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Personal profile

Research Interests

We determine the three-dimensional structures of proteins in order to understand the structural basis for and functional mechanisms of interactions between proteins and between proteins and small molecules that play important roles cell biology.

Training Experience

1989Postdoctoral Fellowship, Harvard University
1993Postdoctoral Fellowship, University of California, San Francisco
1997Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

PhD, Harvard University

… → 1989

Research interests

  • Biophysics
  • Infectious Diseases: Parasite
  • Proteins / Macromolecules
  • Signal Transduction
  • Structural Biology

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Grants

  • Research Output

    • 2329 Citations
    • 34 Article
    • 1 Review article

    Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

    Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

    Research output: Contribution to journalArticle

    12 Scopus citations

    Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

    Klosowiak, J. L., Park, S., Smith, K. P., French, M. E., Focia, P. J., Freymann, D. M. & Rice, S. E., Sep 8 2016, In : Scientific reports. 6, 33019.

    Research output: Contribution to journalArticle

  • 15 Scopus citations

    Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

    Klosowiak, J. L., Focia, P. J., Chakravarthy, S., Landahl, E. C., Freymann, D. M. & Rice, S. E., Nov 1 2013, In : EMBO Reports. 14, 11, p. 968-974 7 p.

    Research output: Contribution to journalArticle

  • 35 Scopus citations

    Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh

    Ramirez, U. D., Focia, P. J. & Freymann, D. M., Sep 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 10, p. 1043-1053 11 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations