Eileen H Bigio

  • 18604 Citations
1989 …2021
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Personal profile

Research Interests

My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.

Certifications and Licenses

Anatomic Pathology
Neuropathology

Training Experience

1989Residency, University of Texas Medical Branch Hospital
1992Fellowship, Parkland Memorial Hospital

Education/Academic qualification

MD, University of Texas

… → 1985

Research interests

  • Aging
  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Cancer: Brain and Nervous System
  • Frontotemporal Dementia
  • Movement Disorders
  • Nervous System Diseases
  • Neuromuscular Disorders
  • Pathology

Fingerprint Dive into the research topics where Eileen H Bigio is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 19 Similar Profiles
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Primary Progressive Aphasia Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
Dementia Medicine & Life Sciences
Pathology Medicine & Life Sciences
Mutation Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences

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Grants 2001 2021

dementia
pilot project
interaction
resources
caregiver
dementia
pilot project
interaction
resources
caregiver
dementia
pilot project
interaction
resources
caregiver
Odorant Receptors
Smell
Olfactory Receptor Neurons
Olfactory Bulb
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Atrophy
Phenotype
Parahippocampal Gyrus
Dentate Gyrus

Research Output 1989 2019

Activated microglia in cortical white matter across cognitive aging trajectories

Gefen, T. D., Kim, G., Bolbolan, K., Geoly, A., Ohm, D., Oboudiyat, C., Shahidehpour, R., Rademaker, A. W., Weintraub, S., Bigio, E. H., Mesulam, M-M., Rogalski, E. & Geula, C., Jan 1 2019, In : Frontiers in Aging Neuroscience. 11, MAY, 094.

Research output: Contribution to journalArticle

Open Access
Microglia
Inflammation Mediators
Gliosis
HLA Antigens
Cognitive Aging

A highly sensitive sandwich ELISA to detect CSF progranulin: A potential biomarker for CNS disorders

Li, Y., Wang, D., Li, Y., Zhu, J., Zhao, J., Deng, Y., Rogalski, E., Bigio, E. H., Rademaker, A. W., Xia, H. & Mao, Q., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 5, p. 406-415 10 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Biomarkers
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Brain Diseases
Apathy
Frontotemporal Lobar Degeneration
Dementia
Alzheimer Disease
Frontotemporal Dementia

Clinical and cortical decline in the aphasic variant of Alzheimer's disease

Rogalski, E., Sridhar, J., Martersteck, A., Rader, B., Cobia, D., Arora, A. K., Fought, A. J., Bigio, E. H., Weintraub, S., Mesulam, M-M. & Rademaker, A. W., Apr 1 2019, In : Alzheimer's and Dementia. 15, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Alzheimer Disease
Language
Amyloid
Atrophy
8 Citations (Scopus)

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases

Rogalski, E., Gefen, T. D., Mao, Q., Connelly, M., Weintraub, S., Geula, C., Bigio, E. H. & Mesulam, M-M., May 1 2019, In : Hippocampus. 29, 5, p. 458-467 10 p.

Research output: Contribution to journalArticle

Episodic Memory
Personality
Autopsy
Entorhinal Cortex
Neocortex