Grants per year
Personal profile
Research Interests
My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.
Certifications and Licenses
| Cardiovascular Disease | |
| Internal Medicine |
Training Experience
| 1981 | Internship, Parkland Memorial Hospital |
| 1983 | Residency, Parkland Memorial Hospital |
| 1987 | Postdoctoral Fellowship, Harvard Medical School |
| 1987 | Fellowship, Brigham & Women's Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Texas Southwestern
… → 1980
Medicine, MD, University of Texas Southwestern
… → 1980
Research interests
- Aging
- Cardiovascular Diseases
- Gene Regulation
- Stem Cells
- Vascular Biology
- Blood and Bleeding Disorders (anemia, clotting, etc.)
- Longevity
- Senescence
- Metabolism
- RNAseq
- Transcriptomics
- Epigenetic age
- Aging-related multimorbidity
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Evolutionary Advantage of Heterozygous PAI-1 Deficiency in Humans
Vaughan, D. E., Duncan, F. E., Eren, M., Richter, C. & Wilsbacher, L. D.
9/15/22 → 8/31/23
Project: Research project
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Evolutionary advantage of heterozygous PAI-1 deficiency in humans
1/1/22 → 12/31/24
Project: Research project
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Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Vaughan, D. E., Burridge, P., Carr, J., Eren, M., Flevaris, P. D., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Wilsbacher, L. D. & Winter, D. R.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
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PAI-1 and Vascular Senescence
Vaughan, D. E., Abdelwahid, E., Eren, M., Flevaris, P. D., Ghosh, A. K., Khan, S. S. & Shah, S. J.
National Heart, Lung, and Blood Institute
8/1/18 → 7/31/23
Project: Research project
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The role of plasminogen activator inhibitor -1 (PAI-1) in chronic kidney disease(CKD)-associated cardiac hypertrophy
1/1/19 → 12/31/20
Project: Research project
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Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults
Simons, L. M., Lorenzo-Redondo, R., Gibson, M., Kinch, S. L., Vandervaart, J. P., Reiser, N. L., Eren, M., Lux, E., McNally, E. M., Tambur, A. R., Vaughan, D. E., Bachta, K. E. R., Demonbreun, A. R., Satchell, K. J. F., Achenbach, C. J., Ozer, E. A., Ison, M. G. & Hultquist, J. F., Mar 2022, In: Open Forum Infectious Diseases. 9, 3, ofac027.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mid-life Epigenetic Age, Neuroimaging Brain Age, and Cognitive Function: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Zheng, Y., Habes, M., Gonzales, M., Pomponio, R., Nasrallah, I., Khan, S., Vaughan, D. E., Davatzikos, C., Seshadri, S., Launer, L., Sorond, F., Sedaghat, S., Wainwright, D., Baccarelli, A., Sidney, S., Bryan, N., Greenland, P., Lloyd-Jones, D., Yaffe, K. & Hou, L., 2022, In: Aging. 14, 4, p. 1691-1712 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of lisinopril treatment on the pathophysiology of PCOS and plasminogen activator inhibitor-1 concentrations in rats
Coskun, B., Ercan, C. M., Togrul, C., Ozhamam, E. U., Coskun, B., Eren, M. & Vaughan, D. E., Jan 2021, In: Reproductive biomedicine online. 42, 1, p. 16-25 10 p.Research output: Contribution to journal › Article › peer-review
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Identification of Cardiac Fibrosis in Young Adults with a Homozygous Frameshift Variant in SERPINE1
Khan, S. S., Shah, S. J., Strande, J. L., Baldridge, A. S., Flevaris, P. D., Puckelwartz, M. J., McNally, E. M., Rasmussen-Torvik, L. J., Lee, D. C., Carr, J. C., Benefield, B. C., Afzal, M. Z., Heiman, M., Gupta, S., Shapiro, A. D. & Vaughan, D. E., Jul 2021, In: JAMA cardiology. 6, 7, p. 841-846 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice
Levine, J. A., Olivares, S., Miyata, T., Vaughan, D. E. & Henkel, A. S., Apr 2021, In: Obesity. 29, 4, p. 713-720 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations