Grants per year
Personal profile
Research Interests
I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.
Training Experience
2002 | Internship, Johns Hopkins University School of Medicine |
2007 | Residency, Johns Hopkins University School of Medicine |
Education/Academic qualification
MD, PhD, University of Chicago
… → 2001
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Grants 2015 2020
Molecular profiles of African American men with localized prostate cancer
8/1/19 → 7/31/20
Project: Research project
Clinical, Environmental, Genetic and Genomic profile of Men with Early Onset Lethal Prostate Cancer
Abdulkadir, S. A., Hussain, M., Jovanovic, B., Meeks, J. J., Morgans, A. K. & Schaeffer, E. M.
12/31/17 → 12/31/19
Project: Research project
Creation and validation of a pre-biopsy nomogram for predicting high-risk prostate cancer in African American men
Jovanovic, B., Murphy, A. B., Schaeffer, E. M. & Yang, X. J.
U.S. Army Medical Research and Materiel Command
9/15/17 → 9/14/20
Project: Research project
Research Output 1999 2019
African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome
Echevarria, M. I., Awasthi, S., Cheng, C. H., Berglund, A. E., Rounbehler, R. J., Gerke, T. A., Takhar, M., Davicioni, E., Klein, E. A., Freedland, S. J., Ross, A. E., Schaeffer, E. M., Den, R. B., Cleveland, J. L., Park, J. Y., Rayford, W. & Yamoah, K., Aug 1 2019, In : Journal of Urology. 202, 2, p. 247-255 9 p.Research output: Contribution to journal › Article
Association of Black Race with Prostate Cancer-Specific and Other-Cause Mortality
Dess, R. T., Hartman, H. E., Mahal, B. A., Soni, P. D., Jackson, W. C., Cooperberg, M. R., Amling, C. L., Aronson, W. J., Kane, C. J., Terris, M. K., Zumsteg, Z. S., Butler, S., Osborne, J. R., Morgan, T. M., Mehra, R., Salami, S. S., Kishan, A. U., Wang, C., Schaeffer, E. M., Roach, M. & 10 others, , Jul 2019, In : JAMA Oncology. 5, 7, p. 975-983 9 p.Research output: Contribution to journal › Article
Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma
Alshalalfa, M., Liu, Y., Wyatt, A. W., Gibb, E. A., Tsai, H. K., Erho, N., Lehrer, J., Takhar, M., Ramnarine, V. R., Collins, C. C., Den, R. B., Schaeffer, E. M., Davicioni, E., Lotan, T. L. & Bismar, T. A., Dec 15 2019, In : International Journal of Cancer. 145, 12, p. 3453-3461 9 p.Research output: Contribution to journal › Article
Corrigendum to: National practice patterns for lymph node irradiation in 197,000 men receiving external beam radiotherapy for localized prostate cancer (Urologic Oncology: Seminars and Original Investigations (2019) 37(6) (353.e1–353.e8), (S1078143918305167), (10.1016/j.urolonc.2018.12.022))
Weiner, A. B., Ko, O. S., Zhu, A., Spratt, D. E., Hu, J. C. & Schaeffer, E. M., Aug 1 2019, In : Urologic Oncology: Seminars and Original Investigations. 37, 8, 1 p.Research output: Contribution to journal › Comment/debate
Current recommendations for prostate cancer genetic testing: NCCN prostate guideline
Mohler, J. L., Higano, C. S., Schaeffer, E. M. & Cheng, H. H., Oct 1 2019, In : The Canadian journal of urology. 26, 5S2, p. 34-37 4 p.Research output: Contribution to journal › Article