Grants per year
Personal profile
Research Interests
Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.
Training Experience
| 2014 | Postdoctoral Fellowship, Harvard University |
Education/Academic qualification
PhD, Imperial College London
… → 2008
Research interests
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genomics
- Neurogenetics
- Neuroscience
- Stem Cells
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Grants
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Neuronal excitability and copy number variation disorders
George Jr, A. L., Kiskinis, E. & Penzes, P.
National Institute of Neurological Disorders and Stroke
9/1/20 → 5/31/25
Project: Research project
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Small GTPase signaling in dendrites and spines
Kiskinis, E., Moskal, J. R., Penzes, P. & Scheidt, K. A.
National Institute of Mental Health
6/10/20 → 5/31/21
Project: Research project
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Developing Patient-Specific Stem Cell Models to Inform New Epilepsy Therapies
1/1/20 → 12/31/24
Project: Research project
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Mitochondrial Stress Response in FUS proteinopathy and related dementia
Fushimi, K., Kessler, J., Kiskinis, E., Wu, J. & Wu, J.
9/30/19 → 9/30/21
Project: Research project
Research Output
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Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
Ortega, J. A., Daley, E. L., Kour, S., Samani, M., Tellez, L., Smith, H. S., Hall, E. A., Esengul, Y. T., Tsai, Y. H., Gendron, T. F., Donnelly, C. J., Siddique, T., Savas, J. N., Pandey, U. B. & Kiskinis, E., Apr 8 2020, In: Neuron. 106, 1, p. 90-107.e13Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Ramesh, N., Daley, E. L., Gleixner, A. M., Mann, J. R., Kour, S., Mawrie, D., Anderson, E. N., Kofler, J., Donnelly, C. J., Kiskinis, E. & Pandey, U. B., Dec 1 2020, In: Acta Neuropathologica Communications. 8, 1, 177.Research output: Contribution to journal › Article › peer-review
Open Access -
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
Charlton, J., Jung, E. J., Mattei, A. L., Bailly, N., Liao, J., Martin, E. J., Giesselmann, P., Brändl, B., Stamenova, E. K., Müller, F. J., Kiskinis, E., Gnirke, A., Smith, Z. D. & Meissner, A., Aug 1 2020, In: Nature Genetics. 52, 8, p. 819-827 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Impact of traumatic brain injury on amyotrophic lateral sclerosis: From bedside to bench
Franz, C. K., Joshi, D., Daley, E. L., Grant, R. A., Dalamagkas, K., Leung, A., Finan, J. D. & Kiskinis, E., 2019, In: Journal of neurophysiology. 122, 3, p. 1174-1185 12 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Peptide–siRNA Supramolecular Particles for Neural Cell Transfection
Hernandez-Garcia, A., Álvarez, Z., Simkin, D., Madhan, A., Pariset, E., Tantakitti, F., de J. Vargas-Dorantes, O., Lee, S. S., Kiskinis, E. & Stupp, S. I., Feb 6 2019, In: Advanced Science. 6, 3, 1801458.Research output: Contribution to journal › Article › peer-review
6 Scopus citations