Eileen H Bigio

  • 22951 Citations
1989 …2020

Research output per year

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Research Output

2013

TREM2 in neurodegeneration: Evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

Rayaprolu, S., Mullen, B., Baker, M., Lynch, T., Finger, E., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., Lippa, C., Josephs, K. A., Knopman, D. S., White, C. L., Caselli, R., Mackenzie, I. R., Miller, B. L., Boczarska-Jedynak, M., Opala, G., Krygowska-Wajs, A. & 13 others, Barcikowska, M., Younkin, S. G., Petersen, R. C., Ertekin-Taner, N., Uitti, R. J., Meschia, J. F., Boylan, K. B., Boeve, B. F., Graff-Radford, N. R., Wszolek, Z. K., Dickson, D. W., Rademakers, R. & Ross, O. A., 2013, In : Molecular neurodegeneration. 8, 1, 19.

Research output: Contribution to journalArticle

212 Scopus citations
51 Scopus citations
2012

Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia

Gefen, T., Gasho, K., Rademaker, A., Lalehzari, M., Weintraub, S., Rogalski, E., Wieneke, C., Bigio, E., Geula, C. & Mesulam, M. M., May 2012, In : Brain. 135, 5, p. 1554-1565 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Whitcomb, D. C., LaRusch, J., Krasinskas, A. M., Klei, L., Smith, J. P., Brand, R. E., Neoptolemos, J. P., Lerch, M. M., Tector, M., Sandhu, B. S., Guda, N. M., Orlichenko, L., Alkaade, S., Amann, S. T., Anderson, M. A., Baillie, J., Banks, P. A., Conwell, D., Coté, G. A., Cotton, P. B. & 30 others, DiSario, J., Farrer, L. A., Forsmark, C. E., Johnstone, M., Gardner, T. B., Gelrud, A., Greenhalf, W., Haines, J. L., Hartman, D. J., Hawes, R. A., Lawrence, C., Lewis, M., Mayerle, J., Mayeux, R., Melhem, N. M., Money, M. E., Muniraj, T., Papachristou, G. I., Pericak-Vance, M. A., Romagnuolo, J., Schellenberg, G. D., Sherman, S., Simon, P., Singh, V. P., Slivka, A., Stolz, D., Sutton, R., Weiss, F. U., Wilcox, C. M. & Zarnescu, N. O., Dec 2012, In : Nature Genetics. 44, 12, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

168 Scopus citations

Correlation of alzheimer disease neuropathologic changes with cognitive status: A review of the literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., Duyckaerts, C., Frosch, M. P., Haroutunian, V., Hof, P. R., Hulette, C. M., Hyman, B. T., Iwatsubo, T., Jellinger, K. A., Jicha, G. A., Kövari, E. & 17 others, Kukull, W. A., Leverenz, J. B., Love, S., MacKenzie, I. R., Mann, D. M., Masliah, E., McKee, A. C., Montine, T. J., Morris, J. C., Schneider, J. A., Sonnen, J. A., Thal, D. R., Trojanowski, J. Q., Troncoso, J. C., Wisniewski, T., Woltjer, R. L. & Beach, T. G., May 2012, In : Journal of neuropathology and experimental neurology. 71, 5, p. 362-381 20 p.

Research output: Contribution to journalReview article

837 Scopus citations

Evidence for a role of the rare p.A152T variant in mapt in increasing the risk for FTD-spectrum and Alzheimer's diseases

Coppola, G., Chinnathambi, S., Lee, J. J. Y., Dombroski, B. A., Baker, M. C., Soto-ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., Lane, J. R., Karydas, A. M., Kenet, R. O., Biernat, J., Wang, L. S., Cotman, C. W., Decarli, C. S., Levey, A. I., Ringman, J. M., Mendez, M. F. & 30 others, Chui, H. C., Le ber, I., Brice, A., Lupton, M. K., Preza, E., Lovestone, S., Powell, J., Graff-radford, N., Petersen, R. C., Boeve, B. F., Lippa, C. F., Bigio, E. H., Mackenzie, I., Finger, E., Kertesz, A., Caselli, R. J., Gearing, M., Juncos, J. L., Ghetti, B., Spina, S., Bordelon, Y. M., Tourtellotte, W. W., Frosch, M. P., Vonsattel, J. P. G., Zarow, C., Beach, T. G., Albin, R. L., Lieberman, A. P., Lee, V. M. & Trojanowski, J. Q., Aug 2012, In : Human molecular genetics. 21, 15, p. 3500-3512 13 p.

Research output: Contribution to journalArticle

145 Scopus citations

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

Rutherford, N. J., Heckman, M. G., DeJesus-Hernandez, M., Baker, M. C., Soto-Ortolaza, A. I., Rayaprolu, S., Stewart, H., Finger, E., Volkening, K., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., Lippa, C., Knopman, D. S., Kretzschmar, H. A., Neumann, M., Caselli, R. J., White, C. L. & 12 others, Mackenzie, I. R., Petersen, R. C., Strong, M. J., Miller, B. L., Boeve, B. F., Uitti, R. J., Boylan, K. B., Wszolek, Z. K., Graff-Radford, N. R., Dickson, D. W., Ross, O. A. & Rademakers, R., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2950.e5-2950.e7

Research output: Contribution to journalArticle

67 Scopus citations

Lymphomatosis cerebri presenting with orthostatic hypotension, anorexia, and paraparesis

Keswani, A., Bigio, E. & Grimm, S., Sep 1 2012, In : Journal of Neuro-Oncology. 109, 3, p. 581-586 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanisms of disease in frontotemporal lobar degeneration: Gain of function versus loss of function effects

Halliday, G., Bigio, E. H., Cairns, N. J., Neumann, M., MacKenzie, I. R. A. & Mann, D. M. A., Sep 1 2012, In : Acta Neuropathologica. 124, 3, p. 373-382 10 p.

Research output: Contribution to journalReview article

59 Scopus citations

Motor neuron disease: The C9orf72 hexanucleotide repeat expansion in FTD and ALS

Bigio, E. H., May 2012, In : Nature Reviews Neurology. 8, 5, p. 249-250 2 p.

Research output: Contribution to journalReview article

12 Scopus citations

National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach

Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. R., Trojanowski, J. Q., Vinters, H. V. & Hyman, B. T., Jan 1 2012, In : Acta Neuropathologica. 123, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

1005 Scopus citations

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. R., Thies, B., Trojanowski, J. Q., Vinters, H. V. & Montine, T. J., Jan 1 2012, In : Alzheimer's and Dementia. 8, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

1027 Scopus citations

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

Nakamura, K., Greenwood, A., Binder, L., Bigio, E. H., Denial, S., Nicholson, L., Zhou, X. Z. & Lu, K. P., Mar 30 2012, In : Cell. 149, 1, p. 232-244 13 p.

Research output: Contribution to journalArticle

137 Scopus citations
2011

An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

Guo, W., Chen, Y., Zhou, X., Kar, A., Ray, P., Chen, X., Rao, E. J., Yang, M., Ye, H., Zhu, L., Liu, J., Xu, M., Yang, Y., Wang, C., Zhang, D., Bigio, E. H., Mesulam, M., Shen, Y., Xu, Q., Fushimi, K. & 1 others, Wu, J. Y., Jul 1 2011, In : Nature Structural and Molecular Biology. 18, 7, p. 822-831 10 p.

Research output: Contribution to journalArticle

179 Scopus citations

ApoE E4 is a Susceptibility Factor in Amnestic but Not Aphasic Dementias

Rogalski, E. J., Rademaker, A., Harrison, T. M., Helenowski, I., Johnson, N., Bigio, E., Mishra, M., Weintraub, S. & Mesulam, M. M., Apr 2011, In : Alzheimer Disease and Associated Disorders. 25, 2, p. 159-163 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ataxin-2 repeat-length variation and neurodegeneration

Ross, O. A., Rutherford, N. J., Baker, M., Soto-Ortolaza, A. I., Carrasquillo, M. M., DeJesus-Hernandez, M., Adamson, J., Li, M., Volkening, K., Finger, E., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., Lippa, C., Woodruff, B. K., Knopman, D. S., White, C. L., Van Gerpen, J. A. & 13 others, Meschia, J. F., Mackenzie, I. R., Boylan, K., Boeve, B. F., Miller, B. L., Strong, M. J., Uitti, R. J., Younkin, S. G., Graff-Radford, N. R., Petersen, R. C., Wszolek, Z. K., Dickson, D. W. & Rademakers, R., Aug 2011, In : Human molecular genetics. 20, 16, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

C9ORF72, the new gene on the block, causes C9FTD/ALS: New insights provided by neuropathology

Bigio, E. H., Dec 2011, In : Acta Neuropathologica. 122, 6, p. 653-655 3 p.

Research output: Contribution to journalEditorial

10 Scopus citations

Calpain-mediated tau cleavage: A mechanism leading to neurodegeneration shared by multiple tauopathies

Ferreira, A. & Bigio, E. H., Jul 2011, In : Molecular Medicine. 17, 7-8, p. 676-685 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Naj, A. C., Jun, G., Beecham, G. W., Wang, L. S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., Larson, E. B., Bird, T. D., Boeve, B. F., Graff-Radford, N. R., De Jager, P. L., Evans, D., Schneider, J. A., Carrasquillo, M. M., Ertekin-Taner, N., Younkin, S. G. & 30 others, Cruchaga, C., Kauwe, J. S. K., Nowotny, P., Kramer, P., Hardy, J., Huentelman, M. J., Myers, A. J., Barmada, M. M., Demirci, F. Y., Baldwin, C. T., Green, R. C., Rogaeva, E., George-Hyslop, P. S., Arnold, S. E., Barber, R., Beach, T., Bigio, E. H., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Carlson, C. S., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cotman, C. W., Cummings, J. L. & Decarli, C., May 2011, In : Nature Genetics. 43, 5, p. 436-443 8 p.

Research output: Contribution to journalArticle

1182 Scopus citations

Detection of protein aggregation in neurodegenerative diseases

Deng, H. X., Bigio, E. H. & Siddique, T., Oct 24 2011, Neurodegeneration: Methods and Protocols. Manfredi, G. & Kawamata, H. (eds.). p. 259-272 14 p. (Methods in Molecular Biology; vol. 793).

Research output: Chapter in Book/Report/Conference proceedingChapter

Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations

Deng, H. X., Bigio, E. H., Zhai, H., Fecto, F., Ajroud, K., Shi, Y., Yan, J., Mishra, M., Ajroud-Driss, S., Heller, S., Sufit, R., Siddique, N., Mugnaini, E. & Siddique, T., Aug 2011, In : Archives of Neurology. 68, 8, p. 1057-1061 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration

Chen, Y., Yang, M., Deng, J., Chen, X., Ye, Y., Zhu, L., Liu, J., Ye, H., Shen, Y., Li, Y., Rao, E. J., Fushimi, K., Zhou, X., Bigio, E. H., Mesulam, M., Xu, Q. & Wu, J. Y., Jun 2011, In : Protein and Cell. 2, 6, p. 477-486 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: A frontotemporal lobar degeneration with FUS proteinopathy

Page, T., Gitcho, M. A., Mosaheb, S., Carter, D., Chakraverty, S., Perry, R. H., Bigio, E. H., Gearing, M., Ferrer, I., Goate, A. M., Cairns, N. J. & Thorpe, J. R., Nov 2011, In : Journal of Molecular Neuroscience. 45, 3, p. 409-421 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration

Chen-Plotkin, A. S., Martinez-Lage, M., Sleiman, P. M. A., Hu, W., Greene, R., Wood, E. M. C., Bing, S., Grossman, M., Schellenberg, G. D., Hatanpaa, K. J., Weiner, M. F., White, C. L., Brooks, W. S., Halliday, G. M., Kril, J. J., Gearing, M., Beach, T. G., Graff-Radford, N. R., Dickson, D. W., Rademakers, R. & 35 others, Boeve, B. F., Pickering-Brown, S. M., Snowden, J., Van Swieten, J. C., Heutink, P., Seelaar, H., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J., Kaye, J. A., Woltjer, R. L., Mesulam, M., Bigio, E., Lladó, A., Miller, B. L., Alzualde, A., Moreno, F., Rohrer, J. D., Mackenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Cruts, M., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bird, T. D., Cairns, N. J., Goate, A., Frosch, M. P., Riederer, P. F., Bogdanovic, N., Lee, V. M. Y., Trojanowski, J. Q. & Van Deerlin, V. M., Apr 2011, In : Archives of Neurology. 68, 4, p. 488-497 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Gigaxonin mutation analysis in patients with NIFID

Dequen, F., Cairns, N. J., Bigio, E. H. & Julien, J. P., Aug 1 2011, In : Neurobiology of Aging. 32, 8, p. 1528-1529 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology

Dakson, A., Yokota, O., Esiri, M., Bigio, E. H., Horan, M., Pendleton, N., Richardson, A., Neary, D., Snowden, J. S., Robinson, A., Davidson, Y. S. & Mann, D. M. A., May 2011, In : Acta Neuropathologica. 121, 5, p. 635-649 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Deng, H. X., Chen, W., Hong, S. T., Boycott, K. M., Gorrie, G. H., Siddique, N., Yang, Y., Fecto, F., Shi, Y., Zhai, H., Jiang, H., Hirano, M., Rampersaud, E., Jansen, G. H., Donkervoort, S., Bigio, E. H., Brooks, B. R., Ajroud, K., Sufit, R. L., Haines, J. L. & 3 others, Mugnaini, E., Pericak-Vance, M. A. & Siddique, T., Sep 8 2011, In : Nature. 477, 7363, p. 211-215 5 p.

Research output: Contribution to journalArticle

713 Scopus citations

Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID)

Armstrong, R. A., Gearing, M., Bigio, E. H., Cruz-Sanchez, F. F., Duyckaerts, C., MacKenzie, I. R. A., Perry, R. H., Skullerud, K., Yokoo, H. & Cairns, N. J., Nov 2011, In : Journal of Neural Transmission. 118, 11, p. 1651-1657 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

TDP-43 variants of frontotemporal lobar degeneration

Bigio, E. H., Nov 2011, In : Journal of Molecular Neuroscience. 45, 3, p. 390-401 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease

Armstrong, R. A., Gearing, M., Bigio, E. H., Cruz-Sanchez, F. F., Duyckaerts, C., MacKenzie, I. R. A., Perry, R. H., Skullerud, K., Yokoo, H. & Cairns, N. J., Feb 2011, In : Acta Neuropathologica. 121, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

Finch, N., Carrasquillo, M. M., Baker, M., Rutherford, N. J., Coppola, G., Dejesus-Hernandez, M., Crook, R., Hunter, T., Ghidoni, R., Benussi, L., Crook, J., Finger, E., Hantanpaa, K. J., Karydas, A. M., Sengdy, P., Gonzalez, J., Seeley, W. W., Johnson, N., Beach, T. G., Mesulam, M-M. & 19 others, Forloni, G., Kertesz, A., Knopman, D. S., Uitti, R., White, C. L., Caselli, R., Lippa, C., Bigio, E. H., Wszolek, Z. K., Binetti, G., MacKenzie, I. R., Miller, B. L., Boeve, B. F., Younkin, S. G., Dickson, D. W., Petersen, R. C., Graff-Radford, N. R., Geschwind, D. H. & Rademakers, R., Feb 1 2011, In : Neurology. 76, 5, p. 467-474 8 p.

Research output: Contribution to journalArticle

140 Scopus citations
2010

Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation

Gliebus, G., Bigio, E. H., Gasho, K., Mishra, M., Caplan, D., Mesulam, M. M. & Geula, C., May 18 2010, In : Neurology. 74, 20, p. 1607-1610 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L. S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., Arnold, S. E., Mann, D. M. A., Pickering-Brown, S. M., Seelaar, H., Heutink, P., Van Swieten, J. C., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J. & 80 others, Hodges, J., Spillantini, M. G., Gilman, S., Lieberman, A. P., Kaye, J. A., Woltjer, R. L., Bigio, E. H., Mesulam, M., Al-Sarraj, S., Troakes, C., Rosenberg, R. N., White, C. L., Ferrer, I., Lladó, A., Neumann, M., Kretzschmar, H. A., Hulette, C. M., Welsh-Bohmer, K. A., Miller, B. L., Alzualde, A., De Munain, A. L., McKee, A. C., Gearing, M., Levey, A. I., Lah, J. J., Hardy, J., Rohrer, J. D., Lashley, T., MacKenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Dekosky, S. T., Van Der Zee, J., Kumar-Singh, S., Van Broeckhoven, C., Mayeux, R., Vonsattel, J. P. G., Troncoso, J. C., Kril, J. J., Kwok, J. B. J., Halliday, G. M., Bird, T. D., Ince, P. G., Shaw, P. J., Cairns, N. J., Morris, J. C., McLean, C. A., Decarli, C., Ellis, W. G., Freeman, S. H., Frosch, M. P., Growdon, J. H., Perl, D. P., Sano, M., Bennett, D. A., Schneider, J. A., Beach, T. G., Reiman, E. M., Woodruff, B. K., Cummings, J., Vinters, H. V., Miller, C. A., Chui, H. C., Alafuzoff, I., Hartikainen, P., Seilhean, D., Galasko, D., Masliah, E., Cotman, C. W., Tũón, M. T., Martínez, M. C. C., Munoz, D. G., Carroll, S. L., Marson, D., Riederer, P. F., Bogdanovic, N., Schellenberg, G. D., Hakonarson, H., Trojanowski, J. Q. & Lee, V. M. Y., Mar 2010, In : Nature Genetics. 42, 3, p. 234-239 6 p.

Research output: Contribution to journalArticle

305 Scopus citations

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis

Deng, H. X., Zhai, H., Bigio, E. H., Yan, J., Fecto, F., Ajroud, K., Mishra, M., Ajroud-Driss, S., Heller, S., Sufit, R., Siddique, N., Mugnaini, E. & Siddique, T., Jun 2010, In : Annals of neurology. 67, 6, p. 739-748 10 p.

Research output: Contribution to journalArticle

223 Scopus citations

FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration

Urwin, H., Josephs, K. A., Rohrer, J. D., MacKenzie, I. R., Neumann, M., Authier, A., Seelaar, H., Van Swieten, J. C., Brown, J. M., Johannsen, P., Nielsen, J. E., Holm, I. E., Dickson, D. W., Rademakers, R., Graff-Radford, N. R., Parisi, J. E., Petersen, R. C., Hatanpaa, K. J., White, C. L., Weiner, M. F. & 27 others, Geser, F., Van Deerlin, V. M., Trojanowski, J. Q., Miller, B. L., Seeley, W. W., Van Der Zee, J., Kumar-Singh, S., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bigio, E. H., Deng, H. X., Halliday, G. M., Kril, J. J., Munoz, D. G., Mann, D. M., Pickering-Brown, S. M., Doodeman, V., Adamson, G., Ghazi-Noori, S., Fisher, E. M. C., Holton, J. L., Revesz, T., Rossor, M. N., Collinge, J., Mead, S. & Isaacs, A. M., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

171 Scopus citations

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: An update

MacKenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., Ince, P. G., Kamphorst, W., Revesz, T., Rozemuller, A. J. M., Kumar-Singh, S., Akiyama, H., Baborie, A., Spina, S., Dickson, D. W., Trojanowski, J. Q. & 1 others, Mann, D. M. A., Jan 2010, In : Acta Neuropathologica. 119, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

599 Scopus citations

Oligodendroglial neoplasms with ganglioglioma-like maturation: A diagnostic pitfall

Perry, A., Burton, S. S., Fuller, G. N., Robinson, C. A., Palmer, C. A., Resch, L., Bigio, E. H., Gujrati, M. & Rosenblum, M. K., Aug 1 2010, In : Acta Neuropathologica. 120, 2, p. 237-252 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

Yokota, O., Davidson, Y., Bigio, E. H., Ishizu, H., Terada, S., Arai, T., Hasegawa, M., Akiyama, H., Sikkink, S., Pickering-Brown, S. & Mann, D. M. A., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease

Bigio, E. H., Mishra, M., Hatanpaa, K. J., White, C. L., Johnson, N., Rademaker, A., Weitner, B. B., Deng, H. X., Dubner, S. D., Weintraub, S. & Mesulam, M., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: Consensus recommendations

Mackenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., Ince, P. G., Kamphorst, W., Revesz, T., Rozemuller, A. J. M., Kumar-Singh, S., Akiyama, H., Baborie, A., Spina, S., Dickson, D. W., Trojanowski, J. Q. & 1 others, Mann, D. M. A., 2009, In : Acta Neuropathologica. 117, 1, p. 15-18 4 p.

