• 805 Citations
20042024

Research output per year

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Personal profile

Research Interests

The overall research objective of Professor Scott’s laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, they aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. They approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants.  By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, they intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials. 

Education/Academic qualification

Biomedical Engineering, PhD, Washington University St. Louis

… → 2009

Biomedical Engineering, ScB, Brown University

… → 2002

Research interests

  • Biomaterials
  • Drug delivery
  • Immunotherapy
  • Nanomaterials
  • Tissue engineering

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Grants

  • Research Output

    Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity

    Bobbala, S., Allen, S. D., Yi, S., Vincent, M., Frey, M., Karabin, N. B. & Scott, E. A., Mar 7 2020, In : Nanoscale. 12, 9, p. 5332-5340 9 p.

    Research output: Contribution to journalArticle

  • XCage: A Tricyclic Octacationic Receptor for Perylene Diimide with Picomolar Affinity in Water

    Liu, W., Bobbala, S., Stern, C. L., Hornick, J. E., Liu, Y., Enciso, A. E., Scott, E. A. & Fraser Stoddart, J., Feb 12 2020, In : Journal of the American Chemical Society. 142, 6, p. 3165-3173 9 p.

    Research output: Contribution to journalArticle

  • A review on recent advancements in ophthalmology devices: Currently in market and under clinical trials

    Nagaraj, R., Bijukumar, D. R., Mathew, B., Scott, E. A. & Mathew, M. T., Aug 1 2019, In : Journal of Drug Delivery Science and Technology. 52, p. 334-345 12 p.

    Research output: Contribution to journalReview article

  • A Supramolecular Approach for Modulated Photoprotection, Lysosomal Delivery, and Photodynamic Activity of a Photosensitizer

    Roy, I., Bobbala, S., Young, R. M., Beldjoudi, Y., Nguyen, M. T., Cetin, M. M., Cooper, J. A., Allen, S., Anamimoghadam, O., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Aug 7 2019, In : Journal of the American Chemical Society. 141, 31, p. 12296-12304 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

    Singh, A., Nandwana, V., Rink, J. S., Ryoo, S. R., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S. & Dravid, V. P., Sep 24 2019, In : ACS nano. 13, 9, p. 10301-10311 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations