Grants per year
Personal profile
Research Interests
Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.
Training Experience
| 2014 | Postdoctoral Fellowship, Harvard University |
Education/Academic qualification
PhD, Imperial College London, UK
… → 2008
Research interests
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genomics
- Neurogenetics
- Neuroscience
- Stem Cells
Fingerprint Dive into the research topics where Evangelos Kiskinis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 25 Similar Profiles
Motor Neurons
Medicine & Life Sciences
Induced Pluripotent Stem Cells
Medicine & Life Sciences
Amyotrophic Lateral Sclerosis
Medicine & Life Sciences
Pluripotent Stem Cells
Medicine & Life Sciences
Co-Repressor Proteins
Medicine & Life Sciences
Stem Cells
Medicine & Life Sciences
Comet Assay
Medicine & Life Sciences
Stem cells
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2014 2024
Mitochondrial Stress Response in FUS proteinopathy and related dementia
Fushimi, K., Kiskinis, E. & Wu, J.
9/30/19 → 9/30/20
Project: Research project
Dementia
RNA-Binding Protein FUS
Alzheimer Disease
Frontotemporal Lobar Degeneration
Molecular Biology
Defining The Mechanisms by Which NEK1 Genetic Variants Associated with ALS Patient Motor Neurons Lead to Motor Neuron Degeneration
National Institute of Neurological Disorders and Stroke
4/1/19 → 3/31/21
Project: Research project
Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
Central Nervous System
Investigation of human neuron models of channelopathy-associated epilepsy
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
Channelopathies
Epilepsy
Neurons
Ion Channels
Genes
The Role of Mitochondria in TDP-43 Proteinopathy
Fushimi, K., Kiskinis, E., Ozdinler, P. H. & Wu, J.
National Institute of Neurological Disorders and Stroke
9/30/18 → 6/30/23
Project: Research project
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Defining The Impaired Proteostasis Network in ALS Patient Motor Neurons
National Institute of Neurological Disorders and Stroke
9/1/18 → 8/31/20
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis
Research Output 2001 2019
Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench
Franz, C. K., Joshi, D., Daley, E. L., Grant, R. A., Dalamagkas, K., Leung, A., Finan, J. D. & Kiskinis, E., Sep 1 2019, In : Journal of neurophysiology. 122, 3, p. 1174-1185 12 p.Research output: Contribution to journal › Article
Amyotrophic Lateral Sclerosis
Brain Concussion
Induced Pluripotent Stem Cells
Motor Neurons
Genetic Predisposition to Disease
1
Citation
(Scopus)
Peptide–siRNA Supramolecular Particles for Neural Cell Transfection
Hernandez-Garcia, A., Alvarez Pinto, Z., Simkin, D., Madhan, A., Pariset, E., Tantakitti, F., de J. Vargas-Dorantes, O., Lee, S. S., Kiskinis, E. & Stupp, S., Feb 6 2019, In : Advanced Science. 6, 3, 1801458.Research output: Contribution to journal › Article
ribonucleic acids
RNA
Transfection
genes
Peptides
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS
Baron, D. M., Matheny, T., Lin, Y. C., Leszyk, J. D., Kenna, K., Gall, K. V., Santos, D. P., Tischbein, M., Funes, S., Hayward, L. J., Kiskinis, E., Landers, J. E., Parker, R., Shaffer, S. A. & Bosco, D. A., Jul 1 2019, In : Human molecular genetics. 28, 13, p. 2143-2160 18 p.Research output: Contribution to journal › Article
Open Access
Amyotrophic Lateral Sclerosis
Proteomics
Proteins
Capsid Proteins
Heat-Shock Proteins
7
Citations
(Scopus)
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
Kiskinis, E., Kralj, J. M., Zou, P., Weinstein, E. N., Zhang, H., Tsioras, K., Wiskow, O., Ortega, J. A., Eggan, K. & Cohen, A. E., Jun 5 2018, In : Stem cell reports. 10, 6, p. 1991-2004 14 p.Research output: Contribution to journal › Article
Electrophysiology
Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells
Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models
Franz, C. K., Puritz, A., Jordan, L. A., Chow, J., Ortega, J. A., Kiskinis, E. & Heckman, C. J., Aug 1 2018, In : Neurorehabilitation and Neural Repair. 32, 8, p. 735-745 11 p.Research output: Contribution to journal › Article
Type A Botulinum Toxins
Botulinum Toxins
Axons
Regeneration
Nerve Transfer