Edward Matthew Schaeffer

  • 7365 Citations

Research output per year

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Personal profile

Research Interests

I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.

Training Experience

2002Internship, Johns Hopkins University School of Medicine
2007Residency, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, PhD, The University of Chicago

… → 2001

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Research Output

A novel immunocompetent model of metastatic prostate cancer-induced bone pain

Liu, Z., Murphy, S. F., Huang, J., Zhao, L., Hall, C. C., Schaeffer, A. J., Schaeffer, E. M. & Thumbikat, P., Jul 1 2020, In : Prostate. 80, 10, p. 782-794 13 p.

Research output: Contribution to journalArticle

  • Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study

    Meyers, T. J., Weiner, A. B., Graff, R. E., Desai, A. S., Cooley, L. F., Catalona, W. J., Hanauer, S. B., Wu, J. D., Schaeffer, E. M., Abdulkadir, S. A., Kundu, S. D. & Witte, J. S., Jan 1 2020, (Accepted/In press) In : International Journal of Cancer.

    Research output: Contribution to journalArticle

  • Association of Presalvage Radiotherapy PSA Levels after Prostatectomy with Outcomes of Long-Term Antiandrogen Therapy in Men with Prostate Cancer

    Dess, R. T., Sun, Y., Jackson, W. C., Jairath, N. K., Kishan, A. U., Wallington, D. G., Mahal, B. A., Stish, B. J., Zumsteg, Z. S., Den, R. B., Hall, W. A., Gharzai, L. A., Jaworski, E. M., Reichert, Z. R., Morgan, T. M., Mehra, R., Schaeffer, E. M., Sartor, O., Nguyen, P. L., Lee, W. R. & 11 others, Rosenthal, S. A., Michalski, J. M., Schipper, M. J., Dignam, J. J., Pisansky, T. M., Zietman, A. L., Sandler, H. M., Efstathiou, J. A., Feng, F. Y., Shipley, W. U. & Spratt, D. E., May 2020, In : JAMA Oncology. 6, 5, p. 735-743 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer

    Faisal, F. A., Murali, S., Kaur, H., Vidotto, T., Guedes, L. B., Salles, D. C., Kothari, V., Tosoian, J. J., Han, S., Hovelson, D. H., Hu, K., Spratt, D. E., Baras, A. S., Tomlins, S. A., Schaeffer, E. M. & Lotan, T. L., Jun 1 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 11, p. 2595-2602 8 p.

    Research output: Contribution to journalArticle

    Open Access