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Personal profile

Research Interests

My research falls under the broad umbrella of aging and dementia and uses a multimodal approach to investigate two aging perspectives: primary progressive aphasia (PPA) in which neurodegenerative disease invades the language network and SuperAging in which individuals are seemingly resistant to the deleterious changes in memory associated with “normal” or more typical cognitive aging. My investigations have provided new fundamental knowledge with translational implications for cognitive aging, dementia, and neurodegenerative disease as well as the cognitive neuroscience of language and memory. Since joining the faculty at the Cognitive Neurology and Alzheimer’s disease Center (CNADC) at Northwestern University Feinberg School of Medicine in 2008, I have led the neuroimaging arm of our NIDCD funded Language in PPA R01 project and the cognitive and neuroimaging arm of the SuperAging study. While structural neuroimaging is my primary method of investigation it is not the only tool I use. My other investigations have explored the role of genetic, developmental and acquired factors in aging and dementia, which demonstrates my capacity to collect and integrate multidisciplinary data. I have a successful history of funding and recently received R01 funding from the NINDS to examine the relationship between clinical decline, brain atrophy and putative underlying pathology using PET amyloid imaging.

Education/Academic qualification

PhD, Northwestern University

… → 2007

Keywords

  • Neurology
  • Frontotemporal Dementia
  • Neuroscience
  • Alzheimer's Disease
  • Aging
  • Primary Progressive Aphasia
  • Quantitative MRI
  • Dementia

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Primary Progressive Aphasia Medicine & Life Sciences
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Pathology Medicine & Life Sciences

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Research Output 2006 2018

  • 1991 Citations
  • 58 Article
  • 4 Review article
  • 2 Letter
  • 1 Comment/debate

A Life Participation Approach to Primary Progressive Aphasia Intervention

Rogalski, E. J. & Khayum, B. Jul 1 2018 In : Seminars in Speech and Language. 39, 3, p. 284-296 13 p., 00689

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Communication
Quality of Life
Language Therapy
Speech Therapy

Associations of MAP2K3 gene variants with superior memory in SuperAgers

for the Alzheimer's Disease Neuroimaging Initiative May 29 2018 In : Frontiers in Aging Neuroscience. 10, MAY, 155

Research output: Contribution to journalArticle

Alzheimer Disease
Neuroimaging
Introns
MAP Kinase Kinase 3
Genes
Primary Progressive Aphasia
DNA-Binding Proteins
Atrophy
Microglia
Phenotype
3 Citations
Episodic Memory
Personality
Autopsy
Entorhinal Cortex
Neocortex
Primary Progressive Aphasia
Microglia
Atrophy
Language
Frontotemporal Lobar Degeneration