Eileen H Bigio

  • 18220 Citations
1989 …2021
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Personal profile

Research Interests

My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.

Certifications and Licenses

Anatomic Pathology
Neuropathology

Training Experience

1989Residency, University of Texas Medical Branch Hospital
1992Fellowship, Parkland Memorial Hospital

Education/Academic qualification

MD, University of Texas

… → 1985

Keywords

  • Aging
  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Frontotemporal Dementia
  • Movement Disorders
  • Nervous System Diseases
  • Neuromuscular Disorders
  • Pathology

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  • 18 Similar Profiles
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Primary Progressive Aphasia Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
Dementia Medicine & Life Sciences
Pathology Medicine & Life Sciences
Mutation Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences

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Grants 2001 2021

dementia
pilot project
interaction
resources
caregiver
dementia
pilot project
interaction
resources
caregiver
dementia
pilot project
interaction
resources
caregiver
Odorant Receptors
Smell
Olfactory Receptor Neurons
Olfactory Bulb
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Atrophy
Phenotype
Parahippocampal Gyrus
Dentate Gyrus

Research Output 1989 2019

A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders

Li, Y., Wang, D., Li, Y., Zhu, J., Zhao, J., Deng, Y., Rogalski, E., Bigio, E. H., Rademaker, A. W., Xia, H. & Mao, Q., May 1 2019, In : Journal of neuropathology and experimental neurology. 78, 5, p. 406-415 10 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Biomarkers
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Brain Diseases

Clinical and cortical decline in the aphasic variant of Alzheimer's disease

Rogalski, E., Sridhar, J., Martersteck, A., Rader, B., Cobia, D., Arora, A. K., Fought, A. J., Bigio, E. H., Weintraub, S., Mesulam, M-M. & Rademaker, A. W., Apr 1 2019, In : Alzheimer's and Dementia. 15, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Alzheimer Disease
Language
Amyloid
Atrophy
5 Citations (Scopus)

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases

Rogalski, E., Gefen, T. D., Mao, Q., Connelly, M., Weintraub, S., Geula, C., Bigio, E. H. & Mesulam, M-M., May 1 2019, In : Hippocampus. 29, 5, p. 458-467 10 p.

Research output: Contribution to journalArticle

Episodic Memory
Personality
Autopsy
Entorhinal Cortex
Neocortex

Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology

Mesulam, M-M., Lalehzari, N., Rahmani, F., Ohm, D., Shahidehpour, R., Kim, G., Gefen, T. D., Weintraub, S., Bigio, E. H. & Geula, C., Apr 2 2019, In : Neurology. 92, 14, p. e1580-e1588

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Denervation
Cholinergic Agents
Pathology
Cholinergic Neurons
14 Citations (Scopus)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein