Grants per year
Personal profile
Research Interests
I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.
Training Experience
2002 | Internship, Johns Hopkins University School of Medicine |
2007 | Residency, Johns Hopkins University School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, PhD, The University of Chicago
… → 2001
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Collaborations and top research areas from the last five years
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The Role of Low Testosterone in Perioperative Surgical Outcomes
Halpern, J. A., Halpern, J. A., Brannigan, R. E., Brannigan, R. E., Schaeffer, E. M. & Schaeffer, E. M.
7/1/22 → 6/30/24
Project: Research project
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The regulatory axis of lncRNA PRCAT71-AR in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/1/21 → 8/31/24
Project: Research project
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Systems Analysis of Drug Resistance in Prostate Cancer
Abdulkadir, S. A., Abdulkadir, S. A., Kothari, V., Schaeffer, E. M. & Schaeffer, E. M.
Rutgers University, the State University of New Jersey, American Cancer Society
7/1/21 → 6/30/25
Project: Research project
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A novel prostate cancer subtyping classifier based on luminal and basal phenotypes
Weiner, A. B., Liu, Y., Hakansson, A., Zhao, X., Proudfoot, J. A., Ho, J., Zhang, J. J. H., Li, E. V., Karnes, R. J., Den, R. B., Kishan, A. U., Reiter, R. E., Hamid, A. A., Ross, A. E., Tran, P. T., Davicioni, E., Spratt, D. E., Attard, G., Lotan, T. L., Lee Kiang Chua, M., & 2 others , 2023, (Accepted/In press) In: cancer.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Association between frailty and low testosterone among men undergoing oncologic surgery
Hudnall, M. T., Greenberg, D., Logan, C., Schaeffer, E. M., Brannigan, R. E., Bentrem, D. J. & Halpern, J. A., Mar 2023, In: Journal of surgical oncology. 127, 3, p. 501-503 3 p.Research output: Contribution to journal › Letter › peer-review
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Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer
Vidotto, T., Imada, E. L., Faisal, F., Murali, S., Mendes, A. A., Kaur, H., Zheng, S., Xu, J., Schaeffer, E. M., Isaacs, W. B., Sfanos, K. S., Marchionni, L. & Lotan, T. L., Feb 8 2023, In: JCI Insight. 8, 3, e162409.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Author Correction: Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials (npj Digital Medicine, (2022), 5, 1, (71), 10.1038/s41746-022-00613-w)
NRG Prostate Cancer AI Consortium, Dec 2023, In: npj Digital Medicine. 6, 1, 27.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
High intratumoral plasma cells content in primary prostate cancer defines a subset of tumors with potential susceptibility to immune-based treatments
Weiner, A. B., Yu, C. Y., Kini, M., Liu, Y., Davicioni, E., Mitrofanova, A., Lotan, T. L. & Schaeffer, E. M., Mar 2023, In: Prostate Cancer and Prostatic Diseases. 26, 1, p. 105-112 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Additional file 1 of Transcriptional landscape of PTEN loss in primary prostate cancer
Imada, E. L. (Creator), Sanchez, D. F. (Creator), Dinalankara, W. (Creator), Vidotto, T. (Creator), Ebot, E. M. (Creator), Tyekucheva, S. (Creator), Franco, G. R. (Creator), Mucci, L. A. (Creator), Loda, M. (Creator), Schaeffer, E. M. (Creator), Lotan, T. (Creator), Marchionni, L. (Creator) & Loda, M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.15058182, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Transcriptional_landscape_of_PTEN_loss_in_primary_prostate_cancer/15058182
Dataset
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Transcriptional landscape of PTEN loss in primary prostate cancer
Imada, E. L. (Creator), Sanchez, D. F. (Creator), Dinalankara, W. (Creator), Vidotto, T. (Creator), Ebot, E. M. (Creator), Tyekucheva, S. (Creator), Franco, G. R. (Creator), Mucci, L. A. (Creator), Loda, M. (Creator), Schaeffer, E. M. (Creator), Lotan, T. (Creator), Marchionni, L. (Creator) & Loda, M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5529321, https://springernature.figshare.com/collections/Transcriptional_landscape_of_PTEN_loss_in_primary_prostate_cancer/5529321
Dataset
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A comparative effectiveness analysis of the PBCG vs. PCPT risks calculators in a multi-ethnic cohort
Carbunaru, S. (Creator), Nettey, O. S. (Contributor), Gogana, P. (Creator), Helenowski, I. B. (Creator), Jovanovic, B. (Creator), Ruden, M. (Creator), Hollowell, C. M. P. (Creator), Sharifi, R. (Contributor), Kittles, R. A. (Creator), Schaeffer, E. M. (Creator), Gann, P. (Creator) & Murphy, A. B. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4760723.v1, https://springernature.figshare.com/collections/A_comparative_effectiveness_analysis_of_the_PBCG_vs_PCPT_risks_calculators_in_a_multi-ethnic_cohort/4760723/1
Dataset