• 3823 Citations
20012023
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Personal profile

Research Interests

Our research is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention.

Training Experience

2014Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, Imperial College London, UK

… → 2008

Keywords

  • Amyotrophic Lateral Sclerosis
  • Cell Biology
  • Genomics
  • Neurogenetics
  • Neuroscience
  • Stem Cells

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Grants 2014 2023

Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
Central Nervous System
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Channelopathies
Epilepsy
Neurons
Ion Channels
Genes
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis
Kidney
Kidney Diseases
Research Personnel
Therapeutics
Nanomedicine

Research Output 2001 2019

Peptide–siRNA Supramolecular Particles for Neural Cell Transfection

Hernandez-Garcia, A., Álvarez, Z., Simkin, D., Madhan, A., Pariset, E., Tantakitti, F., de J. Vargas-Dorantes, O., Lee, S. S., Kiskinis, E. & Stupp, S., Feb 6 2019, In : Advanced Science. 6, 3, 1801458.

Research output: Contribution to journalArticle

ribonucleic acids
RNA
Transfection
genes
Peptides
1 Citation (Scopus)

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS

Kiskinis, E., Kralj, J. M., Zou, P., Weinstein, E. N., Zhang, H., Tsioras, K., Wiskow, O., Ortega, J. A., Eggan, K. & Cohen, A. E., Jun 5 2018, In : Stem cell reports. 10, 6, p. 1991-2004 14 p.

Research output: Contribution to journalArticle

Electrophysiology
Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells
Type A Botulinum Toxins
Botulinum Toxins
Axons
Regeneration
Nerve Transfer

Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models

Franz, C. K., Puritz, A., Jordan, L. A., Chow, J., Ortega, J. A., Kiskinis, E. & Heckman, C. J., Aug 1 2018, In : Neurorehabilitation and Neural Repair. 32, 8, p. 735-745 11 p.

Research output: Contribution to journalArticle

Type A Botulinum Toxins
Botulinum Toxins
Axons
Regeneration
Nerve Transfer

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons

Ichida, J. K., Staats, K. A., Davis-Dusenbery, B. N., Clement, K., Galloway, K. E., Babos, K. N., Shi, Y., Son, E. Y., Kiskinis, E., Atwater, N., Gu, H., Gnirke, A., Meissner, A. & Eggan, K., Nov 1 2018, In : Development (Cambridge). 145, 22, dev168617.

Research output: Contribution to journalArticle

Motor Neurons
Stem Cells
Transcription Factors
RNA Sequence Analysis
Pluripotent Stem Cells