Grants per year
Personal profile
Research Interests
My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.
Certifications and Licenses
Cardiovascular Disease | |
Internal Medicine |
Training Experience
1981 | Internship, Parkland Memorial Hospital |
1983 | Residency, Parkland Memorial Hospital |
1987 | Postdoctoral Fellowship, Harvard Medical School |
1987 | Fellowship, Brigham & Women's Hospital |
Education/Academic qualification
Medicine, MD, University of Texas Southwestern
… → 1980
MD, University of Texas Southwestern Medical Center
… → 1980
Research interests
- Aging
- Cardiovascular Diseases
- Gene Regulation
- Stem Cells
- Vascular Biology
- Blood and Bleeding Disorders (anemia, clotting, etc.)
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Grants
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Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Burridge, P., Carr, J., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
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PAI-1 and Vascular Senescence
Abdelwahid, E., Eren, M., Ghosh, A. K., Khan, S. S., Shah, S. J., Vaughan, D. E. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
8/1/18 → 7/31/22
Project: Research project
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Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease
7/1/18 → 6/30/21
Project: Research project
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A SPECT_CT Scanner for Preclinical Imaging Studies
Budinger, G. S., Haney, C. R., Larson, A. C., O'Halloran, T. V., Perlman, H. R., Procissi, D., Qin, G., Stock, S. R., Vaughan, D. E., Woloschak, G. E., Woodruff, T. K., Zhao, M., Sznajder, J. I., Meade, T. J., Bulun, S. E., Mirkin, C. A., Spies, S. M. & Stupp, S.
Office of the Director, National Institutes of Health
5/1/14 → 4/30/21
Project: Research project
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The role of plasminogen activator inhibitor -1 (PAI-1) in chronic kidney disease(CKD)-associated cardiac hypertrophy
1/1/19 → 12/31/20
Project: Research project
Research Output
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Effects of lisinopril treatment on the pathophysiology of PCOS and plasminogen activator inhibitor-1 concentrations in rats
Coskun, B., Ercan, C. M., Togrul, C., Ozhamam, E. U., Coskun, B., Eren, M. & Vaughan, D. E., Jan 2021, In: Reproductive biomedicine online. 42, 1, p. 16-25 10 p.Research output: Contribution to journal › Article › peer-review
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Identification of Cardiac Fibrosis in Young Adults with a Homozygous Frameshift Variant in SE RPINE1
Khan, S. S., Shah, S. J., Strande, J. L., Baldridge, A. S., Flevaris, P. D., Roy-Puckelwartz, M. J., McNally, E. N., Rasmussen-Torvik, L. J., Lee, D. C., Carr, J. C., Benefield, B. C., Afzal, M. Z., Heiman, M., Gupta, S., Shapiro, A. D. & Vaughan, D. E., 2021, (Accepted/In press) In: JAMA cardiology.Research output: Contribution to journal › Article › peer-review
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Role of PAI-1 in hepatic steatosis and dyslipidemia
Levine, J. A., Oleaga, C., Eren, M., Amaral, A. P., Shang, M., Lux, E., Khan, S. S., Shah, S. J., Omura, Y., Pamir, N., Hay, J., Barish, G., Miyata, T., Tavori, H., Fazio, S. & Vaughan, D. E., Dec 2021, In: Scientific reports. 11, 1, 430.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural insight into the two-step mechanism of pai-1 inhibition by small molecule tm5484
Sillen, M., Miyata, T., Vaughan, D. E., Strelkov, S. V. & Declerck, P. J., Feb 2 2021, In: International journal of molecular sciences. 22, 3, p. 1-14 14 p., 1482.Research output: Contribution to journal › Article › peer-review
Open Access -
Association between plasminogen activator inhibitor-1 in young adulthood and nonalcoholic fatty liver disease in midlife: CARDIA
Campbell, P. T., VanWagner, L. B., Colangelo, L. A., Lewis, C. E., Henkel, A., Ajmera, V. H., Lloyd-Jones, D. M., Vaughan, D. E. & Khan, S. S., May 1 2020, In: Liver International. 40, 5, p. 1111-1120 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations