• 2296 Citations
1984 …2018
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Personal profile

Research Interests

We determine the three-dimensional structures of proteins in order to understand the structural basis for and functional mechanisms of interactions between proteins and between proteins and small molecules that play important roles cell biology.

Training Experience

1989Postdoctoral Fellowship, Harvard University
1993Postdoctoral Fellowship, University of California, San Francisco
1997Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

PhD, Harvard University

… → 1989

Research interests

  • Biophysics
  • Infectious Diseases-parasite
  • Infectious Diseases: Parasite
  • Macromolecules
  • Proteins
  • Proteins / Macromolecules
  • Signal Transduction
  • Structural Biology

Fingerprint Dive into the research topics where Douglas M Freymann is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Signal Recognition Particle Medicine & Life Sciences
GTP Phosphohydrolases Medicine & Life Sciences
Guanosine Triphosphate Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Thermus Medicine & Life Sciences
Proteins Medicine & Life Sciences
Protein Sorting Signals Medicine & Life Sciences
Membrane Glycoproteins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2000 2007

GTP Phosphohydrolases
Tubulin
Guanosine Triphosphate
Microtubules
Microtubule Proteins
Detectors
X rays
Wigglers
Crystallography
Biotechnology
Signal Recognition Particle
GTP Phosphohydrolases
Guanosine Triphosphate
Proteins
Membranes

Research Output 1984 2018

  • 2296 Citations
  • 34 Article
  • 1 Review article
10 Citations (Scopus)

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

Mutagenesis
Anatomy
Molecular Dynamics Simulation
Endoplasmic Reticulum
Cysteine
14 Citations (Scopus)

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Klosowiak, J. L., Park, S., Smith, K. P., French, M. E., Focia, P. J., Freymann, D. M. & Rice, S. E., Sep 8 2016, In : Scientific Reports. 6, 33019.

Research output: Contribution to journalArticle

Lysine
Ubiquitination
GTP Phosphohydrolases
Ubiquitin
Inborn Genetic Diseases
31 Citations (Scopus)

Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

Klosowiak, J. L., Focia, P. J., Chakravarthy, S., Landahl, E. C., Freymann, D. M. & Rice, S. E., Nov 1 2013, In : EMBO Reports. 14, 11, p. 968-974 7 p.

Research output: Contribution to journalArticle

EF Hand Motifs
GTP Phosphohydrolases
Mitochondrial Proteins
Phosphorylation
Nucleotides
13 Citations (Scopus)

Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge)

Freymann, D. M., Nakamura, Y., Focia, P. J., Sakai, R. & Swanson, G. T., Sep 1 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 9, p. 1163-1174 12 p.

Research output: Contribution to journalArticle

Galectin 1
Galectins
Ionotropic Glutamate Receptors
Porifera
Aptitude
3 Citations (Scopus)

Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh

Ramirez, U. D., Focia, P. J. & Freymann, D. M., Sep 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 10, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

Signal Recognition Particle
GTP Phosphohydrolases
Nucleotides
Catalytic Domain
Guanine