Grants per year
Personal profile
Research Interests
My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.
Certifications and Licenses
| Cardiovascular Disease | |
| Internal Medicine |
Training Experience
| 1981 | Internship, Parkland Memorial Hospital |
| 1983 | Residency, Parkland Memorial Hospital |
| 1987 | Postdoctoral Fellowship, Harvard Medical School |
| 1987 | Fellowship, Brigham & Women's Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Texas Southwestern
… → 1980
Medicine, MD, University of Texas Southwestern
… → 1980
Research interests keywords
- Aging
- Cardiovascular Diseases
- Gene Regulation
- Stem Cells
- Vascular Biology
- Blood and Bleeding Disorders (anemia, clotting, etc.)
- Longevity
- Senescence
- Metabolism
- RNAseq
- Transcriptomics
- Epigenetic age
- Aging-related multimorbidity
Fingerprint
Dive into the research topics where Douglas E Vaughan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Role of Endothelin-1 signaling in the development and progression of atrial fibrillation
Pfenniger, A., Arora, R. K., George, A. L., Lee, D. C., Passman, R. S., Roy-Puckelwartz, M. J., Shah, S. J., Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/1/23 → 8/31/28
Project: Research project
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Pleiotropic Role of PAI-1 in Cardiovascular Aging
Vaughan, D. E., Abdala-Valencia, H., Burridge, P., Stoeger, T., Wilsbacher, L. D. & Zhang, W.
National Heart, Lung, and Blood Institute
8/1/23 → 5/31/28
Project: Research project
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Epigenomic landscape of individual- and neighborhood-level social disadvantages and cardiovascular health disparity
Hou, L., Hou, L., Jiang, H., Jiang, H., Joyce, B., Joyce, B., Lloyd-Jones, D. M., Lloyd-Jones, D. M., Vaughan, D. E., Vaughan, D. E., Wilkins, J. T., Wilkins, J. T., Zheng, Y. & Zheng, Y.
9/15/22 → 5/31/26
Project: Research project
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Evolutionary advantage of heterozygous PAI-1 deficiency in humans
1/1/22 → 12/31/24
Project: Research project
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Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Vaughan, D. E., Burridge, P., Carr, J., Eren, M., Flevaris, P. D., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Wilsbacher, L. D. & Winter, D. R.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/24
Project: Research project
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Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Joyce, B. T., Chen, X., Gao, T., Zheng, Y., Nannini, D. R., Liu, L., Henkle, B. E., Kalhan, R., Washko, G., Kunisaki, K. M., Thyagarajan, B., Vaughan, D. E., Gross, M., Jacobs, D. R., Lloyd-Jones, D. & Hou, L., Jul 1 2023, In: Epigenomics. 15, 13, p. 693-703 11 p.Research output: Contribution to journal › Article › peer-review
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Inclusion of epigenetic age acceleration in oncological trials
Mittal, B. B. & Vaughan, D. E., May 2023, In: The Lancet Healthy Longevity. 4, 5, p. e185-e186Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Kim, K., Joyce, B. T., Nannini, D. R., Zheng, Y., Gordon-Larsen, P., Shikany, J. M., Lloyd-Jones, D. M., Hu, M., Nieuwenhuijsen, M. J., Vaughan, D. E., Zhang, K. & Hou, L., Jun 2023, In: Science Advances. 9, 26, eadf8140.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice
Rodriguez, G., Eren, M., Haupfear, I., Viola, K. L., Cline, E. N., Miyata, T., Klein, W. L., Vaughan, D. E. & Dong, H., Dec 2023, In: Psychopharmacology. 240, 12, p. 2641-2655 15 p.Research output: Contribution to journal › Article › peer-review
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Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults
Simons, L. M., Lorenzo-Redondo, R., Gibson, M., Kinch, S. L., Vandervaart, J. P., Reiser, N. L., Eren, M., Lux, E., McNally, E. M., Tambur, A. R., Vaughan, D. E., Bachta, K. E. R., Demonbreun, A. R., Satchell, K. J. F., Achenbach, C. J., Ozer, E. A., Ison, M. G. & Hultquist, J. F., Mar 2022, In: Open Forum Infectious Diseases. 9, 3, ofac027.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Datasets
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ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model
Archer, A. M. (Creator), Saber, R. (Creator), Rose, S. (Creator), Shaffer, A. (Creator), Misharin, A. (Creator), Tsai, F. (Contributor), Haines, G. K. (Contributor), Dominguez, S. (Creator), Eren, M. (Creator), Vaughan, D. E. (Creator), Cuda, C. M. (Creator), Perlman, H. R. (Creator) & Perlman, H. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3644342.v1, https://figshare.com/collections/ApoE_deficiency_exacerbates_the_development_and_sustainment_of_a_semi-chronic_K_BxN_serum_transfer-induced_arthritis_model/3644342/1
Dataset
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Data from: Genetics of plasminogen activator inhibitor-1 (PAI-1) in a Ghanaian population
White, M. J. (Creator), Kodaman, N. M. (Creator), Harder, R. H. (Creator), Asselbergs, F. W. (Creator), Vaughan, D. E. (Creator), Brown, N. J. (Creator), Moore, J. H. (Creator), Williams, S. M. (Creator) & Vaughan, D. E. (Creator), Dryad, Aug 25 2016
DOI: 10.5061/dryad.j2dj4, https://datadryad.org/stash/dataset/doi:10.5061/dryad.j2dj4
Dataset
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Data from: Genetics of plasminogen activator inhibitor-1 (PAI-1) in a Ghanaian population
White, M. J. (Contributor), Kodaman, N. M. (Contributor), Harder, R. H. (Contributor), Asselbergs, F. W. (Contributor), Vaughan, D. E. (Contributor), Brown, N. J. (Contributor), Moore, J. H. (Contributor), Williams, S. M. (Contributor) & Vaughan, D. E. (Contributor), ZENODO, Aug 25 2016
DOI: 10.5061/dryad.j2dj4, https://zenodo.org/record/5004676
Dataset