Eileen H Bigio

  • 22820 Citations
1989 …2020

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2012

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

Nakamura, K., Greenwood, A., Binder, L., Bigio, E. H., Denial, S., Nicholson, L., Zhou, X. Z. & Lu, K. P., Mar 30 2012, In : Cell. 149, 1, p. 232-244 13 p.

Research output: Contribution to journalArticle

137 Scopus citations
2011

An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

Guo, W., Chen, Y., Zhou, X., Kar, A., Ray, P., Chen, X., Rao, E. J., Yang, M., Ye, H., Zhu, L., Liu, J., Xu, M., Yang, Y., Wang, C., Zhang, D., Bigio, E. H., Mesulam, M., Shen, Y., Xu, Q., Fushimi, K. & 1 others, Wu, J. Y., Jul 1 2011, In : Nature Structural and Molecular Biology. 18, 7, p. 822-831 10 p.

Research output: Contribution to journalArticle

177 Scopus citations

ApoE E4 is a Susceptibility Factor in Amnestic but Not Aphasic Dementias

Rogalski, E. J., Rademaker, A., Harrison, T. M., Helenowski, I., Johnson, N., Bigio, E., Mishra, M., Weintraub, S. & Mesulam, M. M., Apr 2011, In : Alzheimer Disease and Associated Disorders. 25, 2, p. 159-163 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ataxin-2 repeat-length variation and neurodegeneration

Ross, O. A., Rutherford, N. J., Baker, M., Soto-Ortolaza, A. I., Carrasquillo, M. M., DeJesus-Hernandez, M., Adamson, J., Li, M., Volkening, K., Finger, E., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., Lippa, C., Woodruff, B. K., Knopman, D. S., White, C. L., Van Gerpen, J. A. & 13 others, Meschia, J. F., Mackenzie, I. R., Boylan, K., Boeve, B. F., Miller, B. L., Strong, M. J., Uitti, R. J., Younkin, S. G., Graff-Radford, N. R., Petersen, R. C., Wszolek, Z. K., Dickson, D. W. & Rademakers, R., Aug 2011, In : Human molecular genetics. 20, 16, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Calpain-mediated tau cleavage: A mechanism leading to neurodegeneration shared by multiple tauopathies

Ferreira, A. & Bigio, E. H., Jul 2011, In : Molecular Medicine. 17, 7-8, p. 676-685 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Naj, A. C., Jun, G., Beecham, G. W., Wang, L. S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., Larson, E. B., Bird, T. D., Boeve, B. F., Graff-Radford, N. R., De Jager, P. L., Evans, D., Schneider, J. A., Carrasquillo, M. M., Ertekin-Taner, N., Younkin, S. G. & 30 others, Cruchaga, C., Kauwe, J. S. K., Nowotny, P., Kramer, P., Hardy, J., Huentelman, M. J., Myers, A. J., Barmada, M. M., Demirci, F. Y., Baldwin, C. T., Green, R. C., Rogaeva, E., George-Hyslop, P. S., Arnold, S. E., Barber, R., Beach, T., Bigio, E. H., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Carlson, C. S., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cotman, C. W., Cummings, J. L. & Decarli, C., May 2011, In : Nature Genetics. 43, 5, p. 436-443 8 p.

Research output: Contribution to journalArticle

1179 Scopus citations

Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations

Deng, H. X., Bigio, E. H., Zhai, H., Fecto, F., Ajroud, K., Shi, Y., Yan, J., Mishra, M., Ajroud-Driss, S., Heller, S., Sufit, R., Siddique, N., Mugnaini, E. & Siddique, T., Aug 2011, In : Archives of Neurology. 68, 8, p. 1057-1061 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration

Chen, Y., Yang, M., Deng, J., Chen, X., Ye, Y., Zhu, L., Liu, J., Ye, H., Shen, Y., Li, Y., Rao, E. J., Fushimi, K., Zhou, X., Bigio, E. H., Mesulam, M., Xu, Q. & Wu, J. Y., Jun 2011, In : Protein and Cell. 2, 6, p. 477-486 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: A frontotemporal lobar degeneration with FUS proteinopathy

Page, T., Gitcho, M. A., Mosaheb, S., Carter, D., Chakraverty, S., Perry, R. H., Bigio, E. H., Gearing, M., Ferrer, I., Goate, A. M., Cairns, N. J. & Thorpe, J. R., Nov 2011, In : Journal of Molecular Neuroscience. 45, 3, p. 409-421 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration

Chen-Plotkin, A. S., Martinez-Lage, M., Sleiman, P. M. A., Hu, W., Greene, R., Wood, E. M. C., Bing, S., Grossman, M., Schellenberg, G. D., Hatanpaa, K. J., Weiner, M. F., White, C. L., Brooks, W. S., Halliday, G. M., Kril, J. J., Gearing, M., Beach, T. G., Graff-Radford, N. R., Dickson, D. W., Rademakers, R. & 35 others, Boeve, B. F., Pickering-Brown, S. M., Snowden, J., Van Swieten, J. C., Heutink, P., Seelaar, H., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J., Kaye, J. A., Woltjer, R. L., Mesulam, M., Bigio, E., Lladó, A., Miller, B. L., Alzualde, A., Moreno, F., Rohrer, J. D., Mackenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Cruts, M., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bird, T. D., Cairns, N. J., Goate, A., Frosch, M. P., Riederer, P. F., Bogdanovic, N., Lee, V. M. Y., Trojanowski, J. Q. & Van Deerlin, V. M., Apr 2011, In : Archives of Neurology. 68, 4, p. 488-497 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Gigaxonin mutation analysis in patients with NIFID

Dequen, F., Cairns, N. J., Bigio, E. H. & Julien, J. P., Aug 1 2011, In : Neurobiology of Aging. 32, 8, p. 1528-1529 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology

Dakson, A., Yokota, O., Esiri, M., Bigio, E. H., Horan, M., Pendleton, N., Richardson, A., Neary, D., Snowden, J. S., Robinson, A., Davidson, Y. S. & Mann, D. M. A., May 2011, In : Acta Neuropathologica. 121, 5, p. 635-649 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Deng, H. X., Chen, W., Hong, S. T., Boycott, K. M., Gorrie, G. H., Siddique, N., Yang, Y., Fecto, F., Shi, Y., Zhai, H., Jiang, H., Hirano, M., Rampersaud, E., Jansen, G. H., Donkervoort, S., Bigio, E. H., Brooks, B. R., Ajroud, K., Sufit, R. L., Haines, J. L. & 3 others, Mugnaini, E., Pericak-Vance, M. A. & Siddique, T., Sep 8 2011, In : Nature. 477, 7363, p. 211-215 5 p.

Research output: Contribution to journalArticle

709 Scopus citations

Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID)

Armstrong, R. A., Gearing, M., Bigio, E. H., Cruz-Sanchez, F. F., Duyckaerts, C., MacKenzie, I. R. A., Perry, R. H., Skullerud, K., Yokoo, H. & Cairns, N. J., Nov 2011, In : Journal of Neural Transmission. 118, 11, p. 1651-1657 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

TDP-43 variants of frontotemporal lobar degeneration

Bigio, E. H., Nov 2011, In : Journal of Molecular Neuroscience. 45, 3, p. 390-401 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease

Armstrong, R. A., Gearing, M., Bigio, E. H., Cruz-Sanchez, F. F., Duyckaerts, C., MacKenzie, I. R. A., Perry, R. H., Skullerud, K., Yokoo, H. & Cairns, N. J., Feb 2011, In : Acta Neuropathologica. 121, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

Finch, N., Carrasquillo, M. M., Baker, M., Rutherford, N. J., Coppola, G., Dejesus-Hernandez, M., Crook, R., Hunter, T., Ghidoni, R., Benussi, L., Crook, J., Finger, E., Hantanpaa, K. J., Karydas, A. M., Sengdy, P., Gonzalez, J., Seeley, W. W., Johnson, N., Beach, T. G., Mesulam, M-M. & 19 others, Forloni, G., Kertesz, A., Knopman, D. S., Uitti, R., White, C. L., Caselli, R., Lippa, C., Bigio, E. H., Wszolek, Z. K., Binetti, G., MacKenzie, I. R., Miller, B. L., Boeve, B. F., Younkin, S. G., Dickson, D. W., Petersen, R. C., Graff-Radford, N. R., Geschwind, D. H. & Rademakers, R., Feb 1 2011, In : Neurology. 76, 5, p. 467-474 8 p.

Research output: Contribution to journalArticle

139 Scopus citations
2010

Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation

Gliebus, G., Bigio, E. H., Gasho, K., Mishra, M., Caplan, D., Mesulam, M. M. & Geula, C., May 18 2010, In : Neurology. 74, 20, p. 1607-1610 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L. S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., Arnold, S. E., Mann, D. M. A., Pickering-Brown, S. M., Seelaar, H., Heutink, P., Van Swieten, J. C., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J. & 80 others, Hodges, J., Spillantini, M. G., Gilman, S., Lieberman, A. P., Kaye, J. A., Woltjer, R. L., Bigio, E. H., Mesulam, M., Al-Sarraj, S., Troakes, C., Rosenberg, R. N., White, C. L., Ferrer, I., Lladó, A., Neumann, M., Kretzschmar, H. A., Hulette, C. M., Welsh-Bohmer, K. A., Miller, B. L., Alzualde, A., De Munain, A. L., McKee, A. C., Gearing, M., Levey, A. I., Lah, J. J., Hardy, J., Rohrer, J. D., Lashley, T., MacKenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Dekosky, S. T., Van Der Zee, J., Kumar-Singh, S., Van Broeckhoven, C., Mayeux, R., Vonsattel, J. P. G., Troncoso, J. C., Kril, J. J., Kwok, J. B. J., Halliday, G. M., Bird, T. D., Ince, P. G., Shaw, P. J., Cairns, N. J., Morris, J. C., McLean, C. A., Decarli, C., Ellis, W. G., Freeman, S. H., Frosch, M. P., Growdon, J. H., Perl, D. P., Sano, M., Bennett, D. A., Schneider, J. A., Beach, T. G., Reiman, E. M., Woodruff, B. K., Cummings, J., Vinters, H. V., Miller, C. A., Chui, H. C., Alafuzoff, I., Hartikainen, P., Seilhean, D., Galasko, D., Masliah, E., Cotman, C. W., Tũón, M. T., Martínez, M. C. C., Munoz, D. G., Carroll, S. L., Marson, D., Riederer, P. F., Bogdanovic, N., Schellenberg, G. D., Hakonarson, H., Trojanowski, J. Q. & Lee, V. M. Y., Mar 2010, In : Nature Genetics. 42, 3, p. 234-239 6 p.

Research output: Contribution to journalArticle

305 Scopus citations

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis

Deng, H. X., Zhai, H., Bigio, E. H., Yan, J., Fecto, F., Ajroud, K., Mishra, M., Ajroud-Driss, S., Heller, S., Sufit, R., Siddique, N., Mugnaini, E. & Siddique, T., Jun 2010, In : Annals of neurology. 67, 6, p. 739-748 10 p.

Research output: Contribution to journalArticle

222 Scopus citations

FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration

Urwin, H., Josephs, K. A., Rohrer, J. D., MacKenzie, I. R., Neumann, M., Authier, A., Seelaar, H., Van Swieten, J. C., Brown, J. M., Johannsen, P., Nielsen, J. E., Holm, I. E., Dickson, D. W., Rademakers, R., Graff-Radford, N. R., Parisi, J. E., Petersen, R. C., Hatanpaa, K. J., White, C. L., Weiner, M. F. & 27 others, Geser, F., Van Deerlin, V. M., Trojanowski, J. Q., Miller, B. L., Seeley, W. W., Van Der Zee, J., Kumar-Singh, S., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bigio, E. H., Deng, H. X., Halliday, G. M., Kril, J. J., Munoz, D. G., Mann, D. M., Pickering-Brown, S. M., Doodeman, V., Adamson, G., Ghazi-Noori, S., Fisher, E. M. C., Holton, J. L., Revesz, T., Rossor, M. N., Collinge, J., Mead, S. & Isaacs, A. M., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

171 Scopus citations

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: An update

MacKenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., Ince, P. G., Kamphorst, W., Revesz, T., Rozemuller, A. J. M., Kumar-Singh, S., Akiyama, H., Baborie, A., Spina, S., Dickson, D. W., Trojanowski, J. Q. & 1 others, Mann, D. M. A., Jan 2010, In : Acta Neuropathologica. 119, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

599 Scopus citations

Oligodendroglial neoplasms with ganglioglioma-like maturation: A diagnostic pitfall

Perry, A., Burton, S. S., Fuller, G. N., Robinson, C. A., Palmer, C. A., Resch, L., Bigio, E. H., Gujrati, M. & Rosenblum, M. K., Aug 1 2010, In : Acta Neuropathologica. 120, 2, p. 237-252 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

Yokota, O., Davidson, Y., Bigio, E. H., Ishizu, H., Terada, S., Arai, T., Hasegawa, M., Akiyama, H., Sikkink, S., Pickering-Brown, S. & Mann, D. M. A., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease

Bigio, E. H., Mishra, M., Hatanpaa, K. J., White, C. L., Johnson, N., Rademaker, A., Weitner, B. B., Deng, H. X., Dubner, S. D., Weintraub, S. & Mesulam, M., Jul 2010, In : Acta Neuropathologica. 120, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

Foulds, P. G., Davidson, Y., Mishra, M., Hobson, D. J., Humphreys, K. M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E. H., Benson, F. E., Allsop, D. & Mann, D. M. A., Nov 2009, In : Acta Neuropathologica. 118, 5, p. 647-658 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

Gitcho, M. A., Bigio, E. H., Mishra, M., Johnson, N., Weintraub, S., Mesulam, M., Rademakers, R., Chakraverty, S., Cruchaga, C., Morris, J. C., Goate, A. M. & Cairns, N. J., Nov 2009, In : Acta Neuropathologica. 118, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2008

Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S. & Bigio, E. H., Jun 2008, In : Annals of neurology. 63, 6, p. 709-719 11 p.

Research output: Contribution to journalArticle

349 Scopus citations

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

De Felice, F. G., Wu, D., Lambert, M. P., Fernandez, S. J., Velasco, P. T., Lacor, P. N., Bigio, E. H., Jerecic, J., Acton, P. J., Shughrue, P. J., Chen-Dodson, E., Kinney, G. G. & Klein, W. L., Sep 1 2008, In : Neurobiology of Aging. 29, 9, p. 1334-1347 14 p.

Research output: Contribution to journalArticle

294 Scopus citations

Association of GSK3B with Alzheimer disease and frontotemporal dementia

Schaffer, B. A. J., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E. & Geschwind, D. H., Oct 2008, In : Archives of Neurology. 65, 10, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

71 Scopus citations

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

Mukherjee, O., Wang, J., Gitcho, M., Chakraverty, S., Taylor-Reinwald, L., Shears, S., Kauwe, J. S. K., Norton, J., Levitch, D., Bigio, E. H., Hatanpaa, K. J., White, C. L., Morris, J. C., Cairns, N. J. & Goate, A., Apr 2008, In : Human mutation. 29, 4, p. 512-521 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Novel mutations in TARDBP(TDP-43) in patients with familial amyotrophic lateral sclerosis

Rutherford, N. J., Zhang, Y. J., Baker, M., Gass, J. M., Finch, N. C. A., Xu, Y. F., Stewart, H., Kelley, B. J., Kuntz, K., Crook, R. J. P., Sreedharan, J., Vance, C., Sorenson, E., Lippa, C., Bigio, E. H., Geschwind, D. H., Knopman, D. S., Mitsumoto, H., Petersen, R. C., Cashman, N. R. & 11 others, Hutton, M., Shaw, C. E., Boylan, K. B., Boeve, B., Graff-Radford, N. R., Wszolek, Z. K., Caselli, R. J., Dickson, D. W., Mackenzie, I. R., Petrucelli, L. & Rademakers, R., Sep 2008, In : PLoS genetics. 4, 9, e1000193.

Research output: Contribution to journalArticle

308 Scopus citations

TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: A midwest-southwest consortium for FTLD study

Hatanpaa, K. J., Bigio, E. H., Cairns, N. J., Womack, K. B., Weintraub, S., Morris, J. C., Foong, C., Xiao, G., Hladik, C., Mantanona, T. Y. & White, C. L., Apr 2008, In : Journal of neuropathology and experimental neurology. 67, 4, p. 271-279 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

TDP-43 A315T mutation in familial motor neuron disease

Gitcho, M. A., Baloh, R. H., Chakraverty, S., Mayo, K., Norton, J. B., Levitch, D., Hatanpaa, K. J., White, C. L., Bigio, E. H., Caselli, R., Baker, M., Al-Lozi, M. T., Morris, J. C., Pestronk, A., Rademakers, R., Goate, A. M. & Cairns, N. J., Apr 2008, In : Annals of neurology. 63, 4, p. 535-538 4 p.

Research output: Contribution to journalArticle

471 Scopus citations
2007

Clinicopathologic correlation in PGRN mutations

Davion, S., Johnson, N., Weintraub, S., Mesulam, M-M., Engberg, A., Mishra, M., Baker, M., Adamson, J., Hutton, M., Rademakers, R. & Bigio, E. H., Jan 1 2007, In : Neurology. 69, 11, p. 1113-1121 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions

Mishra, M., Paunesku, T., Woloschak, G. E., Siddique, T., Zhu, L., Lin, S., Greco, K. & Bigio, E. H., Jul 1 2007, In : Acta Neuropathologica. 114, 1, p. 81-94 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms

Melquist, S., Craig, D. W., Huentelman, M. J., Crook, R., Pearson, J. V., Baker, M., Zismann, V. L., Gass, J., Adamson, J., Szelinger, S., Corneveaux, J., Cannon, A., Coon, K. D., Lincoln, S., Adler, C., Tuite, P., Calne, D. B., Bigio, E. H., Uitti, R. J., Wszolek, Z. K. & 8 others, Golbe, L. I., Caselli, R. J., Graff-Radford, N., Litvan, I., Farrer, M. J., Dickson, D. W., Hutton, M. & Stephan, D. A., Apr 2007, In : American journal of human genetics. 80, 4, p. 769-778 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease

Grudzien, A., Shaw, P., Weintraub, S., Bigio, E., Mash, D. C. & Mesulam, M. M., Mar 1 2007, In : Neurobiology of Aging. 28, 3, p. 327-335 9 p.

Research output: Contribution to journalArticle

225 Scopus citations

Monoclonal antibodies that target pathological assemblies of Aβ

Lambert, M. P., Velasco, P. T., Chang, L., Viola, K. L., Fernandez, S., Lacor, P. N., Khuon, D., Gong, Y., Bigio, E. H., Shaw, P., De Felice, F. G., Krafft, G. A. & Klein, W. L., Jan 2007, In : Journal of neurochemistry. 100, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

249 Scopus citations

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: Consensus of the Consortium for Frontotemporal Lobar Degeneration

Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M. Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., Duyckaerts, C., Lowe, J. S., Holm, I. E., Tolnay, M., Okamoto, K., Yokoo, H., Murayama, S., Woulfe, J., Munoz, D. G., Dickson, D. W. & 3 others, Ince, P. G., Trojanowski, J. Q. & Mann, D. M. A., Jul 2007, In : Acta Neuropathologica. 114, 1, p. 5-22 18 p.

Research output: Contribution to journalArticle

792 Scopus citations

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

Mackenzie, I. R. A., Bigio, E. H., Ince, P. G., Geser, F., Neumann, M., Cairns, N. J., Kwong, L. K., Forman, M. S., Ravits, J., Stewart, H., Eisen, A., McClusky, L., Kretzschmar, H. A., Monoranu, C. M., Highley, J. R., Kirby, J., Siddique, T., Shaw, P. J., Lee, V. M. Y. & Trojanowski, J. Q., May 2007, In : Annals of neurology. 61, 5, p. 427-434 8 p.

Research output: Contribution to journalArticle

603 Scopus citations

Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative

Rademakers, R., Baker, M., Gass, J., Adamson, J., Huey, E. D., Momeni, P., Spina, S., Coppola, G., Karydas, A. M., Stewart, H., Johnson, N., Hsiung, G. Y., Kelley, B., Kuntz, K., Steinbart, E., Wood, E. M. C., Yu, C. E., Josephs, K., Sorenson, E., Womack, K. B. & 30 others, Weintraub, S., Pickering-Brown, S. M., Schofield, P. R., Brooks, W. S., Van Deerlin, V. M., Snowden, J., Clark, C. M., Kertesz, A., Boylan, K., Ghetti, B., Neary, D., Schellenberg, G. D., Beach, T. G., Mesulam, M., Mann, D., Grafman, J., Mackenzie, I. R., Feldman, H., Bird, T., Petersen, R., Knopman, D., Boeve, B., Geschwind, D. H., Miller, B., Wszolek, Z., Lippa, C., Bigio, E. H., Dickson, D., Graff-Radford, N. & Hutton, M., Oct 2007, In : Lancet Neurology. 6, 10, p. 857-868 12 p.

Research output: Contribution to journalArticle

171 Scopus citations

Phosphorylation and cleavage of tau in non-AD tauopathies

Guillozet-Bongaarts, A. L., Glajch, K. E., Libson, E. G., Cahill, M. E., Bigio, E., Berry, R. W. & Binder, L. I., May 1 2007, In : Acta Neuropathologica. 113, 5, p. 513-520 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Progranulin mutations in primary progressive aphasia: The PPA1 and PPA3 families

Mesulam, M., Johnson, N., Krefft, T. A., Gass, J. M., Cannon, A. D., Adamson, J. L., Bigio, E. H., Weintraub, S., Dickson, D. W., Hutton, M. L. & Graff-Radford, N. R., Jan 2007, In : Archives of Neurology. 64, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

121 Scopus citations

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

Cairns, N. J., Neumann, M., Bigio, E. H., Holm, I. E., Troost, D., Hatanpaa, K. J., Foong, C., White, C. L., Schneider, J. A., Kretzschmar, H. A., Carter, D., Taylor-Reinwald, L., Paulsmeyer, K., Strider, J., Gitcho, M., Goate, A. M., Morris, J. C., Mishra, M., Kwong, L. K., Stieber, A. & 5 others, Xu, Y., Forman, M. S., Trojanowski, J. Q., Lee, V. M. Y. & Mackenzie, I. R. A., Jul 2007, In : American Journal of Pathology. 171, 1, p. 227-240 14 p.

Research output: Contribution to journalArticle

369 Scopus citations
2006

An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies

de Silva, R., Lashley, T., Strand, C., Shiarli, A. M., Shi, J., Tian, J., Bailey, K. L., Davies, P., Bigio, E. H., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G., MacKenzie, J., Ravid, R., Dickson, D., Wszolek, Z. & 6 others, Iwatsubo, T., Pickering-Brown, S. M., Holton, J., Lees, A., Revesz, T. & Mann, D. M. A., Apr 2006, In : Acta Neuropathologica. 111, 4, p. 329-340 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease

Shiarli, A. M., Jennings, R., Shi, J., Bailey, K., Davidson, Y., Tian, J., Bigio, E. H., Ghetti, B., Murrell, J. R., Delisle, M. B., Mirra, S., Crain, B., Zolo, P., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G. & 8 others, MacKenzie, J., Khan, N., Ravid, R., Dickson, D., Wszolek, Z., Iwatsubo, T., Pickering-Brown, S. M. & Mann, D. M. A., Aug 2006, In : Neuropathology and Applied Neurobiology. 32, 4, p. 374-387 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

Deng, H. X., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G. H., Khan, M. S., Hung, W. Y., Bigio, E. H., Lukas, T., Dal Canto, M. C., O'Halloran, T. V. & Siddique, T., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7142-7147 6 p.

Research output: Contribution to journalArticle

323 Scopus citations

Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID)

Momeni, P., Cairns, N. J., Perry, R. H., Bigio, E. H., Gearing, M., Singleton, A. B. & Hardy, J., May 2006, In : Neurobiology of Aging. 27, 5, p. 778.e1-778.e6

Research output: Contribution to journalArticle

22 Scopus citations

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

Gass, J., Cannon, A., Mackenzie, I. R., Boeve, B., Baker, M., Adamson, J., Crook, R., Melquist, S., Kuntz, K., Petersen, R., Josephs, K., Pickering-Brown, S. M., Graff-Radford, N., Uitti, R., Dickson, D., Wszolek, Z., Gonzalez, J., Beach, T. G., Bigio, E., Johnson, N. & 10 others, Weintraub, S., Mesulam, M., White, C. L., Woodruff, B., Caselli, R., Hsiung, G. Y., Feldman, H., Knopman, D., Hutton, M. & Rademakers, R., Oct 15 2006, In : Human molecular genetics. 15, 20, p. 2988-3001 14 p.

Research output: Contribution to journalArticle

435 Scopus citations