• 1622 Citations

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.

Education/Academic qualification

PhD, University of Pennsylvania

… → 2006

Research interests

  • Aging
  • Cell Biology
  • Fibrosis
  • Reproduction
  • Women's Health / Women's Reproductive Health

Fingerprint Dive into the research topics where Francesca Elizabeth Duncan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


  • Research Output

    Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation

    Quan, N., Harris, L. R., Halder, R., Trinidad, C. V., Johnson, B. W., Horton, S., Kimler, B. F., Pritchard, M. T. & Duncan, F. E., Feb 12 2020, In : Biology of reproduction. 102, 1, p. 133-144 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Emerging roles for the nucleolus 2019

    Baserga, S. J., DiMario, P. J. & Duncan, F. E., Apr 17 2020, In : Journal of Biological Chemistry. 295, 16, p. 5535-5537 3 p.

    Research output: Contribution to journalArticle

    Open Access

    Low molecular weight hyaluronan induces an inflammatory response in ovarian stromal cells and impairs gamete development in vitro

    Rowley, J. E., Amargant, F., Zhou, L. T., Galligos, A., Simon, L. E., Pritchard, M. T. & Duncan, F. E., Feb 1 2020, In : International journal of molecular sciences. 21, 3, 1036.

    Research output: Contribution to journalArticle

    Open Access
  • Ovulation and ovarian wound healing are impaired with advanced reproductive age

    Mara, J. N., Zhou, L. T., Larmore, M., Johnson, B., Ayiku, R., Amargant, F., Pritchard, M. T. & Duncan, F. E., May 31 2020, In : Aging. 12, 10, p. 9686-9713 28 p.

    Research output: Contribution to journalArticle

  • The long view: Considering spindle orientation in image analysis

    Balough, J. L., Fontaine, A. S. E., Machlin, J. H., Rowley, J. E., Simon, L. E., Duncan, F. E. & Hornick, J. E., Feb 1 2020, In : Molecular reproduction and development. 87, 2, 1 p.

    Research output: Contribution to journalComment/debate