Grants per year
Personal profile
Research Interests
Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.
Training Experience
| 2014 | Postdoctoral Fellowship, Harvard University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Endocrinology, PhD, Imperial College London
… → 2008
Research interests
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genomics
- Neurogenetics
- Neuroscience
- Stem Cells
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Weintraub, S., Allada, R., Bevan, M. D., Caraveo Piso, G., Carvill, G. L., Chan, S., Contractor, A., Disterhoft, J. F., Dombeck, D. A., Dong, H., Ferreira, A. B., Flanagan, M. E., Gefen, T. D., Geula, C., Gratton, C., He, C., Kahnt, T., Kalb, R. G., Kennedy, A., Kessler, J., Kiskinis, E., Klein, W. L., Kozorovitskiy, Y., Krainc, D., Li, L., Mazzulli, J., Mesulam, M., Miller, R. J., Morimoto, R. I., Opal, P., Ozdinler, H., Paller, K., Parisiadou, L., Penzes, P., Pinto, L., Prakriya, M., Reber, P. J., Roberts, A. L., Rogalski, E., Savas, J. N., Surmeier Jr, D. J., Swanson, G. T., Voss, J. L., Zee, P. C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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Investigating NEK1 haploinsufficiency in human motor neurons
2/1/22 → 1/31/23
Project: Research project
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Kinetic Imaging Plate Reader for Drug Discovery and Biology
George, A. L., Arispe, L., Bass, J., Burridge, P., DeCaen, P. G., Gianneschi, N., Horvath, C. M., Kiskinis, E., Klein, W. L., Miller, R. J., Morimoto, R. I., Moskal, J. R., Penzes, P., Prakriya, M., Scheidt, K. A., Surmeier Jr, D. J. & Vafabakhsh, R.
Office of the Director, National Institutes of Health
9/1/21 → 8/31/23
Project: Research project
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Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
Simkin, D., Papakis, V., Bustos, B. I., Ambrosi, C. M., Ryan, S. J., Baru, V., Williams, L. A., Dempsey, G. T., McManus, O. B., Landers, J. E., Lubbe, S. J., George, A. L. & Kiskinis, E., Apr 12 2022, In: Stem cell reports. 17, 4, p. 993-1008 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
Gleixner, A. M., Verdone, B. M., Otte, C. G., Anderson, E. N., Ramesh, N., Shapiro, O. R., Gale, J. R., Mauna, J. C., Mann, J. R., Copley, K. E., Daley, E. L., Ortega, J. A., Cicardi, M. E., Kiskinis, E., Kofler, J., Pandey, U. B., Trotti, D. & Donnelly, C. J., Dec 2022, In: Nature communications. 13, 1, 3380.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
‘Channeling’ therapeutic discovery for epileptic encephalopathy through iPSC technologies
Simkin, D., Ambrosi, C., Marshall, K. A., Williams, L. A., Eisenberg, J., Gharib, M., Dempsey, G. T., George, A. L., McManus, O. B. & Kiskinis, E., May 2022, In: Trends in Pharmacological Sciences. 43, 5, p. 392-405 14 p.Research output: Contribution to journal › Review article › peer-review
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A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
Sonobe, Y., Aburas, J., Krishnan, G., Fleming, A. C., Ghadge, G., Islam, P., Warren, E. C., Gu, Y., Kankel, M. W., Brown, A. E. X., Kiskinis, E., Gendron, T. F., Gao, F. B., Roos, R. P. & Kratsios, P., Dec 2021, In: Nature communications. 12, 1, 6025.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury
Álvarez, Z., Kolberg-Edelbrock, A. N., Sasselli, I. R., Ortega, J. A., Qiu, R., Syrgiannis, Z., Mirau, P. A., Chen, F., Chin, S. M., Weigand, S., Kiskinis, E. & Stupp, S. I., Nov 12 2021, In: Science. 374, 6569, p. 848-856 9 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations