Grants per year
Personal profile
Research Interests
My laboratory is interested in signaling mechanisms which control T helper cell differentiation and traffic. We are currently focused on two areas: functions of p38 MAP kinases (MAPK) and the role of a transcription factor KLF2 in these processes. Towards this end, we have produced novel mouse models which will allow us to test the role of the different isoforms of p38 (of which there are 4) in T helper differentiation and expression of key leukocyte adhesion molecules; and to determine the role of KLF2 downregulation in T helper biology generally.
Training Experience
| 1985 | Postdoctoral Fellowship, Stanford University |
| 1990 | Postdoctoral Fellowship, University of Iowa |
Education/Academic qualification
PhD, Stanford University
… → 1984
Research interests
- Gene Regulation
- Immunology
- Inflammation
- Molecular Genetics
- Stem Cells
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Grants
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Diverse Functions of p38α MAPK in T Helper Differentiation
National Institute of Allergy and Infectious Diseases
4/1/17 → 3/31/21
Project: Research project
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Probing the Functions of KLF2 Downregulation
National Institute of Allergy and Infectious Diseases
4/1/16 → 3/31/20
Project: Research project
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C-033: Common bone marrow homing pathways for HSC and SCLC stem cells
Searle Funds at The Chicago Community Trust
1/1/11 → 12/31/17
Project: Research project
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Genetic Mechanisms which Control Hematopoietic Cell Migration
National Heart, Lung, and Blood Institute
9/16/08 → 8/31/11
Project: Research project
Research Output
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Functions of smad transcription factors in TGF-β1-induced selectin ligand expression on murine CD4 Th cells
Ebel, M. E. & Kansas, G. S., Oct 1 2016, In: Journal of Immunology. 197, 7, p. 2627-2634 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK
Ebel, M. E., Awe, O., Kaplan, M. H. & Kansas, G. S., Jun 15 2015, In: Journal of Immunology. 194, 12, p. 5781-5788 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Defining the functional boundaries of the murine α1,3- fucosyltransferase Fut7 reveals a remarkably compact locus
Ebel, M. E. & Kansas, G. S., Mar 7 2014, In: Journal of Biological Chemistry. 289, 10, p. 6341-6349 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection
Sarraj, B., Ye, J., Akl, A. I., Chen, G., Wang, J. J., Zhang, Z. J., Abadja, F., Abecassis, M. M., Miller, S. D., Kansas, G. S. & Ansari, M. J. I., Aug 19 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12145-12150 6 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Therapeutic inflammatory monocyte modulation using immune-modifying microparticles
Getts, D. R., Terry, R. L., Getts, M. T., Deffrasnes, C., Müller, M., Vreden, C., Ashhurst, T. M., Chami, B., McCarthy, D., Wu, H., Jin, M., Martin, A., Shae, L. D., Witting, P., Kansas, G. S., Kühn, J., Hafezi, W., Campbell, I. L., Reilly, D., Say, J. & 8 others, , Jan 15 2014, In: Science translational medicine. 6, 219, 219ra7.Research output: Contribution to journal › Article › peer-review
191 Scopus citations