Eileen H Bigio

  • 21674 Citations
1989 …2020

Research output per year

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Personal profile

Research Interests

My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.

Certifications and Licenses

Anatomic Pathology
Neuropathology

Training Experience

1989Residency, University of Texas Medical Branch Hospital
1992Fellowship, Parkland Memorial Hospital

Education/Academic qualification

MD, University of Texas

… → 1985

Research interests

  • Aging
  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Frontotemporal Dementia
  • Movement Disorders
  • Nervous System Diseases
  • Neuromuscular Disorders
  • Pathology

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Grants

  • Research Output

    Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

    Moore, K. M., Nicholas, J., Grossman, M., McMillan, C. T., Irwin, D. J., Massimo, L., Van Deerlin, V. M., Warren, J. D., Fox, N. C., Rossor, M. N., Mead, S., Bocchetta, M., Boeve, B. F., Knopman, D. S., Graff-Radford, N. R., Forsberg, L. K., Rademakers, R., Wszolek, Z. K., van Swieten, J. C., Jiskoot, L. C. & 151 others, Meeter, L. H., Dopper, E. GP., Papma, J. M., Snowden, J. S., Saxon, J., Jones, M., Pickering-Brown, S., Le Ber, I., Camuzat, A., Brice, A., Caroppo, P., Ghidoni, R., Pievani, M., Benussi, L., Binetti, G., Dickerson, B. C., Lucente, D., Krivensky, S., Graff, C., Öijerstedt, L., Fallström, M., Thonberg, H., Ghoshal, N., Morris, J. C., Borroni, B., Benussi, A., Padovani, A., Galimberti, D., Scarpini, E., Fumagalli, G. G., Mackenzie, I. R., Hsiung, G. Y. R., Sengdy, P., Boxer, A. L., Rosen, H., Taylor, J. B., Synofzik, M., Wilke, C., Sulzer, P., Hodges, J. R., Halliday, G., Kwok, J., Sanchez-Valle, R., Lladó, A., Borrego-Ecija, S., Santana, I., Almeida, M. R., Tábuas-Pereira, M., Moreno, F., Barandiaran, M., Indakoetxea, B., Levin, J., Danek, A., Rowe, J. B., Cope, T. E., Otto, M., Anderl-Straub, S., de Mendonça, A., Maruta, C., Masellis, M., Black, S. E., Couratier, P., Lautrette, G., Huey, E. D., Sorbi, S., Nacmias, B., Laforce, R., Tremblay, M. P. L., Vandenberghe, R., Damme, P. V., Rogalski, E. J., Weintraub, S., Gerhard, A., Onyike, C. U., Ducharme, S., Papageorgiou, S. G., Ng, A. S. L., Brodtmann, A., Finger, E., Guerreiro, R., Bras, J., Rohrer, J. D., Heller, C., Convery, R. S., Woollacott, I. OC., Shafei, R. M., Graff-Radford, J., Jones, D. T., Dheel, C. M., Savica, R., Lapid, M. I., Baker, M., Fields, J. A., Gavrilova, R., Domoto-Reilly, K., Poos, J. M., Van der Ende, E. L., Panman, J. L., Donker Kaat, L., Seelaar, H., Richardson, A., Frisoni, G., Mega, A., Fostinelli, S., Chiang, H. H., Alberici, A., Arighi, A., Fenoglio, C., Heuer, H., Miller, B., Karydas, A., Fong, J., João Leitão, M., Santiago, B., Duro, D., Ferreira, C., Gabilondo, A., De Arriba, M., Tainta, M., Zulaica, M., Ferreira, C., Semler, E., Ludolph, A., Landwehrmeyer, B., Volk, A. E., Miltenberger, G., Verdelho, A., Afonso, S., Tartaglia, M. C., Freedman, M., Rogaeva, E., Ferrari, C., Piaceri, I., Bessi, V., Lombardi, G., St-Onge, F., Doré, M. C., Bruffaerts, R., Vandenbulcke, M., Van den Stock, J., Mesulam, M. M., Bigio, E., Koros, C., Papatriantafyllou, J., Kroupis, C., Stefanis, L., Shoesmith, C., Robertson, E., Coppola, G., Da Silva Ramos, E. M. & Geschwind, D., Feb 2020, In : The Lancet Neurology. 19, 2, p. 145-156 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations

    APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort

    Weintraub, S., Teylan, M., Rader, B., Chan, K. C. G., Bollenbeck, M., Kukull, W. A., Coventry, C., Rogalski, E., Bigio, E. & Mesulam, M. M., Feb 11 2020, In : Neurology. 94, 6, p. e607-e612

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Calbindin-D28K, parvalbumin, and calretinin in young and aged human locus coeruleus

    Lamerand, S., Shahidehpour, R., Ayala, I., Gefen, T., Mesulam, M. M., Bigio, E. & Geula, C., Oct 2020, In : Neurobiology of Aging. 94, p. 243-249 7 p.

    Research output: Contribution to journalArticle

  • Distribution of TDP-43 Pathology in Hippocampal Synaptic Relays Suggests Transsynaptic Propagation in Frontotemporal Lobar Degeneration

    Jamshidi, P., Kim, G., Shahidehpour, R. K., Bolbolan, K., Gefen, T., Bigio, E. H., Mesulam, M. M. & Geula, C., Jun 1 2020, In : Journal of neuropathology and experimental neurology. 79, 6, p. 585-591 7 p.

    Research output: Contribution to journalArticle

  • Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    The Alzheimer’s Disease Genetics Consortium, Dec 1 2020, In : Nature communications. 11, 1, 667.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations