• 577 Citations
20042023
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Personal profile

Research Interests

The overall research objective of my laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, we aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. We approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants.  By validating our immunostimulatory nanomaterials in mouse models for heart disease, melanoma, Chagas disease and hemophagocytic lymphohistiocytosis (HLH) we intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.

Education/Academic qualification

Biomedical Engineering, PhD, Washington University St. Louis

… → 2009

Biomedical Engineering, ScB, Brown University

… → 2002

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Grants 2014 2023

Kidney
Kidney Diseases
Research Personnel
Therapeutics
Nanomedicine
Hydrogel
Immunotherapy
Tumor Microenvironment
Immunomodulation
Neoplasms
Nanostructures
Dendritic Cells
Atherosclerosis
Apolipoprotein B-100
Adaptive Immunity
Mycolic Acids
Mycobacterium tuberculosis
Nanoparticles
Vaccines
Lipids

Research Output 2004 2018

  • 577 Citations
  • 31 Article
  • 5 Conference contribution
  • 2 Review article
  • 1 Chapter

Benchmarking Bicontinuous Nanospheres against Polymersomes for in Vivo Biodistribution and Dual Intracellular Delivery of Lipophilic and Water-Soluble Payloads

Allen, S. D., Bobbala, S., Karabin, N. B., Modak, M. & Scott, E. A., Oct 10 2018, In : ACS Applied Materials and Interfaces. 10, 40, p. 33857-33866 10 p.

Research output: Contribution to journalArticle

Nanospheres
Benchmarking
Water
Polyethylene glycols
Polypropylenes
3 Citations

ExTzBox: A Glowing Cyclophane for Live-Cell Imaging

Roy, I., Bobbala, S., Zhou, J., Nguyen, M. T., Nalluri, S. K. M., Wu, Y., Ferris, D. P., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7206-7212 7 p.

Research output: Contribution to journalArticle

Imaging techniques
Macrophages
Fluorescent Dyes
Viologens
Photobleaching
6 Citations

Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres

Bobbala, S., Allen, S. D. & Scott, E. A., Mar 21 2018, In : Nanoscale. 10, 11, p. 5078-5088 11 p.

Research output: Contribution to journalArticle

Nanospheres
Lipids
Polyethylene glycols
Molecules
Immunization

Influences of nanocarrier morphology on therapeutic immunomodulation

Frey, M., Bobbala, S., Karabin, N. & Scott, E. A., Jan 1 2018, In : Nanomedicine. 13, 14, p. 1795-1811 17 p.

Research output: Contribution to journalReview article

Immunomodulation
Nanostructures
immune response
targeting
Cytotoxicity

Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles

Stack, T., Vahabikashi, A., Johnson, M. & Scott, E. A., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Cytology
Ophthalmology
Sulfur Compounds
Hydraulic structures
Molecular biology