Grants per year
Personal profile
Research Interests
DNA and proteins are non-randomly localized within the nucleus of the cell. Professor Brickner's lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.
Education/Academic qualification
Biology/Biological Sciences, PhD, University of Michigan
… → 1999
Biology/Biological Sciences, BA, University of California, Santa Barbara
… → 1991
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Grants
- 3 Finished
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Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. (PD/PI) & Brickner, D. G. (Other)
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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DNA zip codes and the spatial organization of the yeast genome
Brickner, J. H. (PD/PI) & Brickner, D. G. (Other)
National Institute of General Medical Sciences
4/1/16 → 8/31/17
Project: Research project
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DNA zip codes and the spatial organization of the yeast genome
Brickner, J. H. (PD/PI) & Brickner, D. G. (Other)
National Institute of General Medical Sciences
4/1/13 → 3/31/16
Project: Research project
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ChEC-seq2: an improved chromatin endogenous cleavage sequencing method and bioinformatic analysis pipeline for mapping in vivo protein-DNA interactions
Vanbelzen, J., Duan, C., Brickner, D. G. & Brickner, J. H., Mar 1 2024, In: NAR Genomics and Bioinformatics. 6, 1, lqae012.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory
Sump, B., Brickner, D. G., D'urso, A., Kim, S. H. & Brickner, J. H., May 2022, In: eLife. 11, e77646.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter- chromosomal movement
Sumner, M. C., Torrisi, S. B., Brickner, D. G. & Brickner, J. H., May 2021, In: eLife. 10, 66238.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome
Brickner, D. G., Randise-Hinchliff, C., Corbin, M. L., Liang, J. M., Kim, S., Sump, B., D'Urso, A., Kim, S. H., Satomura, A., Schmit, H., Coukos, R., Hwang, S., Watson, R. & Brickner, J. H., Jun 17 2019, In: Developmental Cell. 49, 6, p. 936-947.e4Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
The dynamic three-dimensional organization of the diploid yeast genome
Kim, S., Liachko, I., Brickner, D. G., Cook, K., Noble, W. S., Brickner, J. H., Shendure, J. & Dunham, M. J., May 24 2017, In: eLife. 6, e23623.Research output: Contribution to journal › Article › peer-review
42 Scopus citations