• Source: Scopus
20062020

Research output per year

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Personal profile

Research Interests

Faculty Member, Center for Synthetic Biology We develop high-throughput methods for protein biophysics and protein design, with a focus on protein therapeutics. Key questions include: How do protein sequence and structure determine folding stability, conformational dynamics, and resistance to aggregation/degradation-inducing stresses? Can we quantitatively predict these protein "phenotypes" from genotype (sequence) using computational modeling? How do we design protein therapeutics that optimize these phenotypes for a particular application? To answer these questions, we combine large-scale de novo computational protein design with high-throughput methods such as display selections, mass spectrometry proteomics, and next-generation sequencing, enabling us to test thousands of proteins in parallel. By combining these technologies, we seek to develop efficient "design-test-analyze" cycles, iterating our way to an improved, quantitative understanding of protein biophysics and more advanced protein therapeutics.

Training Experience

2019Postdoctoral Fellowship, University of Washington, Institute for Protein Design

Education/Academic qualification

PhD, University of California, San Francisco

… → 2013

Research interests

  • Biochemistry: Proteins
  • Bioengineering
  • Biologic Therapies
  • Biophysics
  • Computational Biology
  • Drug Discovery
  • Proteins / Macromolecules
  • Proteomics

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