Grants per year
Personal profile
Research Interests
My research focuses predominantly on understanding physiological processes mediated by glutamate receptors, which are signaling proteins that respond to glutamate, the predominant excitatory neurotransmitter in the vertebrate central nervous system. Aberrant glutamate receptor signaling has been implicated in a number of pathological conditions, including epilepsy, schizophrenia and neuropathic pain; because these proteins are critical to brain function, they also are involved in most neurological diseases to varying degrees. Furthermore, modulation of glutamate receptors underlies models of learning and memory such as long-term potentiation and depression. The critical roles played by glutamate receptors in neurophysiological and neuropathological processes provide a strong impetus for understanding these fascinating molecules at many levels of study.
Training Experience
1995 | Postdoctoral Fellowship, University College, England |
1998 | Postdoctoral Fellowship, The Salk Institute |
Education/Academic qualification
Pharmacology, PhD, University of California at Los Angeles
… → 1993
Research interests keywords
- Cellular Electrophysiology
- Drug Discovery
- Epilepsy
- Nervous System Diseases
- Neurobiology
- Neuroscience
- Pain
- Pharmacology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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The Physiology of Store-Operated Channels in the Nervous System
Prakriya, M., Swanson, G. T. & Yamashita, M.
National Institute of Neurological Disorders and Stroke
5/1/23 → 4/30/31
Project: Research project
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Regulation of kainate receptor expression in cone bipolar cells
Contractor, A., DeVries, S. H., Swanson, G. T., Zhu, Y. & Xu, J.
9/30/22 → 5/31/26
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Weintraub, S., Allada, R., Bevan, M. D., Caraveo Piso, G., Carvill, G. L., Chan, S., Contractor, A., Disterhoft, J. F., Dombeck, D. A., Dong, H., Ferreira, A. B., Flanagan, M. E., Gefen, T. D., Geula, C., Gratton, C., He, C., Kahnt, T., Kalb, R. G., Kennedy, A., Kessler, J., Kiskinis, E., Klein, W. L., Kozorovitskiy, Y., Krainc, D., Li, L., Mazzulli, J., Mesulam, M., Miller, R. J., Morimoto, R. I., Opal, P., Ozdinler, H., Paller, K., Parisiadou, L., Penzes, P., Pinto, L., Prakriya, M., Reber, P. J., Roberts, A. L., Rogalski, E., Savas, J. N., Surmeier Jr, D. J., Swanson, G. T., Voss, J. L., Zee, P. C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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Kainate Receptors as a Target for the Anticonvulsant Perampanel
National Institute of Neurological Disorders and Stroke
4/1/22 → 3/31/24
Project: Research project
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Subproject for Dr. Swanson
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/25
Project: Research project
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Postoperative risk of IDH-mutant glioma–associated seizures and their potential management with IDH-mutant inhibitors
Drumm, M. R., Wang, W., Sears, T. K., Bell-Burdett, K., Javier, R., Cotton, K. Y., Webb, B., Byrne, K., Unruh, D., Thirunavu, V., Walshon, J., Steffens, A., McCortney, K., Lukas, R. V., Phillips, J. J., Mohamed, E., Finan, J. D., Santana-Santos, L., Heimberger, A. B., Franz, C. K., & 4 others , Jun 15 2023, In: Journal of Clinical Investigation. 133, 12, e168035.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The Antiseizure Drug Perampanel Is a Subunit-Selective Negative Allosteric Modulator of Kainate Receptors
Taniguchi, S., Stolz, J. R. & Swanson, G. T., Jul 13 2022, In: Journal of Neuroscience. 42, 28, p. 5499-5509 11 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome
Govind, A. P., Jeyifous, O., Russell, T. A., Yi, Z., Weigel, A. V., Ramaprasad, A., Newell, L., Ramos, W., Valbuena, F. M., Casler, J. C., Yan, J. Z., Glick, B. S., Swanson, G. T., Lippincott-Schwartz, J. & Green, W. N., Sep 2021, In: eLife. 10, e68910.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders
Stolz, J. R., Foote, K. M., Veenstra-Knol, H. E., Pfundt, R., ten Broeke, S. W., de Leeuw, N., Roht, L., Pajusalu, S., Part, R., Rebane, I., Õunap, K., Stark, Z., Kirk, E. P., Lawson, J. A., Lunke, S., Christodoulou, J., Louie, R. J., Rogers, R. C., Davis, J. M., Innes, A. M., & 19 others , Sep 2 2021, In: American journal of human genetics. 108, 9, p. 1692-1709 18 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a dravet syndrome mouse model
Yan, W. W., Xia, M., Chiang, J., Levitt, A., Hawkins, N., Kearney, J., Swanson, G. T., Chetkovich, D. & Nobis, W. P., 2021, In: eNeuro. 8, 3, ENEURO.0306-20.2021.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations
Datasets
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4AGR : Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4agr/pdb, https://www.rcsb.org/structure/4AGR
Dataset
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CCDC 854489: Experimental Crystal Structure Determination
Sakurada, T. (Creator), Gill, M. B. (Creator), Frausto, S. (Creator), Copits, B. (Creator), Noguchi, K. (Creator), Shimamoto, K. (Creator), Swanson, G. T. (Creator), Sakai, R. (Creator) & Sakurada, T. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxp55x, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxp55x&sid=DataCite
Dataset
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CCDC 900962: Experimental Crystal Structure Determination
Juknaitě, L. (Contributor), Sugamata, Y. (Contributor), Tokiwa, K. (Contributor), Ishikawa, Y. (Contributor), Takamizawa, S. (Contributor), Eng, A. (Contributor), Sakai, R. (Contributor), Pickering, D. S. (Contributor), Frydenvang, K. (Contributor), Swanson, G. T. (Contributor), Kastrup, J. S. (Contributor) & Oikawa, M. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.ccz7j90, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.ccz7j90&sid=DataCite
Dataset
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4AGG : Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4agg/pdb, https://www.rcsb.org/structure/4AGG
Dataset
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4AGV : Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4agv/pdb, https://www.rcsb.org/structure/4AGV
Dataset