Grants per year
Personal profile
Research Interests
The overarching focus of their research is the process of osteogenic differentiation, or the differentiation of stem cells into bone-forming cells. Aiming to develop musculoskeletal tissue regenerative technologies that are both safer and more effective than currently available products, their bone regeneration work includes the development of novel approaches to induce bone growth, such as the use of peptide amphiphile nanofiber scaffolds to deliver ultra low-dose growth factor, enhance the utility of autograft bone, and deliver stem cells to promote bone regeneration. They also work to develop 3D-printed osteoregenerative scaffolds, with a goal to create products that elicit high rates of spine fusion without the need for exogenous growth factors, such as bone morphogenetic protein-2. The Hsu group’s bone toxicology team continues to explore the molecular mechanisms by which pervasive environmental contaminants—such as those present in cigarette smoke—inhibit osteoblastic differentiation and bone healing. Their major focus is dioxin-like compounds and other aryl hydrocarbons, which are potent carcinogens that also inhibit bone healing. Their work ultimately aims to identify a therapeutic approach to mitigate those inhibitory effects, with a particular interest in natural phytochemical-based therapeutics (or “nutraceuticals”), such as resveratrol. They have found that resveratrol, which is found in red wine, provides protection against the effects of cigarette smoke on bone forming cells, and they are now exploring the utility nanofiber scaffolds to co-deliver low-dose growth factor and resveratrol or other phytochemicals in a setting of cigarette smoke exposure.
After receiving her bachelor’s degree from Vanderbilt University, Erin Hsu completed her PhD in Molecular Toxicology at UCLA in 2007, where she studied the role of the Aryl hydrocarbon receptor in both carcinogenesis and phytochemical-based chemoprevention. After completing post-doctoral training in the laboratory of Dr. Christopher Bradfield in the University of Wisconsin McArdle Laboratory for Cancer Research, Erin joined the Feinberg School of Medicine's Department of Orthopaedic Surgery, where she pursues research focused on bone regeneration and healing. As resident faculty in the Simpson Querrey Institute for BioNanotechnology (SQI), the Hsu group’s laboratory space is located within this state-of-the-art facility, in close proximity to many of their materials scientist collaborators. Erin also serves as Assistant Director of the Simpson Querrey Institute.
Education/Academic qualification
PhD, University of California at Los Angeles
… → 2007
PhD, University of California at Los Angeles
… → 2007
Research interests
- Biologic Therapies
- Environmental Health
- Molecular Biology
- Nanotechnology
- Orthopedics
- Signal Transduction
- Toxicology
- Transdisciplinary Research
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Grants
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A Mechanistic and Pre-clinical Assessment of BioRestore™ Bioactive Glass as a Synthetic Bone Graft Substitute for Osteoinduction and Spine Fusion
Hsu, E. L. & Yun, C.
6/28/19 → 6/28/22
Project: Research project
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Supramolecular nanofibers for recombinant growth factor-free spine fusion
Hsu, E. L., Hsu, W. K., Stock, S. R. & Stupp, S.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/12/18 → 4/30/23
Project: Research project
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Rat Paraspinal Neuroinflammation Model-to Study Host Response to rhPDGF-BB Combined with a Beta-tricalcium Phosphate (b-TCP)/Bovine Collagen Matrix
Hsu, E. L., Hsu, W. K. & Yun, C.
Wright Medical Technology, Inc.
5/9/18 → 5/9/21
Project: Research project
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Subproject for 3-D printed hyperelastic bone composites for bone regeneration and spine fusion
Hsu, E. L. & Shah, R. N.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
4/1/16 → 3/1/21
Project: Research project
Research Output
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Influence of Geometry and Architecture on the in Vivo Success of 3D-Printed Scaffolds for Spinal Fusion
Hallman, M., Driscoll, J. A., Lubbe, R., Jeong, S., Chang, K., Haleem, M., Jakus, A., Pahapill, R., Yun, C., Shah, R., Hsu, W. K., Stock, S. R. & Hsu, E. L., Jan 1 2021, In: Tissue Engineering - Part A. 27, 1-2, p. 26-36 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Driscoll, J. A., Lubbe, R., Jakus, A. E., Chang, K., Haleem, M., Yun, C., Singh, G., Schneider, A. D., Katchko, K. M., Soriano, C., Newton, M., Maerz, T., Li, X., Baker, K., Hsu, W. K., Shah, R. N., Stock, S. R. & Hsu, E. L., Feb 2020, In: Tissue Engineering - Part A. 26, 3-4, p. 157-166 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Growth Factors, Carrier Materials, and Bone Repair
Hsu, E. L. & Stock, S. R., 2020, Handbook of Experimental Pharmacology. Springer Science and Business Media Deutschland GmbH, p. 121-156 36 p. (Handbook of Experimental Pharmacology; vol. 262).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Nanostructured Biomaterials for Bone Regeneration
Lyons, J. G., Plantz, M. A., Hsu, W. K., Hsu, E. L. & Minardi, S., Aug 21 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 922.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration
Chen, C. H., Hsu, E. L. & Stupp, S. I., Dec 2020, In: Bone. 141, 115565.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations