Edward Matthew Schaeffer

  • 5968 Citations
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Personal profile

Research Interests

I am Chair of the Department of Urology at Feinberg School of Medicine and Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. My clinical and research focus is the diagnosis and treatment of men with prostate cancer. I have published more than 250 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. My previous work has demonstrated that aggressive (high-risk), localized prostate cancer is frequently lethal and undertreated. I developed a molecular signature which identifies the most lethal prostate cancers, sometimes upwards of 10 years before the effects of the tumors are observed. I am now taking this work to the next level by modeling which chemotherapies and hormonal therapies could effectively treat these rare, aggressive tumors. My discoveries have greatly advanced the basic scientific understanding of biologic differences in prostate cancers in men of African descent. In recent work, I demonstrated a more aggressive biologic subset of cancers in African American men, which helps to explain why African American men are twice as likely to die from prostate cancer as Caucasian men. My team’s findings include distinctive anatomic locations of tumors in African American patients, molecular expression signatures of cancers in African American patients that demonstrate decreased reliance on androgen signaling, novel solid tumor gene fusions, and divergent biomarker panels signaling aggressive disease. I am continuing this work and hope to identify additional outliers in African American prostate cancers that impact metastatic disease risk.

Training Experience

2002Internship, Johns Hopkins University School of Medicine
2007Residency, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, PhD, University of Chicago

… → 2001

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Grants 2015 2020

Research Output 1999 2019

Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer

Berglund, A. E., Rounbehler, R. J., Gerke, T., Awasthi, S., Cheng, C. H., Takhar, M., Davicioni, E., Alshalalfa, M., Erho, N., Klein, E. A., Freedland, S. J., Ross, A. E., Schaeffer, E. M., Trock, B. J., Den, R. B., Cleveland, J. L., Park, J. Y., Dhillon, J. & Yamoah, K., May 1 2019, In : Prostate Cancer and Prostatic Diseases. 22, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
1 Citation (Scopus)

Inflammatory Bowel Disease and the Risk of Prostate Cancer

Burns, J. A., Weiner, A. B., Catalona, W. J., Li, E. V., Schaeffer, E. M., Hanauer, S. B., Strong, S. A., Burns, J., Hussain, M. & Kundu, S. D., May 1 2019, In : European urology. 75, 5, p. 846-852 7 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Prostatic Neoplasms
Prostate-Specific Antigen
Safety Management


Faisal, F., Alshalalfa, M., Davicioni, E., Karnes, R. J., Isaacs, W., Lotan, T. & Schaeffer, E. M., Apr 1 2019, In : The Journal of urology. 201, p. e979

Research output: Contribution to journalArticle

Open Access
Androgen Receptors
Prostatic Neoplasms
Neuroendocrine Cells

National practice patterns for lymph node irradiation in 197,000 men receiving external beam radiotherapy for localized prostate cancer

Weiner, A. B., Ko, O. S., Zhu, A., Spratt, D. E., Hu, J. C. & Schaeffer, E. M., Jun 1 2019, In : Urologic Oncology: Seminars and Original Investigations. 37, 6, p. 353.e1-353.e8

Research output: Contribution to journalArticle

Prostatic Neoplasms
Lymph Nodes
4 Citations (Scopus)

Outcomes of very high-risk prostate cancer after radical prostatectomy: Validation study from 3 centers

Sundi, D., Tosoian, J. J., Nyame, Y. A., Alam, R., Achim, M., Reichard, C. A., Li, J., Wilkins, L., Schwen, Z., Han, M., Davis, J. W., Klein, E. A., Schaeffer, E. M., Stephenson, A. J., Ross, A. E. & Chapin, B. F., Feb 1 2019, In : Cancer. 125, 3, p. 391-397 7 p.

Research output: Contribution to journalArticle

Validation Studies
Prostatic Neoplasms
Confidence Intervals