Grants per year
Personal profile
Research Interests
Our research is focused on the role of viral microRNAs in herpesviral oncogenesis
Education/Academic qualification
Biology, PhD, Heidelberg University
… → 2005
Research interests keywords
- MicroRNA
- Viral Oncology
- Virology
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Dive into the research topics where Eva Gottwein is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing KSHV-Infected Lymphatic Endothelial Cell-Based Models of Kaposi’s Sarcoma
Gottwein, E. (PD/PI) & Qiang, W. (Co-Investigator)
7/9/24 → 6/30/26
Project: Research project
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Mechanisms of KSHV-induced endothelial cell loss of contact inhibition of proliferation
Gottwein, E. (PD/PI), Gottwein, E. (PD/PI), Bartom, E. T. (Co-Investigator) & Bartom, E. T. (Co-Investigator)
7/1/23 → 6/30/28
Project: Research project
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Transcriptional Control of Cellular Survival and Proliferation in KSHV-transformed B Cells
Gottwein, E. (PD/PI), Gottwein, E. (PD/PI), Bartom, E. T. (Co-Investigator), Bartom, E. T. (Co-Investigator) & Ntziachristos, P. (Co-Investigator)
3/1/20 → 3/31/25
Project: Research project
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KSHV-induced oncogenic changes in a primary human lymphatic endothelial cell model of Kaposi's Sarcoma
Gottwein, E. (PD/PI) & Qiang, W. (Co-Investigator)
8/1/21 → 7/31/24
Project: Research project
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Deregulation of tumor suppressive pathways by KSHV microRNAs
Gottwein, E. (PD/PI)
7/1/16 → 6/30/21
Project: Research project
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Retargeting target-directed microRNA-decay sites to highly expressed viral or cellular miRNAs
Ortega, J. A., Liang, Z., Xu, J. K. & Gottwein, E., Dec 11 2024, In: Nucleic acids research. 52, 22, p. 14171-14183 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death
Kuehnle, N., Osborne, S. M., Liang, Z., Manzano, M. & Gottwein, E., May 2023, In: Cell Death and Differentiation. 30, 5, p. 1221-1234 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Druggable host gene dependencies in primary effusion lymphoma
Kuehnle, N. & Gottwein, E., Oct 2022, In: Current Opinion in Virology. 56, 101270.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Kaposi’s sarcoma-associated herpesvirus drives a super-enhancer-mediated survival gene expression program in primary effusion lymphoma
Manzano, M., Günther, T., Ju, H., Nicholas, J., Bartom, E. T., Grundhoff, A. & Gottwein, E., Jul 1 2020, In: mBio. 11, 4, p. 1-23 23 p., e01457-20.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
Wang, C., Zhang, L., Ke, L., Ding, W., Jiang, S., Li, D., Narita, Y., Hou, I., Liang, J., Li, S., Xiao, H., Gottwein, E., Kaye, K. M., Teng, M. & Zhao, B., Dec 2020, In: Nature communications. 11, 1, 6318.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations
Datasets
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Unambiguous Identification of miRNA:target site Interactions by Different Types of Ligation Reactions
Grosswendt, S. (Contributor), Filipchyk, A. (Contributor), Manzano, M. (Contributor), Klironomos, F. (Contributor), Schilling, M. (Contributor), Herzog, M. (Contributor), Gottwein, E. (Contributor) & Rajewsky, N. (Contributor), Gene Expression Omnibus, Mar 25 2014
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE56180
Dataset
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The viral and cellular microRNA targetome in lymphoblastoid cell lines
Gottwein, E. (Contributor), Kang, D. (Contributor), Hafner, M. (Contributor), Feederle, R. (Contributor), Tuschl, T. (Contributor) & Ohler, U. (Contributor), ArrayExpress, 2012
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41437
Dataset
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microRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina]
Gottwein, E. (Contributor), Mukherjee, N. (Contributor), Hafner, M. (Contributor), Shamulailatpam, P. (Contributor), Tuschl, T. (Contributor) & Ohler, U. (Contributor), ArrayExpress, 2011
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32109
Dataset
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Morrison et al. mRNA expression dependence on miRNA seed presence
Bartom, E. T. (Creator) & Gottwein, E. (Creator), Code Ocean, 2019
DOI: 10.24433/co.1360162.v1, https://codeocean.com/capsule/5364796/tree/v1
Dataset