• 20571 Citations
1993 …2020

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2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture

Godbe, J. M., Freeman, R., Burbulla, L. F., Lewis, J., Krainc, D. & Stupp, S. I., Feb 10 2020, In : ACS Biomaterials Science and Engineering. 6, 2, p. 1196-1207 12 p.

Research output: Contribution to journalArticle

Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity

Valdez, C., Ysselstein, D., Young, T. J., Zheng, J. & Krainc, D., Mar 27 2020, In : Human molecular genetics. 29, 5, p. 716-726 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019
7 Scopus citations

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L. F., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes

Trajkovic, K., Valdez, C., Ysselstein, D. & Krainc, D., Feb 2019, In : PloS one. 14, 2, e0211727.

Research output: Contribution to journalArticle

1 Scopus citations

Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity

Tsunemi, T., Perez-Rosello, T., Ishiguro, Y., Yoroisaka, A., Jeon, S., Hamada, K., Rammonhan, M., Wong, Y. C., Xie, Z., Akamatsu, W., Mazzulli, J., Surmeier Jr, D. J., Hattori, N. & Krainc, D., Jul 17 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 29, p. 5760-5772 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Ysselstein, D., Nguyen, M., Young, T. J., Severino, A., Schwake, M., Merchant, K. & Krainc, D., Dec 1 2019, In : Nature communications. 10, 1, 5570.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2

Wong, Y. C., Peng, W. & Krainc, D., Aug 5 2019, In : Developmental Cell. 50, 3, p. 339-354.e4

Research output: Contribution to journalArticle

5 Scopus citations
2018

Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function

Kim, M. J., Jeon, S., Burbulla, L. F. & Krainc, D., Jun 1 2018, In : Human molecular genetics. 27, 11, p. 1972-1988 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

Causevic, M., Dominko, K., Malnar, M., Vidatic, L., Cermak, S., Pigoni, M., Kuhn, P. H., Colombo, A., Havas, D., Flunkert, S., McDonald, J., Gunnersen, J. M., Hutter-Paier, B., Tahirovic, S., Windisch, M., Krainc, D., Lichtenthaler, S. F. & Hecimovic, S., Jul 2018, In : PloS one. 13, 7, e0200344.

Research output: Contribution to journalArticle

3 Scopus citations

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Münchau, A., Krainc, D. & Klein, C., Oct 1 2018, In : Brain. 141, 10, p. 3052-3064 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
32 Scopus citations

Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

Wong, Y. C., Ysselstein, D. & Krainc, D., Feb 15 2018, In : Nature. 554, 7692, p. 382-386 5 p.

Research output: Contribution to journalArticle

134 Scopus citations

Recessive mutations in >VPS13D cause childhood onset movement disorders

Gauthier, J., Meijer, I. A., Lessel, D., Mencacci, N. E., Krainc, D., Hempel, M., Tsiakas, K., Prokisch, H., Rossignol, E., Helm, M. H., Rodan, L. H., Karamchandani, J., Carecchio, M., Lubbe, S. J., Telegrafi, A., Henderson, L. B., Lorenzo, K., Wallace, S. E., Glass, I. A., Hamdan, F. F. & 3 others, Michaud, J. L., Rouleau, G. A. & Campeau, P. M., Jun 2018, In : Annals of neurology. 83, 6, p. 1089-1095 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

Zheng, J., Chen, L., Skinner, O. S., Ysselstein, D., Remis, J., Lansbury, P., Skerlj, R., Mrosek, M., Heunisch, U., Krapp, S., Charrow, J., Schwake, M., Kelleher, N. L., Silverman, R. B. & Krainc, D., May 9 2018, In : Journal of the American Chemical Society. 140, 18, p. 5914-5924 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Analysis of blood-based gene expression in idiopathic Parkinson disease

Shamir, R., Klein, C., Amar, D., Vollstedt, E. J., Bonin, M., Usenovic, M., Wong, Y. C., Maver, A., Poths, S., Safer, H., Corvol, J. C., Lesage, S., Lavi, O., Deuschl, G., Kuhlenbaeumer, G., Pawlack, H., Ulitsky, I., Kasten, M., Riess, O., Brice, A. & 2 others, Peterlin, B. & Krainc, D., Oct 17 2017, In : Neurology. 89, 16, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dopamine oxidation mediates a human-specific cascade of mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C., Strojny, C., Savas, J., Kiskinis, E., Zhuang, X., Kruger, R., Surmeier, J. D. & Krainc, D., 2017, In : Science.

Research output: Contribution to journalArticle

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.

