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Research Output 2001 2019

  • 1652 Citations
  • 36 Article
  • 3 Review article
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2019

A Novel Gene Underlies Bleomycin-Response Variation in Caenorhabditis elegans

Brady, S. C., Zdraljevic, S., Bisaga, K. W., Tanny, R. E., Cook, D. E., Lee, D., Wang, Y. & Andersen, E. C., Aug 1 2019, In : Genetics. 212, 4, p. 1453-1468 16 p.

Research output: Contribution to journalArticle

Open Access
Bleomycin
Caenorhabditis elegans
Genes
Clustered Regularly Interspaced Short Palindromic Repeats
Chromosome Mapping
2 Citations (Scopus)

Natural variation in C. Elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

Zdraljevic, S., Fox, B. W., Strand, C., Panda, O., Tenjo, F. J., Brady, S. C., Crombie, T. A., Doench, J. G., Schroeder, F. C. & Andersen, E. C., Apr 1 2019, In : eLife. 8, e40260.

Research output: Contribution to journalArticle

Open Access
Branched Chain Amino Acids
Arsenic
Metabolism
Toxicity
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)

Selection and gene flow shape niche-associated variation in pheromone response

Lee, D., Zdraljevic, S., Cook, D. E., Frézal, L., Hsu, J. C., Sterken, M. G., Riksen, J. A. G., Wang, J., Kammenga, J. E., Braendle, C., Félix, M. A., Schroeder, F. C. & Andersen, E. C., Oct 1 2019, In : Nature Ecology and Evolution. 3, 10, p. 1455-1463 9 p.

Research output: Contribution to journalArticle

pheromone
pheromones
gene flow
niche
niches
2018
6 Citations (Scopus)

Discovery of genomic intervals that underlie nematode responses to benzimidazoles

Zamanian, M., Cook, D. E., Zdraljevic, S., Brady, S. C., Lee, D., Lee, J. & Andersen, E. C., Mar 30 2018, In : PLoS Neglected Tropical Diseases. 12, 3, e0006368.

Research output: Contribution to journalArticle

Benzimidazoles
Quantitative Trait Loci
Anthelmintics
Caenorhabditis elegans
Communicable Disease Control
2 Citations (Scopus)

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles

Hahnel, S. R., Zdraljevic, S., Rodriguez, B. C., Zhao, Y., McGrath, P. T. & Andersen, E. C., Oct 1 2018, In : PLoS pathogens. 14, 10, e1007226.

Research output: Contribution to journalArticle

Benzimidazoles
Caenorhabditis elegans
Tubulin
Innate Immunity
Albendazole
3 Citations (Scopus)

Shared genomic regions underlie natural variation in diverse toxin responses

Evans, K. S., Brady, S. C., Bloom, J. S., Tanny, R. E., Cook, D. E., Giuliani, S. E., Hippleheuser, S. W., Zamanian, M. & Andersen, E. C., Dec 1 2018, In : Genetics. 210, 4, p. 1509-1525 17 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Genetic Loci
Chromosome Mapping
Caenorhabditis elegans
Heavy Metals
2017
49 Citations (Scopus)

Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics

García-González, A. P., Ritter, A. D., Shrestha, S., Andersen, E. C., Yilmaz, L. S. & Walhout, A. J. M., Apr 20 2017, In : Cell. 169, 3, p. 431-441.e8

Research output: Contribution to journalArticle

Metabolism
Bacteria
Fluorouracil
Pharmaceutical Preparations
Neoplasms
32 Citations (Scopus)

CeNDR, the Caenorhabditis elegans natural diversity resource

Cook, D. E., Zdraljevic, S., Roberts, J. P. & Andersen, E. C., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D650-D657

Research output: Contribution to journalArticle

Caenorhabditis elegans
Genome
Natural Resources
Genome-Wide Association Study
Genomics
6 Citations (Scopus)

Correlations of genotype with climate parameters suggest Caenorhabditis elegans niche adaptations

Evans, K. S., Zhao, Y., Brady, S. C., Long, L., McGrath, P. T. & Andersen, E. C., Jan 1 2017, In : G3: Genes, Genomes, Genetics. 7, 1, p. 289-298 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Climate
Quantitative Trait Loci
Genotype
Temperature
10 Citations (Scopus)

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

Zdraljevic, S., Strand, C., Seidel, H. S., Cook, D. E., Doench, J. G. & Andersen, E. C., Jul 1 2017, In : PLoS genetics. 13, 7, e1006891.

Research output: Contribution to journalArticle

DNA topoisomerase (ATP-hydrolysing)
Type II DNA Topoisomerase
Poisons
amino acid substitution
Amino Acid Substitution
6 Citations (Scopus)

Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species

Laricchia, K. M., Zdraljevic, S., Cook, D. E. & Andersen, E. C., Sep 1 2017, In : Molecular biology and evolution. 34, 9, p. 2187-2202 16 p.

