Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
20062022

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Personal profile

Research Interests

Faculty Member, Center for Synthetic Biology We develop high-throughput methods for protein biophysics and protein design, with a focus on protein therapeutics. Key questions include: How do protein sequence and structure determine folding stability, conformational dynamics, and resistance to aggregation/degradation-inducing stresses? Can we quantitatively predict these protein "phenotypes" from genotype (sequence) using computational modeling? How do we design protein therapeutics that optimize these phenotypes for a particular application? To answer these questions, we combine large-scale de novo computational protein design with high-throughput methods such as display selections, mass spectrometry proteomics, and next-generation sequencing, enabling us to test thousands of proteins in parallel. By combining these technologies, we seek to develop efficient "design-test-analyze" cycles, iterating our way to an improved, quantitative understanding of protein biophysics and more advanced protein therapeutics.

Training Experience

2019Postdoctoral Fellowship, University of Washington, Institute for Protein Design

Education/Academic qualification

Biophysics, PhD, University of California, San Francisco

… → 2013

Research interests

  • Biochemistry: Proteins
  • Bioengineering
  • Biologic Therapies
  • Biophysics
  • Computational Biology
  • Drug Discovery
  • Proteins / Macromolecules
  • Proteomics

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