Grants per year
Personal profile
Research Interests
The overall research objective of Professor Scott’s laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, they aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. They approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants. By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, they intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Engineering, PhD, Washington University St. Louis
… → 2009
Biomedical Engineering, ScB, with Honors, Brown University
… → 2002
Research interests keywords
- Biomaterials
- Drug delivery
- Immunotherapy
- Nanomaterials
- Tissue engineering
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Biomed Core
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/23 → 6/30/28
Project: Research project
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Validation of a Tolerogenic Nanotherapy for Islet Transplantation in a Non-Human Primate Model
Scott, E. A., Burke, J. A. & Zhang, X.
7/1/23 → 6/30/26
Project: Research project
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A Nanocarrier Platform for Targeting Schlemm's Canal Cells
Johnson, M., Scott, E. A., Quaggin, S. E., Thomson, B. R. & Zhang, H. F.
9/30/22 → 7/31/26
Project: Research project
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Toward Translation of an Immunotherapeutic Nanomedicine for Neuroblastoma
Vanderbilt University, National Cancer Institute
7/1/22 → 6/30/26
Project: Research project
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A universal multi-drug encapsulation and delivery system employing supramolecular nanogels that self-assemble via dynamic sulfone bonding
Scott, E. A. & Qiao, B.
National Institute of Biomedical Imaging and Bioengineering
8/1/21 → 4/30/25
Project: Research project
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Drug delivery targets and strategies to address mast cell diseases
Rische, C. H., Thames, A. N., Krier-Burris, R. A., O’Sullivan, J. A., Bochner, B. S. & Scott, E. A., 2023, In: Expert Opinion on Drug Delivery. 20, 2, p. 205-222 18 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides
Bhushan, N. P., Stack, T., Scott, E. A., Shull, K. R., Mathew, B. & Bijukumar, D., Feb 2023, In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 111, 2, p. 343-353 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Multimodal STEM Investigation of Polymer Damage Processes Induced by Electron Beam Irradiation
Lescott, C., Bobbala, S., Modak, M., Dos Reis, R., Scott, E. A. & Dravid, V. P., Feb 1 2023, In: Microscopy and Microanalysis. 29, 1, p. 16-26 11 p.Research output: Contribution to journal › Article › peer-review
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Nanomedicine in kidney disease
Bishop, B., Sharma, S. & Scott, E. A., Jul 1 2023, In: Current opinion in nephrology and hypertension. 32, 4, p. 366-376 11 p.Research output: Contribution to journal › Review article › peer-review
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Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells
Morgun, E., Zhu, J., Almunif, S., Bobbala, S., Aguilar, M. S., Wang, J., Conner, K., Cui, Y., Cao, L., Seshadri, C., Scott, E. A. & Wang, C. R., Jun 2023, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Datasets
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CCDC 1952503: Experimental Crystal Structure Determination
Liu, W. (Contributor), Bobbala, S. (Contributor), Stern, C. L. (Contributor), Hornick, J. E. (Contributor), Liu, Y. (Contributor), Enciso, A. E. (Contributor), Scott, E. A. (Contributor) & Stoddart, J. F. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc23jqzc, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23jqzc&sid=DataCite
Dataset
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CCDC 1903587: Experimental Crystal Structure Determination
Roy, I. (Contributor), Bobbala, S. (Contributor), Young, R. M. (Contributor), Beldjoudi, Y. (Contributor), Nguyen, M. T. (Contributor), Cetin, M. M. (Contributor), Cooper, J. A. (Contributor), Allen, S. (Contributor), Anamimoghadam, O. (Contributor), Scott, E. A. (Contributor), Wasielewski, M. R. (Contributor), Stoddart, J. F. (Contributor) & Wasielewski, M. R. (Contributor), Cambridge Crystallographic Data Centre, 2019
DOI: 10.5517/ccdc.csd.cc21wv1v, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc21wv1v&sid=DataCite
Dataset
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CCDC 1831001: Experimental Crystal Structure Determination
Roy, I. (Creator), Bobbala, S. (Creator), Zhou, J. (Creator), Nguyen, M. T. (Creator), Nalluri, S. K. M. (Creator), Wu, Y. (Creator), Ferris, D. P. (Creator), Scott, E. A. (Creator), Wasielewski, M. R. (Creator), Stoddart, J. F. (Creator) & Wasielewski, M. R. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1zg9k9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1zg9k9&sid=DataCite
Dataset
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CCDC 1952500: Experimental Crystal Structure Determination
Liu, W. (Contributor), Bobbala, S. (Contributor), Stern, C. L. (Contributor), Hornick, J. E. (Contributor), Liu, Y. (Contributor), Enciso, A. E. (Contributor), Scott, E. A. (Contributor) & Stoddart, J. F. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc23jqw8, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23jqw8&sid=DataCite
Dataset
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CCDC 1952501: Experimental Crystal Structure Determination
Liu, W. (Contributor), Bobbala, S. (Contributor), Stern, C. L. (Contributor), Hornick, J. E. (Contributor), Liu, Y. (Contributor), Enciso, A. E. (Contributor), Scott, E. A. (Contributor) & Stoddart, J. F. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc23jqx9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23jqx9&sid=DataCite
Dataset