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Research Output 2004 2019

2019

A review on recent advancements in ophthalmology devices: Currently in market and under clinical trials

Nagaraj, R., Bijukumar, D. R., Mathew, B., Scott, E. A. & Mathew, M. T., Aug 1 2019, In : Journal of Drug Delivery Science and Technology. 52, p. 334-345 12 p.

Research output: Contribution to journalReview article

Ophthalmology
Clinical Trials
Equipment and Supplies
Eye Diseases
Macular Degeneration
1 Citation (Scopus)

A Supramolecular Approach for Modulated Photoprotection, Lysosomal Delivery, and Photodynamic Activity of a Photosensitizer

Roy, I., Bobbala, S., Young, R. M., Beldjoudi, Y., Nguyen, M. T., Cetin, M. M., Cooper, J. A., Allen, S., Anamimoghadam, O., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Aug 7 2019, In : Journal of the American Chemical Society. 141, 31, p. 12296-12304 9 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Photosensitizers
Cells
Photodynamic therapy
Pigments
1 Citation (Scopus)

Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

Singh, A., Nandwana, V., Rink, J. S., Ryoo, S. R., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S. & Dravid, V. P., Sep 24 2019, In : ACS nano. 13, 9, p. 10301-10311 11 p.

Research output: Contribution to journalArticle

lipid metabolism
Scavenger Receptors
Cholesterol
biomimetics
Biomimetics
8 Citations (Scopus)

Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

Allen, S. D., Liu, Y. G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J. & Scott, E. A., Feb 2019, In : Biomaterials Science. 7, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Micelles
Polyethylene glycols
Anti-Inflammatory Agents
Polypropylenes
Polydispersity

Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery

Modak, M., Nandwana, V., Dravid, V. P. & Scott, E. A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanospheres
Ethylene Glycol
Nanostructures
Magnetic resonance
Drug delivery
4 Citations (Scopus)

On the advancement of polymeric bicontinuous nanospheres toward biomedical applications

Allen, S. D., Bobbala, S., Karabin, N. B. & Scott, E. A., Mar 2019, In : Nanoscale Horizons. 4, 2, p. 321-338 18 p.

Research output: Contribution to journalReview article

Nanospheres
Lipids
Liposomes
Encapsulation
Polymers

Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy

Yi, S., Zhang, X., Sangji, M. H., Liu, Y., Allen, S. D., Xiao, B., Bobbala, S., Braverman, C. L., Cai, L., Hecker, P. I., DeBerge, M., Thorp, E. B., Temel, R. E., Stupp, S. & Scott, E. A., Oct 1 2019, In : Advanced Functional Materials. 29, 42, 1904399.

Research output: Contribution to journalArticle

Modulation
modulation
cells
lesions
arteriosclerosis

Versatile assembly of polymeric bicontinuous nanospheres via flash nanoprecipitation

Bobbala, S., Allen, S., Karabin, N. & Scott, E. A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanospheres
Lipids
Benchmarking
Porosity
Self assembly
2018
4 Citations (Scopus)

Benchmarking Bicontinuous Nanospheres against Polymersomes for in Vivo Biodistribution and Dual Intracellular Delivery of Lipophilic and Water-Soluble Payloads

Allen, S. D., Bobbala, S., Karabin, N. B., Modak, M. & Scott, E. A., Oct 10 2018, In : ACS Applied Materials and Interfaces. 10, 40, p. 33857-33866 10 p.

Research output: Contribution to journalArticle

Nanospheres
Benchmarking
Water
Polyethylene glycols
Polypropylenes
23 Citations (Scopus)

ExTzBox: A Glowing Cyclophane for Live-Cell Imaging

Roy, I., Bobbala, S., Zhou, J., Nguyen, M. T., Nalluri, S. K. M., Wu, Y., Ferris, D. P., Scott, E. A., Wasielewski, M. R. & Stoddart, J. F., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7206-7212 7 p.

Research output: Contribution to journalArticle

Imaging techniques
Macrophages
Fluorescent Dyes
Viologens
Photobleaching
19 Citations (Scopus)

Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres

Bobbala, S., Allen, S. D. & Scott, E. A., Mar 21 2018, In : Nanoscale. 10, 11, p. 5078-5088 11 p.

Research output: Contribution to journalArticle

Nanospheres
Lipids
Polyethylene glycols
Molecules
Immunization

Immune theranostics

Scott, E. A., Dec 1 2018, In : Bridge. 48, 4, p. 35-39 5 p.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Induction of mycobacterium tuberculosislipid-specific t cell responses by pulmonary delivery of mycolic acid-loaded polymeric micellar nanocarriers

Shang, S., Kats, D., Cao, L., Morgun, E., Velluto, D., He, Y., Xu, Q., Wang, C. R. & Scott, E. A., Nov 27 2018, In : Frontiers in immunology. 9, NOV, 02709.

Research output: Contribution to journalArticle

Mycolic Acids
Mycobacterium
Lung
T-Lymphocytes
Mycobacterium tuberculosis
3 Citations (Scopus)

Influences of nanocarrier morphology on therapeutic immunomodulation

Frey, M., Bobbala, S., Karabin, N. & Scott, E., Jan 1 2018, In : Nanomedicine. 13, 14, p. 1795-1811 17 p.

Research output: Contribution to journalReview article

Immunomodulation
Nanostructures
immune response
targeting
Cytotoxicity
4 Citations (Scopus)

Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles

Stack, T., Vahabikashi, A., Johnson, M. & Scott, E. A., Jul 1 2018, In : Journal of Biomedical Materials Research - Part A. 106, 7, p. 1771-1779 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Micelles
Canals
Block copolymers
Stiffness
7 Citations (Scopus)

Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration

Allen, S. D., Liu, Y. G., Bobbala, S., Cai, L., Hecker, P. I., Temel, R. & Scott, E. A., Oct 1 2018, In : Nano Research. 11, 10, p. 5689-5703 15 p.

Research output: Contribution to journalArticle

Polyethylene glycols
Polypropylenes
Macrophages
Liver
Toxicity
Immunologic Adjuvants
Nanostructures
Proteins
Biological Phenomena
Nanostructured materials
5 Citations (Scopus)

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes

Du, F., Bobbala, S., Yi, S. & Scott, E. A., Jul 28 2018, In : Journal of Controlled Release. 282, p. 90-100 11 p.

Research output: Contribution to journalArticle

Hydrogels
Water
Permeability
Temperature
Membranes
16 Citations (Scopus)

Sustained micellar delivery via inducible transitions in nanostructure morphology

Karabin, N. B., Allen, S., Kwon, H. K., Bobbala, S., Firlar, E., Shokuhfar, T., Shull, K. R. & Scott, E. A., Dec 1 2018, In : Nature communications. 9, 1, 624.

Research output: Contribution to journalArticle

Nanostructures
Hydrogel
Subcutaneous Injections
Scaffolds
delivery
2017
6 Citations (Scopus)

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Zhang, S., Yeap, X. Y., DeBerge, M., Naresh, N. K., Wang, K., Jiang, Z., Wilcox, J. E., White, S. M., Morrow, J. P., Burridge, P. W., Procissi, D., Scott, E. A., Frazier, W. & Thorp, E. B., Aug 2017, In : JACC: Basic to Translational Science. 2, 4, p. 386-397 12 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion
Phagocytosis
Cardiac Myocytes
Blocking Antibodies
Phagocytes
18 Citations (Scopus)

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation

Allen, S., Osorio, O., Liu, Y. G. & Scott, E., Sep 28 2017, In : Journal of Controlled Release. 262, p. 91-103 13 p.

Research output: Contribution to journalArticle

Nanospheres
Immunomodulation
Micelles
Sirolimus
Immunosuppressive Agents
7 Citations (Scopus)
Copolymer
Oxidation
Fluorescence
Polyethylene glycols
Block copolymers
7 Citations (Scopus)

Overcoming Immune Dysregulation with Immunoengineered Nanobiomaterials

Scott, E. A., Karabin, N. B. & Augsornworawat, P., Jun 21 2017, In : Annual Review of Biomedical Engineering. 19, p. 57-84 28 p.

Research output: Contribution to journalArticle

Immune system
Complex networks
Pathology
Biomaterials
Large scale systems
43 Citations (Scopus)

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

Dowling, D. J., Scott, E. A., Scheid, A., Bergelson, I., Joshi, S., Pietrasanta, C., Brightman, S., Sanchez-Schmitz, G., Van Haren, S. D., Ninković, J., Kats, D., Guiducci, C., de Titta, A., Bonner, D. K., Hirosue, S., Swartz, M. A., Hubbell, J. A. & Levy, O., Nov 2017, In : Journal of Allergy and Clinical Immunology. 140, 5, p. 1339-1350 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
BCG Vaccine
Adaptive Immunity
Innate Immunity
Nanoparticles
2016
18 Citations (Scopus)

Engineering Nanomaterials to Address Cell-Mediated Inflammation in Atherosclerosis

Allen, S. D., Liu, Y. G. & Scott, E. A., 2016, In : Regenerative Engineering and Translational Medicine. 2, 1, p. 37-50 14 p.

Research output: Contribution to journalArticle

Nanostructures
Nanostructured materials
Atherosclerosis
Inflammation
Cells
22 Citations (Scopus)

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis

Yi, S., Allen, S. D., Liu, Y. G., Ouyang, B. Z., Li, X., Augsornworawat, P., Thorp, E. B. & Scott, E. A., Dec 27 2016, In : ACS nano. 10, 12, p. 11290-11303 14 p.

Research output: Contribution to journalArticle

arteriosclerosis
Nanostructures
Micelles
cells
Nanostructured materials
2014

Controlled Release Strategies in Tissue Engineering

Rice, J. J., Martino, M. M., Scott, E. A. & Hubbell, J. A., Dec 10 2014, Tissue Engineering: Second Edition. Elsevier Inc, p. 347-392 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tissue engineering
Cell signaling
Biomolecules
Biomaterials
Engineers

Vesicle photonics in biology with a focus on single cell analysis

Vasdekis, A. E., Scott, E. A., Hubbell, J. A. & Saltis, D., Dec 22 2014, 2014 IEEE Photonics Conference, IPC 2014. Institute of Electrical and Electronics Engineers Inc., p. 3-4 2 p. 6994960. (2014 IEEE Photonics Conference, IPC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

biology
Photonics
Self assembly
Gases
photonics
2013

Optical manipulation of vesicles for optofluidic applications

Vasdekis, A. E., Scott, E. A., O'Neil, C. P., Psaltis, D. & Hubbell, J. A., Dec 11 2013, Optical Trapping and Optical Micromanipulation X. Vol. 8810. 88101R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optofluidics
Vesicles
Manipulation
manipulators
Photons
62 Citations (Scopus)

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles

Stano, A., Scott, E. A., Dane, K. Y., Swartz, M. A. & Hubbell, J. A., Jun 1 2013, In : Biomaterials. 34, 17, p. 4339-4346 8 p.

Research output: Contribution to journalArticle

T-cells
Antigens
Nanoparticles
Immunity
Proteins
12 Citations (Scopus)

Vesicle photonics

Vasdekis, A. E., Scott, E. A., Roke, S., Hubbell, J. A. & Psaltis, D., Jul 1 2013, In : Annual Review of Materials Research. 43, p. 283-305 23 p.

Research output: Contribution to journalReview article

Photonics
Photons
Membranes
Optical tweezers
Amphiphiles
2012
98 Citations (Scopus)

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

Scott, E. A., Stano, A., Gillard, M., Maio-Liu, A. C., Swartz, M. A. & Hubbell, J. A., Sep 1 2012, In : Biomaterials. 33, 26, p. 6211-6219 9 p.

Research output: Contribution to journalArticle

T-cells
Antigens
Dendritic Cells
Vaccines
Chemical activation
4 Citations (Scopus)

Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry

Ovod, V., Scott, E. A., Flake, M. M., Parker, S. R., Bateman, R. J. & Elbert, D. L., Mar 1 2012, In : Journal of Biomedical Materials Research - Part A. 100 A, 3, p. 622-631 10 p.

Research output: Contribution to journalArticle

Polyethylene Terephthalates
Platelets
Polyethylene terephthalates
Fibrinogen
Lysine
50 Citations (Scopus)

Precision intracellular delivery based on optofluidic polymersome rupture

Vasdekis, A. E., Scott, E. A., O'Neil, C. P., Psaltis, D. & Hubbell, J. A., Sep 25 2012, In : ACS nano. 6, 9, p. 7850-7857 8 p.

Research output: Contribution to journalArticle

delivery
Cytology
Photosensitizing Agents
Photosensitizers
payloads
2011

Colloidal materials for modulating the immune response

Hubbell, J. A., Swartz, M. A., Simeoni, E., Stano, A., Nembrini, C., Ballester, M., Thomas, S. N., Hirosue, S., Van Der Vlies, A. J., O'Neil, C. P., Velluto, D., Eby, J. & Scott, E. A., Jan 1 2011, Materials Engineering and Sciences Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 537-539 3 p. (Materials Engineering and Sciences Division - Core Programming Topic at the 2011 AIChE Annual Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dendritic cell targeting by polymersomes for vaccine development

Stano, A., Scott, E., Simeoni, E., Nembrini, C., Swartz, M. & Hubbell, J., Dec 1 2011, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, ESB 2011.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vaccines
Dendritic Cells
2010
73 Citations (Scopus)

Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen

Scott, E. A., Nichols, M. D., Kuntz-Willits, R. & Elbert, D. L., Jan 1 2010, In : Acta Biomaterialia. 6, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Microspheres
Scaffolds
Polyethylene glycols
Cells
2009
28 Citations (Scopus)

Factors affecting size and swelling of poly(ethylene glycol) microspheres formed in aqueous sodium sulfate solutions without surfactants

Nichols, M. D., Scott, E. A. & Elbert, D. L., Oct 1 2009, In : Biomaterials. 30, 29, p. 5283-5291 9 p.

Research output: Contribution to journalArticle

Sodium sulfate
Ethylene Glycol
Microspheres
Surface-Active Agents
Polyethylene glycols
7 Citations (Scopus)

Use of lorenz titanium implants in orbital fracture repair

Chang, S. H., Custer, P. L., Mohadjer, Y. & Scott, E., Mar 1 2009, In : Ophthalmic Plastic and Reconstructive Surgery. 25, 2, p. 119-122 4 p.

Research output: Contribution to journalArticle

Orbital Fractures
Titanium
Orbital Implants
Diplopia
Oculomotor Muscles
2008

Covalent layer-by-layer strategies for biomaterials coatings

Elbert, D. L., Kim, J. & Scott, E. A., Dec 1 2008, 8th World Biomaterials Congress 2008. 1 p. (8th World Biomaterials Congress 2008; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biocompatible Materials
Biomaterials
Coatings
43 Citations (Scopus)

Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate

Wacker, B. K., Alford, S. K., Scott, E. A., Thakur, M. D., Longmore, G. D. & Elbert, D. L., Jan 1 2008, In : Biophysical Journal. 94, 1, p. 273-285 13 p.

Research output: Contribution to journalArticle

Hydrogels
Cell Movement
Endothelial Cells
Cell Adhesion
Integrins
69 Citations (Scopus)

Protein adsorption and cell adhesion on nanoscale bioactive coatings formed from poly(ethylene glycol) and albumin microgels

Scott, E. A., Nichols, M. D., Cordova, L. H., George, B. J., Jun, Y. S. & Elbert, D. L., Dec 1 2008, In : Biomaterials. 29, 34, p. 4481-4493 13 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Cell adhesion
Cell Adhesion
Polyethylene glycols
Adsorption
11 Citations (Scopus)

Stable isotope labeling tandem mass spectrometry (SILT): Integration with peptide identification and extension to data-dependent scans

Elbert, D. L., Mawuenyega, K. G., Scott, E. A., Wildsmith, K. R. & Bateman, R. J., Oct 1 2008, In : Journal of Proteome Research. 7, 10, p. 4546-4556 11 p.

Research output: Contribution to journalArticle

Isotope Labeling
Tandem Mass Spectrometry
Isotopes
Labeling
Mass spectrometry
2007
16 Citations (Scopus)

Mass spectrometric mapping of fibrinogen conformations at poly(ethylene terephthalate) interfaces

Scott, E. A. & Elbert, D. L., Sep 1 2007, In : Biomaterials. 28, 27, p. 3904-3917 14 p.

Research output: Contribution to journalArticle

Polyethylene Terephthalates
Polyethylene terephthalates
Fibrinogen
Conformations
Adsorption
2006
45 Citations (Scopus)

Delivery of Sphingosine 1-phosphate from poly(ethylene glycol) hydrogels

Wacker, B. K., Scott, E. A., Kaneda, M. M., Alford, S. K. & Elbert, D. L., Apr 1 2006, In : Biomacromolecules. 7, 4, p. 1335-1343 9 p.

Research output: Contribution to journalArticle

Sphingosines
Hydrogels
Lipids
Polyethylene glycols
Phosphates
2005

In vitro and in vivo analysis of antide delivery from multi-phase microspheres fabricated via solvent removal

Branton, J. F., Cheifetz, P. M., Scott, E. A., Bubbers, E. J. & Mathiowitz, E., Nov 29 2005, In : Israel Journal of Chemistry. 45, 4, p. 445-456 12 p.

Research output: Contribution to journalArticle

Microspheres
Testosterone
Hormone Antagonists
Anhydrides
Gonadotropins
31 Citations (Scopus)

Proteomic analysis of protein adsorption: Serum amyloid P adsorbs to materials and promotes leukocyte adhesion

Kim, J. K., Scott, E. A. & Elbert, D. L., Oct 1 2005, In : Journal of Biomedical Materials Research - Part A. 75, 1, p. 199-209 11 p.

Research output: Contribution to journalArticle

Amyloid
Polyethylene Terephthalates
Adhesion
Polydimethylsiloxane
Proteins
2004
3 Citations (Scopus)

Degradation of multi-phase microspheres fabricated via solvent removal

Godbee, J., Pattamunuch, P., Scott, E. & Mathiowitz, E., May 1 2004, In : Journal of Microencapsulation. 21, 3, p. 331-352 22 p.

Research output: Contribution to journalArticle

lactic acid
Lactic acid
Microspheres
degradation
Degradation
10 Citations (Scopus)

Role of solvent/non-solvent ratio on microsphere formation using the solvent removal method

Godbee, J., Scott, E., Pattamunuch, P., Chen, S. & Mathiowitz, E., Mar 1 2004, In : Journal of Microencapsulation. 21, 2, p. 151-160 10 p.

Research output: Contribution to journalArticle

Microspheres
Viscosity
Polymers
viscosity
polymers