Eric G Neilson

  • 22387 Citations
1979 …2017
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Personal profile

Research Interests

The principal goal of Neilson’s research is to understand the nephritogenic immune response in autoimmune renal disease. This research runs the gamut of immunologic mechanisms to understanding the development or organ fibrogenesis and cellular transdifferentiation. His studies critically analyze the immunogenetic and interactional events surrounding T cell activation, effector T cell differentiation, immune modulation of renal tubular cells and fibroblasts in anti-basement membrane diseases, and with this understanding, develop experimental strategies which can attenuate the expression of renal injury. Neilson has a particularly active interest in the cell fate of fibroblasts during fibrogenesis in transgenic mice. More recently he has been interested in how breast cancer cells use the same programs when they metastasize. His research uses trangenic and knockin mice, cell sorting, biochemical methosds of protein identification, molecular cloning and mutagenesis, as well as cell culture and confocal microscopy.

Eric G. Neilson, MD, is the Vice President for Medical Affairs and the Lewis Landsberg Dean at Northwestern University Feinberg School of Medicine. A medical graduate of the University of Alabama in Birmingham, he trained in internal medicine and nephrology at the Hospital of the University of Pennsylvania. After 23 years at the University of Pennsylvania as the C. Mahlon Kline Professor of Medicine, chief of the Renal-Electrolyte and Hypertension Division, and director of the Penn Center for Molecular Studies of Kidney Diseases, he moved to the Vanderbilt University School of Medicine to serve for 13 years as the Hugh Jackson Morgan Professor and Chairman of the Department of Medicine. Neilson is a member of the American Society for Clinical Investigation, the Association of American Physicians, the American Clinical and Climatological Association, the Interurban Clinical Club, the Association of Subspecialty Professors, and the Association of Professors of Medicine. He has been a member of the Scientific Advisory Board of Biostratum Inc., and NephroGenex, Inc., and is the holder of two patents. Neilson is also a past recipient of the Young Investigator Award, the Barry M. Brenner Lecture, the Robert Schrier Lecture, the President’s Medal, the John P. Peters Award from the American Society of Nephrology, and a MERIT Award from the National Institutes of Health. In 1998, he was the recipient of an A. N. Richards Distinguished Achievement Award from the University of Pennsylvania School of Medicine, and, in 2003, he received the Distinguished Professor Award from the Association of Subspecialty Professors, now renamed the "Eric G. Neilson, M.D., Distinguished Professor Award." In 2006, Neilson received the Distinguished Alumnus Award from the University of Alabama Medical Alumni Association, and, in 2010, he was awarded the Robert H. Williams, MD, Distinguished Chair of Medicine Award from the Association of Professors of Medicine. He is a 2016 fellow of the American Academy of Arts and Sciences. Neilson is an active teacher of clinical medicine and has trained numerous graduate students and post-doctoral fellows in his laboratory. He has a special interest in the training of physician-scientists, has edited a book entitled What’s Past is Prologue—The Personal Stories Of Women In Science At The Vanderbilt University School of Medicine to help mentor women interested in biomedical research, and has helped initiate the Vanderbilt Prize for women scientists. Twenty-one of his former laboratory students and fellows have become professors of medicine, twenty-three of his former fellows and faculty are now department chairs, and fifteen are associate/assistant deans, vice-chancellors, or provosts. Neilson’s earlier research program was funded by the National Institutes of Health, the American Heart Association, and the March of Dimes, and he has made important contributions to understanding the cell fate of fibroblasts in fibrogenesis, the expression of the nephritogenic immune response, and the biochemical characterization of nephritic antigens. He has published more than 300 scientific articles, reviews, commentaries, editorials, and books, and has edited, in collaboration with William Couser, MD, a major medical textbook entitled Immunological Renal Diseases. From 2007-2013 he served as Editor-in-Chief of the Journal of the American Society of Nephrology (JASN), the leading kidney journal in the world.

Certifications and Licenses

Nephrology
Internal Medicine

Training Experience

1976Internship, University of Pennsylvania Hospitals
1978Residency, University of Pennsylvania Hospitals
1979Fellowship, University of Pennsylvania Hospitals
1980Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

MD, University of Alabama

… → 1975

Keywords

  • Autoimmune Diseases
  • Nephrology

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  • 3 Similar Profiles
Interstitial Nephritis Medicine & Life Sciences
Kidney Medicine & Life Sciences
Basement Membrane Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Collagen Type IV Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences

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Research Output 1979 2017

14 Citations (Scopus)

S100A4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma

Chow, K. H., Park, H. J., George, J., Yamamoto, K., Gallup, A. D., Graber, J. H., Chen, Y., Jiang, W., Steindler, D. A., Neilson, E. G., Kim, B. Y. S. & Yun, K., Oct 1 2017, In : Cancer Research. 77, 19, p. 5360-5373 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Stem Cells
Biomarkers
Neoplasms
8 Citations (Scopus)

Teaching medical students about conflicts of interest

Wayne, D. B., Green, M. & Neilson, E. G., May 2 2017, In : JAMA - Journal of the American Medical Association. 317, 17, p. 1733-1734 2 p.

Research output: Contribution to journalShort survey

Interprofessional Relations
Organizational Policy
Financial Support
Professional Role
Medical Faculties

Teaching Medical Students About Conflicts of Interest

Wayne, DB., Green, M. & Neilson, EG., May 2 2017, In : Journal of the American Medical Association. 317, 17, p. 1733-1734 2 p.

Research output: Contribution to journalArticle

JASN's silver jubilee

Nath, K. A., Neilson, E. G., Couser, W. G., Tisher, C. C. & Grantham, J. J., Jul 1 2015, In : Journal of the American Society of Nephrology. 26, 7, p. 1477-1478 2 p.

Research output: Contribution to journalEditorial

Nephrology
Anniversaries and Special Events
Silver

Managing, Funding, and Supporting Research

Johnson, C. A., Chisholm, R. L. & Neilson, E. G., Apr 7 2015, The Transformation of Academic Health Centers: Meeting the Challenges of Healthcare's Changing Landscape. Elsevier Inc, p. 149-158 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Research
Conflict of Interest
Exploratory Behavior
Aptitude
Organized Financing