Research output: Contribution to journalArticle

194 Scopus citations

Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies

Völker, J. M., Dergai, M., Abriata, L. A., Mingard, Y., Ysselstein, D., Krainc, D., Peraro, M. D., Von Mollard, G. F., Fasshauer, D., Koliwer, J. & Schwake, M., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1391-1398 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

Al-Ramahi, I., Giridharan, S. S. P., Chen, Y. C., Patnaik, S., Safren, N., Hasegawa, J., de Haro, M., Gee, A. K. W., Titus, S. A., Jeong, H., Clarke, J., Krainc, D., Zheng, W., Irvine, R. F., Barmada, S., Ferrer, M., Southall, N., Weisman, L. S., Botas, J. & Marugan, J. J., Dec 26 2017, In : eLife. 6, e29123.

Research output: Contribution to journalArticle

15 Scopus citations

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

Conrad, K. S., Cheng, T. W., Ysselstein, D., Heybrock, S., Hoth, L. R., Chrunyk, B. A., Am Ende, C. W., Krainc, D., Schwake, M., Saftig, P., Liu, S., Qiu, X. & Ehlers, M. D., Dec 1 2017, In : Nature communications. 8, 1, 1908.

Research output: Contribution to journalArticle

11 Scopus citations

Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway

Trajkovic, K., Jeong, H. & Krainc, D., Jan 1 2017, In : Journal of Neuroscience. 37, 37, p. 9000-9012 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G., Wszolek, Z. K. & Krainc, D., Dec 2017, In : Human molecular genetics. 26, 24, p. 4861-4872 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
20 Scopus citations
2016

Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson’s patient midbrain neurons

Mazzulli, J. R., Zunke, F., Tsunemi, T., Toker, N. J., Jeon, S., Burbulla, L. F., Patnaik, S., Sidransky, E., Marugan, J. J., Sue, C. M. & Krainc, D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7693-7706 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Challenges to neurology residency education in today's health care environment

Bega, D. & Krainc, D., Sep 1 2016, In : Annals of neurology. 80, 3, p. 315-320 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Zunke, F., Andresen, L., Wesseler, S., Groth, J., Arnold, P., Rothaug, M., Mazzulli, J. R., Krainc, D., Blanz, J., Saftig, P. & Schwake, M., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3791-3796 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

Zheng, J., Chen, L., Schwake, M., Silverman, R. B. & Krainc, D., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8508-8520 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence

Mazzulli, J. R., Burbulla, L. F., Krainc, D. & Ischiropoulos, H., Feb 16 2016, In : Analytical Chemistry. 88, 4, p. 2399-2405 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism

Domingo, A., Amar, D., Grütz, K., Lee, L. V., Rosales, R., Brüggemann, N., Jamora, R. D., Cutiongco-dela Paz, E., Rolfs, A., Dressler, D., Walter, U., Krainc, D., Lohmann, K., Shamir, R., Klein, C. & Westenberger, A., Aug 1 2016, In : Cellular and Molecular Life Sciences. 73, 16, p. 3205-3215 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease

Hsieh, C. H., Shaltouki, A., Gonzalez, A. E., Bettencourt da Cruz, A., Burbulla, L. F., St. Lawrence, E., Schüle, B., Krainc, D., Palmer, T. D. & Wang, X., Dec 1 2016, In : Cell Stem Cell. 19, 6, p. 709-724 16 p.

Research output: Contribution to journalArticle

132 Scopus citations

Identification of TMEM230 mutations in familial Parkinson's disease

Deng, H. X., Shi, Y., Yang, Y., Ahmeti, K. B., Miller, N., Huang, C., Cheng, L., Zhai, H., Deng, S., Nuytemans, K., Corbett, N. J., Kim, M. J., Deng, H., Tang, B., Yang, Z., Xu, Y., Chan, P., Huang, B., Gao, X. P., Song, Z. & 14 others, Liu, Z., Fecto, F., Siddique, N., Foroud, T., Jankovic, J., Ghetti, B., Nicholson, D. A., Krainc, D., Melen, O., Vance, J. M., Pericak-Vance, M. A., Ma, Y. C., Rajput, A. H. & Siddique, T., Jul 1 2016, In : Nature Genetics. 48, 7, p. 733-739 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Lysosomal trafficking defects link Parkinson’s disease with Gaucher’s disease

Wong, Y. C. & Krainc, D., Nov 1 2016, In : Movement Disorders. 31, 11, p. 1610-1618 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
12 Scopus citations

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Chung, S. Y., Kishinevsky, S., Mazzulli, J. R., Graziotto, J., Mrejeru, A., Mosharov, E. V., Puspita, L., Valiulahi, P., Sulzer, D., Milner, T. A., Taldone, T., Krainc, D., Studer, L. & Shim, J. W., Oct 11 2016, In : Stem cell reports. 7, 4, p. 664-677 14 p.

