Grants per year
Personal profile
Research Interests
My laboratory is interested in signaling mechanisms which control T helper cell differentiation and traffic. We are currently focused on two areas: functions of p38 MAP kinases (MAPK) and the role of a transcription factor KLF2 in these processes. Towards this end, we have produced novel mouse models which will allow us to test the role of the different isoforms of p38 (of which there are 4) in T helper differentiation and expression of key leukocyte adhesion molecules; and to determine the role of KLF2 downregulation in T helper biology generally.
Training Experience
| 1985 | Postdoctoral Fellowship, Stanford University |
| 1990 | Postdoctoral Fellowship, University of Iowa |
Education/Academic qualification
PhD, Stanford University
… → 1984
Research interests
- Gene Regulation
- Immunology
- Inflammation
- Molecular Genetics
- Stem Cells
Fingerprint Dive into the research topics where Geoffrey Scott Kansas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
P-Selectin
Medicine & Life Sciences
L-Selectin
Medicine & Life Sciences
Selectins
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
E-Selectin
Medicine & Life Sciences
galactoside 3-fucosyltransferase
Medicine & Life Sciences
Leukocytes
Medicine & Life Sciences
T-Lymphocytes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2020
Diverse Functions of p38α MAPK in T Helper Differentiation
National Institute of Allergy and Infectious Diseases
4/1/17 → 3/31/20
Project: Research project
p38 Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases
Protein Isoforms
Th1 Cells
Helper-Inducer T-Lymphocytes
Probing the Functions of KLF2 Downregulation
National Institute of Allergy and Infectious Diseases
4/1/16 → 3/31/20
Project: Research project
Down-Regulation
Myeloid Cells
Adipocytes
Lysine
Blood Vessels
C-033: Common bone marrow homing pathways for HSC and SCLC stem cells
Searle Funds at The Chicago Community Trust
1/1/11 → 12/31/17
Project: Research project
Genetic Mechanisms which Control Hematopoietic Cell Migration
National Heart, Lung, and Blood Institute
9/16/08 → 8/31/11
Project: Research project
Research Output 1981 2016
7
Citations
(Scopus)
Functions of smad transcription factors in TGF-β1-induced selectin ligand expression on murine CD4 Th cells
Ebel, M. E. & Kansas, G. S., Oct 1 2016, In : Journal of Immunology. 197, 7, p. 2627-2634 8 p.Research output: Contribution to journal › Article
Selectins
Transcription Factors
Ligands
Cytokines
T-Lymphocytes
10
Citations
(Scopus)
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK
Ebel, M. E., Awe, O., Kaplan, M. H. & Kansas, G. S., Jun 15 2015, In : Journal of Immunology. 194, 12, p. 5781-5788 8 p.Research output: Contribution to journal › Article
Selectins
p38 Mitogen-Activated Protein Kinases
Cytokines
Ligands
T-Lymphocytes
6
Citations
(Scopus)
Defining the functional boundaries of the murine α1,3- fucosyltransferase Fut7 reveals a remarkably compact locus
Ebel, M. E. & Kansas, G. S., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6341-6349 9 p.Research output: Contribution to journal › Article
galactoside 3-fucosyltransferase
Gene expression
Gene Expression
Traffic control
Leukocytes
18
Citations
(Scopus)
Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection
Sarraj, B., Ye, J., Akl, A. I., Chen, G., Wang, J. J., Zhang, Z. J., Abadja, F., Abecassis, M. M., Miller, S. D., Kansas, G. S. & Ansari, M. J. I., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12145-12150 6 p.Research output: Contribution to journal › Article
Selectins
Allografts
Leukocytes
T-Lymphocytes
Graft Survival
151
Citations
(Scopus)
Therapeutic inflammatory monocyte modulation using immune-modifying microparticles
Getts, D. R., Terry, R. L., Getts, M. T., Deffrasnes, C., Müller, M., Vreden, C., Ashhurst, T. M., Chami, B., McCarthy, D., Wu, H., Jin, M., Martin, A., Shae, L. D., Witting, P., Kansas, G. S., Kühn, J., Hafezi, W., Campbell, I. L., Reilly, D., Say, J. & 8 others, , Jan 15 2014, In : Science Translational Medicine. 6, 219, 219ra7.Research output: Contribution to journal › Article
Monocytes
Therapeutics
Spleen
Opsonin Proteins
Thioglycolates