Grants per year
Personal profile
Research Interests
My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.
Certifications and Licenses
| Cardiovascular Disease | |
| Internal Medicine |
Training Experience
| 1981 | Internship, Parkland Memorial Hospital |
| 1983 | Residency, Parkland Memorial Hospital |
| 1987 | Postdoctoral Fellowship, Harvard Medical School |
| 1987 | Fellowship, Brigham & Women's Hospital |
Education/Academic qualification
MD, University of Texas - Southwestern
… → 1980
Keywords
- Aging
- Cardiovascular Diseases
- Gene Regulation
- Stem Cells
- Vascular Biology
- Blood and Bleeding Disorders (anemia, clotting, etc.)
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Plasminogen Activator Inhibitor 1
Medicine & Life Sciences
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Medicine & Life Sciences
Plasminogen Activators
Medicine & Life Sciences
Bradykinin
Medicine & Life Sciences
Renin-Angiotensin System
Medicine & Life Sciences
Peptidyl-Dipeptidase A
Medicine & Life Sciences
Myocardial Infarction
Medicine & Life Sciences
Blood Vessels
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2008 2023
Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Burridge, P., Carr, J., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
Plasminogen Activator Inhibitor 1
Fibrosis
Mutation
Cardiomyopathies
Cardiac Myocytes
The role of plasminogen activator inhibitor -1 (PAI-1) in chronic kidney disease(CKD)-associated cardiac hypertrophy
1/1/19 → 12/31/20
Project: Research project
Plasminogen Activator Inhibitor 1
Cardiomegaly
Chronic Renal Insufficiency
Hypertrophy
Transgenic Mice
PAI-1 and Vascular Senescence
Abdelwahid, E., Eren, M., Ghosh, A. K., Khan, S. S., Shah, S. J., Vaughan, D. E. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
8/1/18 → 7/31/22
Project: Research project
Plasminogen Activator Inhibitor 1
Blood Vessels
Cardiovascular System
Population
Personal Financing
Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease
7/1/18 → 6/30/20
Project: Research project
Air Pollutants
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Environmental Pollutants
Cardiovascular Diseases
Development of a Novel RA/Atherosclerosis Mouse Model
Misharin, A., Perlman, H. R. & Vaughan, D. E.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/16 → 8/31/19
Project: Research project
Research Output 1986 2019
Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis
Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.Research output: Contribution to journal › Article
Open Access
Cardiomegaly
Fibrosis
Hypertension
Epigenomics
Myofibroblasts
EPIGENETIC TREATMENT APPROACHES TO CARDIOVASCULAR DISEASE
Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641Research output: Chapter in Book/Report/Conference proceeding › Chapter
4
Citations
(Scopus)
A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis
Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.Research output: Contribution to journal › Article
Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
10
Citations
(Scopus)
A null mutation in SERPINE1 protects against biological aging in humans
Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., Miyata, T., Gupta, S., Shapiro, A. D. & Vaughan, D. E., Jan 1 2017, In : Science Advances. 3, 11, eaao1617.Research output: Contribution to journal › Article
Plasminogen Activators
Amish
Mutation
Cell Aging
Telomere
6
Citations
(Scopus)
Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan
Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.Research output: Contribution to journal › Article
Restoration
Down-Regulation
Aging of materials
Cell Aging
Cardiomegaly