Edward Matthew Schaeffer

  • 6760 Citations
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Personal profile

Research Interests

I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.

Training Experience

2002Internship, Johns Hopkins University School of Medicine
2007Residency, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, PhD, University of Chicago

… → 2001

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  • 14 Similar Profiles
Prostatic Neoplasms Medicine & Life Sciences
Prostatectomy Medicine & Life Sciences
Urinary Tract Infections Medicine & Life Sciences
Prostate Medicine & Life Sciences
Prostatitis Medicine & Life Sciences
Prostate-Specific Antigen Medicine & Life Sciences
Biopsy Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2015 2020

Research Output 1999 2020

Educational Material on Prostate Cancer Screening is Overly Complex and Fails to Meet Recommended Layperson Readability Guidelines

Rooney, M. K., Morgans, A. K., Chen, R. C., Golden, D. W., Meeks, J. J., Auffenberg, G., Kundu, S. D., Schaeffer, E. M., Hussain, M. H., Kalapurakal, J. A. & Sachdev, S., Jan 2020, In : Urology. 135, p. 1-3 3 p.

Research output: Contribution to journalEditorial

A comparative effectiveness analysis of the PBCG vs. PCPT risks calculators in a multi-ethnic cohort

Carbunaru, S., Nettey, O. S., Gogana, P., Helenowski, I. B., Jovanovic, B., Ruden, M., Hollowell, C. M. P., Sharifi, R., Kittles, R. A., Schaeffer, E., Gann, P. & Murphy, A. B., Nov 27 2019, In : BMC Urology. 19, 1, 121.

Research output: Contribution to journalArticle

Open Access
Prostatic Neoplasms
Prostate-Specific Antigen

African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome

Echevarria, M. I., Awasthi, S., Cheng, C. H., Berglund, A. E., Rounbehler, R. J., Gerke, T. A., Takhar, M., Davicioni, E., Klein, E. A., Freedland, S. J., Ross, A. E., Schaeffer, E. M., Den, R. B., Cleveland, J. L., Park, J. Y., Rayford, W. & Yamoah, K., Aug 1 2019, In : Journal of Urology. 202, 2, p. 247-255 9 p.

Research output: Contribution to journalArticle

Open Access
African Americans
Prostatic Neoplasms
12 Citations (Scopus)

Association of Black Race with Prostate Cancer-Specific and Other-Cause Mortality

Dess, R. T., Hartman, H. E., Mahal, B. A., Soni, P. D., Jackson, W. C., Cooperberg, M. R., Amling, C. L., Aronson, W. J., Kane, C. J., Terris, M. K., Zumsteg, Z. S., Butler, S., Osborne, J. R., Morgan, T. M., Mehra, R., Salami, S. S., Kishan, A. U., Wang, C., Schaeffer, E. M., Roach, M. & 10 others, Pisansky, T. M., Shipley, W. U., Freedland, S. J., Sandler, H. M., Halabi, S., Feng, F. Y., Dignam, J. J., Nguyen, P. L., Schipper, M. J. & Spratt, D. E., Jul 2019, In : JAMA Oncology. 5, 7, p. 975-983 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Veterans Health
Phase III Clinical Trials

Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma

Alshalalfa, M., Liu, Y., Wyatt, A. W., Gibb, E. A., Tsai, H. K., Erho, N., Lehrer, J., Takhar, M., Ramnarine, V. R., Collins, C. C., Den, R. B., Schaeffer, E. M., Davicioni, E., Lotan, T. L. & Bismar, T. A., Dec 15 2019, In : International Journal of Cancer. 145, 12, p. 3453-3461 9 p.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Carcinoma
Small Cell Carcinoma
Prostatic Neoplasms
Histone Deacetylase Inhibitors