Grants per year
Personal profile
Research Interests
Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.
Education/Academic qualification
PhD, University of Pennsylvania
… → 2006
Research interests
- Aging
- Cell Biology
- Fibrosis
- Reproduction
- Women's Health / Women's Reproductive Health
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Grants
Targeting a critical aging pathway to prolong reproductive lifespan
1/28/20 → 8/31/21
Project: Research project
Extremely Long Lived Proteins and Female Reproductive Aging
Duncan, F. E., Savas, J. N. & Savas, J. N.
National Institute of Child Health and Human Development
5/15/19 → 4/30/21
Project: Research project
Sperm Safes: Maximizing the preservation and recovery of limited numbers of male germ cells
Pediatric Oncofertility Research Foundation
3/1/19 → 2/28/22
Project: Research project
Homeostatic to reactive hyaluronan matrices in ovarian reproductive aging
National Institute of Child Health and Human Development
2/6/18 → 1/31/23
Project: Research project
Optimization of fixation conditions to detect hyaluronan in a tissue-specific manner
6/15/18 → 8/3/19
Project: Research project
Research Output
Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation
Quan, N., Harris, L. R., Halder, R., Trinidad, C. V., Johnson, B. W., Horton, S., Kimler, B. F., Pritchard, M. T. & Duncan, F. E., Feb 12 2020, In : Biology of reproduction. 102, 1, p. 133-144 12 p.Research output: Contribution to journal › Article
2
Scopus
citations
Low molecular weight hyaluronan induces an inflammatory response in ovarian stromal cells and impairs gamete development in vitro
Rowley, J. E., Amargant, F., Zhou, L. T., Galligos, A., Simon, L. E., Pritchard, M. T. & Duncan, F. E., Feb 1 2020, In : International journal of molecular sciences. 21, 3, 1036.Research output: Contribution to journal › Article
Open Access
The long view: Considering spindle orientation in image analysis
Balough, J. L., Fontaine, A. S. E., Machlin, J. H., Rowley, J. E., Simon, L. E., Duncan, F. E. & Hornick, J. E., Feb 1 2020, In : Molecular reproduction and development. 87, 2, 1 p.Research output: Contribution to journal › Comment/debate
Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver
Rowley, J. E., Rubenstein, G. E., Manuel, S. L., Johnson, N. L., Surgnier, J., Kapitsinou, P. P., Duncan, F. E. & Pritchard, M. T., Jan 1 2020, In : Journal of Histochemistry and Cytochemistry. 68, 1, p. 75-91 17 p.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation
Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.Research output: Contribution to journal › Article
4
Scopus
citations