Eric G Neilson

  • 23769 Citations
1979 …2020

Research output per year

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Personal profile

Research Interests

The principal goal of Neilson’s research is to understand the nephritogenic immune response in autoimmune renal disease. This research runs the gamut of immunologic mechanisms to understanding the development or organ fibrogenesis and cellular transdifferentiation. His studies critically analyze the immunogenetic and interactional events surrounding T cell activation, effector T cell differentiation, immune modulation of renal tubular cells and fibroblasts in anti-basement membrane diseases, and with this understanding, develop experimental strategies which can attenuate the expression of renal injury. Neilson has a particularly active interest in the cell fate of fibroblasts during fibrogenesis in transgenic mice. More recently he has been interested in how breast cancer cells use the same programs when they metastasize. His research uses trangenic and knockin mice, cell sorting, biochemical methosds of protein identification, molecular cloning and mutagenesis, as well as cell culture and confocal microscopy.

Eric G. Neilson, MD, is the Vice President for Medical Affairs and the Lewis Landsberg Dean at Northwestern University Feinberg School of Medicine. A medical graduate of the University of Alabama in Birmingham, he trained in internal medicine and nephrology at the Hospital of the University of Pennsylvania. After 23 years at the University of Pennsylvania as the C. Mahlon Kline Professor of Medicine, chief of the Renal-Electrolyte and Hypertension Division, and director of the Penn Center for Molecular Studies of Kidney Diseases, he moved to the Vanderbilt University School of Medicine to serve for 13 years as the Hugh Jackson Morgan Professor and Chairman of the Department of Medicine. Neilson is a member of the American Society for Clinical Investigation, the Association of American Physicians, the American Clinical and Climatological Association, the Interurban Clinical Club, the Association of Subspecialty Professors, and the Association of Professors of Medicine. He has been a member of the Scientific Advisory Board of Biostratum Inc., and NephroGenex, Inc., and is the holder of two patents. Neilson is also a past recipient of the Young Investigator Award, the Barry M. Brenner Lecture, the Robert Schrier Lecture, the President’s Medal, the John P. Peters Award from the American Society of Nephrology, and a MERIT Award from the National Institutes of Health. In 1998, he was the recipient of an A. N. Richards Distinguished Achievement Award from the University of Pennsylvania School of Medicine, and, in 2003, he received the Distinguished Professor Award from the Association of Subspecialty Professors, now renamed the "Eric G. Neilson, M.D., Distinguished Professor Award." In 2006, Neilson received the Distinguished Alumnus Award from the University of Alabama Medical Alumni Association, and, in 2010, he was awarded the Robert H. Williams, MD, Distinguished Chair of Medicine Award from the Association of Professors of Medicine. He is a 2016 fellow of the American Academy of Arts and Sciences. Neilson is an active teacher of clinical medicine and has trained numerous graduate students and post-doctoral fellows in his laboratory. He has a special interest in the training of physician-scientists, has edited a book entitled What’s Past is Prologue—The Personal Stories Of Women In Science At The Vanderbilt University School of Medicine to help mentor women interested in biomedical research, and has helped initiate the Vanderbilt Prize for women scientists. Twenty-one of his former laboratory students and fellows have become professors of medicine, twenty-three of his former fellows and faculty are now department chairs, and fifteen are associate/assistant deans, vice-chancellors, or provosts. Neilson’s earlier research program was funded by the National Institutes of Health, the American Heart Association, and the March of Dimes, and he has made important contributions to understanding the cell fate of fibroblasts in fibrogenesis, the expression of the nephritogenic immune response, and the biochemical characterization of nephritic antigens. He has published more than 300 scientific articles, reviews, commentaries, editorials, and books, and has edited, in collaboration with William Couser, MD, a major medical textbook entitled Immunological Renal Diseases. From 2007-2013 he served as Editor-in-Chief of the Journal of the American Society of Nephrology (JASN), the leading kidney journal in the world.

Certifications and Licenses

Internal Medicine
Nephrology

Training Experience

1976Internship, University of Pennsylvania Hospitals
1978Residency, University of Pennsylvania Hospitals
1979Fellowship, University of Pennsylvania Hospitals
1980Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

MD, University of Alabama

… → 1975

Research interests

  • Autoimmune Diseases
  • Nephrology

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Research Output

Continuity with patients, preceptors, and peers improves primary care training: A randomized medical education trial

Henschen, B. L., Liss, D. T., Golden, B. P., Cameron, K. A., Bierman, J. A., Ryan, E., Gard, L. A., Neilson, E. G., Wayne, D. B. & Evans, D. B., Jan 1 2020, (Accepted/In press) In : Academic Medicine. p. 425-434 10 p.

Research output: Contribution to journalArticle

Open Access
  • Origin and functional heterogeneity of fibroblasts

    LeBleu, V. S. & Neilson, E. G., Mar 1 2020, In : FASEB Journal. 34, 3, p. 3519-3536 18 p.

    Research output: Contribution to journalReview article

    Open Access
  • 2 Scopus citations

    Medical Education 2020 - Charting a Path Forward

    Green, M., Wayne, D. B. & Neilson, E. G., Sep 10 2019, In : JAMA - Journal of the American Medical Association. 322, 10, p. 934-935 2 p.

    Research output: Contribution to journalEditorial

    1 Scopus citations

    S100A4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma

    Chow, K. H., Park, H. J., George, J., Yamamoto, K., Gallup, A. D., Graber, J. H., Chen, Y., Jiang, W., Steindler, D. A., Neilson, E. G., Kim, B. Y. S. & Yun, K., Oct 1 2017, In : Cancer Research. 77, 19, p. 5360-5373 14 p.

    Research output: Contribution to journalArticle

  • 30 Scopus citations

    Teaching medical students about conflicts of interest

    Wayne, D. B., Green, M. & Neilson, E. G., May 2 2017, In : JAMA - Journal of the American Medical Association. 317, 17, p. 1733-1734 2 p.

    Research output: Contribution to journalShort survey

    12 Scopus citations