Grants per year
Personal profile
Research Interests
My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.
Certifications and Licenses
| Anatomic Pathology | |
| Neuropathology |
Training Experience
| 1989 | Residency, University of Texas Medical Branch Hospital |
| 1992 | Fellowship, Parkland Memorial Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Texas
… → 1985
Research interests keywords
- Aging
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Frontotemporal Dementia
- Movement Disorders
- Nervous System Diseases
- Neuromuscular Disorders
- Pathology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype
Geula, C. (PD/PI), Geula, C. (PD/PI), Bigio, E. H. (Co-Investigator), Bigio, E. H. (Co-Investigator), Dong, H. (Co-Investigator), Dong, H. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Vassar, R. J. (Co-Investigator), Vassar, R. J. (Co-Investigator), Zhang, H. (Other) & Zhang, H. (Other)
National Institute of Neurological Disorders and Stroke
4/1/20 → 3/31/25
Project: Research project
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Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes
Gefen, T. D. (PD/PI), Gefen, T. D. (PD/PI), Bigio, E. H. (Co-Investigator), Bigio, E. H. (Co-Investigator), Geula, C. (Co-Investigator), Geula, C. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Rademaker, A. W. (Co-Investigator), Rademaker, A. W. (Co-Investigator), Rogalski, E. (Co-Investigator), Rogalski, E. (Co-Investigator), Rogalski, E. (Co-Investigator), Zhang, H. (Co-Investigator), Zhang, H. (Co-Investigator), Vassar, R. J. (Other), Vassar, R. J. (Other), Weintraub, S. (Other) & Weintraub, S. (Other)
1/15/20 → 12/31/24
Project: Research project
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Alzheimer's Disease Core Center
Mesulam, M.-M. (PD/PI), Vassar, R. J. (PD/PI), Bigio, E. H. (Co-Investigator), Geula, C. (Co-Investigator), Hurley, R. S. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Morhardt, D. J. (Co-Investigator), Rademaker, A. W. (Co-Investigator), Rogalski, E. (Co-Investigator), Weintraub, S. (Co-Investigator) & Disterhoft, J. F. (Other)
8/1/16 → 6/30/22
Project: Research project
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Subproject for Mapping and function of odorant receptors in the human olfactory system
Gottfried, J. A. (PD/PI), Bigio, E. H. (Co-PD/PI), Geula, C. (Co-PD/PI), Tan, B.K.-H. (Co-PD/PI) & Gottfried, J. A. (Subproject PI)
National Institute on Deafness and Other Communication Disorders
12/1/14 → 11/30/20
Project: Research project
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Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype
Geula, C. (PD/PI), Bigio, E. H. (Co-Investigator), Dong, H. (Co-Investigator), Mesulam, M.-M. (Co-Investigator) & Vassar, R. J. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
8/1/14 → 3/31/20
Project: Research project
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MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
Pick's disease International Consortium, May 2024, In: The Lancet Neurology. 23, 5, p. 487-499 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Kawles, A., Keszycki, R., Minogue, G., Zouridakis, A., Ayala, I., Gill, N. P., Macomber, A., Lubbat, V., Coventry, C., Rogalski Miller, E. J., Weintraub, S., Mao, Q., Flanagan, M. E., Zhang, H., Castellani, R., Bigio, E. H., Mesulam, M. M., Geula, C. & Gefen, T., Dec 2024, In: Acta Neuropathologica Communications. 12, 1, 31.Research output: Contribution to journal › Article › peer-review
Open Access -
Differential vulnerability of the dentate gyrus to tauopathies in dementias
Kawles, A., Minogue, G., Zouridakis, A., Keszycki, R., Gill, N., Nassif, C., Coventry, C., Zhang, H., Rogalski, E., Flanagan, M. E., Castellani, R., Bigio, E. H., Mesulam, M. M., Geula, C. & Gefen, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 1.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with Transactive Response DNA-binding Protein 43
Minogue, G., Kawles, A., Zouridakis, A., Keszycki, R., Macomber, A., Lubbat, V., Gill, N., Mao, Q., Flanagan, M. E., Zhang, H., Castellani, R., Bigio, E. H., Mesulam, M. M., Geula, C. & Gefen, T., Dec 2023, In: Annals of neurology. 94, 6, p. 1036-1047 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Shades of gray in human white matter
Zouridakis, A., Ayala, I., Minogue, G., Kawles, A., Keszycki, R., Macomber, A., Bigio, E. H., Geula, C., Mesulam, M. M. & Gefen, T., Dec 2023, In: Journal of Comparative Neurology. 531, 18, p. 2109-2120 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator), Özdinler, P. H. (Contributor) & Roos, R. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497
Dataset
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Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Lui, H. (Contributor), Zhang, J. (Contributor), Makinson, S. R. (Contributor), Cahill, M. K. (Contributor), Kelley, K. W. (Contributor), Huang, H.-Y. (Contributor), Shang, Y. (Contributor), Oldham, M. C. (Contributor), Martens, L. H. (Contributor), Gao, F. (Contributor), Coppola, G. (Contributor), Sloan, S. A. (Contributor), Bigio, E. H. (Contributor), MacKenzie, I. R. (Contributor), Seeley, W. W. (Contributor), Karydas, A. (Contributor), Miller, B. L. (Contributor), Borroni, B. (Contributor), Ghidoni, R. (Contributor), Farese, R. V. (Contributor), Paz, J. T. (Contributor), Barres, B. A. (Contributor) & Huang, E. J. (Contributor), Gene Expression Omnibus, Nov 17 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75083
Dataset