Grants per year
Personal profile
Research Interests
Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.
Training Experience
| 2014 | Postdoctoral Fellowship, Harvard University |
Education/Academic qualification
PhD, Imperial College London
… → 2008
Research interests
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genomics
- Neurogenetics
- Neuroscience
- Stem Cells
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Grants
Developing Patient-Specific Stem Cell Models to Inform New Epilepsy Therapies
1/1/20 → 12/31/24
Project: Research project
Mitochondrial Stress Response in FUS proteinopathy and related dementia
Fushimi, K., Kiskinis, E. & Wu, J.
9/30/19 → 9/30/20
Project: Research project
Investigation of human neuron models of channelopathy-associated epilepsy
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
The Role of Mitochondria in TDP-43 Proteinopathy
Fushimi, K., Kiskinis, E., Ozdinler, P. H. & Wu, J.
National Institute of Neurological Disorders and Stroke
9/30/18 → 6/30/23
Project: Research project
Research Output
Impact of traumatic brain injury on amyotrophic lateral sclerosis: From bedside to bench
Franz, C. K., Joshi, D., Daley, E. L., Grant, R. A., Dalamagkas, K., Leung, A., Finan, J. D. & Kiskinis, E., Jan 1 2019, In : Journal of neurophysiology. 122, 3, p. 1174-1185 12 p.Research output: Contribution to journal › Review article
1
Scopus
citations
Peptide–siRNA Supramolecular Particles for Neural Cell Transfection
Hernandez-Garcia, A., Álvarez, Z., Simkin, D., Madhan, A., Pariset, E., Tantakitti, F., de J. Vargas-Dorantes, O., Lee, S. S., Kiskinis, E. & Stupp, S. I., Feb 6 2019, In : Advanced Science. 6, 3, 1801458.Research output: Contribution to journal › Article
2
Scopus
citations
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS
Baron, D. M., Matheny, T., Lin, Y. C., Leszyk, J. D., Kenna, K., Gall, K. V., Santos, D. P., Tischbein, M., Funes, S., Hayward, L. J., Kiskinis, E., Landers, J. E., Parker, R., Shaffer, S. A. & Bosco, D. A., Jul 1 2019, In : Human molecular genetics. 28, 13, p. 2143-2160 18 p.Research output: Contribution to journal › Article
Open Access
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
Kiskinis, E., Kralj, J. M., Zou, P., Weinstein, E. N., Zhang, H., Tsioras, K., Wiskow, O., Ortega, J. A., Eggan, K. & Cohen, A. E., Jun 5 2018, In : Stem cell reports. 10, 6, p. 1991-2004 14 p.Research output: Contribution to journal › Article
10
Scopus
citations
Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models
Franz, C. K., Puritz, A., Jordan, L. A., Chow, J., Ortega, J. A., Kiskinis, E. & Heckman, C. J., Aug 1 2018, In : Neurorehabilitation and Neural Repair. 32, 8, p. 735-745 11 p.Research output: Contribution to journal › Article