Grants per year
Personal profile
Research Interests
Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.
Education/Academic qualification
PhD, University of Pennsylvania
… → 2006
Research interests
- Aging
- Cell Biology
- Fibrosis
- Reproduction
- Women's Health / Women's Reproductive Health
Fingerprint Dive into the research topics where Francesca Elizabeth Duncan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 17 Similar Profiles
Oocytes
Medicine & Life Sciences
Fertility Preservation
Medicine & Life Sciences
Ovum
Medicine & Life Sciences
Ovary
Medicine & Life Sciences
Aneuploidy
Medicine & Life Sciences
Meiosis
Medicine & Life Sciences
Eggs
Medicine & Life Sciences
Fertility
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2017 2023
Extremely Long Lived Proteins and Female Reproductive Aging
Duncan, F. E., Savas, J. N. & Savas, J. N.
National Institute of Child Health and Human Development
5/15/19 → 4/30/21
Project: Research project
Proteins
Oocytes
Ovary
Germ Cells
Meiotic Prophase I
Sperm Safes: Maximizing the preservation and recovery of limited numbers of male germ cells
Pediatric Oncofertility Research Foundation
3/1/19 → 2/29/20
Project: Research project
Germ Cells
Spermatozoa
Technology
Homeostatic to reactive hyaluronan matrices in ovarian reproductive aging
National Institute of Child Health and Human Development
2/6/18 → 1/31/23
Project: Research project
Hyaluronic Acid
Ovum
Fibrosis
Inflammation
Fertility
Optimization of fixation conditions to detect hyaluronan in a tissue-specific manner
6/15/18 → 8/3/19
Project: Research project
Inflammatory Biomarkers of Female Reproductive Aging and Potential
Northwestern Memorial Hospital
9/1/17 → 8/31/19
Project: Research project
Research Output 2004 2019
Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation
Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.Research output: Contribution to journal › Article
Eggs
Ovum
Spermatozoa
Zinc
zinc
Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization
Zhou, L. T., Romar, R., Pavone, M., Soriano-Úbeda, C., Zhang, J. X., Slawson, C. & Duncan, F. E., May 1 2019, In : Molecular reproduction and development. 86, 5, p. 543-557 15 p.Research output: Contribution to journal › Article
Fertilization
Oocytes
Homeostasis
Meiosis
Proteins
Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
Dipali, S. S., Ferreira, C. R., Zhou, L. T., Pritchard, M. T. & Duncan, F. E., Jun 12 2019, In : Reproductive Biology and Endocrinology. 17, 1, 46.Research output: Contribution to journal › Article
Open Access
Adipose Tissue
Adipocytes
Lipids
Ovary
Triglycerides
Identifying the reproductive toxicity of biocompatible 3d-printed dental resins
Rogers, H. B., Zaniker, E., Zhou, L., Kusuhara, A., Duncan, F. E. & Woodruff, T. K., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Synthetic Resins
Biocompatible Materials
Biomaterials
Toxicity
Resins
1
Citation
(Scopus)
Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility
Singh, V. P., Yueh, W. T., Gerton, J. L. & Duncan, F. E., Jan 1 2019, In : Reproduction. 157, 3, p. 305-316 12 p.Research output: Contribution to journal › Article
Oogenesis
Oocytes
Fertility
S Phase
Chromosome Segregation