Research output: Contribution to journalArticle

DNA Transposable Elements
Caenorhabditis elegans
transposons
genome
Genome
10 Citations (Scopus)

The genetic basis of natural variation in a phoretic behavior

Lee, D., Yang, H., Kim, J., Brady, S., Zdraljevic, S., Zamanian, M., Kim, H., Paik, Y. K., Kruglyak, L., Andersen, E. C. & Lee, J., Dec 1 2017, In : Nature communications. 8, 1, 273.

Research output: Contribution to journalArticle

Isopoda
loci
Assays
Association reactions
RNA
8 Citations (Scopus)

VCF-kit: Assorted utilities for the variant call format

Cook, D. E. & Andersen, E. C., May 15 2017, In : Bioinformatics. 33, 10, p. 1581-1582 2 p.

Research output: Contribution to journalArticle

Information Storage and Retrieval
Genotype
Population
Dendrogram
Genetic Variation
2016
13 Citations (Scopus)

Copper oxide nanoparticles impact several toxicological endpoints and cause neurodegeneration in caenorhabditis elegans

Mashock, M. J., Zanon, T., Kappell, A. D., Petrella, L. N., Andersen, E. C. & Hristova, K. R., Dec 1 2016, In : PloS one. 11, 12, e0167613.

Research output: Contribution to journalArticle

Copper oxides
Caenorhabditis elegans
nanoparticles
endpoints
Nanoparticles
7 Citations (Scopus)

Mutation is a sufficient and robust predictor of genetic variation for mitotic spindle traits in Caenorhabditis elegans

Farhadifar, R., Ponciano, J. M., Andersen, E. C., Needleman, D. J. & Baer, C. F., Aug 1 2016, In : Genetics. 203, 4, p. 1859-1870 12 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Caenorhabditis elegans
Mutation
Genetic Selection
Cell Division
10 Citations (Scopus)

Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans

Large, E. E., Xu, W., Zhao, Y., Brady, S. C., Long, L., Butcher, R. A., Andersen, E. C. & McGrath, P. T., Jul 1 2016, In : PLoS Genetics. 12, 7, e1006219.

Research output: Contribution to journalArticle

Caenorhabditis elegans
life history trait
Chromatin
chromatin
fitness
28 Citations (Scopus)

The genetic basis of natural variation in Caenorhabditis elegans telomere length

Cook, D. E., Zdraljevic, S., Tanny, R. E., Seo, B., Riccardi, D. D., Noble, L. M., Rockman, M. V., Alkema, M. J., Braendle, C., Kammenga, J. E., Wang, J., Kruglyak, L., Félix, M. A., Lee, J. & Andersen, E. C., Sep 1 2016, In : Genetics. 204, 1, p. 371-383 13 p.

Research output: Contribution to journalArticle

Telomere
Caenorhabditis elegans
Genomic Instability
Oligosaccharides
Oligonucleotides
2015
28 Citations (Scopus)

A powerful new quantitative genetics platform, combining caenorhabditis elegans high-throughput fitness assays with a large collection of recombinant strains

Andersen, E. C., Shimko, T. C., Crissman, J. R., Ghosh, R., Bloom, J. S., Seidel, H. S., Gerke, J. P. & Kruglyak, L., Jan 1 2015, In : G3: Genes, Genomes, Genetics. 5, 5, p. 911-920 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Quantitative Trait Loci
Fertility
Growth
Neuropeptide Receptors
18 Citations (Scopus)

A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite

Balla, K. M., Andersen, E. C., Kruglyak, L. & Troemel, E. R., Jan 1 2015, In : PLoS pathogens. 11, 2, e1004583.

Research output: Contribution to journalArticle

Immunity
Parasites
Microsporidia
Larva
Infection
38 Citations (Scopus)

Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans hawaiian strain CB4856

Thompson, O. A., Snoek, L. B., Nijveen, H., Sterken, M. G., Volkers, R. J. M., Brenchley, R., van’t Hof, A., Bevers, R. P. J., Cossins, A. R., Yanai, I., Hajnal, A., Schmid, T., Perkins, J. D., Spencer, D., Kruglyak, L., Andersen, E. C., Moerman, D. G., Hillier, L. D. W., Kammenga, J. E. & Waterston, R. H., Jul 1 2015, In : Genetics. 200, 3, p. 975-989 15 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Nucleotides
Genome
Chromosomes
Cytoplasmic and Nuclear Receptors
33 Citations (Scopus)

Scaling, selection, and evolutionary dynamics of the mitotic spindle

Farhadifar, R., Baer, C. F., Valfort, A. C., Andersen, E. C., Müller-Reichert, T., Delattre, M. & Needleman, D. J., Mar 16 2015, In : Current Biology. 25, 6, p. 732-740 9 p.

