Grants per year
Personal profile
Research Interests
The overall research objective of Professor Scott’s laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, they aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. They approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants. By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, they intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.
Education/Academic qualification
Biomedical Engineering, PhD, Washington University St. Louis
… → 2009
Biomedical Engineering, ScB, Brown University
… → 2002
Research interests
- Biomaterials
- Drug delivery
- Immunotherapy
- Nanomaterials
- Tissue engineering
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
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Acquisition of a K2 Camera for Soft Matter Transmission Electron Microscopy
Dichtel, W., Dravid, V. P., Farha, O. K., Gianneschi, N., Joester, D., Meade, T. J., Mirkin, C. A., Mrksich, M., Scott, E. A., Stupp, S., Weiss, E. A. & Wu, J.
Office of the Director, National Institutes of Health
8/12/19 → 8/11/24
Project: Research project
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Multiplexed cellular MRI for quantitative assessment of vascular plaque instability
7/1/19 → 6/30/21
Project: Research project
Research Output
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An Injectable Hydrogel Platform for Sustained Delivery of Anti-inflammatory Nanocarriers and Induction of Regulatory T Cells in Atherosclerosis
Yi, S., Karabin, N. B., Zhu, J., Bobbala, S., Lyu, H., Li, S., Liu, Y., Frey, M., Vincent, M. & Scott, E. A., Jun 5 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 542.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity
Bobbala, S., Allen, S. D., Yi, S., Vincent, M., Frey, M., Karabin, N. B. & Scott, E. A., Mar 7 2020, In: Nanoscale. 12, 9, p. 5332-5340 9 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Employment of targeted nanoparticles for imaging of cellular processes in cardiovascular disease
Modak, M., Frey, M. A., Yi, S., Liu, Y. & Scott, E. A., Dec 2020, In: Current Opinion in Biotechnology. 66, p. 59-68 10 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
High density display of an anti-angiogenic peptide on micelle surfaces enhances their inhibition of αvβ3 integrin-mediated neovascularization in vitro
Nagaraj, R., Stack, T., Yi, S., Mathew, B., Shull, K. R., Scott, E. A., Mathew, M. T. & Bijukumar, D. R., Mar 2020, In: Nanomaterials. 10, 3, 581.Research output: Contribution to journal › Article › peer-review
Open Access -
Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone–sulfone bonding
Du, F., Qiao, B., Nguyen, T. D., Vincent, M. P., Bobbala, S., Yi, S., Lescott, C., Dravid, V. P., Olvera de la Cruz, M. & Scott, E. A., Dec 1 2020, In: Nature communications. 11, 1, 4896.Research output: Contribution to journal › Article › peer-review
Open Access