• 2086 Citations
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Personal profile

Research Interests

Dr. Dorothy Sit is an Associate Professor at Northwestern University Feinberg School of Medicine. Dr. Sit’s main clinical research focus is on the development of treatments for women with mood disorders. Dr. Sit’s clinical work is devoted to the care of women with major mood disorders during the childbearing years including pre-conception planning, pregnancy and postpartum. With NIMH grant support, Dr. Sit recently completed a clinical trial confirming the efficacy of bright light therapy for bipolar depression and discovered that light therapy at midday versus an inactive placebo comparator induced a potent antidepressant response in depressed bipolar patients. She presented the findings at the 2016 Annual Meeting of the Society for Light Treatment and Biological Rhythms and abstracts at the American Psychiatric Association 168th Annual Meeting and the Society for Biological Psychiatry, 70th Annual Scientific Meeting. Given the robust effects, Dr. Sit is developing new research studies to investigate putative neural and visual biomarkers of response with support from NARSAD (Brain and Behavioral Research Foundation), and to explore the potential brain-related mechanisms underlying therapeutic light. As a clinician-educator, Dr. Sit serves on the women’s mental health fellowship curriculum committee and provides lectures and training for residents and fellows on the diagnosis, risks/benefit assessment and clinical management of women with depression, bipolar disorder or schizophrenia during pregnancy and postpartum. Dr. Sit serves on the Scientific Advisory Committee for the not-for-profit Center for Environmental Therapeutics and as Vice-President for the Society for Light Treatment and Biological Rhythms. She also provides peer reviews of manuscripts being considered for publication in major journals including the American Journal of Psychiatry and others.

Training Experience

1994Residency, University of Toronto, Canada
2001Residency, University of Massachusetts Medical Center
2002Fellowship, University of Massachusetts Medical Center

Education/Academic qualification

MD, University of Toronto

… → 1992

Research interests

  • Bipolar Disorder
  • Depression
  • Psychiatry
  • Women's Health / Women's Reproductive Health

Fingerprint Dive into the research topics where Dorothy Sit is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 17 Similar Profiles
Postpartum Depression Medicine & Life Sciences
Bipolar Disorder Medicine & Life Sciences
Depression Medicine & Life Sciences
Postpartum Period Medicine & Life Sciences
Mothers Medicine & Life Sciences
Serotonin Uptake Inhibitors Medicine & Life Sciences
Major Depressive Disorder Medicine & Life Sciences
Pregnancy Medicine & Life Sciences

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Research Output 2004 2019

Bipolar disorder and psychotropic medication: Impact on pregnancy and neonatal outcomes

Wisner, K. L., Sit, D., O'Shea, K., Bogen, D. L., Clark, C. T., Pinheiro, E., Yang, A. & Ciolino, J. D., Jan 15 2019, In : Journal of Affective Disorders. 243, p. 220-225 6 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Bipolar Disorder
Street Drugs
Postpartum Period
Postpartum Depression
Health Planning

Use of “Lights” for Bipolar Depression

Sit, D. & Haigh, S., Jun 1 2019, In : Current psychiatry reports. 21, 6, 45.

Research output: Contribution to journalReview article

Bipolar Disorder
Antimanic Agents
Mood Disorders

Validity of the WHIPLASHED as a tool to identify bipolar disorder in women

Mahmoud, D. R., Yang, A., Ciolino, J. D., Fisher, S. D., Sit, D., Pinheiro, E., Pendergrast, T., O'Shea, K., Wisner, K. L. & Clark, C. T., Mar 1 2019, In : Journal of Affective Disorders. 246, p. 69-73 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Depressive Disorder
Self Report
27 Citations (Scopus)

Adjunctive bright light therapy for bipolar depression: A randomized double-blind placebo-controlled trial

Sit, D. K., McGowan, J., Wiltrout, C., Diler, R. S., Dills, J., Luther, J., Yang, A., Ciolino, J. D., Seltman, H., Wisniewski, S. R., Terman, M. & Wisner, K. L., Feb 1 2018, In : American Journal of Psychiatry. 175, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

Bipolar Disorder