Personal profile

Research Interests

My research falls under the broad umbrella of aging and dementia and uses a multimodal approach to investigate two aging perspectives: primary progressive aphasia (PPA) in which neurodegenerative disease invades the language network and SuperAging in which individuals are seemingly resistant to the deleterious changes in memory associated with “normal” or more typical cognitive aging. My investigations have provided new fundamental knowledge with translational implications for cognitive aging, dementia, and neurodegenerative disease as well as the cognitive neuroscience of language and memory. Since joining the faculty at the Cognitive Neurology and Alzheimer’s disease Center (CNADC) at Northwestern University Feinberg School of Medicine in 2008, I have led the neuroimaging arm of our NIDCD funded Language in PPA R01 project and the cognitive and neuroimaging arm of the SuperAging study. While structural neuroimaging is my primary method of investigation it is not the only tool I use. My other investigations have explored the role of genetic, developmental and acquired factors in aging and dementia, which demonstrates my capacity to collect and integrate multidisciplinary data. I have a successful history of funding and recently received R01 funding from the NINDS to examine the relationship between clinical decline, brain atrophy and putative underlying pathology using PET amyloid imaging.

Keywords

  • Neurology
  • Frontotemporal Dementia
  • Neuroscience
  • Alzheimer's Disease
  • Aging
  • Primary Progressive Aphasia
  • Quantitative MRI
  • Dementia

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 7 Similar Profiles
Primary Progressive Aphasia Medicine & Life Sciences
Language Medicine & Life Sciences
Atrophy Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Dementia Medicine & Life Sciences
Semantics Medicine & Life Sciences
Pathology Medicine & Life Sciences
Temporal Lobe Medicine & Life Sciences

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Research Output 2006 2018

  • 1736 Citations
  • 53 Article
  • 4 Review article
  • 2 Letter

Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease

Gefen, T., Papastefan, S. T., Rezvanian, A., Bigio, E. H., Weintraub, S., Rogalski, E., Mesulam, M. M. & Geula, C. Feb 1 2018 In : Cortex. 99, p. 69-77 9 p.

Research output: Research - peer-reviewArticle

Gyrus Cinguli
Alzheimer Disease
Neurons
Cognitive Dysfunction
Neurofibrillary Tangles
3 Citations

A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

Lopez, A. , Lee, S. E. , Wojta, K. , Ramos, E. M. , Klein, E. , Chen, J. , Boxer, A. L. , Gorno-Tempini, M. L. , Geschwind, D. H. , Schlotawa, L. , Ogryzko, N. V. , Bigio, E. H. , Rogalski, E. , Weintraub, S. , Mesulam, M. M. , Fleming, A. , Coppola, G. , Miller, B. L. , Rubinsztein, D. C. , Agosta, F. & 35 others Alberici, A., Babacan-Yildiz, G., Bennett, D. A., Bilguvar, K., Borroni, B., Caglayan, A. O., Combarros, O., Comi, G., Cortés, E. P., Ferrer, I., Genç, Ş., Gunel, M., Gylys, K. H., Indakoetxea, B., Karageorgiou, C. E., Karydas, A., Kilic, U., De Munain, A. L., Magnani, G., Mahley, R. W., Boneschi, F. M., Martinez, J., Mazzeo, S., Moreno, F., Padovani, A., Papatriantafyllou, J., Rogaeva, E., Sanchez-Juan, P., Santangelo, R., Small, G. W., Tarawneh, R., Tartaglia, M. C., Vonsattel, J. P. G., Yener, G. & Tauopathy Genetics Consortium Apr 1 2017 In : Brain. 140, 4, p. 1128-1146 19 p.

Research output: Research - peer-reviewArticle

Frontotemporal Dementia
Autophagy
Zebrafish
Alleles
Allele
11 Citations

Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

Mattsson, N. , Andreasson, U. , Zetterberg, H. , Blennow, K. , Weiner, M. W. , Aisen, P. , Toga, A. W. , Petersen, R. , Jack, C. R. , Jagust, W. , Trojanowki, J. Q. , Shaw, L. M. , Beckett, L. , Green, R. C. , Saykin, A. J. , Morris, J. , Khachaturian, Z. , Sorensen, G. , Carrillo, M. , Kuller, L. & 292 others Raichle, M., Holtzman, D., Paul, S., Davies, P., Fillit, H., Hefti, F., Mesulam, M. M., Potter, W., Snyder, P., Lilly, E., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Balasubramanian, A. B., Mason, J., Sim, I., Harvey, D., Bernstein, M., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Fox, N., Thompson, P., Schuff, N., DeCarli, C., Landau, S., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Cairns, N. J., Franklin, E., Taylor-Reinwald, L., Lee, V., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Shen, L., Faber, K., Kim, S., Nho, K., Potkin, S., Thal, L., Albert, M., Frank, R., Hsiao, J., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Schneider, L. S., Pawluczyk, S., Becerra, M., Teodoro, L., Spann, B. M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J. L., Lord, J. L., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Pavlik, V., Shibley, V., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L. S., Bell, K. L., Ances, B., Morris, J. C., Carroll, M., Creech, M. L., Mintun, M. A., Schneider, S., Oliver, A., Marson, D., Geldmacher, D., Love, M. N., Griffith, R., Clark, D., Brockington, J., Roberson, E., Grossman, H., Mitsis, E., Shah, R. C., De Toledo-Morrell, L., Duara, R., Greig-Custo, M. T., Barker, W., Onyike, C., D'Agostino, D., Kielb, S., Sadowski, M., Sheikh, M. O., Ulysse, A., Gaikwad, M., Doraiswamy, P. M., Petrella, J. R., Borges-Neto, S., Wong, T. Z., Coleman, E., Arnold, S. E., Karlawish, J. H., Wolk, D. A., Clark, C. M., Smith, C. D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Lopez, O. L., Oakley, M. A., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Preda, A., Nguyen, D., Womack, K., Mathews, D., Quiceno, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Swerdlow, R. H., Brooks, W. M., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H. S., Lu, P. H., Bartzokis, G., Graff-Radford, N. R., Parfitt, F., Poki-Walker, K., Farlow, M. R., Hake, A. M., Matthews, B. R., Brosch, J. R., Herring, S., Van Dyck, C. H., Carson, R. E., MacAvoy, M. G., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Hsiung, G. Y. R., Mudge, B., Sossi, V., Feldman, H., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Rogalski, E., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M. N., Belden, C. M., Jacobson, S. A., Sirrel, S. A., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C. M., Tariot, P., Burke, A., Milliken, A. M., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Kelley, B., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Flashman, L. A., Seltzer, M., Hynes, M. L., Santulli, R. B., Sink, K. M., Gordineer, L., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Tremont, G., Daiello, L. A., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pasternak, S., Rachinsky, I., Rogers, J., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Smith, K. E., Koleva, H., Nam, K. W., Shim, H., Relkin, N., Chiang, G., Lin, M., Ravdin, L., Smith, A., Raj, B. A., Fargher, K. & Alzheimer's Disease Neuroimaging Initiative May 1 2017 In : JAMA Neurology. 74, 5, p. 557-566 10 p.

Research output: Research - peer-reviewArticle

Intermediate Filaments
Alzheimer Disease
Light
Biomarkers
Cognitive Dysfunction
1 Citations

Cerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia

Oboudiyat, C., Gefen, T., Varelas, E., Weintraub, S., Rogalski, E., Bigio, E. H. & Mesulam, M. M. May 1 2017 In : Alzheimer's and Dementia. 13, 5, p. 598-601 4 p.

Research output: Research - peer-reviewArticle

Cerebrospinal Fluid
Dementia
Alzheimer Disease
Pathology
Biomarkers

Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent

Bonakdarpour, B., Rogalski, E. J., Wang, A., Sridhar, J., Mesulam, M. M. & Hurley, R. S. May 1 2017 In : Alzheimer Disease and Associated Disorders. 31, 2, p. 101-106 6 p.

Research output: Research - peer-reviewArticle

Primary Progressive Aphasia
Atrophy
Language
Broca Aphasia
Neurodegenerative Diseases