• 1542 Citations
20042023

Research output per year

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Personal profile

Research Interests

Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.

Education/Academic qualification

PhD, University of Pennsylvania

… → 2006

Research interests

  • Aging
  • Cell Biology
  • Fibrosis
  • Reproduction
  • Women's Health / Women's Reproductive Health

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Grants

  • Research Output

    Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation

    Quan, N., Harris, L. R., Halder, R., Trinidad, C. V., Johnson, B. W., Horton, S., Kimler, B. F., Pritchard, M. T. & Duncan, F. E., Feb 12 2020, In : Biology of reproduction. 102, 1, p. 133-144 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Low molecular weight hyaluronan induces an inflammatory response in ovarian stromal cells and impairs gamete development in vitro

    Rowley, J. E., Amargant, F., Zhou, L. T., Galligos, A., Simon, L. E., Pritchard, M. T. & Duncan, F. E., Feb 1 2020, In : International journal of molecular sciences. 21, 3, 1036.

    Research output: Contribution to journalArticle

    Open Access
  • The long view: Considering spindle orientation in image analysis

    Balough, J. L., Fontaine, A. S. E., Machlin, J. H., Rowley, J. E., Simon, L. E., Duncan, F. E. & Hornick, J. E., Feb 1 2020, In : Molecular reproduction and development. 87, 2, 1 p.

    Research output: Contribution to journalComment/debate

    Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver

    Rowley, J. E., Rubenstein, G. E., Manuel, S. L., Johnson, N. L., Surgnier, J., Kapitsinou, P. P., Duncan, F. E. & Pritchard, M. T., Jan 1 2020, In : Journal of Histochemistry and Cytochemistry. 68, 1, p. 75-91 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

    Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations