Grants per year
Personal profile
Research Interests
Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.
Training Experience
| 2014 | Postdoctoral Fellowship, Harvard University |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Endocrinology, PhD, Imperial College London
… → 2008
Research interests
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genomics
- Neurogenetics
- Neuroscience
- Stem Cells
Fingerprint
Dive into the research topics where Evangelos Kiskinis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Kinetic Imaging Plate Reader for Drug Discovery and Biology
George Jr., A. L., Arispe, L., Bass, J., Burridge, P., DeCaen, P. G., Gianneschi, N., Horvath, C. M., Kiskinis, E., Klein, W. L., Miller, R. J., Morimoto, R. I., Moskal, J. R., Penzes, P., Prakriya, M., Scheidt, K. A., Surmeier Jr, D. J. & Vafabakhsh, R.
Office of the Director, National Institutes of Health
9/1/21 → 8/31/22
Project: Research project
-
CRISPR-Cas9 Gene Therapy for ALS Enhanced by TJ-Targeted Barrier Modulation
University of Texas at Dallas, U.S. Army Medical Research and Materiel Command
6/1/21 → 5/31/23
Project: Research project
-
Neuronal excitability and copy number variation disorders
Penzes, P., George Jr., A. L., Kiskinis, E., Forrest, M. & Zaccard, C. R.
National Institute of Neurological Disorders and Stroke
9/1/20 → 5/31/25
Project: Research project
-
Small GTPase signaling in dendrites and spines
Penzes, P., Kiskinis, E., Moskal, J. R., Scheidt, K. A., Parnell, E. L. & Zaccard, C. R.
National Institute of Mental Health
6/10/20 → 5/31/22
Project: Research project
-
Dyshomeostatic modulation of ca2+-activated k+ channels in a human neuronal model of kcnq2 encephalopathy
Simkin, D., Marshall, K. A., Vanoye, C. G., Desai, R. R., Bustos, B. I., Piyevsky, B. N., Ortega, J. A., Forrest, M., Robertson, G. L., Penzes, P., Laux, L. C., Lubbe, S. J., Millichap, J. J., George, A. L. & Kiskinis, E., Feb 2021, In: eLife. 10, p. 1-32 32 p., e64434.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial
Wainger, B. J., Macklin, E. A., Vucic, S., McIlduff, C. E., Paganoni, S., Maragakis, N. J., Bedlack, R., Goyal, N. A., Rutkove, S. B., Lange, D. J., Rivner, M. H., Goutman, S. A., Ladha, S. S., Mauricio, E. A., Baloh, R. H., Simmons, Z., Pothier, L., Kassis, S. B., La, T., Hall, M. & 29 others, , Feb 2021, In: JAMA Neurology. 78, 2, p. 186-196 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
Ortega, J. A., Daley, E. L., Kour, S., Samani, M., Tellez, L., Smith, H. S., Hall, E. A., Esengul, Y. T., Tsai, Y. H., Gendron, T. F., Donnelly, C. J., Siddique, T., Savas, J. N., Pandey, U. B. & Kiskinis, E., Apr 8 2020, In: Neuron. 106, 1, p. 90-107.e13Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Ramesh, N., Daley, E. L., Gleixner, A. M., Mann, J. R., Kour, S., Mawrie, D., Anderson, E. N., Kofler, J., Donnelly, C. J., Kiskinis, E. & Pandey, U. B., Dec 1 2020, In: Acta Neuropathologica Communications. 8, 1, 177.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
Charlton, J., Jung, E. J., Mattei, A. L., Bailly, N., Liao, J., Martin, E. J., Giesselmann, P., Brändl, B., Stamenova, E. K., Müller, F. J., Kiskinis, E., Gnirke, A., Smith, Z. D. & Meissner, A., Aug 1 2020, In: Nature Genetics. 52, 8, p. 819-827 9 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations