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Personal profile

Research Interests

I am a neuroscientist and Associate Professor of Psychiatry and Behavioral Sciences at Northwestern University’s Feinberg School of Medicine. I currently serve as Associate Director of the Mesulam Center for Cognitive Neurology and Alzheimer Disease and as Imaging Core Leader of our NIA-funded Alzheimer’s Disease Center. My research falls under the broad umbrella of aging and dementia and uses a multimodal approach to investigate two aging perspectives: primary progressive aphasia (PPA) in which neurodegenerative disease invades the language network and SuperAging in which individuals are seemingly resistant to the deleterious changes in memory associated with “normal” or more typical cognitive aging. I receive research support from the National Institutes of Health and other philanthropic sources. My investigations assist in defining the clinical and anatomical features of different dementia syndromes over the course of disease as well as identifying genetic and other risk factors. My lab uses advanced neuroimaging techniques including tau and amyloid PET as well as MRI. I also develop educational programs, support groups, and person-centered intervention programs for families and individuals living with dementia. We are currently running a clinical trial investigating the effectiveness of Communication Bridge, a telemedicine person-centered intervention to maximize quality of life for individuals with dementia.

Education/Academic qualification

PhD, Northwestern University

… → 2007

Research interests

  • Aging
  • Alzheimer's Disease
  • Dementia
  • Frontotemporal Dementia
  • Magnetic Resonance Imaging (MRI)
  • Molecular Imaging
  • Neurology
  • Neuroscience
  • Primary Progressive Aphasia
  • Quantitative MRI
  • Structural and Functional Neuroimaging

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Grants

  • Research Output

    Open Access
  • Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration

    ARTFL and LEFFTDS consortia, Jan 1 2020, In : Alzheimer's and Dementia. 16, 1, p. 49-59 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease

    Ohm, D. T., Fought, A. J., Rademaker, A., Kim, G., Sridhar, J., Coventry, C., Gefen, T., Weintraub, S., Bigio, E., Mesulam, M. M., Rogalski, E. & Geula, C., Mar 1 2020, In : Brain Pathology. 30, 2, p. 332-344 13 p.

    Research output: Contribution to journalArticle

  • Activated microglia in cortical white matter across cognitive aging trajectories

    Gefen, T., Kim, G., Bolbolan, K., Geoly, A., Ohm, D., Oboudiyat, C., Shahidehpour, R., Rademaker, A., Weintraub, S., Bigio, E. H., Marsel Mesulam, M., Rogalski, E. & Geula, C., Jan 1 2019, In : Frontiers in Aging Neuroscience. 11, MAY, 094.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    A highly sensitive sandwich ELISA to detect CSF progranulin: A potential biomarker for CNS disorders

    Li, Y., Wang, D., Li, Y., Zhu, J., Zhao, J., Deng, Y., Rogalski, E. J., Bigio, E. H., Rademaker, A. W., Xia, H. & Mao, Q., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 5, p. 406-415 10 p.

    Research output: Contribution to journalArticle