Grants per year
Personal profile
Research Interests
Research in the Turek laboratory is focused on the study of sleep and circadian rhythms, with special interest in identifying genes that regulate sleep and circadian rhythms. Ongoing work on sleep and circadian rhythms includes an investigation of: (1) the neurochemical, molecular, and cellular events involved in the entrainment, generation and expression of circadian rhythms arising from a central biological clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, (2) the genetics of the circadian clock system and the molecular genetic mechanisms underlying the sleep-wake cycle, (3) the feedback effects of the sleep-wake cycle on the circadian clock regulating the timing of that cycle, (4) the effects of advanced age on the expression of behavioral and endocrine rhythms, and on the expression of circadian clock genes, 5) the links between sleep, circadian rhythms and energy metabolism, (6) the role of melatonin in modulating sleep and circadian rhythms, (7) the role of disrupted circadian rhythms on peripheral and central disease/disorders, and (8) the effects of stress, circadian dysregulation and sleep loss/fragmentation on the intestinal microbiota, including studies of twin men and mice on the International Space Station.
In addition to the work on rodents, his lab have established extensive collaborations with clinical researchers. Studies in humans are aimed at shifting the human clock in an attempt to alleviate mental and physical problems that are associated with disorders in circadian time-keeping, particularly in the elderly and in shift-workers. In addition, they are using both pharmacological and non-pharmacological approaches to determine if they can reverse the effects of aging on the circadian clock system in both rodents and humans. Their sleep, circadian and metabolic studies are focused on how disruption in these interactions can lead to obesity, diabetes CVD, and gastrointestinal disorders.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biological Sciences, PhD, Stanford University
… → 1973
Biology, BS, Michigan State University
… → 1969
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Collaborations and top research areas from the last five years
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Rodent Research Standard Housing Mission: Multidisciplinary Approach to Understanding Spaceflight Responses.
Vitaterna, M. H. & Turek, F. W.
2/7/23 → 2/6/25
Project: Research project
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Mechanisms Underlying Sleep Disturbances in Parkinson's Disease
Turek, F. W., Jiang, P. & Vitaterna, M. H.
U.S. Army Medical Research and Materiel Command
9/30/21 → 9/29/25
Project: Research project
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Training Grant in Circadian and Sleep Research
Turek, F. W., Zee, P. C. & Vitaterna, M. H.
National Heart, Lung, and Blood Institute
3/1/20 → 2/28/25
Project: Research project
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Effects of Partial Gravity on Multi-system Mammalian Physiology: Microbiome and Related Systems
Vitaterna, M. H., Jiang, P. & Turek, F. W.
9/1/20 → 8/31/23
Project: Research project
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Pittendrigh Remembered
Block, G. D., Davis, F. C., Johnson, C. H., Pittendrigh, C. S., Schwartz, W. J., Turek, F. W. & Van Gelder, R. N., Jun 2023, In: Journal of biological rhythms. 38, 3, p. 221-241 21 p.Research output: Contribution to journal › Article › peer-review
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A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
Bowers, S. J., Summa, K. C., Thompson, R. S., González, A., Vargas, F., Olker, C., Jiang, P., Lowry, C. A., Dorrestein, P. C., Knight, R., Wright, K. P., Fleshner, M., Turek, F. W. & Vitaterna, M. H., May 24 2022, In: Frontiers in Neuroscience. 16, 889211.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice
Zhou, L., Fitzpatrick, K., Olker, C., Vitaterna, M. H. & Turek, F. W., May 2022, In: European Journal of Neuroscience. 55, 9-10, p. 2939-2954 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Neurobiology of Circadian Rhythm Regulation
Rosenwasser, A. M. & Turek, F. W., Jun 2022, In: Sleep Medicine Clinics. 17, 2, p. 141-150 10 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Adverse impact of polyphasic sleep patterns in humans: Report of the National Sleep Foundation sleep timing and variability consensus panel
Weaver, M. D., Sletten, T. L., Foster, R. G., Gozal, D., Klerman, E. B., Rajaratnam, S. M. W., Roenneberg, T., Takahashi, J. S., Turek, F. W., Vitiello, M. V., Young, M. W. & Czeisler, C. A., Jun 2021, In: Sleep Health. 7, 3, p. 293-302 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
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Resource competition shapes biological rhythms and promotes temporal niche differentiation in a community simulation
Gao, V. D. (Contributor), Morley-Fletcher, S. (Contributor), Maccari, S. (Contributor), Vitaterna, M. H. (Contributor) & Turek, F. W. (Contributor), ZENODO, Aug 17 2021
DOI: 10.5061/dryad.gf1vhhmmj, https://zenodo.org/record/5213766
Dataset
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Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight
Jiang, P. (Creator), Green, S. J. (Creator), Chlipala, G. E. (Creator), Turek, F. W. (Creator) & Vitaterna, M. H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4614026.v1, https://springernature.figshare.com/collections/Reproducible_changes_in_the_gut_microbiome_suggest_a_shift_in_microbial_and_host_metabolism_during_spaceflight/4614026/1
Dataset
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Additional file 1: of Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight
Jiang, P. (Creator), Green, S. J. (Creator), Chlipala, G. E. (Creator), Turek, F. W. (Creator) & Vitaterna, M. H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.9461870, https://springernature.figshare.com/articles/Additional_file_1_of_Reproducible_changes_in_the_gut_microbiome_suggest_a_shift_in_microbial_and_host_metabolism_during_spaceflight/9461870
Dataset
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Resource competition shapes biological rhythms and promotes temporal niche differentiation in a community simulation
Gao, V. D. (Creator), Morley-Fletcher, S. (Creator), Maccari, S. (Creator), Vitaterna, M. H. (Creator) & Turek, F. W. (Creator), Dryad, 2020
DOI: 10.5061/dryad.gf1vhhmmj, https://datadryad.org/stash/dataset/doi:10.5061/dryad.gf1vhhmmj
Dataset