• 15881 Citations
1986 …2022
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Personal profile

Research Interests

My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.

Certifications and Licenses

Cardiovascular Disease
Internal Medicine

Training Experience

1981Internship, Parkland Memorial Hospital
1983Residency, Parkland Memorial Hospital
1987Postdoctoral Fellowship, Harvard Medical School
1987Fellowship, Brigham & Women's Hospital

Education/Academic qualification

MD, University of Texas - Southwestern

… → 1980

Keywords

  • Aging
  • Blood and Bleeding Disorders (anemia / clotting / etc.)
  • Cardiovascular Diseases
  • Gene Regulation
  • Stem Cells
  • Vascular Biology

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Grants 2008 2022

Plasminogen Activator Inhibitor 1
Cardiomegaly
Chronic Renal Insufficiency
Hypertrophy
Transgenic Mice
Plasminogen Activator Inhibitor 1
Blood Vessels
Cardiovascular System
Population
Personal Financing
Air Pollutants
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Environmental Pollutants
Cardiovascular Diseases

Research Output 1986 2018

EPIGENETIC TREATMENT APPROACHES TO CARDIOVASCULAR DISEASE

Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
8 Citations

A null mutation in SERPINE1 protects against biological aging in humans

Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., Miyata, T., Gupta, S., Shapiro, A. D. & Vaughan, D. E., Jan 1 2017, In : Science Advances. 3, 11, eaao1617.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Amish
Mutation
Cell Aging
Telomere
5 Citations

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Restoration
Down-Regulation
Aging of materials
Cell Aging
Cardiomegaly
10 Citations

Epigenetics in Reactive and Reparative Cardiac Fibrogenesis: The Promise of Epigenetic Therapy

Ghosh, A. K., Rai, R., Flevaris, P. D. & Vaughan, D. E., Aug 1 2017, In : Journal of Cellular Physiology. 232, 8, p. 1941-1956 16 p.

Research output: Contribution to journalReview article

Epigenomics
Extracellular Matrix Proteins
Fibrosis
Heart Failure
Aging of materials