• 3912 Citations
20012023
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Personal profile

Research Interests

Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.

Training Experience

2014Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, Imperial College London, UK

… → 2008

Research interests

  • Amyotrophic Lateral Sclerosis
  • Cell Biology
  • Genomics
  • Neurogenetics
  • Neuroscience
  • Stem Cells

Fingerprint Dive into the research topics where Evangelos Kiskinis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 25 Similar Profiles
Motor Neurons Medicine & Life Sciences
Induced Pluripotent Stem Cells Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Pluripotent Stem Cells Medicine & Life Sciences
Co-Repressor Proteins Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Comet Assay Medicine & Life Sciences
Stem cells Chemical Compounds

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Grants 2014 2023

Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
Central Nervous System
Channelopathies
Epilepsy
Neurons
Ion Channels
Genes
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis
Kidney
Kidney Diseases
Research Personnel
Therapeutics
Nanomedicine

Research Output 2001 2019

Peptide–siRNA Supramolecular Particles for Neural Cell Transfection

Hernandez-Garcia, A., Álvarez, Z., Simkin, D., Madhan, A., Pariset, E., Tantakitti, F., de J. Vargas-Dorantes, O., Lee, S. S., Kiskinis, E. & Stupp, S., Feb 6 2019, In : Advanced Science. 6, 3, 1801458.

Research output: Contribution to journalArticle

ribonucleic acids
RNA
Transfection
genes
Peptides

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS

Baron, D. M., Matheny, T., Lin, Y. C., Leszyk, J. D., Kenna, K., Gall, K. V., Santos, D. P., Tischbein, M., Funes, S., Hayward, L. J., Kiskinis, E., Landers, J. E., Parker, R., Shaffer, S. A. & Bosco, D. A., Jul 1 2019, In : Human molecular genetics. 28, 13, p. 2143-2160 18 p.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Proteomics
Proteins
Capsid Proteins
Heat-Shock Proteins
4 Citations (Scopus)

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS

Kiskinis, E., Kralj, J. M., Zou, P., Weinstein, E. N., Zhang, H., Tsioras, K., Wiskow, O., Ortega, J. A., Eggan, K. & Cohen, A. E., Jun 5 2018, In : Stem cell reports. 10, 6, p. 1991-2004 14 p.

Research output: Contribution to journalArticle

Electrophysiology
Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells

Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models

Franz, C. K., Puritz, A., Jordan, L. A., Chow, J., Ortega, J. A., Kiskinis, E. & Heckman, C. J., Aug 1 2018, In : Neurorehabilitation and Neural Repair. 32, 8, p. 735-745 11 p.

Research output: Contribution to journalArticle

Type A Botulinum Toxins
Botulinum Toxins
Axons
Regeneration
Nerve Transfer

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons

Ichida, J. K., Staats, K. A., Davis-Dusenbery, B. N., Clement, K., Galloway, K. E., Babos, K. N., Shi, Y., Son, E. Y., Kiskinis, E., Atwater, N., Gu, H., Gnirke, A., Meissner, A. & Eggan, K., Nov 1 2018, In : Development (Cambridge). 145, 22, dev168617.

Research output: Contribution to journalArticle

Motor Neurons
Stem Cells
Transcription Factors
RNA Sequence Analysis
Pluripotent Stem Cells