Grants per year
Personal profile
Research Interests
Dr. Dorothy Sit is an Associate Professor at Northwestern University Feinberg School of Medicine. Dr. Sit’s main clinical research focus is on the development of treatments for women with mood disorders. Dr. Sit’s clinical work is devoted to the care of women with major mood disorders during the childbearing years including pre-conception planning, pregnancy and postpartum. With NIMH grant support, Dr. Sit recently completed a clinical trial confirming the efficacy of bright light therapy for bipolar depression and discovered that light therapy at midday versus an inactive placebo comparator induced a potent antidepressant response in depressed bipolar patients. She presented the findings at the 2016 Annual Meeting of the Society for Light Treatment and Biological Rhythms and abstracts at the American Psychiatric Association 168th Annual Meeting and the Society for Biological Psychiatry, 70th Annual Scientific Meeting. Given the robust effects, Dr. Sit is developing new research studies to investigate putative neural and visual biomarkers of response with support from NARSAD (Brain and Behavioral Research Foundation), and to explore the potential brain-related mechanisms underlying therapeutic light. As a clinician-educator, Dr. Sit serves on the women’s mental health fellowship curriculum committee and provides lectures and training for residents and fellows on the diagnosis, risks/benefit assessment and clinical management of women with depression, bipolar disorder or schizophrenia during pregnancy and postpartum. Dr. Sit serves on the Scientific Advisory Committee for the not-for-profit Center for Environmental Therapeutics and as Vice-President for the Society for Light Treatment and Biological Rhythms. She also provides peer reviews of manuscripts being considered for publication in major journals including the American Journal of Psychiatry and others.
Training Experience
1994 | Residency, University of Toronto, Canada |
2001 | Residency, University of Massachusetts Medical Center |
2002 | Fellowship, University of Massachusetts Medical Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Toronto
… → 1992
Research interests keywords
- Bipolar Disorder
- Depression
- Psychiatry
- Women's Health / Women's Reproductive Health
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Collaborations and top research areas from the last five years
Grants
- 1 Finished
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NIFEDIPINE PTB SUPPLEMENT Pharmacogenetic Risks Operating in Failure of Nifedipine to Delay Pre-Term Birth
Wisner, K. L. (PD/PI) & Sit, D. (Co-Investigator)
University of Illinois at Chicago, National Institute of Child Health and Human Development
9/15/20 → 2/28/21
Project: Research project
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Bright Light Therapy for Major Depressive Disorder in Adolescent Outpatients: A Preliminary Study
Ballard, R., Parkhurst, J. T., Gadek, L. K., Julian, K. M., Yang, A., Pasetes, L. N., Goel, N. & Sit, D. K., Mar 2024, In: Clocks and Sleep. 6, 1, p. 56-71 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Depression in Persons with Epilepsy: Lessons from Case Review
Abell, K., Sit, D. K. & Wisner, K. L., May 1 2024, In: Journal of clinical psychopharmacology. 44, 3, p. 272-277 6 p.Research output: Contribution to journal › Article › peer-review
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Differentiating Depressive Symptoms From Side Effects in Individuals With Major Depressive Disorder With Postpartum Onset
Pulido, C. M., Walson, I. S., Yang, A., Stika, C. S., Sit, D. K. & Wisner, K. L., 2024, (Accepted/In press) In: Journal of clinical psychopharmacology. 1928.Research output: Contribution to journal › Article › peer-review
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Mental Health and Behavioral Disorders in Pregnancy
Wisner, K. L., Sit, D. K. Y., Miller, E. S., Monk, C., Oberlander, T. F. & Huybrechts, K. F., Jan 1 2024, Gabbe's Obstetrics: Normal and Problem Pregnancies, Ninth Edition. Elsevier, p. 1135-1157.e5Research output: Chapter in Book/Report/Conference proceeding › Chapter
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The association between neighborhood deprivation and engagement in mental healthcare after implementation of the perinatal collaborative care model
Polnaszek, B. E., Mwenda, K. M., Nelson, L. D., Sit, D. K., Lewkowitz, A. K. & Miller, E. S., Jul 2024, In: American journal of obstetrics and gynecology. 231, 1, p. e1-e8Research output: Contribution to journal › Letter › peer-review
Datasets
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Supplemental Material, S10 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lam, R. W. (Creator), Teng, M. Y. (Creator), Jung, Y.-E. (Creator), Evans, V. C. (Creator), Gottlieb, J. F. (Creator), Chakrabarty, T. (Creator), Michalak, E. E. (Creator), Murphy, J. K. (Creator), Yatham, L. N. (Creator) & Sit, D. K. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.11365520, https://sage.figshare.com/articles/Supplemental_Material_S10_-_Light_Therapy_for_Patients_With_Bipolar_Depression_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials/11365520
Dataset
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Supplemental Material, S11 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lam, R. W. (Creator), Teng, M. Y. (Creator), Jung, Y.-E. (Creator), Evans, V. C. (Creator), Gottlieb, J. F. (Creator), Chakrabarty, T. (Creator), Michalak, E. E. (Creator), Murphy, J. K. (Creator), Yatham, L. N. (Creator) & Sit, D. K. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.11365523, https://sage.figshare.com/articles/Supplemental_Material_S11_-_Light_Therapy_for_Patients_With_Bipolar_Depression_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials/11365523
Dataset
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Supplemental Material, S3 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lam, R. W. (Creator), Teng, M. Y. (Creator), Jung, Y.-E. (Creator), Evans, V. C. (Creator), Gottlieb, J. F. (Creator), Chakrabarty, T. (Creator), Michalak, E. E. (Creator), Murphy, J. K. (Creator), Yatham, L. N. (Creator) & Sit, D. K. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.11365535, https://sage.figshare.com/articles/Supplemental_Material_S3_-_Light_Therapy_for_Patients_With_Bipolar_Depression_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials/11365535
Dataset
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Supplemental Material, S1 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lam, R. W. (Creator), Teng, M. Y. (Creator), Jung, Y.-E. (Creator), Evans, V. C. (Creator), Gottlieb, J. F. (Creator), Chakrabarty, T. (Creator), Michalak, E. E. (Creator), Murphy, J. K. (Creator), Yatham, L. N. (Creator) & Sit, D. K. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.11365517, https://sage.figshare.com/articles/Supplemental_Material_S1_-_Light_Therapy_for_Patients_With_Bipolar_Depression_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials/11365517
Dataset
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Supplemental Material, S5 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lam, R. W. (Creator), Teng, M. Y. (Creator), Jung, Y.-E. (Creator), Evans, V. C. (Creator), Gottlieb, J. F. (Creator), Chakrabarty, T. (Creator), Michalak, E. E. (Creator), Murphy, J. K. (Creator), Yatham, L. N. (Creator) & Sit, D. K. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.11365547, https://sage.figshare.com/articles/Supplemental_Material_S5_-_Light_Therapy_for_Patients_With_Bipolar_Depression_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials/11365547
Dataset