• 16101 Citations
1986 …2023
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Personal profile

Research Interests

My primary clinical interest is in adult cardiovascular disease. My practice has focused on the management and treatment of patients with coronary artery disease. I am also interested in the diagnosis and management of arterial thrombosis. My research interests align with these clinical interests. My primary investigative focus is and has been on the mammalian plasminogen activator system and the role this system plays in cardiovascular disease. We apply a multidisciplinary approach in this effort, and utilize molecular and cellular approaches, as well as animal and human studies.

Certifications and Licenses

Cardiovascular Disease
Internal Medicine

Training Experience

1981Internship, Parkland Memorial Hospital
1983Residency, Parkland Memorial Hospital
1987Postdoctoral Fellowship, Harvard Medical School
1987Fellowship, Brigham & Women's Hospital

Education/Academic qualification

MD, University of Texas - Southwestern

… → 1980


  • Aging
  • Cardiovascular Diseases
  • Gene Regulation
  • Stem Cells
  • Vascular Biology
  • Blood and Bleeding Disorders (anemia, clotting, etc.)

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Grants 2008 2023

Plasminogen Activator Inhibitor 1
Chronic Renal Insufficiency
Transgenic Mice
Plasminogen Activator Inhibitor 1
Blood Vessels
Cardiovascular System
Personal Financing
Air Pollutants
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Environmental Pollutants
Cardiovascular Diseases

Research Output 1986 2019

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

Research output: Contribution to journalArticle

Open Access


Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Mesangial Cells
10 Citations (Scopus)

A null mutation in SERPINE1 protects against biological aging in humans

Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., Miyata, T., Gupta, S., Shapiro, A. D. & Vaughan, D. E., Jan 1 2017, In : Science Advances. 3, 11, eaao1617.

Research output: Contribution to journalArticle

Plasminogen Activators
Cell Aging
6 Citations (Scopus)

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Aging of materials
Cell Aging