Gayle E Woloschak

My research is focused on two general areas: radiobiology and bionanotechnology. Work in radiobiology includes studies of the molecular biology of radiation responses, particularly radiation toxicities, radiation effects, dose-, dose-rate, and radiation quality issues and other general areas of radiobiology. In addition, my laboratory houses the tissues and data from mojority of the radiobilogical experiments conducted in US between 1950-1990's (http://janus.northwestern.edu). In addition to sharing these data and materials with the radiobiological community, my group is investigating the archive as well; we are applying new statistical approaches on old datasets and new experimental approaches for investigation of formalin fixed and paraffin embedded materials. Work with micro-RNA microarrays, and use of X-ray fluorescence microscopy for histopathological analysis fall into this research. Work in bionanotechnology includes development and investigation of multifunctional nanoconstructs, increasing contrast for biomedical imaging (MRI and CT), enabling delivery of small molecules (such as chemotherapeutic drugs, flavonoids etc.) and producing cytotoxic reactive oxygen species to fortify effect of radiotherapy.