• 2374 Citations

Research output per year

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Personal profile

Research Interests

Dr. Dorothy Sit is an Associate Professor at Northwestern University Feinberg School of Medicine. Dr. Sit’s main clinical research focus is on the development of treatments for women with mood disorders. Dr. Sit’s clinical work is devoted to the care of women with major mood disorders during the childbearing years including pre-conception planning, pregnancy and postpartum. With NIMH grant support, Dr. Sit recently completed a clinical trial confirming the efficacy of bright light therapy for bipolar depression and discovered that light therapy at midday versus an inactive placebo comparator induced a potent antidepressant response in depressed bipolar patients. She presented the findings at the 2016 Annual Meeting of the Society for Light Treatment and Biological Rhythms and abstracts at the American Psychiatric Association 168th Annual Meeting and the Society for Biological Psychiatry, 70th Annual Scientific Meeting. Given the robust effects, Dr. Sit is developing new research studies to investigate putative neural and visual biomarkers of response with support from NARSAD (Brain and Behavioral Research Foundation), and to explore the potential brain-related mechanisms underlying therapeutic light. As a clinician-educator, Dr. Sit serves on the women’s mental health fellowship curriculum committee and provides lectures and training for residents and fellows on the diagnosis, risks/benefit assessment and clinical management of women with depression, bipolar disorder or schizophrenia during pregnancy and postpartum. Dr. Sit serves on the Scientific Advisory Committee for the not-for-profit Center for Environmental Therapeutics and as Vice-President for the Society for Light Treatment and Biological Rhythms. She also provides peer reviews of manuscripts being considered for publication in major journals including the American Journal of Psychiatry and others.

Training Experience

1994Residency, University of Toronto, Canada
2001Residency, University of Massachusetts Medical Center
2002Fellowship, University of Massachusetts Medical Center

Education/Academic qualification

MD, University of Toronto

… → 1992

Research interests

  • Bipolar Disorder
  • Depression
  • Psychiatry
  • Women's Health / Women's Reproductive Health

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Research Output

Carbon monoxide: a critical physiological regulator sensitive to light

Oren, D. A., Sit, D. K., Goudarzi, S. H. & Wisner, K. L., Dec 1 2020, In : Translational psychiatry. 10, 1, 87.

Research output: Contribution to journalArticle

Open Access
  • Photothérapie pour les patients souffrant de dépression bipolaire: Revue systématique et méta-analyse d’essais randomisés contrôlés

    Translated title of the contribution: Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled TrialsLam, R. W., Teng, M. Y., Jung, Y. E., Evans, V. C., Gottlieb, J. F., Chakrabarty, T., Michalak, E. E., Murphy, J. K., Yatham, L. N. & Sit, D. K., May 1 2020, In : Canadian Journal of Psychiatry. 65, 5, p. 290-300 11 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Bipolar disorder and psychotropic medication: Impact on pregnancy and neonatal outcomes

    Wisner, K. L., Sit, D., O'Shea, K., Bogen, D. L., Clark, C. T., Pinheiro, E., Yang, A. & Ciolino, J. D., Jan 15 2019, In : Journal of Affective Disorders. 243, p. 220-225 6 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations
  • 2 Scopus citations

    The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology

    Gottlieb, J. F., Benedetti, F., Geoffroy, P. A., Henriksen, T. E. G., Lam, R. W., Murray, G., Phelps, J., Sit, D., Swartz, H. A., Crowe, M., Etain, B., Frank, E., Goel, N., Haarman, B. C. M., Inder, M., Kallestad, H., Jae Kim, S., Martiny, K., Meesters, Y., Porter, R. & 7 others, Riemersma-van der Lek, R. F., Ritter, P. S., Schulte, P. F. J., Scott, J., Wu, J. C., Yu, X. & Chen, S., Dec 1 2019, In : Bipolar Disorders. 21, 8, p. 741-773 33 p.

    Research output: Contribution to journalReview article

    Open Access
  • 16 Scopus citations