Erwin Goldberg

2022

Editorial: Endocrine and paracrine regulation of spermatogenesis

Goldberg, E., Lishko, P. V., Papadopoulos, V. & Zirkin, B., Jul 26 2022, In: Frontiers in Endocrinology. 13, 984409.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance

Harakal, J., Qiao, H., Wheeler, K., Rival, C., Paul, A. G. A., Hardy, D. M., Cheng, C. Y., Goldberg, E. & Tung, K. S. K., May 26 2022, In: Frontiers in immunology. 13, 809247.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2021

A plant root extract, triptonide, is a reversible male contraceptive in mice and monkeys

Goldberg, E., Jun 1 2021, In: Biology of reproduction. 104, 6, p. 1187-1188 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

The sperm-specific form of lactate dehydrogenase is required for fertility and is an attractive target for male contraception (a review)

Goldberg, E., Mar 1 2021, In: Biology of reproduction. 104, 3, p. 521-526 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

2020

Celebrating the Silver Anniversary of the North American Testis Workshop

Robaire, B., Eddy, M., Goldberg, E., Griswold, M., Heckert, L., McCarrey, J., Orgebin-Crist, M. C., Papadopoulos, V., Trasler, J., Wright, W., Yan, W. & Zirkin, B., Jul 1 2020, In: Andrology. 8, 4, p. 820-824 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Preclinical contraceptive development for men and women

Johnston, D. S. & Goldberg, E., Aug 1 2020, In: Biology of reproduction. 103, 2, p. 147-156 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2018

Spermatids

Zirkin, B. R. & Goldberg, E., Jan 1 2018, Encyclopedia of Reproduction. Elsevier, p. 42-46 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Spermatogenesis: Overview

Goldberg, E. & Zirkin, B. R., Jan 1 2018, Encyclopedia of Reproduction. Elsevier, p. 13-18 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

2017

Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Tung, K. S. K., Harakal, J., Qiao, H., Rival, C., Li, J. C. H., Paul, A. G. A., Wheeler, K., Pramoonjago, P., Grafer, C. M., Sun, W., Sampson, R. D., Wong, E. W. P., Reddi, P. P., Deshmukh, U. S., Hardy, D. M., Tang, H., Cheng, C. Y. & Goldberg, E., Mar 1 2017, In: Journal of Clinical Investigation. 127, 3, p. 1046-1060 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

2016

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis

Teng, X., Emmett, M. J., Lazar, M. A., Goldberg, E. & Rabinowitz, J. D., Sep 16 2016, In: ACS chemical biology. 11, 9, p. 2420-2427 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Male fertility and obesity: Are ghrelin, leptin and glucagon-like peptide-1 pharmacologically relevant?

Alves, M. G., Jesus, T. T., Sousa, M., Goldberg, E., Silva, B. M. & Oliveira, P. F., Feb 1 2016, In: Current Pharmaceutical Design. 22, 7, p. 783-791 9 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2014

Male contraception: Another holy grail

Murdoch, F. E. & Goldberg, E., Jan 15 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 2, p. 419-424 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

28 Scopus citations

Male contraception: Past, present and future

Payne, C. & Goldberg, E., 2014, In: Current Molecular Pharmacology. 7, 2, p. 175-181 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2013

Glycolysis and mitochondrial respiration in mouse LDHC-Null sperm

Odet, F., Gabel, S., London, R. E., Goldberg, E. & Eddy, E. M., Apr 2013, In: Biology of reproduction. 88, 4, 95.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Human lactate dehydrogenase a (LDHA) rescues mouse LDHC-Null sperm function

Tang, H., Duan, C., Bleher, R. & Goldberg, E., Apr 2013, In: Biology of reproduction. 88, 4, 96.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2012

A-MYB (MYBL1) stimulates murine testis-specific ldhc expression via the cAMP-responsive element (CRE) site

Tang, H. & Goldberg, E., Feb 1 2012, In: Biology of reproduction. 86, 2, 30.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2011

Lactate dehydrogenase C and energy metabolism in mouse sperm

Odet, F., Gabel, S. A., Williams, J., London, R. E., Goldberg, E. & Eddy, E. M., Sep 1 2011, In: Biology of reproduction. 85, 3, p. 556-564 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

2010

LDHC: The ultimate testis-specific gene

Goldberg, E., Eddy, E. M., Duan, C. & Odet, F., Jan 2010, In: Journal of andrology. 31, 1, p. 86-94 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

2009

Computational analyses of mammalian lactate dehydrogenases: Human, mouse, opossum and platypus LDHs

Holmes, R. S. & Goldberg, E., Oct 2009, In: Computational Biology and Chemistry. 33, 5, p. 379-385 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation

Tang, H. & Goldberg, E., Mar 2009, In: Journal of andrology. 30, 2, p. 157-167 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2008

Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility

Odet, F., Duan, C., Willis, W. D., Goulding, E. H., Kung, A., Eddy, E. M. & Goldberg, E., Jul 2008, In: Biology of reproduction. 79, 1, p. 26-34 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

182 Scopus citations

Regulation of murine lactate dehydrogenase C (Ldhc) gene expression

Tang, H. H., Kung, A. & Goldberg, E., Mar 2008, In: Biology of reproduction. 78, 3, p. 455-461 7 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Testis specific lactate dehydrogenase as target for immunoliposomes

Dutta, R. C. & Goldberg, E., Jul 2008, In: American Journal of Reproductive Immunology. 60, 1, p. 26-32 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2006

Testis-specific lactate dehydrogenase (LDH-C₄; Ldh3) in murine oocytes and preimplantation embryos

Coonrod, S., Vitale, A., Duan, C., Bristol-Gould, S., Herr, J. & Goldberg, E., Jul 2006, In: Journal of andrology. 27, 4, p. 502-509 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Utilization of citrate and lactate through a lactate dehydrogenase and ATP-regulated pathway in boar spermatozoa

Medrano, A., Fernández-Novell, J. M., Ramió, L., Alvarez, J., Goldberg, E., Rivera, M. M., Guinovart, J. J., Rigau, T. & Rodríguez-Gil, J. E., Mar 1 2006, In: Molecular reproduction and development. 73, 3, p. 369-378 10 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

2004

Heat-induced apoptosis of mouse meiotic cells is suppressed by ectopic expression of testis-specific calpastatin

Somwaru, L., Li, S., Doglio, L., Goldberg, E. & Zirkin, B. R., 2004, In: Journal of andrology. 25, 4, p. 506-513 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2003

Abundance of Repetitive Sequence Elements in the Mouse Testis-Specific Lactate Dehydrogenase-C Gene

Olsson, P. G., Tsujioka, H., Narisawa, S., Goldberg, E. & Millan, J. L., 2003, In: Journal of andrology. 24, 6, p. 918-920 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

A Transgenic Analysis of Mouse Lactate Dehydrogenase c Promoter Activity in the Testis

Kroft, T. L., Li, S., Doglio, L. & Goldberg, E., 2003, In: Journal of andrology. 24, 6, p. 843-852 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix

Shen, H., Goldberg, E. & Saltzman, W. M., Jan 17 2003, In: Journal of Controlled Release. 86, 2-3, p. 339-348 10 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Inhibition of lactate dehydrogenase C₄ (LDH-C₄) blocks capacitation of mouse sperm in vitro

Duan, C. & Goldberg, E., 2003, In: Cytogenetic and Genome Research. 103, 3-4, p. 352-359 8 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

2002

Generation and in vitro differentiation of a spermatogonial cell line

Feng, L. X., Chen, Y., Dettin, L., Reijo Pera, R. A., Herr, J. C., Goldberg, E. & Dym, M., Jul 19 2002, In: Science. 297, 5580, p. 392-395 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

242 Scopus citations

Smad4 overexpression causes germ cell ablation and Leydig cell hyperplasia in transgenic mice

Narula, A., Kilen, S., Ma, E., Kroeger, J., Goldberg, E. & Woodruff, T. K., Nov 1 2002, In: American Journal of Pathology. 161, 5, p. 1723-1734 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Testis-specific cytochrome c-null mice produce functional sperm but undergo early testicular atrophy

Narisawa, S., Hecht, N. B., Goldberg, E., Boatright, K. M., Reed, J. C. & Millán, J. L., 2002, In: Molecular and cellular biology. 22, 15, p. 5554-5562 9 p.

