Edwin Smith

  • 5096 Citations
19982021

Research output per year

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Research Output

  • 5096 Citations
  • 39 Article
  • 7 Review article
  • 2 Comment/debate
  • 2 Short survey
2020

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release

Aoi, Y., Smith, E. R., Shah, A. P., Rendleman, E. J., Marshall, S. A., Woodfin, A. R., Chen, F. X., Shiekhattar, R. & Shilatifard, A., Apr 16 2020, In : Molecular cell. 78, 2, p. 261-274.e5

Research output: Contribution to journalArticle

2 Scopus citations

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Douillet, D., Sze, C. C., Ryan, C., Piunti, A., Shah, A. P., Ugarenko, M., Marshall, S. A., Rendleman, E. J., Zha, D., Helmin, K. A., Zhao, Z., Cao, K., Morgan, M. A., Singer, B. D., Bartom, E. T., Smith, E. R. & Shilatifard, A., Jan 1 2020, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Correction to: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (Nature Communications, (2018), 9, 1, (4406), 10.1038/s41467-018-06543-0)

Chung, C. Y., Berson, A., Kennerdell, J. R., Sartoris, A., Unger, T., Porta, S., Kim, H. J., Smith, E. R., Shilatifard, A., Van Deerlin, V., Lee, V. M. Y., Chen-Plotkin, A. & Bonini, N. M., Dec 1 2019, In : Nature communications. 10, 1, 555.

Research output: Contribution to journalComment/debate

2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Chung, C. Y., Berson, A., Kennerdell, J. R., Sartoris, A., Unger, T., Porta, S., Kim, H. J., Smith, E. R., Shilatifard, A., Van Deerlin, V., Lee, V. M. Y., Chen-Plotkin, A. & Bonini, N. M., Dec 1 2018, In : Nature communications. 9, 1, 4406.

Research output: Contribution to journalArticle

10 Scopus citations

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

Cao, K., Collings, C. K., Morgan, M. A., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Smith, E. R. & Shilatifard, A., Jan 2018, In : Science Advances. 4, 1, eaap8747.

Research output: Contribution to journalArticle

12 Scopus citations

Born to run: Control of transcription elongation by RNA polymerase II

Chen, F. X., Smith, E. & Shilatifard, A., Jul 1 2018, In : Nature Reviews Molecular Cell Biology. 19, 7, p. 464-478 15 p.

Research output: Contribution to journalReview article

52 Scopus citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E. & Shilatifard, A., Oct 18 2018, In : Cell. 175, 3, p. 766-779.e17

Research output: Contribution to journalArticle

18 Scopus citations

TET2 coactivates gene expression through demethylation of enhancers

Wang, L., Ozark, P. A., Smith, E. R., Zhao, Z., Marshall, S. A., Rendleman, E. J., Piunti, A., Ryan, C., Whelan, A. L., Helmin, K. A., Morgan, M. A., Zou, L., Singer, B. D. & Shilatifard, A., Nov 7 2018, In : Science Advances. 4, 11, eaau6986.

Research output: Contribution to journalArticle

15 Scopus citations
2017

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Rickels, R., Herz, H. M., Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y. H., Wang, L., Rendleman, E. J., Marshall, S. A., Krueger, A., Bartom, E. T., Piunti, A., Smith, E. R., Abshiru, N. A., Kelleher, N. L., Dorsett, D. & Shilatifard, A., Nov 1 2017, In : Nature Genetics. 49, 11, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

Hu, D., Gao, X., Cao, K., Morgan, M. A., Mas, G., Smith, E. R., Volk, A. G., Bartom, E. T., Crispino, J. D., Di Croce, L. & Shilatifard, A., Feb 2 2017, In : Molecular cell. 65, 3, p. 460-475.e6

Research output: Contribution to journalArticle

32 Scopus citations

PAF1 regulation of promoter-proximal pause release via enhancer activation

Chen, F. X., Xie, P., Collings, C. K., Cao, K., Aoi, Y., Marshall, S. A., Rendleman, E. J., Ugarenko, M., Ozark, P. A., Zhang, A., Shiekhattar, R., Smith, E. R., Zhang, M. Q. & Shilatifard, A., Sep 22 2017, In : Science. 357, 6357, p. 1294-1298 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Liang, K., Volk, A. G., Haug, J. S., Marshall, S. A., Woodfin, A. R., Bartom, E. T., Gilmore, J. M., Florens, L., Washburn, M. P., Sullivan, K. D., Espinosa, J. M., Cannova, J., Zhang, J., Smith, E. R., Crispino, J. D. & Shilatifard, A., Jan 12 2017, In : Cell. 168, 1-2, p. 59-72.e13

Research output: Contribution to journalArticle

46 Scopus citations
2016

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Luo, Z., Lin, C., Woodfin, A. R., Bartom, E. T., Gao, X., Smith, E. R. & Shilatifard, A., Jan 1 2016, In : Genes and Development. 30, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells

De Kumar, B., Parrish, M. E., Slaughter, B. D., Unruh, J. R., Gogol, M., Seidel, C., Paulson, A., Li, H., Gaudenz, K., Peak, A., McDowell, W., Fleharty, B., Ahn, Y., Lin, C., Smith, E., Shilatifard, A. & Krumlauf, R., Aug 1 2015, In : Genome research. 25, 8, p. 1229-1243 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing

Liang, K., Gao, X., Gilmore, J. M., Florens, L., Washburn, M. P., Smith, E. & Shilatifard, A., Jan 1 2015, In : Molecular and cellular biology. 35, 6, p. 928-938 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

Chen, F. X., Woodfin, A. R., Gardini, A., Rickels, R. A., Marshall, S. A., Smith, E. R., Shiekhattar, R. & Shilatifard, A., Aug 27 2015, In : Cell. 162, 5, p. 1003-1015 13 p.

Research output: Contribution to journalArticle

80 Scopus citations

Zic2 is an enhancer-binding factor required for embryonic stem cell specification

Luo, Z., Gao, X., Lin, C., Smith, E., Marshall, S. A., Swanson, S. K., Florens, L., Washburn, M. P. & Shilatifard, A., Feb 19 2015, In : Molecular cell. 57, 4, p. 685-694 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2014

Context dependency of Set1/ COMPASS-mediated histone H3 Lys4 trimethylation

Thornton, J. L., Westfield, G. H., Takahashi, Y. H., Cook, M., Gao, X., Woodfin, A. R., Lee, J. S., Morgan, M. A., Jackson, J., Smith, E. R., Couture, J. F., Skiniotis, G. & Shilatifard, A., Jan 15 2014, In : Genes and Development. 28, 2, p. 115-120 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Enhancer biology and enhanceropathies

Smith, E. & Shilatifard, A., Mar 2014, In : Nature Structural and Molecular Biology. 21, 3, p. 210-219 10 p.

Research output: Contribution to journalReview article

135 Scopus citations
2013

The little elongation complex functions at initiation and elongation phases of snRNA gene transcription

Hu, D., Smith, E., Garruss, A., Mohaghegh, N., Varberg, J., Lin, C., Jackson, J., Gao, X., Saraf, A., Florens, L., Washburn, M., Eissenberg, J. & Shilatifard, A., Aug 22 2013, In : Molecular cell. 51, 4, p. 493-505 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

Hu, D., Garruss, A. S., Gao, X., Morgan, M. A., Cook, M., Smith, E. R. & Shilatifard, A., Sep 1 2013, In : Nature Structural and Molecular Biology. 20, 9, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

95 Scopus citations

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers

Hu, D., Gao, X., Morgan, M. A., Herz, H. M., Smith, E. R. & Shilatifard, A., Dec 2013, In : Molecular and cellular biology. 33, 23, p. 4745-4754 10 p.

Research output: Contribution to journalArticle

170 Scopus citations

Transcriptional elongation checkpoint control in development and disease

Smith, E. & Shilatifard, A., May 15 2013, In : Genes and Development. 27, 10, p. 1079-1088 10 p.

Research output: Contribution to journalReview article

46 Scopus citations
2011

Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC)

Lin, C., Garrett, A. S., de Kumar, B., Smith, E. R., Gogol, M., Seidel, C., Krumlauf, R. & Shilatifard, A., Jul 15 2011, In : Genes and Development. 25, 14, p. 1486-1498 13 p.

Research output: Contribution to journalArticle

108 Scopus citations

Human mediator subunit MED26 functions as a docking site for transcription elongation factors

Takahashi, H., Parmely, T. J., Sato, S., Tomomori-Sato, C., Banks, C. A. S., Kong, S. E., Szutorisz, H., Swanson, S. K., Martin-Brown, S., Washburn, M. P., Florens, L., Seidel, C. W., Lin, C., Smith, E. R., Shilatifard, A., Conaway, R. C. & Conaway, J. W., Jul 8 2011, In : Cell. 146, 1, p. 92-104 13 p.

Research output: Contribution to journalArticle

202 Scopus citations

The COMPASS family of H3K4 methylases in Drosophila

Mohan, M., Herz, H. M., Smith, E. R., Zhang, Y., Jackson, J., Washburn, M. P., Florens, L., Eissenberg, J. C. & Shilatifard, A., Nov 1 2011, In : Molecular and cellular biology. 31, 21, p. 4310-4318 9 p.

Research output: Contribution to journalArticle

123 Scopus citations

The Little Elongation Complex Regulates Small Nuclear RNA Transcription

Smith, E. R., Lin, C., Garrett, A. S., Thornton, J., Mohaghegh, N., Hu, D., Jackson, J., Saraf, A., Swanson, S. K., Seidel, C., Florens, L., Washburn, M. P., Eissenberg, J. C. & Shilatifard, A., Dec 23 2011, In : Molecular cell. 44, 6, p. 954-965 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

The super elongation complex (SEC) and MLL in development and disease

Smith, E., Lin, C. & Shilatifard, A., Apr 1 2011, In : Genes and Development. 25, 7, p. 661-672 12 p.

