Grants per year
Personal profile
Research Interests
The overall research objective of Professor Scott’s laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, they aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. They approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants. By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, they intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.
Education/Academic qualification
Biomedical Engineering, PhD, Washington University St. Louis
… → 2009
Biomedical Engineering, ScB, Brown University
… → 2002
Research interests
- Biomaterials
- Drug delivery
- Immunotherapy
- Nanomaterials
- Tissue engineering
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
Acquisition of a K2 Camera for Soft Matter Transmission Electron Microscopy
Dichtel, W., Dravid, V. P., Farha, O. K., Gianneschi, N., Joester, D., Meade, T. J., Mirkin, C. A., Mrksich, M., Scott, E. A., Stupp, S., Weiss, E. A. & Wu, J.
Office of the Director, National Institutes of Health
8/12/19 → 8/11/24
Project: Research project
Multiplexed cellular MRI for quantitative assessment of vascular plaque instability
7/1/19 → 6/30/21
Project: Research project
Subproject for SP0046885 Luo Core B
Jin, J., Kandela, I., Luo, X., Mathew, J., Schiltz, G. E., Scott, E. A., Vanoye, C. G. & Wertheim, J. A.
National Institute of Diabetes, Digestive and Kidney Diseases
8/1/18 → 7/31/23
Project: Research project
Research Output
Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity
Bobbala, S., Allen, S. D., Yi, S., Vincent, M., Frey, M., Karabin, N. B. & Scott, E. A., Mar 7 2020, In : Nanoscale. 12, 9, p. 5332-5340 9 p.Research output: Contribution to journal › Article
XCage: A Tricyclic Octacationic Receptor for Perylene Diimide with Picomolar Affinity in Water
Liu, W., Bobbala, S., Stern, C. L., Hornick, J. E., Liu, Y., Enciso, A. E., Scott, E. A. & Fraser Stoddart, J., Feb 12 2020, In : Journal of the American Chemical Society. 142, 6, p. 3165-3173 9 p.Research output: Contribution to journal › Article
A review on recent advancements in ophthalmology devices: Currently in market and under clinical trials
Nagaraj, R., Bijukumar, D. R., Mathew, B., Scott, E. A. & Mathew, M. T., Aug 1 2019, In : Journal of Drug Delivery Science and Technology. 52, p. 334-345 12 p.Research output: Contribution to journal › Review article
A Supramolecular Approach for Modulated Photoprotection, Lysosomal Delivery, and Photodynamic Activity of a Photosensitizer
Roy, I., Bobbala, S., Young, R. M., Beldjoudi, Y., Nguyen, M. T., Cetin, M. M., Cooper, J. A., Allen, S., Anamimoghadam, O., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Aug 7 2019, In : Journal of the American Chemical Society. 141, 31, p. 12296-12304 9 p.Research output: Contribution to journal › Article
1
Scopus
citations
Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma
Singh, A., Nandwana, V., Rink, J. S., Ryoo, S. R., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S. & Dravid, V. P., Sep 24 2019, In : ACS nano. 13, 9, p. 10301-10311 11 p.Research output: Contribution to journal › Article
1
Scopus
citations