alpha-Synuclein
Zinc
Synucleins
Clioquinol
Glucosylceramidase
2013
74 Citations (Scopus)

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

Schultheis, P. J., Fleming, S. M., Clippinger, A. K., Lewis, J., Tsunemi, T., Giasson, B., Dickson, D. W., Mazzulli, J. R., Bardgett, M. E., Haik, K. L., Ekhator, O., Chava, A. K., Howard, J., Gannon, M., Hoffman, E., Chen, Y., Prasad, V., Linn, S. C., Tamargo, R. J., Westbroek, W. & 3 others, Sidransky, E., Krainc, D. & Shull, G. E., May 1 2013, In : Human molecular genetics. 22, 10, p. 2067-2082 16 p., ddt057.

Research output: Contribution to journalArticle

Synucleins
Neuronal Ceroid-Lipofuscinoses
Lipofuscin
Cerebellum
Parkinson Disease
31 Citations (Scopus)

Glucocerebrosidase mutations in a Serbian Parkinson's disease population

Kumar, K. R., Ramirez, A., Göbel, A., Kresojević, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V. & Grünewald, A., Feb 1 2013, In : European Journal of Neurology. 20, 2, p. 402-405 4 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Parkinson Disease
Mutation
Population
Haplotypes
323 Citations (Scopus)

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J. W., Kriks, S., Taldone, T., Fusaki, N., Tomishima, M. J., Krainc, D., Milner, T. A., Rossi, D. J. & Studer, L., Dec 5 2013, In : Cell Stem Cell. 13, 6, p. 691-705 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Parkinson Disease
Lamin Type A
Premature Aging
Phenotype
255 Citations (Scopus)

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., Mungenast, A. E., Muffat, J., Mitalipova, M., Pluth, M. D., Jui, N. T., Schul̈e, B., Lippard, S. J., Tsai, L. H., Krainc, D., Buchwald, S. L. & 2 others, Jaenisch, R. & Lindquist, S., Jan 1 2013, In : Science. 342, 6161, p. 983-987 5 p.

Research output: Contribution to journalArticle

Synucleins
Induced Pluripotent Stem Cells
Yeasts
Neurons
Parkinson Disease
15 Citations (Scopus)

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Li, X., Uemura, K., Hashimoto, T., Nasser-Ghodsi, N., Arimon, M., Lill, C. M., Palazzolo, I., Krainc, D., Hyman, B. T. & Berezovska, O., Feb 1 2013, In : Neurobiology of Disease. 50, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

Presenilin-1
Amyloid beta-Protein Precursor
Amyloid
Amyloid Precursor Protein Secretases
Alzheimer Disease
4 Citations (Scopus)

Pharmacological upregulation of pgc1α in oligodendrocytes: Implications for huntington’s disease

Xiang, Z. & Krainc, D., Jan 1 2013, In : Journal of Huntington's Disease. 2, 1, p. 101-105 5 p.

Research output: Contribution to journalArticle

Huntington Disease
Oligodendroglia
Up-Regulation
Pharmacology
Energy Metabolism
136 Citations (Scopus)

Phosphatase and tensin homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent ubiquitination of endogenous parkin attenuates mitophagy: Study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D. & Klein, C., Jan 25 2013, In : Journal of Biological Chemistry. 288, 4, p. 2223-2237 15 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Induced Pluripotent Stem Cells
Ubiquitination
Fibroblasts
Stem cells
77 Citations (Scopus)

Targeting H3K4 trimethylation in Huntington disease

Vashishtha, M., Ng, C. W., Yildirim, F., Gipson, T. A., Kratter, I. H., Bodai, L., Song, W., Lau, A., Labadorf, A., Vogel-Ciernia, A., Troncosco, J., Ross, C. A., Bates, G. P., Krainc, D., Sadri-Vakili, G., Finkbeiner, S., Lawrence Marsh, J., Housman, D. E., Fraenkel, E. & Thompson, L. M., Aug 6 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. E3027-E3036

Research output: Contribution to journalArticle

Huntington Disease
Neurons
Epigenomics
Histones
Genes
2012
157 Citations (Scopus)

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

Usenovic, M., Tresse, E., Mazzulli, J. R., Taylor, J. P. & Krainc, D., Mar 21 2012, In : Journal of Neuroscience. 32, 12, p. 4240-4246 7 p.

Research output: Contribution to journalArticle

Synucleins
Neurons
Lysosome-Associated Membrane Glycoproteins
Lewy Bodies
Mutation
20 Citations (Scopus)

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Palada, V., Terzić, J., Mazzulli, J., Bwala, G., Hagenah, J., Peterlin, B., Hung, A. Y., Klein, C. & Krainc, D., Apr 2012, In : Neurobiology of Aging. 33, 4, p. 836.e1-836.e3

Research output: Contribution to journalArticle

Histamine N-Methyltransferase
Parkinson Disease
Histamine
Neurotransmitter Agents
Meta-Analysis