Elizabeth Thomas Bartom

  • 1018 Citations
20002023
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Research Output 2000 2019

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2019

Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1

De Pooter, R. F., Dias, S., Chowdhury, M., Bartom, E. T., Okoreeh, M. K., Sigvardsson, M. & Kee, B. L., May 15 2019, In : Journal of Immunology. 202, 10, p. 2837-2842 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Basic Helix-Loop-Helix Transcription Factors
Transcription Factors
Stem Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma

RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity within a loop domain

Rollins, M. G., Jha, S., Bartom, E. T. & Walsh, D., Jun 1 2019, In : Journal of cell science. 132, 12, jcs228908.

Research output: Contribution to journalArticle

Open Access
Protein Biosynthesis
Eukaryotic Initiation Factors
Poxviridae
5' Untranslated Regions
Ribosomes
5 Citations (Scopus)

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Zhao, Z., Wang, L., Volk, A. G., Birch, N. W., Stoltz, K. L., Bartom, E. T., Marshall, S. A., Rendleman, E. J., Nestler, C. M., Shilati, J., Schiltz, G. E., Crispino, J. D. & Shilatifard, A., Jan 1 2019, In : Genes and Development. 33, 1-2, p. 61-74 14 p.

Research output: Contribution to journalArticle

Aspartate Ammonia-Lyase
Threonine
Leukemia
Casein Kinase II
Therapeutics

Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Qi, J., Esfahani, D. R., Huang, T., Ozark, P., Bartom, E. T., Hashizume, R., Bonner, E. R., An, S., Horbinski, C. M., James, C. D. & Saratsis, A. M., May 15 2019, In : Acta Neuropathologica Communications. 7, 1, 75.

Research output: Contribution to journalArticle

Open Access
Brain Stem Neoplasms
Tenascin
Glioma
Biomarkers
Pediatrics
8 Citations (Scopus)
Open Access
Glioblastoma
Immunosuppression
Immunotherapy
Central Nervous System
Incidence

The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family

Morrison, K., Manzano, M., Chung, K., Schipma, M. J., Bartom, E. T. & Gottwein, E., Dec 3 2019, In : Cell reports. 29, 10, p. 2961-2969.e6

Research output: Contribution to journalArticle

Open Access
Human Herpesvirus 8
MicroRNAs
Tumors
Oncogenic viruses
Oncogenic Viruses
9 Citations (Scopus)

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 others, Goosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y. H., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Specific Proteases
T-Cell Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromatin
2 Citations (Scopus)

β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer

Zhao, Z., Wang, L., Bartom, E., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J., Chandel, N. & Shilatifard, A., Jul 31 2019, In : Science Advances. 5, 7, eaax0698.

Research output: Contribution to journalArticle

Open Access
gene expression
cancer
proteins
glucose
chromatin
2018
1 Citation (Scopus)

6mer seed toxicity in tumor suppressive microRNAs

Gao, Q. Q., Putzbach, W. E., Murmann, A. E., Chen, S., Sarshad, A. A., Peter, J. M., Bartom, E. T., Hafner, M. & Peter, M. E., Dec 1 2018, In : Nature communications. 9, 1, 4504.

Research output: Contribution to journalArticle

MicroRNAs
toxicity
Toxicity
Seed
Tumors
23 Citations (Scopus)

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

Fantini, D., Glaser, A. P., Rimar, K. J., Wang, Y., Schipma, M. J., Varghese, N., Rademaker, A. W., Behdad, A., Yellapa, A., Yu, Y., Sze, C. C. L., Wang, L., Zhao, Z., Crawford, S. E., Hu, D., Licht, J. D., Collings, C. K., Bartom, E. T., Theodorescu, D., Shilatifard, A. & 1 others, Meeks, J. J., Apr 1 2018, In : Oncogene. 37, 14, p. 1911-1925 15 p.

Research output: Contribution to journalArticle

Molecular Models
Urinary Bladder Neoplasms
Carcinogens
Muscles
Neoplasms
8 Citations (Scopus)

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

Volk, A., Liang, K., Suraneni, P., Li, X., Zhao, J., Bulic, M., Marshall, S., Pulakanti, K., Malinge, S., Taub, J., Ge, Y., Rao, S., Bartom, E., Shilatifard, A. & Crispino, J. D., Nov 12 2018, In : Cancer Cell. 34, 5, p. 707-723.e7

Research output: Contribution to journalArticle

Hematopoiesis
Leukemia
Chromatin Assembly and Disassembly
Chromatin
Transcription Factors
2 Citations (Scopus)

CD95/fas ligand mRNA is toxic to cells

Putzbach, W., Haluck-Kangas, A., Gao, Q. Q., Sarshad, A. A., Bartom, E. T., Stults, A., Qadir, A. S., Hafner, M. & Peter, M. E., Oct 2018, In : eLife. 7, e38621.

Research output: Contribution to journalArticle

Fas Ligand Protein
Poisons
Messenger RNA
RNA-Induced Silencing Complex
Genes
9 Citations (Scopus)

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

Murmann, A. E., Gao, Q. Q., Putzbach, W. E., Patel, M., Bartom, E. T., Law, C. Y., Bridgeman, B., Chen, S., Mcmahon, K. M., Thaxton, C. S. & Peter, M. E., Mar 2018, In : EMBO Reports. 19, 3, e45336.

Research output: Contribution to journalArticle

Trinucleotide Repeats
Poisons
Small Interfering RNA
Cells
Trinucleotide Repeat Expansion
15 Citations (Scopus)

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

Mandelin, A. M., Homan, P. J., Shaffer, A. M., Cuda, C. M., Dominguez, S. T., Bacalao, E., Carns, M., Hinchcliff, M., Lee, J., Aren, K., Thakrar, A., Montgomery, A. B., Bridges, S. L., Bathon, J. M., Atkinson, J. P., Fox, D. A., Matteson, E. L., Buckley, C. D., Pitzalis, C., Parks, D. & 16 others, Hughes, L. B., Geraldino-Pardilla, L., Ike, R., Phillips, K., Wright, K., Filer, A., Kelly, S., Ruderman, E. M., Morgan, V., Abdala-Valencia, H., Misharin, A. V., Budinger, G. S., Bartom, E. T., Pope, R. M., Perlman, H. & Winter, D. R., Jun 2018, In : Arthritis and Rheumatology. 70, 6, p. 841-854 14 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Macrophages
Biopsy
RNA Sequence Analysis
Osteoarthritis
4 Citations (Scopus)

ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis

DiGiuseppe, S., Rollins, M. G., Bartom, E. T. & Walsh, D., May 1 2018, In : Cell reports. 23, 5, p. 1249-1258 10 p.

Research output: Contribution to journalArticle

Poxviridae
Gene expression
Interferons
Gene Expression
Poly A
2017
34 Citations (Scopus)

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

Bearings (structural)
Isocitrate Dehydrogenase
Gene encoding
Methylation
Differentiation Antigens
7 Citations (Scopus)

EZH2 regulates the developmental timing of effectors of the pre-Antigen receptor checkpoints

Jacobsen, J. A., Woodard, J., Mandal, M., Clark, M. R., Bartom, E. T., Sigvardsson, M. & Kee, B. L., Jun 15 2017, In : Journal of Immunology. 198, 12, p. 4682-4691 10 p.

Research output: Contribution to journalArticle

Antigen Receptors
Lymphocytes
B-Lymphocytes
T-Lymphocytes
36 Citations (Scopus)

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Rickels, R., Herz, H. M., Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y. H., Wang, L., Rendleman, E. J., Marshall, S. A., Krueger, A., Bartom, E. T., Piunti, A., Smith, E. R., Abshiru, N. A., Kelleher, N. L., Dorsett, D. & Shilatifard, A., Nov 1 2017, In : Nature Genetics. 49, 11, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

Histones
Drosophila
Embryonic Structures
Alleles
Methyltransferases
15 Citations (Scopus)

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

Putzbach, W., Gao, Q. Q., Patel, M., Van Dongen, S., Haluck-Kangas, A., Sarshad, A. A., Bartom, E. T., Kim, K. Y. A., Scholtens, D. M., Hafner, M., Zhao, J. C., Murmann, A. E. & Peter, M. E., Oct 24 2017, In : eLife. 6, e29702.

Research output: Contribution to journalArticle

Fas Ligand Protein
Genes
Cells
Cell death
Cell Death
150 Citations (Scopus)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Fibrosis
Macrophages
Lung
Monocytes
31 Citations (Scopus)

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

Hu, D., Gao, X., Cao, K., Morgan, M. A., Mas, G., Smith, E. R., Volk, A. G., Bartom, E. T., Crispino, J. D., Di Croce, L. & Shilatifard, A., Feb 2 2017, In : Molecular cell. 65, 3, p. 460-475.e6

Research output: Contribution to journalArticle

Epigenomics
Germ Cells
Methylation
Embryonic Development
Gene Expression Regulation
13 Citations (Scopus)

SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression

Cao, K., Collings, C. K., Marshall, S. A., Morgan, M. A., Rendleman, E. J., Wang, L., Sze, C. C., Sun, T., Bartom, E. T. & Shilatifard, A., Apr 15 2017, In : Genes and Development. 31, 8, p. 787-801 15 p.

Research output: Contribution to journalArticle

Homeobox Genes
Gene Expression Regulation
Transcriptional Activation
Long Noncoding RNA
Untranslated RNA
42 Citations (Scopus)

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Liang, K., Volk, A. G., Haug, J. S., Marshall, S. A., Woodfin, A. R., Bartom, E. T., Gilmore, J. M., Florens, L., Washburn, M. P., Sullivan, K. D., Espinosa, J. M., Cannova, J., Zhang, J., Smith, E. R., Crispino, J. D. & Shilatifard, A., Jan 12 2017, In : Cell. 168, 1-2, p. 59-72.e13

Research output: Contribution to journalArticle

Leukemia
Genes
Degradation
Myeloid-Lymphoid Leukemia Protein
Cell proliferation
97 Citations (Scopus)

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M., Kelleher, N. L., James, C. D. & Shilatifard, A., Apr 1 2017, In : Nature Medicine. 23, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Glioma
Tumors
Proteins
Nucleosomes
2016
24 Citations (Scopus)

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Luo, Z., Lin, C., Woodfin, A. R., Bartom, E. T., Gao, X., Smith, E. R. & Shilatifard, A., Jan 1 2016, In : Genes and Development. 30, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

Alleles
Gene Expression
DNA
Transcription Factors
Genomic Imprinting
2015
6 Citations (Scopus)

ExScalibur: A high-performance cloud-enabled suite for whole exome germline and somatic mutation identification

Bao, R., Hernandez, K., Huang, L., Kang, W., Bartom, E., Onel, K., Volchenboum, S. & Andrade, J., Aug 13 2015, In : PloS one. 10, 8, e0135800.

Research output: Contribution to journalArticle

Computing Methodologies
Exome
somatic mutation
Germ-Line Mutation
germ cells
48 Citations (Scopus)

Translatome analyses capture of opposing tissuespecific brassinosteroid signals orchestrating root meristem differentiation

Vragović, K., Selaa, A., Friedlander-Shani, L., Fridman, Y., Hacham, Y., Holland, N., Bartom, E., Mockler, T. C. & Savaldi-Goldstein, S., Jan 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 3, p. 923-928 6 p.

Research output: Contribution to journalArticle

Brassinosteroids
Meristem
Growth
Epidermis
Genes
2013
15 Citations (Scopus)

Comparison of the genome sequences of "Candidatus portiera aleyrodidarum" primary endosymbionts of the whitefly bemisia tabaci B and Q biotypes

Jiang, Z. F., Xia, F., Johnson, K. W., Brown, C. D., Bartom, E., Tuteja, J. H., Stevens, R., Grossman, R. L., Brumin, M., White, K. P. & Ghanim, M., Mar 1 2013, In : Applied and Environmental Microbiology. 79, 5, p. 1757-1759 3 p.

Research output: Contribution to journalArticle

whitefly
Hemiptera
biotype
endosymbiont
Bemisia tabaci
81 Citations (Scopus)

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

McNerney, M. E., Brown, C. D., Wang, X., Bartom, E. T., Karmakar, S., Bandlamudi, C., Yu, S., Ko, J., Sandall, B. P., Stricker, T., Anastasi, J., Grossman, R. L., Cunningham, J. M., Le Beau, M. M. & White, K. P., Feb 7 2013, In : Blood. 121, 6, p. 975-983 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 7
Chromosomes
Tumor Suppressor Genes
Acute Myeloid Leukemia
Tumors
2011
111 Citations (Scopus)

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

Mandal, M., Powers, S. E., Maienschein-Cline, M., Bartom, E. T., Hamel, K. M., Kee, B. L., Dinner, A. R. & Clark, M. R., Dec 1 2011, In : Nature Immunology. 12, 12, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

Epigenetic Repression
Interleukin-7 Receptors
Histones
Immunoglobulin Subunits
Activating Transcription Factors
11 Citations (Scopus)

Genetic pathways leading to therapy-related myeloid neoplasms

Stoddart, A., McNerney, M. E., Bartom, E., Bergerson, R., Young, D. J., Qian, Z., Wang, J., Fernald, A. A., Davis, E. M., Larson, R. A., White, K. P. & Le Beau, M. M., Jan 1 2011, In : Mediterranean Journal of Hematology and Infectious Diseases. 3, 1, e2011019.

Research output: Contribution to journalArticle

Second Primary Neoplasms
Cytogenetic Analysis
Gene Expression Profiling
Hematopoietic Stem Cells
Genetic Therapy
2006
21 Citations (Scopus)

PROBER: Oligonucleotide FISH probe design software

Navin, N., Grubor, V., Hicks, J., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Månér, S., Sebat, J., Zetterberg, A. & Wigler, M., Oct 1 2006, In : Bioinformatics. 22, 19, p. 2437-2438 2 p.

Research output: Contribution to journalArticle

Software Design
In Situ Hybridization
Oligonucleotide Probes
Oligonucleotides
Software design
2004
22 Citations (Scopus)

Distribution of short paired duplications in mammalian genomes

Thomas, E. E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B. & Wigler, M., Jul 13 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 28, p. 10349-10354 6 p.

Research output: Contribution to journalArticle

Pan troglodytes
Genome
Caenorhabditis elegans
Arabidopsis
Proteins
16 Citations (Scopus)

Exploring the characteristics of sequence elements in proximal promoters of human genes

Bina, M., Wyss, P., Ren, W., Szpankowski, W., Thomas, E., Randhawa, R., Reddy, S., John, P. M., Pares-Matos, E. I., Stein, A., Xu, H. & Lazarus, S. A., Dec 1 2004, In : Genomics. 84, 6, p. 929-940 12 p.

Research output: Contribution to journalArticle

Transcription Factors
Binding Sites
Genes
Gene Expression
Transcription Initiation Site
2003
53 Citations (Scopus)

Annotating large genomes with exact word matches

Healy, J., Thomas, E. E., Schwartz, J. T. & Wigler, M., Oct 1 2003, In : Genome research. 13, 10, p. 2306-2315 10 p.

Research output: Contribution to journalArticle

Genome
Human Genome
Oligonucleotide Probes
Chromosomes
2001
31 Citations (Scopus)

The microsatellites of Escherichia coli: Rapidly evolving repetitive DNAs in a non-pathogenic prokaryote

Metzgar, D., Thomas, E., Davis, C., Field, D. & Wills, C., Jan 30 2001, In : Molecular Microbiology. 39, 1, p. 183-190 8 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Escherichia coli
DNA
Escherichia
Genome
2000
19 Citations (Scopus)

MAGPIE/EGRET annotation of the 2.9-mb Drosophila melanogaster Adh region

Gaasterland, T., Sczyrba, A., Thomas, E., Aytekin-Kurban, G., Gordon, P. & Sensen, C. W., Apr 1 2000, In : Genome research. 10, 4, p. 502-510 9 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Genome
Exons
Microbial Genome
Software