Research output: Contribution to journalArticle

Cytology
mitotic spindle apparatus
Spindle Apparatus
Biodiversity
Chromosomes
4 Citations (Scopus)

The red death meets the abdominal bristle: Polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans

Etienne, V., Andersen, E. C., Ponciano, J. M., Blanton, D., Cadavid, A., Joyner-Matos, J., Matsuba, C., Tabman, B. & Baer, C. F., Jan 1 2015, In : Evolution. 69, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

setae (animal)
Caenorhabditis elegans
mutation
pathogen
death
2014
42 Citations (Scopus)

A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology

Andersen, E. C., Bloom, J. S., Gerke, J. P. & Kruglyak, L., Feb 1 2014, In : PLoS genetics. 10, 2, e1004156.

Research output: Contribution to journalArticle

Neuropeptide Receptors
Caenorhabditis elegans
gene expression
physiology
Fertility
10 Citations (Scopus)

COPASutils: An R package for reading, processing, and visualizing data from copas large-particle flow cytometers

Shimko, T. C. & Andersen, E. C., Oct 20 2014, In : PloS one. 9, 10, 0111090.

Research output: Contribution to journalArticle

Anopheles gambiae
Workflow
Caenorhabditis elegans
Zebrafish
Danio rerio
2013
35 Citations (Scopus)

Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest

Félix, M. A., Jovelin, R., Ferrari, C., Han, S., Cho, Y. R., Andersen, E. C., Cutter, A. D. & Braendle, C., Jan 16 2013, In : BMC Evolutionary Biology. 13, 1, 10.

Research output: Contribution to journalArticle

Caenorhabditis
tropical rain forests
rainforest
nematode
species richness
2012
174 Citations (Scopus)

Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

Andersen, E. C., Gerke, J. P., Shapiro, J. A., Crissman, J. R., Ghosh, R., Bloom, J. S., Félix, M. A. & Kruglyak, L., Mar 1 2012, In : Nature Genetics. 44, 3, p. 285-290 6 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Chromosomes
Metagenomics
Developmental Biology
Population Genetics
72 Citations (Scopus)

Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans

Ghosh, R., Andersen, E. C., Shapiro, J. A., Gerke, J. P. & Kruglyak, L., Feb 3 2012, In : Science. 335, 6068, p. 574-578 5 p.

Research output: Contribution to journalArticle

Chloride Channels
Anthelmintics
Caenorhabditis elegans
Population Genetics
Streptomyces
2011
5 Citations (Scopus)
Homologous Recombination
Saccharomyces cerevisiae
Plasmids
Polymerase Chain Reaction
Ligation
2010
58 Citations (Scopus)

Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line

Bessler, J. B., Andersen, E. C. & Villeneuve, A. M., Jan 1 2010, In : PLoS Genetics. 6, 1, e1000830.

Research output: Contribution to journalArticle

germ cell
Caenorhabditis elegans
Germ Cells
Chromatin
chromatin
378 Citations (Scopus)

Variability in gene expression underlies incomplete penetrance

Raj, A., Rifkin, S. A., Andersen, E. & Van Oudenaarden, A., Feb 18 2010, In : Nature. 463, 7283, p. 913-918 6 p.

Research output: Contribution to journalArticle

Penetrance
Gene Regulatory Networks
Gene Expression
Embryonic Structures
Mutation
2009
122 Citations (Scopus)

A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans

Reddy, K. C., Andersen, E. C., Kruglyak, L. & Kim, D. H., Jan 16 2009, In : Science. 323, 5912, p. 382-384 3 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Innate Immunity
Neuropeptide Y Receptors
Oxygen
Avoidance Learning
2008
15 Citations (Scopus)

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates

Andersen, E. C., Saffer, A. M. & Horvitz, H. R., Aug 1 2008, In : Genetics. 179, 4, p. 2001-2012 12 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Synthetic Genes
Mutation
Genetic Enhancement
Genes
2007
27 Citations (Scopus)

DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans

Reddien, P. W., Andersen, E. C., Huang, M. C. & Horvitz, H. R., Apr 1 2007, In : Genetics. 175, 4, p. 1719-1733 15 p.

Research output: Contribution to journalArticle

Zinc Fingers
Caenorhabditis elegans
Cell Death
Proteins
Genes
84 Citations (Scopus)

Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development

Andersen, E. C. & Horvitz, H. R., Aug 1 2007, In : Development. 134, 16, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Caenorhabditis elegans
Histone Code
Caenorhabditis elegans Proteins
2006
37 Citations (Scopus)

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates

Andersen, E. C., Lu, X. & Horvitz, H. R., Jul 1 2006, In : Development. 133, 14, p. 2695-2704 10 p.

Research output: Contribution to journalArticle

Nucleosomes
Phenotype
Synthetic Genes
Chromatin Assembly and Disassembly
Caenorhabditis elegans
2001
211 Citations (Scopus)

Patterns of gene expression during Drosophila mesoderm development

Furlong, E. E. M., Andersen, E. C., Null, B., White, K. P. & Scott, M. P., Aug 31 2001, In : Science. 293, 5535, p. 1629-1633 5 p.

Research output: Contribution to journalArticle

Mesoderm
Drosophila
Embryonic Structures
Gene Expression
Vertebrates