Research output: Contribution to journalArticle

72 Scopus citations

Parkin modulates endosomal organization and function of the endo-lysosomal pathway

Song, P., Trajkovic, K., Tsunemi, T. & Krainc, D., Feb 24 2016, In : Journal of Neuroscience. 36, 8, p. 2425-2437 13 p.

Research output: Contribution to journalArticle

52 Scopus citations
125 Scopus citations
2014

ATP13A2/PARK9 regulates secretion of exosomes and α-Synuclein

Tsunemi, T., Hamada, K. & Krainc, D., Nov 12 2014, In : Journal of Neuroscience. 34, 46, p. 15281-15287 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Rothaug, M., Zunke, F., Mazzulli, J. R., Schweizer, M., Altmeppen, H., Lüllmann-Rauche, R., Kallemeijn, W. W., Gaspar, P., Aerts, J. M., Glatzel, M., Saftig, P., Krainc, D., Schwake, M. & Blanz, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15573-15578 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models

Knight, A. L., Yan, X., Hamamichi, S., Ajjuri, R. R., Mazzulli, J. R., Zhang, M. W., Daigle, J. G., Zhang, S., Borom, A. R., Roberts, L. R., Lee, S. K., DeLeon, S. M., Viollet-Djelassi, C., Krainc, D., O'Donnell, J. M., Caldwell, K. A. & Caldwell, G. A., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 145-157 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

Tsunemi, T. & Krainc, D., 2014, In : Human Molecular Genetics. 23, 11, p. 2791-2801 11 p., ddt572.

Research output: Contribution to journalArticle

82 Scopus citations
2013

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

Schultheis, P. J., Fleming, S. M., Clippinger, A. K., Lewis, J., Tsunemi, T., Giasson, B., Dickson, D. W., Mazzulli, J. R., Bardgett, M. E., Haik, K. L., Ekhator, O., Chava, A. K., Howard, J., Gannon, M., Hoffman, E., Chen, Y., Prasad, V., Linn, S. C., Tamargo, R. J., Westbroek, W. & 3 others, Sidransky, E., Krainc, D. & Shull, G. E., May 1 2013, In : Human molecular genetics. 22, 10, p. 2067-2082 16 p., ddt057.

Research output: Contribution to journalArticle

78 Scopus citations

Glucocerebrosidase mutations in a Serbian Parkinson's disease population

Kumar, K. R., Ramirez, A., Göbel, A., Kresojević, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V. & Grünewald, A., Feb 1 2013, In : European Journal of Neurology. 20, 2, p. 402-405 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J. W., Kriks, S., Taldone, T., Fusaki, N., Tomishima, M. J., Krainc, D., Milner, T. A., Rossi, D. J. & Studer, L., Dec 5 2013, In : Cell Stem Cell. 13, 6, p. 691-705 15 p.

Research output: Contribution to journalArticle

348 Scopus citations

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., Mungenast, A. E., Muffat, J., Mitalipova, M., Pluth, M. D., Jui, N. T., Schul̈e, B., Lippard, S. J., Tsai, L. H., Krainc, D., Buchwald, S. L. & 2 others, Jaenisch, R. & Lindquist, S., Jan 1 2013, In : Science. 342, 6161, p. 983-987 5 p.

Research output: Contribution to journalArticle

264 Scopus citations

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Li, X., Uemura, K., Hashimoto, T., Nasser-Ghodsi, N., Arimon, M., Lill, C. M., Palazzolo, I., Krainc, D., Hyman, B. T. & Berezovska, O., Feb 1 2013, In : Neurobiology of Disease. 50, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pharmacological upregulation of pgc1α in oligodendrocytes: Implications for huntington’s disease

Xiang, Z. & Krainc, D., Jan 1 2013, In : Journal of Huntington's Disease. 2, 1, p. 101-105 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phosphatase and tensin homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent ubiquitination of endogenous parkin attenuates mitophagy: Study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D. & Klein, C., Jan 25 2013, In : Journal of Biological Chemistry. 288, 4, p. 2223-2237 15 p.

Research output: Contribution to journalArticle

144 Scopus citations

Targeting H3K4 trimethylation in Huntington disease

Vashishtha, M., Ng, C. W., Yildirim, F., Gipson, T. A., Kratter, I. H., Bodai, L., Song, W., Lau, A., Labadorf, A., Vogel-Ciernia, A., Troncosco, J., Ross, C. A., Bates, G. P., Krainc, D., Sadri-Vakili, G., Finkbeiner, S., Lawrence Marsh, J., Housman, D. E., Fraenkel, E. & Thompson, L. M., Aug 6 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. E3027-E3036

Research output: Contribution to journalArticle

81 Scopus citations