Research output: Contribution to journalEditorial

312 Scopus citations

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

Foulds, P. G., Davidson, Y., Mishra, M., Hobson, D. J., Humphreys, K. M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E. H., Benson, F. E., Allsop, D. & Mann, D. M. A., Nov 2009, In : Acta Neuropathologica. 118, 5, p. 647-658 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

Gitcho, M. A., Bigio, E. H., Mishra, M., Johnson, N., Weintraub, S., Mesulam, M., Rademakers, R., Chakraverty, S., Cruchaga, C., Morris, J. C., Goate, A. M. & Cairns, N. J., Nov 2009, In : Acta Neuropathologica. 118, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2008

Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S. & Bigio, E. H., Jun 2008, In : Annals of neurology. 63, 6, p. 709-719 11 p.

Research output: Contribution to journalArticle

350 Scopus citations

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

De Felice, F. G., Wu, D., Lambert, M. P., Fernandez, S. J., Velasco, P. T., Lacor, P. N., Bigio, E. H., Jerecic, J., Acton, P. J., Shughrue, P. J., Chen-Dodson, E., Kinney, G. G. & Klein, W. L., Sep 1 2008, In : Neurobiology of Aging. 29, 9, p. 1334-1347 14 p.

Research output: Contribution to journalArticle

294 Scopus citations

Association of GSK3B with Alzheimer disease and frontotemporal dementia

Schaffer, B. A. J., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E. & Geschwind, D. H., Oct 2008, In : Archives of Neurology. 65, 10, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

71 Scopus citations

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

Mukherjee, O., Wang, J., Gitcho, M., Chakraverty, S., Taylor-Reinwald, L., Shears, S., Kauwe, J. S. K., Norton, J., Levitch, D., Bigio, E. H., Hatanpaa, K. J., White, C. L., Morris, J. C., Cairns, N. J. & Goate, A., Apr 2008, In : Human mutation. 29, 4, p. 512-521 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Novel mutations in TARDBP(TDP-43) in patients with familial amyotrophic lateral sclerosis

Rutherford, N. J., Zhang, Y. J., Baker, M., Gass, J. M., Finch, N. C. A., Xu, Y. F., Stewart, H., Kelley, B. J., Kuntz, K., Crook, R. J. P., Sreedharan, J., Vance, C., Sorenson, E., Lippa, C., Bigio, E. H., Geschwind, D. H., Knopman, D. S., Mitsumoto, H., Petersen, R. C., Cashman, N. R. & 11 others, Hutton, M., Shaw, C. E., Boylan, K. B., Boeve, B., Graff-Radford, N. R., Wszolek, Z. K., Caselli, R. J., Dickson, D. W., Mackenzie, I. R., Petrucelli, L. & Rademakers, R., Sep 2008, In : PLoS genetics. 4, 9, e1000193.

Research output: Contribution to journalArticle

309 Scopus citations

TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: A midwest-southwest consortium for FTLD study

Hatanpaa, K. J., Bigio, E. H., Cairns, N. J., Womack, K. B., Weintraub, S., Morris, J. C., Foong, C., Xiao, G., Hladik, C., Mantanona, T. Y. & White, C. L., Apr 2008, In : Journal of neuropathology and experimental neurology. 67, 4, p. 271-279 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
17 Scopus citations

TDP-43 A315T mutation in familial motor neuron disease

Gitcho, M. A., Baloh, R. H., Chakraverty, S., Mayo, K., Norton, J. B., Levitch, D., Hatanpaa, K. J., White, C. L., Bigio, E. H., Caselli, R., Baker, M., Al-Lozi, M. T., Morris, J. C., Pestronk, A., Rademakers, R., Goate, A. M. & Cairns, N. J., Apr 2008, In : Annals of neurology. 63, 4, p. 535-538 4 p.

Research output: Contribution to journalArticle

472 Scopus citations