Grants per year
Personal profile
Research Interests
I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.
Training Experience
| 2002 | Internship, Johns Hopkins University School of Medicine |
| 2007 | Residency, Johns Hopkins University School of Medicine |
Education/Academic qualification
MD, PhD, The University of Chicago
… → 2001
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Grants
Molecular profiles of African American men with localized prostate cancer
8/1/19 → 7/31/20
Project: Research project
Clinical, Environmental, Genetic and Genomic profile of Men with Early Onset Lethal Prostate Cancer
Abdulkadir, S. A., Hussain, M., Jovanovic, B., Meeks, J. J., Morgans, A. K. & Schaeffer, E. M.
12/31/17 → 12/31/20
Project: Research project
Research Output
Association between surgical approach and survival following resection of abdominopelvic malignancies
Yuce, T. K., Ellis, R. J., Chung, J., Merkow, R. P., Yang, A. D., Soper, N. J., Tanner, E. J., Schaeffer, E. M., Bilimoria, K. Y. & Auffenberg, G. B., Mar 1 2020, In : Journal of surgical oncology. 121, 4, p. 620-629 10 p.Research output: Contribution to journal › Article
Educational Material on Prostate Cancer Screening is Overly Complex and Fails to Meet Recommended Layperson Readability Guidelines
Rooney, M. K., Morgans, A. K., Chen, R. C., Golden, D. W., Meeks, J. J., Auffenberg, G., Kundu, S. D., Schaeffer, E. M., Hussain, M. H., Kalapurakal, J. A. & Sachdev, S., Jan 2020, In : Urology. 135, p. 1-3 3 p.Research output: Contribution to journal › Editorial
Genomic and clinical characterization of stromal infiltration markers in prostate cancer
Mahal, B. A., Alshalalfa, M., Zhao, S. G., Beltran, H., Chen, W. S., Chipidza, F., Davicioni, E., Karnes, R. J., Ku, S. Y., Lotan, T. L., Muralidhar, V., Rebbeck, T. R., Schaeffer, E. M., Spratt, D. E., Feng, F. Y. & Nguyen, P. L., Jan 1 2020, (Accepted/In press) In : Cancer.Research output: Contribution to journal › Article
Re: Premenopausal Women with Recurrent Urinary Tract Infections Have Lower Quality of Life
Schaeffer, E. M., Jan 1 2020, In : The Journal of urology. 203, 1, p. 11-12 2 p.Research output: Contribution to journal › Comment/debate
Re: Clinical Characteristics of Postoperative Febrile Urinary Tract Infections after Ureteroscopic Lithotripsy
Schaeffer, E. M., Jan 1 2020, In : The Journal of urology. 203, 1, 1 p.Research output: Contribution to journal › Comment/debate