Frank Dieter Eckerdt

  • 1145 Citations
20022019

Research output per year

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Research Output

  • 1145 Citations
  • 25 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article
2019

Inhibitory effects of SEL201 in acute myeloid leukemia

Kosciuczuk, E. M., Kar, A. K., Blyth, G. T., Fischietti, M., Abedin, S., Mina, A. A., Siliezar, R., Rzymski, T., Brzozka, K., Eklund, E. A., Beauchamp, E. M., Eckerdt, F., Saleiro, D. & Platanias, L. C., Jan 1 2019, In : Oncotarget. 10, 67, p. 7112-7121 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma

Eckerdt, F., Clymer, J., Bell, J. B., Beauchamp, E. M., Blyth, G. T., Goldman, S. & Platanias, L. C., Dec 1 2019, In : Scientific reports. 9, 1, 12822.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Potent antineoplastic effects of combined PI3Kα-MNK inhibition in medulloblastoma

Eckerdt, F., Bell, J. B., Beauchamp, E. M., Clymer, J., Blyth, G. T., Kosciuczuk, E. M., Ma, Q., Chen, D. Z., Horbinski, C., Goldman, S., Munshi, H. G., Hashizume, R. & Platanias, L. C., Jun 1 2019, In : Molecular Cancer Research. 17, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer

Brisard, D., Eckerdt, F., Marsh, L. A., Blyth, G. T., Jain, S., Cristofanilli, M., Horiuchi, D. & Platanias, L. C., Dec 1 2018, In : Oncotarget. 9, 99, p. 37305-37318 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential response of glioma stem cells to arsenic trioxide therapy is regulated by MNK1 and mRNA translation

Bell, J. B., Eckerdt, F., Dhruv, H. D., Finlay, D., Peng, S., Kim, S., Kroczynska, B., Beauchamp, E. M., Alley, K., Clymer, J., Goldman, S., Cheng, S. Y., James, C. D., Nakano, I., Horbinski, C., Mazar, A. P., Vuori, K., Kumthekar, P., Raizer, J., Berens, M. E. & 1 others, Platanias, L. C., Jan 2018, In : Molecular Cancer Research. 16, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma

Bell, J. B., Rink, J. S., Eckerdt, F., Clymer, J., Goldman, S., Thaxton, C. S. & Platanias, L. C., Dec 1 2018, In : Scientific reports. 8, 1, 1211.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma

Arslan, A. D., Sassano, A., Saleiro, D., Lisowski, P., Kosciuczuk, E. M., Fischietti, M., Eckerdt, F., Fish, E. N. & Platanias, L. C., Oct 26 2017, In : Oncogene. 36, 43, p. 6006-6019 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Differential regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNK) and eIF4E in pancreatic cancer

Kumar, K., Chow, C. R., Ebine, K., Arslan, A. D., Kwok, B., Bentrem, D. J., Eckerdt, F. D., Platanias, L. C. & Munshi, H. G., Feb 2016, In : Molecular Cancer Research. 14, 2, p. 216-227 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo

Kosciuczuk, E. M., Saleiro, D., Kroczynska, B., Beauchamp, E. M., Eckerdt, F., Blyth, G. T., Abedin, S. M., Giles, F. J., Altman, J. K. & Platanias, L. C., Jul 21 2016, In : Blood. 128, 3, p. 410-414 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

MNK inhibition disrupts mesenchymal glioma stem cells and prolongs survival in a mouse model of glioblastoma

Bell, J. B., Eckerdt, F. D., Alley, K., Magnusson, L. P., Hussain, H., Bi, Y., Arslan, A. D., Clymer, J., Alvarez, A. A., Goldman, S., Cheng, S. Y., Nakano, I., Horbinski, C., Davuluri, R. V., David James, C. & Platanias, L. C., Oct 1 2016, In : Molecular Cancer Research. 14, 10, p. 984-993 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110a inhibition

Iqbal, A., Eckerdt, F., Bell, J., Nakano, I., Giles, F. J., Cheng, S. Y., Lulla, R. R., Goldman, S. & Platanias, L. C., May 31 2016, In : Oncotarget. 7, 22, p. 33192-33201 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

LIN-9 phosphorylation on Threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression

Eckerdt, F., Perez-Neut, M. & Colamonici, O. R., Jan 27 2014, In : PloS one. 9, 1, e87620.

Research output: Contribution to journalArticle

2 Scopus citations

Regulation of greatwall kinase by protein stabilization and nuclear localization

Yamamoto, T. M., Wang, L., Fisher, L. A., Eckerdt, F. D. & Peng, A., Nov 15 2014, In : Cell Cycle. 13, 22, p. 3565-3575 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

Eckerdt, F., Beauchamp, E., Bell, J., Iqbal, A., Su, B., Fukunaga, R., Lulla, R. R., Goldman, S. & Platanias, L. C., Jan 1 2014, In : Oncotarget. 5, 18, p. 8442-8451 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation

Eckerdt, F., Yamamoto, T. M., Lewellyn, A. L. & Maller, J. L., Mar 8 2011, In : Current Biology. 21, 5, p. 428-432 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding

Pascreau, G., Eckerdt, F., Churchill, M. E. A. & Maller, J. L., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 2932-2937 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2009

Phosphorylation of p53 is regulated by TPX2-Aurora A in Xenopus oocytes

Pascreau, G., Eckerdt, F., Lewellyn, A. L., Prigent, C. & Maller, J. L., Feb 27 2009, In : Journal of Biological Chemistry. 284, 9, p. 5497-5505 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A

Eckerdt, F., Pascreau, G., Phistry, M., Lewellyn, A. L., DePaoli-Roach, A. A. & Maller, J. L., Aug 1 2009, In : Cell Cycle. 8, 15, p. 2413-2419 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008

Spindle Pole Regulation by a Discrete Eg5-Interacting Domain in TPX2

Eckerdt, F., Eyers, P. A., Lewellyn, A. L., Prigent, C. & Maller, J. L., Apr 8 2008, In : Current Biology. 18, 7, p. 519-525 7 p.

Research output: Contribution to journalArticle

50 Scopus citations
2006

Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck

Solbach, C., Roller, M., Eckerdt, F., Peters, S. & Knecht, R., Oct 9 2006, In : BMC cancer. 6, 242.

Research output: Contribution to journalArticle

19 Scopus citations
2005

Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells

Eckerdt, F., Yuan, J., Saxena, K., Martin, B., Kappel, S., Lindenau, C., Kramer, A., Neumann, S., Daum, S., Fischer, G., Dikic, I., Kaufmann, M. & Strebhardt, K., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 36575-36583 9 p.

Research output: Contribution to journalArticle

76 Scopus citations
2004

Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells

Yuan, J., Yan, R., Krämer, A., Eckerdt, F., Roller, M., Kaufmann, M. & Strebhardt, K., Jul 29 2004, In : Oncogene. 23, 34, p. 5843-5852 10 p.

Research output: Contribution to journalArticle

155 Scopus citations
2002

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1

Yuan, J., Eckerdt, F., Bereiter-Hahn, J., Kurunci-Csacsko, E., Kaufmann, M. & Strebhardt, K., Nov 28 2002, In : Oncogene. 21, 54, p. 8282-8292 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Efficient internalization of the polo-box of polo-like kinase 1 fused to an antennapedia peptide results in inhibition of cancer cell proliferation

Yuan, J., Krämer, A., Eckerdt, F., Kaufmann, M. & Strebhardt, K., Aug 1 2002, In : Cancer Research. 62, 15, p. 4186-4190 5 p.

Research output: Contribution to journalArticle

51 Scopus citations