Grants per year
Personal profile
Research Interests
Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.
Education/Academic qualification
PhD, Cell & Molecular Biology, University of Pennsylvania
… → 2006
Research interests keywords
- Aging
- Cell Biology
- Fibrosis
- Reproduction
- Women's Health / Women's Reproductive Health
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Upper Midwest Summit for Reproductive Science
National Institute of Child Health and Human Development
8/1/23 → 7/31/28
Project: Research project
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm
O'Neill, K. E., Maher, J. Y., Laronda, M. M., Duncan, F. E., LeDuc, R. D., Lujan, M. E., Oktay, K. H., Pouch, A. M., Segars, J. H., Tsui, E. L., Zelinski, M. B., Halvorson, L. M. & Gomez-Lobo, V., Mar 2023, In: American journal of obstetrics and gynecology. 228, 3, p. 270-275.e4Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates
Zhang, J., Goods, B. A., Pattarawat, P., Wang, Y., Haining, T., Zhang, Q., Shalek, A. K., Duncan, F. E., Woodruff, T. K. & Xiao, S., Apr 1 2023, In: Biology of reproduction. 108, 4, p. 629-644 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Associations of childhood allergies with parental reproductive and allergy history
Gowett, M. Q., Perry, S. S., Aggarwal, R., Zhou, L. T., Pavone, M. E., Duncan, F. E. & Cheng, W. S., Jun 2023, In: Journal of Assisted Reproduction and Genetics. 40, 6, p. 1349-1359 11 p.Research output: Contribution to journal › Article › peer-review
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Call for papers: cyclical function of the female reproductive tract
Boiani, M. & Duncan, F. E., May 1 2023, In: Molecular human reproduction. 29, 5, gaad016.Research output: Contribution to journal › Editorial › peer-review
Open Access -
CD38 regulates ovarian function and fecundity via NAD+ metabolism
Perrone, R., Ashok Kumaar, P. V., Haky, L., Hahn, C., Riley, R., Balough, J., Zaza, G., Soygur, B., Hung, K., Prado, L., Kasler, H. G., Tiwari, R., Matsui, H., Hormazabal, G. V., Heckenbach, I., Scheibye-Knudsen, M., Duncan, F. E. & Verdin, E., Oct 20 2023, In: iScience. 26, 10, 107949.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary
Grover, A. R. (Creator), Kimler, B. F. (Creator) & Duncan, F. E. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4217291, https://figshare.com/collections/Use_of_a_Small_Animal_Radiation_Research_Platform_SARRP_facilitates_analysis_of_systemic_versus_targeted_radiation_effects_in_the_mouse_ovary/4217291
Dataset
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Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver
Rowley, J. E. (Creator), Rubenstein, G. E. (Creator), Manuel, S. L. (Contributor), Johnson, N. L. (Creator), Surgnier, J. (Creator), Kapitsinou, P. (Creator), Duncan, F. E. (Creator) & Pritchard, M. T. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.c.4737347.v1, https://sage.figshare.com/collections/Tissue-specific_Fixation_Methods_Are_Required_for_Optimal_In_Situ_Visualization_of_Hyaluronan_in_the_Ovary_Kidney_and_Liver/4737347/1
Dataset
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Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
Dipali, S. S. (Creator), Ferreira, C. R. (Creator), Zhou, L. T. (Contributor), Pritchard, M. T. (Creator) & Duncan, F. E. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4539929.v1, https://springernature.figshare.com/collections/Histologic_analysis_and_lipid_profiling_reveal_reproductive_age-associated_changes_in_peri-ovarian_adipose_tissue/4539929/1
Dataset