Douglas E Vaughan

Professor, Medicine, Cardiology Division
Chairperson, Medicine
Irving S Cutter Professor, Medicine, Cardiology Division
Driskill Graduate Training Program in Life Sciences

Phone+1 312 926 9436
Emaild-vaughan@northwestern.edu

Source: Scopus

Research activity per year

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Personal profile

Research Interests

My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.

Certifications and Licenses

	Cardiovascular Disease
	Internal Medicine

Training Experience

1981	Internship, Parkland Memorial Hospital
1983	Residency, Parkland Memorial Hospital
1987	Postdoctoral Fellowship, Harvard Medical School
1987	Fellowship, Brigham & Women's Hospital

Education/Academic qualification

Medicine, MD, University of Texas Southwestern

… → 1980

MD, University of Texas Southwestern Medical Center

… → 1980

Research interests

Aging
Cardiovascular Diseases
Gene Regulation
Stem Cells
Vascular Biology
Blood and Bleeding Disorders (anemia, clotting, etc.)

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4 Active
19 Finished

Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Burridge, P., Carr, J., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
PAI-1 and Vascular Senescence
Abdelwahid, E., Eren, M., Ghosh, A. K., Khan, S. S., Shah, S. J., Vaughan, D. E. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
8/1/18 → 7/31/22
Project: Research project
Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease
Ghosh, A. K. & Vaughan, D. E.
American Heart Association
7/1/18 → 6/30/21
Project: Research project
A SPECT_CT Scanner for Preclinical Imaging Studies
Budinger, G. S., Haney, C. R., Larson, A. C., O'Halloran, T. V., Perlman, H. R., Procissi, D., Qin, G., Stock, S. R., Vaughan, D. E., Woloschak, G. E., Woodruff, T. K., Zhao, M., Sznajder, J. I., Meade, T. J., Bulun, S. E., Mirkin, C. A., Spies, S. M. & Stupp, S.
Office of the Director, National Institutes of Health
5/1/14 → 4/30/21
Project: Research project
The role of plasminogen activator inhibitor -1 (PAI-1) in chronic kidney disease(CKD)-associated cardiac hypertrophy
Vaughan, D. E.
American Heart Association
1/1/19 → 12/31/20
Project: Research project

17443 Citations
209 Article
24 Review article
10 Editorial
4 Letter
More

Effects of lisinopril treatment on the pathophysiology of PCOS and plasminogen activator inhibitor-1 concentrations in rats
Coskun, B., Ercan, C. M., Togrul, C., Ozhamam, E. U., Coskun, B., Eren, M. & Vaughan, D. E., Jan 2021, In: Reproductive biomedicine online. 42, 1, p. 16-25 10 p.
Research output: Contribution to journal › Article › peer-review
Identification of Cardiac Fibrosis in Young Adults with a Homozygous Frameshift Variant in SE RPINE1
Khan, S. S., Shah, S. J., Strande, J. L., Baldridge, A. S., Flevaris, P. D., Roy-Puckelwartz, M. J., McNally, E. N., Rasmussen-Torvik, L. J., Lee, D. C., Carr, J. C., Benefield, B. C., Afzal, M. Z., Heiman, M., Gupta, S., Shapiro, A. D. & Vaughan, D. E., 2021, (Accepted/In press) In: JAMA cardiology.
Research output: Contribution to journal › Article › peer-review
Role of PAI-1 in hepatic steatosis and dyslipidemia
Levine, J. A., Oleaga, C., Eren, M., Amaral, A. P., Shang, M., Lux, E., Khan, S. S., Shah, S. J., Omura, Y., Pamir, N., Hay, J., Barish, G., Miyata, T., Tavori, H., Fazio, S. & Vaughan, D. E., Dec 2021, In: Scientific reports. 11, 1, 430.
Research output: Contribution to journal › Article › peer-review

Open Access
Structural insight into the two-step mechanism of pai-1 inhibition by small molecule tm5484
Sillen, M., Miyata, T., Vaughan, D. E., Strelkov, S. V. & Declerck, P. J., Feb 2 2021, In: International journal of molecular sciences. 22, 3, p. 1-14 14 p., 1482.
Research output: Contribution to journal › Article › peer-review

Open Access
Association between plasminogen activator inhibitor-1 in young adulthood and nonalcoholic fatty liver disease in midlife: CARDIA
Campbell, P. T., VanWagner, L. B., Colangelo, L. A., Lewis, C. E., Henkel, A., Ajmera, V. H., Lloyd-Jones, D. M., Vaughan, D. E. & Khan, S. S., May 1 2020, In: Liver International. 40, 5, p. 1111-1120 10 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations