• 1484 Citations
20042023
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Personal profile

Research Interests

Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.

Education/Academic qualification

PhD, University of Pennsylvania

… → 2006

Research interests

  • Aging
  • Cell Biology
  • Fibrosis
  • Reproduction
  • Women's Health / Women's Reproductive Health

Fingerprint Dive into the research topics where Francesca Elizabeth Duncan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 19 Similar Profiles
Oocytes Medicine & Life Sciences
Fertility Preservation Medicine & Life Sciences
Ovary Medicine & Life Sciences
Ovum Medicine & Life Sciences
Aneuploidy Medicine & Life Sciences
Meiosis Medicine & Life Sciences
Eggs Medicine & Life Sciences
Ovarian Follicle Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2017 2023

Research Output 2004 2020

1 Citation (Scopus)

Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver

Rowley, J. E., Rubenstein, G. E., Manuel, S. L., Johnson, N. L., Surgnier, J., Kapitsinou, P. P., Duncan, F. E. & Pritchard, M. T., Jan 1 2020, In : Journal of Histochemistry and Cytochemistry. 68, 1, p. 75-91 17 p.

Research output: Contribution to journalArticle

Open Access
Tissue Fixation
Hyaluronic Acid
Ovary
Kidney
Liver
3 Citations (Scopus)

Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

Research output: Contribution to journalArticle

Eggs
Ovum
Spermatozoa
Zinc
zinc
1 Citation (Scopus)

Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization

Zhou, L. T., Romar, R., Pavone, M., Soriano-Úbeda, C., Zhang, J. X., Slawson, C. & Duncan, F. E., May 1 2019, In : Molecular reproduction and development. 86, 5, p. 543-557 15 p.

Research output: Contribution to journalArticle

Fertilization
Oocytes
Homeostasis
Meiosis
Proteins

Fertility Preservation

Duncan, F. E., Feinberg, E. C., Brannigan, R. E., Edmonds, M., Ataman, L. & Woodruff, T. K., Jan 1 2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc, p. 857-886.e6

Research output: Chapter in Book/Report/Conference proceedingChapter

Fertility Preservation
Fertility
Reproductive Health
Survivors
Neoplasms
1 Citation (Scopus)

Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue

Dipali, S. S., Ferreira, C. R., Zhou, L. T., Pritchard, M. T. & Duncan, F. E., Jun 12 2019, In : Reproductive Biology and Endocrinology. 17, 1, 46.

Research output: Contribution to journalArticle

Open Access
Adipose Tissue
Adipocytes
Lipids
Ovary
Triglycerides