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Research Interests
The overarching focus of their research is the process of osteogenic differentiation, or the differentiation of stem cells into bone-forming cells. Aiming to develop musculoskeletal tissue regenerative technologies that are both safer and more effective than currently available products, their bone regeneration work includes the development of novel approaches to induce bone growth, such as the use of peptide amphiphile nanofiber scaffolds to deliver ultra low-dose growth factor, enhance the utility of autograft bone, and deliver stem cells to promote bone regeneration. They also work to develop 3D-printed osteoregenerative scaffolds, with a goal to create products that elicit high rates of spine fusion without the need for exogenous growth factors, such as bone morphogenetic protein-2. The Hsu group’s bone toxicology team continues to explore the molecular mechanisms by which pervasive environmental contaminants—such as those present in cigarette smoke—inhibit osteoblastic differentiation and bone healing. Their major focus is dioxin-like compounds and other aryl hydrocarbons, which are potent carcinogens that also inhibit bone healing. Their work ultimately aims to identify a therapeutic approach to mitigate those inhibitory effects, with a particular interest in natural phytochemical-based therapeutics (or “nutraceuticals”), such as resveratrol. They have found that resveratrol, which is found in red wine, provides protection against the effects of cigarette smoke on bone forming cells, and they are now exploring the utility nanofiber scaffolds to co-deliver low-dose growth factor and resveratrol or other phytochemicals in a setting of cigarette smoke exposure.
After receiving her bachelor’s degree from Vanderbilt University, Erin Hsu completed her PhD in Molecular Toxicology at UCLA in 2007, where she studied the role of the Aryl hydrocarbon receptor in both carcinogenesis and phytochemical-based chemoprevention. After completing post-doctoral training in the laboratory of Dr. Christopher Bradfield in the University of Wisconsin McArdle Laboratory for Cancer Research, Erin joined the Feinberg School of Medicine's Department of Orthopaedic Surgery, where she pursues research focused on bone regeneration and healing. As resident faculty in the Simpson Querrey Institute for BioNanotechnology (SQI), the Hsu group’s laboratory space is located within this state-of-the-art facility, in close proximity to many of their materials scientist collaborators. Erin also serves as Assistant Director of the Simpson Querrey Institute.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of California at Los Angeles
… → 2007
Research interests keywords
- Biologic Therapies
- Environmental Health
- Molecular Biology
- Nanotechnology
- Orthopedics
- Signal Transduction
- Toxicology
- Transdisciplinary Research
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Collaborations and top research areas from the last five years
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Preclinical Investigation of the Impact of E-cigarettes on Spinal Fusion
Hsu, E. L. (PD/PI), Hsu, E. L. (PD/PI), Gibly, R. F. (Co-Investigator), Gibly, R. F. (Co-Investigator), Hsu, W. K. (Co-Investigator) & Hsu, W. K. (Co-Investigator)
Orthopaedic Research and Education Foundation
4/12/23 → 7/16/25
Project: Research project
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The impact of E-cigarette vaping on bone metabolism
Gibly, R. F. (PD/PI) & Hsu, E. L. (Co-PD/PI)
Pediatric Orthopaedic Society of North America
6/1/21 → 5/31/23
Project: Research project
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3D Printed 2D Piezoelectric Materials to Deliver Stem Cells for Bone Repair and Regeneration
Hsu, E. L. (PD/PI) & Minardi, S. (PD/PI)
Cervical Spine Research Society
10/1/20 → 12/1/21
Project: Research project
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A BMP-2-binding nanofiber—Demineralized bone matrix composite scaffold as a bone graft substitute for spinal fusion
Hsu, E. L. (PD/PI), Hsu, W. K. (Co-Investigator), Stock, S. R. (Co-Investigator), Stupp, S. (Co-Investigator) & Minardi, S. (Other)
Musculoskeletal Transplant Foundation, Inc.
8/1/19 → 7/31/23
Project: Research project
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A Mechanistic and Pre-clinical Assessment of BioRestore™ Bioactive Glass as a Synthetic Bone Graft Substitute for Osteoinduction and Spine Fusion
Hsu, E. L. (PD/PI) & Yun, C. (Other)
6/28/19 → 6/28/22
Project: Research project
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3D-ink-extruded titanium scaffolds with porous struts and bioactive supramolecular polymers for orthopedic implants
Misiaszek, J. P., Sather, N. A., Goodwin, A. M., Brecount, H. J., Kurapaty, S. S., Inglis, J. E., Hsu, E. L., Stupp, S. I., Stock, S. R. & Dunand, D. C., Oct 15 2024, In: Acta Biomaterialia. 188, p. 446-459 14 p.Research output: Contribution to journal › Article › peer-review
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A Mechanistic and Preclinical Assessment of BioRestore Bioactive Glass as a Synthetic Bone Graft Extender and Substitute for Osteoinduction and Spine Fusion
Fred, E. J., Minardi, S., Goodwin, A. M., Nandurkar, T. S., Plantz, M. A., Lyons, J. G., Paul, J. T., Foley, J. P., Wintring, A. J., Furman, A. A., Jeong, S., Yun, C., Stock, S. R., Hsu, W. K. & Hsu, E. L., Aug 1 2024, In: Clinical spine surgery. 37, 7, p. 315-321 7 p.Research output: Contribution to journal › Article › peer-review
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Biodistribution and biodegradation of a novel peptide amphiphile implant in a rat spinal fusion model
Pagadala, M., Hiltzik, D., Inglis, J., Goodwin, A., Kurapaty, S., Brecount, H., Lee, J., Jacome, F., Laiwalla, R., Cho, S., Sather, N. A., Waters Hayashi, E. A., Haney, C. R., Sponenburg, R., Hsu, W. K., Stupp, S. I., Hsu, E. L. K. & Gibly, R., Sep 2024, In: Spine Journal. 24, 9, p. S62-S63Research output: Contribution to journal › Conference article › peer-review
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A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor
McClendon, M. T., Ji, W., Greene, A. C., Sai, H., Sangji, M. H., Sather, N. A., Chen, C. H., Lee, S. S., Katchko, K., Jeong, S. S., Kannan, A., Weiner, J., Cook, R., Driscoll, A., Lubbe, R., Chang, K., Haleem, M., Chen, F., Qiu, R. & Chun, D. & 4 others, , Nov 2023, In: Biomaterials. 302, 122357.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Optimization of peptide amphiphile-lipid raft interaction by changing peptide amphiphile lipophilicity
Zhou, Y., Fyrner, T., Chen, C. H., Sather, N. A., Hsu, E. L., Stupp, S. I. & Snead, M. L., Jul 1 2023, In: Acta Biomaterialia. 164, p. 377-386 10 p.Research output: Contribution to journal › Article › peer-review
Open Access