Research output: Contribution to journalReview article

212 Scopus citations
2010

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

Lin, C., Smith, E. R., Takahashi, H., Lai, K. C., Martin-Brown, S., Florens, L., Washburn, M. P., Conaway, J. W., Conaway, R. C. & Shilatifard, A., Feb 12 2010, In : Molecular cell. 37, 3, p. 429-437 9 p.

Research output: Contribution to journalArticle

342 Scopus citations
153 Scopus citations

The Language of Histone Crosstalk

Lee, J. S., Smith, E. & Shilatifard, A., Sep 3 2010, In : Cell. 142, 5, p. 682-685 4 p.

Research output: Contribution to journalShort survey

354 Scopus citations
2009

Developmental biology: Histone cross-talk in stem cells

Smith, E. & Shilatifard, A., Jan 9 2009, In : Science. 323, 5911, p. 221-222 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II

Wang, P., Lin, C., Smith, E. R., Guo, H., Sanderson, B. W., Wu, M., Gogol, M., Alexander, T., Seidel, C., Wiedemann, L. M., Ge, K., Krumlauf, R. & Shilatifard, A., Nov 1 2009, In : Molecular and cellular biology. 29, 22, p. 6074-6085 12 p.

Research output: Contribution to journalArticle

229 Scopus citations
2008

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II

Smith, E. R., Min, G. L., Winter, B., Droz, N. M., Eissenberg, J. C., Shiekhattar, R. & Shilatifard, A., Feb 1 2008, In : Molecular and cellular biology. 28, 3, p. 1041-1046 6 p.

Research output: Contribution to journalArticle

95 Scopus citations
28 Scopus citations

The MLE subunit of the Drosophila MSL complex uses its ATPase activity for dosage compensation and its helicase activity for targeting

Morra, R., Smith, E. R., Yokoyama, R. & Lucchesi, J. C., Feb 1 2008, In : Molecular and cellular biology. 28, 3, p. 958-966 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007
16 Scopus citations

Covalent modifications of histones during development and disease pathogenesis

Bhaumik, S. R., Smith, E. & Shilatifard, A., Nov 1 2007, In : Nature Structural and Molecular Biology. 14, 11, p. 1008-1016 9 p.

Research output: Contribution to journalReview article

455 Scopus citations

The A, B, Gs of silencing

Smith, E. & Shilatifard, A., May 15 2007, In : Genes and Development. 21, 10, p. 1141-1144 4 p.

Research output: Contribution to journalReview article

9 Scopus citations
2006
2005

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16

Smith, E. R., Cayrou, C., Huang, R., Lane, W. S., Côté, J. & Lucchesi, J. C., Nov 1 2005, In : Molecular and cellular biology. 25, 21, p. 9175-9188 14 p.

Research output: Contribution to journalArticle

216 Scopus citations

Involvement of human MOF in ATM function

Gupta, A., Sharma, G. G., Young, C. S. H., Agarwal, M., Smith, E. R., Paull, T. T., Lucchesi, J. C., Khanna, K. K., Ludwig, T. & Pandita, T. K., Jun 1 2005, In : Molecular and cellular biology. 25, 12, p. 5292-5305 14 p.

Research output: Contribution to journalArticle

169 Scopus citations

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

Dou, Y., Milne, T. A., Tackett, A. J., Smith, E. R., Fukuda, A., Wysocka, J., Allis, C. D., Chait, B. T., Hess, J. L. & Roeder, R. G., Jun 17 2005, In : Cell. 121, 6, p. 873-885 13 p.

Research output: Contribution to journalArticle

462 Scopus citations
2001

Linking Global Histone Acetylation to the Transcription Enhancement of X-chromosomal Genes in Drosophila Males

Smith, E. R., Allis, C. D. & Lucchesi, J. C., Aug 24 2001, In : Journal of Biological Chemistry. 276, 34, p. 31483-31486 4 p.

Research output: Contribution to journalArticle

121 Scopus citations
2000

A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF

Neal, K. C., Pannuti, A., Smith, E. R. & Lucchesi, J. C., Jan 31 2000, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1490, 1-2, p. 170-174 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation

Smith, E. R., Pannuti, A., Gu, W., Steurnagel, A., Cook, R. G., Allis, C. D. & Lucchesi, J. C., Jan 2000, In : Molecular and cellular biology. 20, 1, p. 312-318 7 p.

Research output: Contribution to journalArticle

235 Scopus citations
1998

Cloning of drosophila GCN5: Conserved features among metazoan GCN5 family members

Smith, E. R., Belote, J. M., Schiltz, R. L., Yang, X. J., Moore, P. A., Berger, S. L., Nakatani, Y. & Allis, C. D., Jun 15 1998, In : Nucleic acids research. 26, 12, p. 2948-2954 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

ESA1 is a histone acetyltransferase that is essential for growth in yeast

Smith, E. R., Eisen, A., Gu, W., Sattah, M., Pannuti, A., Zhou, J., Cook, R. G., Lucchesi, J. C. & Allis, C. D., Mar 31 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 7, p. 3561-3565 5 p.

Research output: Contribution to journalArticle

245 Scopus citations