• 1386 Citations
20042023
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Personal profile

Research Interests

Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.

Education/Academic qualification

PhD, University of Pennsylvania

… → 2006

Research interests

  • Aging
  • Cell Biology
  • Fibrosis
  • Reproduction
  • Women's Health / Women's Reproductive Health

Fingerprint Dive into the research topics where Francesca Elizabeth Duncan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 19 Similar Profiles
Oocytes Medicine & Life Sciences
Fertility Preservation Medicine & Life Sciences
Ovum Medicine & Life Sciences
Ovary Medicine & Life Sciences
Aneuploidy Medicine & Life Sciences
Meiosis Medicine & Life Sciences
Eggs Medicine & Life Sciences
Fertility Medicine & Life Sciences

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Grants 2017 2023

Research Output 2004 2019

Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

Research output: Contribution to journalArticle

Eggs
Ovum
Spermatozoa
Zinc
zinc
1 Citation (Scopus)

Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization

Zhou, L. T., Romar, R., Pavone, M., Soriano-Úbeda, C., Zhang, J. X., Slawson, C. & Duncan, F. E., May 1 2019, In : Molecular reproduction and development. 86, 5, p. 543-557 15 p.

Research output: Contribution to journalArticle

Fertilization
Oocytes
Homeostasis
Meiosis
Proteins

Fertility Preservation

Duncan, F. E., Feinberg, E. C., Brannigan, R. E., Edmonds, M., Ataman, L. & Woodruff, T. K., Jan 1 2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc, p. 857-886.e6

Research output: Chapter in Book/Report/Conference proceedingChapter

Fertility Preservation
Fertility
Reproductive Health
Survivors
Neoplasms

Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue

Dipali, S. S., Ferreira, C. R., Zhou, L. T., Pritchard, M. T. & Duncan, F. E., Jun 12 2019, In : Reproductive Biology and Endocrinology. 17, 1, 46.

Research output: Contribution to journalArticle

Open Access
Adipose Tissue
Adipocytes
Lipids
Ovary
Triglycerides

Identifying the reproductive toxicity of biocompatible 3d-printed dental resins

Rogers, H. B., Zaniker, E., Zhou, L., Kusuhara, A., Duncan, F. E. & Woodruff, T. K., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Synthetic Resins
Biocompatible Materials
Biomaterials
Toxicity
Resins