Grants per year
Personal profile
Research Interests
My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.
Certifications and Licenses
| Anatomic Pathology | |
| Neuropathology |
Training Experience
| 1989 | Residency, University of Texas Medical Branch Hospital |
| 1992 | Fellowship, Parkland Memorial Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Texas
… → 1985
Research interests keywords
- Aging
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Frontotemporal Dementia
- Movement Disorders
- Nervous System Diseases
- Neuromuscular Disorders
- Pathology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype
Geula, C., Bigio, E. H., Dong, H., Mesulam, M., Vassar, R. J. & Zhang, H.
National Institute of Neurological Disorders and Stroke
4/1/20 → 3/31/25
Project: Research project
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Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes
Gefen, T. D., Bigio, E. H., Geula, C., Mesulam, M., Rademaker, A. W., Rogalski, E., Zhang, H., Vassar, R. J. & Weintraub, S.
1/15/20 → 12/31/24
Project: Research project
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Alzheimer's Disease Core Center
Mesulam, M., Vassar, R. J., Bigio, E. H., Geula, C., Hurley, R. S., Mesulam, M., Morhardt, D. J., Rademaker, A. W., Rogalski, E., Weintraub, S. & Disterhoft, J. F.
8/1/16 → 6/30/22
Project: Research project
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Subproject for Mapping and function of odorant receptors in the human olfactory system
Gottfried, J. A., Bigio, E. H., Geula, C., Tan, B. K. & Gottfried, J. A.
National Institute on Deafness and Other Communication Disorders
12/1/14 → 11/30/20
Project: Research project
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Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype
Geula, C., Bigio, E. H., Dong, H., Mesulam, M. & Vassar, R. J.
National Institute of Neurological Disorders and Stroke
8/1/14 → 3/31/20
Project: Research project
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Differential vulnerability of the dentate gyrus to tauopathies in dementias
Kawles, A., Minogue, G., Zouridakis, A., Keszycki, R., Gill, N., Nassif, C., Coventry, C., Zhang, H., Rogalski, E., Flanagan, M. E., Castellani, R., Bigio, E. H., Mesulam, M. M., Geula, C. & Gefen, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 1.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Shades of gray in human white matter
Zouridakis, A., Ayala, I., Minogue, G., Kawles, A., Keszycki, R., Macomber, A., Bigio, E. H., Geula, C., Mesulam, M. M. & Gefen, T., 2023, (Accepted/In press) In: Journal of Comparative Neurology.Research output: Contribution to journal › Article › peer-review
Open Access -
What every neuropathologist needs to know: condensed protocol work-up for clinical dementia syndromes
Multz, R. A., Spencer, C., Matos, A., Ajroud, K., Zamudio, C., Bigio, E., Mao, Q., Medeiros, R. A., Ahrendsen, J. T., Castellani, R. J. & Flanagan, M. E., Jan 20 2023, In: Journal of neuropathology and experimental neurology. 82, 2, p. 103-109 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-Type C
Kawles, A., Nishihira, Y., Feldman, A., Gill, N., Minogue, G., Keszycki, R., Coventry, C., Spencer, C., Lilek, J., Ajroud, K., Coppola, G., Rademakers, R., Rogalski, E., Weintraub, S., Zhang, H., Flanagan, M. E., Bigio, E. H., Mesulam, M. M., Geula, C., Mao, Q., & 1 others, Mar 1 2022, In: Brain. 145, 3, p. 1069-1078 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology
Martersteck, A., Ayala, I., Ohm, D. T., Spencer, C., Coventry, C., Weintraub, S., Bigio, E. H., Mesulam, M. M., Geula, C. & Rogalski, E., Dec 2022, In: Acta Neuropathologica Communications. 10, 1, 111.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Lui, H. (Contributor), Zhang, J. (Contributor), Makinson, S. R. (Contributor), Cahill, M. K. (Contributor), Kelley, K. W. (Contributor), Huang, H. (Contributor), Shang, Y. (Contributor), Oldham, M. C. (Contributor), Martens, L. H. (Contributor), Gao, F. (Contributor), Coppola, G. (Contributor), Sloan, S. A. (Contributor), Bigio, E. H. (Contributor), MacKenzie, I. R. (Contributor), Seeley, W. W. (Contributor), Karydas, A. (Contributor), Miller, B. L. (Contributor), Borroni, B. (Contributor), Ghidoni, R. (Contributor), Farese, R. V. (Contributor), Paz, J. T. (Contributor), Barres, B. A. (Contributor) & Huang, E. J. (Contributor), Gene Expression Omnibus, 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75083
Dataset
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator), Ozdinler, H. (Contributor) & Weintraub, S. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497.v1, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497/1
Dataset