Grants per year
Personal profile
Research Interests
Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cell & Molecular Biology, University of Pennsylvania
… → 2006
Research interests keywords
- Aging
- Cell Biology
- Fibrosis
- Reproduction
- Women's Health / Women's Reproductive Health
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Human ovarian stiffness as a novel noninvasive marker of female reproductive longevity and systemic health
Duncan, F. E. (PD/PI) & Duncan, F. E. (PD/PI)
9/1/24 → 8/31/26
Project: Research project
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Ovarian Stiffness as a Novel Biomarker to Improve Pelvic Imaging for Early Ovarian Cancer Screening
Duncan, F. E. (PD/PI), Babayev, E. (Co-PD/PI) & Wagner, A. F. (Co-Investigator)
Northwestern Memorial Foundation
7/1/24 → 8/31/27
Project: Research project
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Development of allosteric kinase inhibitors for nonhormonal contraception
Duncan, F. E. (PD/PI), Duncan, F. E. (PD/PI), Duncan, F. E. (PD/PI), Lee, H. C. (Co-Investigator), Lee, H. C. (Co-Investigator) & Lee, H. C. (Co-Investigator)
Schrodinger, Inc., Bill & Melinda Gates Foundation
10/1/23 → 9/30/25
Project: Research project
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Evaluating diverse technologies for detecting and validating senescent cells in vivo
Duncan, F. E. (PD/PI), Duncan, F. E. (PD/PI), Pavone, M. (Co-Investigator) & Pavone, M. (Co-Investigator)
Buck Institute for Research on Aging, National Cancer Institute
9/1/23 → 8/31/25
Project: Research project
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Upper Midwest Summit for Reproductive Science
Duncan, F. E. (PD/PI)
National Institute of Child Health and Human Development
8/1/23 → 7/31/28
Project: Research project
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Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells
Hashim, P. H., Perry, M. J., Pritchard, M. T., Gerton, J. L. & Duncan, F. E., May 2025, In: Reproduction. 169, 5, e250042.Research output: Contribution to journal › Review article › peer-review
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Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop
Yano Maher, J. C., Zelinski, M. B., Oktay, K. H., Duncan, F. E., Segars, J. H., Lujan, M. E., Lou, H., Yun, B. H., Hanfling, S. N., Schwartz, L. E., Laronda, M. M., Halvorson, L. M., O'Neill, K. E. & Gomez-Lobo, V., May 2025, In: Fertility and Sterility. 123, 5, p. 761-778 18 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A new initiative for 2024: increasing peer review transparency at MHR
Boiani, M. & Duncan, F. E., Apr 1 2024, In: Molecular human reproduction. 30, 4, gaae014.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
Bomba-Warczak, E. K., Velez, K. M., Zhou, L. T., Guillermier, C., Edassery, S., Steinhauser, M. L., Savas, J. N. & Duncan, F. E., Sep 30 2024, In: eLife. 13Research output: Contribution to journal › Article › peer-review
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Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation
Zaniker, E. J., Zhang, J., Russo, D., Huang, R., Suritis, K., Drake, R. S., Barlow-Smith, E., Shalek, A. K., Woodruff, T. K., Xiao, S., Goods, B. A. & Duncan, F. E., Dec 2024, In: Communications Biology. 7, 1, 1374.Research output: Contribution to journal › Article › peer-review
Datasets
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Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver
Rowley, J. E. (Creator), Rubenstein, G. E. (Creator), Manuel, S. L. (Contributor), Johnson, N. L. (Creator), Surgnier, J. (Creator), Kapitsinou, P. P. (Creator), Duncan, F. E. (Creator) & Pritchard, M. T. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.c.4737347, https://sage.figshare.com/collections/Tissue-specific_Fixation_Methods_Are_Required_for_Optimal_In_Situ_Visualization_of_Hyaluronan_in_the_Ovary_Kidney_and_Liver/4737347
Dataset
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Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary
Grover, A. R. (Creator), Kimler, B. F. (Creator) & Duncan, F. E. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4217291, https://figshare.com/collections/Use_of_a_Small_Animal_Radiation_Research_Platform_SARRP_facilitates_analysis_of_systemic_versus_targeted_radiation_effects_in_the_mouse_ovary/4217291
Dataset
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Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
Dipali, S. S. (Creator), Ferreira, C. R. (Creator), Zhou, L. T. (Contributor), Pritchard, M. T. (Creator) & Duncan, F. E. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4539929, https://springernature.figshare.com/collections/Histologic_analysis_and_lipid_profiling_reveal_reproductive_age-associated_changes_in_peri-ovarian_adipose_tissue/4539929
Dataset