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

2001

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: Upregulation in transgenic mice blocks spermatogenesis in pachytene

Kroft, T. L., Patterson, J., Joon Won Yoon, W. Y., Doglio, L., Walterhouse, D. O., Iannaccone, P. M. & Goldberg, E., 2001, In: Biology of reproduction. 65, 6, p. 1663-1671 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Immune response of male baboons to testis-specific LDH-C₄

Goldberg, E., VandeBerg, J. L., Mahony, M. C. & Doncel, G. F., 2001, In: Contraception. 64, 2, p. 93-98 6 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

ldhc Expression in Non-germ Cell Nuclei is Repressed by NF-I Binding

Jethanandani, P. & Goldberg, E., Sep 21 2001, In: Journal of Biological Chemistry. 276, 38, p. 35414-35421 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Methylation of CpG dinucleotides alters binding and silences testis-specific transcription directed by the mouse lactate dehydrogenase C promoter

Kroft, T. L., Jethanandani, P., McLean, D. J. & Goldberg, E., 2001, In: Biology of reproduction. 65, 5, p. 1522-1527 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Selective active site inhibitors of human lactate dehydrogenases A₄, B₄, and C₄

Yu, Y., Deck, J. A., Hunsaker, L. A., Deck, L. M., Royer, R. E., Goldberg, E. & Vander Jagt, D. L., Jul 1 2001, In: Biochemical Pharmacology. 62, 1, p. 81-89 9 p.

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

2000

A novel N-terminal domain directs membrane localization of mouse testis-specific calpastatin

Li, S. & Goldberg, E., 2000, In: Biology of reproduction. 63, 6, p. 1594-1600 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Baboon spermatozoa-zona pellucida binding assay

Mahony, M. C., Rice, K., Goldberg, E. & Doncel, G., Mar 2000, In: Contraception. 61, 3, p. 235-240 6 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Calpain and calpastatin are located between the plasma membrane and outer acrosomal membrane of cynomolgus macaque spermatozoa

Yudin, A. I., Goldberg, E., Robertson, K. R. & Overstreet, J. W., 2000, In: Journal of andrology. 21, 5, p. 721-729 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Identification of a novel testis-specific leucine-rich protein in humans and mice

Xue, J. C. & Goldberg, E., 2000, In: Biology of reproduction. 62, 5, p. 1278-1284 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Molecular cloning and characterization of functional domains of a human testis-specific isoform of calpastatin

Li, S., Liang, Z. G., Wang, G. Y., Yavetz, B., Kim, E. D. & Goldberg, E., 2000, In: Biology of reproduction. 63, 1, p. 172-178 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

1999

DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter

Ambhaikar, M. & Goldberg, E., 1999, In: Molecular reproduction and development. 52, 4, p. 360-365 6 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

1998

Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: Transcription factor Sp1 plays a major role

Bonny, C., Cooker, L. A. & Goldberg, E., Mar 1998, In: Biology of reproduction. 58, 3, p. 754-759 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa

Diekman, A. B., Olson, G. & Goldberg, E., Jul 1998, In: Molecular reproduction and development. 50, 3, p. 284-293 10 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Human testis-specific lactate dehydrogenase-C promoter drives overexpression of mouse lactate dehydrogenase-1 cDNA in testes of transgenic mice

Markert, C. L., Amet, T. M. & Goldberg, E., Sep 1998, In: Journal of Experimental Zoology. 282, 1-2, p. 171-178 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC

Li, S., Zhou, W., Doglio, L. & Goldberg, E., Nov 20 1998, In: Journal of Biological Chemistry. 273, 47, p. 31191-31194 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

1997

Colinear synthesis of an antigen-specific B-cell epitope with a 'promiscuous' tetanus toxin T-cell epitope: A synthetic peptide immunocontraceptive

O'Hern, P. A., Liang, Z. G., Bambra, C. S. & Goldberg, E., Nov 1997, In: Vaccine. 15, 16, p. 1761-1766 6 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

GLI binds the promoter of testis specific lactate dehydrogenase

Kroft, C. T. L. & Goldberg, E., Dec 1 1997, In: FASEB Journal. 11, 9, p. A1381

Research output: Contribution to journal › Article › peer-review

Erwin Goldberg

Research Output

Search results