Grants per year
Personal profile
Research Interests
The overall research objective of my laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, we aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. We approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants. By validating our immunostimulatory nanomaterials in mouse models for heart disease, melanoma, Chagas disease and hemophagocytic lymphohistiocytosis (HLH) we intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.
Education/Academic qualification
Biomedical Engineering, PhD, Washington University St. Louis
… → 2009
Biomedical Engineering, ScB, Brown University
… → 2002
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2014 2023
Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulations
National Institute of Allergy and Infectious Diseases
11/8/18 → 10/31/20
Project: Research project
Synthetic Vaccines
Attenuated Vaccines
Immunization
Vaccination
Vaccines
Subproject for SP0046885 Luo Core B
Jin, J., Kandela, I., Luo, X., Mathew, J., Schiltz, G. E., Scott, E. A., Vanoye, C. G. & Wertheim, J. A.
National Institute of Diabetes, Digestive and Kidney Diseases
8/1/18 → 7/31/23
Project: Research project
Kidney
Kidney Diseases
Research Personnel
Therapeutics
Nanomedicine
Investigating the impact of tumor heterogeneity on sustained low dosage immunotherapy via a peritumoral immunotheranostic hydrogel
7/1/18 → 6/30/21
Project: Research project
Hydrogel
Immunotherapy
Tumor Microenvironment
Immunomodulation
Neoplasms
Nanostructure-enhanced Targeting of Dendritic Cells to Elicit Treg Responses in the Treatment of Atherosclerosis
7/1/17 → 6/30/19
Project: Research project
Nanostructures
Dendritic Cells
Atherosclerosis
Apolipoprotein B-100
Adaptive Immunity
Development of Lipid-based Nanoparticle Vaccines Against Mycobacterium tuberculosis
National Institute of Allergy and Infectious Diseases
1/25/17 → 12/31/18
Project: Research project
Mycolic Acids
Mycobacterium tuberculosis
Nanoparticles
Vaccines
Lipids
Research Output 2004 2018
Benchmarking Bicontinuous Nanospheres against Polymersomes for in Vivo Biodistribution and Dual Intracellular Delivery of Lipophilic and Water-Soluble Payloads
Allen, S. D., Bobbala, S., Karabin, N. B., Modak, M. & Scott, E. A., Oct 10 2018, In : ACS Applied Materials and Interfaces. 10, 40, p. 33857-33866 10 p.Research output: Contribution to journal › Article
Nanospheres
Benchmarking
Water
Polyethylene glycols
Polypropylenes
ExTzBox: A Glowing Cyclophane for Live-Cell Imaging
Roy, I., Bobbala, S., Zhou, J., Nguyen, M. T., Nalluri, S. K. M., Wu, Y., Ferris, D. P., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7206-7212 7 p.Research output: Contribution to journal › Article
Imaging techniques
Macrophages
Fluorescent Dyes
Viologens
Photobleaching
Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres
Bobbala, S., Allen, S. D. & Scott, E. A., Mar 21 2018, In : Nanoscale. 10, 11, p. 5078-5088 11 p.Research output: Contribution to journal › Article
Nanospheres
Lipids
Polyethylene glycols
Molecules
Immunization
Influences of nanocarrier morphology on therapeutic immunomodulation
Frey, M., Bobbala, S., Karabin, N. & Scott, E. A., Jan 1 2018, In : Nanomedicine. 13, 14, p. 1795-1811 17 p.Research output: Contribution to journal › Review article
Immunomodulation
Nanostructures
immune response
targeting
Cytotoxicity
Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles
Stack, T., Vahabikashi, A., Johnson, M. & Scott, E. A., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.Research output: Contribution to journal › Article
Cytology
Ophthalmology
Sulfur Compounds
Hydraulic structures
Molecular biology