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Personal profile

Research Interests

My research focuses predominantly on understanding physiological processes mediated by glutamate receptors, which are signaling proteins that respond to glutamate, the predominant excitatory neurotransmitter in the vertebrate central nervous system. Aberrant glutamate receptor signaling has been implicated in a number of pathological conditions, including epilepsy, schizophrenia and neuropathic pain; because these proteins are critical to brain function, they also are involved in most neurological diseases to varying degrees. Furthermore, modulation of glutamate receptors underlies models of learning and memory such as long-term potentiation and depression. The critical roles played by glutamate receptors in neurophysiological and neuropathological processes provide a strong impetus for understanding these fascinating molecules at many levels of study.

Training Experience

1995Postdoctoral Fellowship, University College, England
1998Postdoctoral Fellowship, The Salk Institute

Education/Academic qualification

PhD, University of California at Los Angeles

… → 1993

Research interests

  • Cellular Electrophysiology
  • Drug Discovery
  • Epilepsy
  • Nervous System Diseases
  • Neurobiology
  • Neuroscience
  • Pain
  • Pharmacology

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Grants

  • Research Output

  • Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function

    Foote, K. M., Lyman, K. A., Han, Y., Michailidis, I. E., Heuermann, R. J., Mandikian, D., Trimmer, J. S., Swanson, G. T. & Chetkovich, D. M., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15743-15758 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

    Xu, D., Robinson, A. P., Ishii, T., Duncan, DA. S., Alden, T. D., Goings, G. E., Ifergan, I., Podojil, J. R., Penaloza-MacMaster, P., Kearney, J. A., Swanson, G. T., Miller, S. D. & Koh, S., Apr 1 2018, In : Journal of Experimental Medicine. 215, 4, p. 1169-1186 18 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins

    Smith, K. R., Jones, K. A., Kopeikina, K. J., Burette, A. C., Copits, B. A., Yoon, S., Forrest, M. P., Fawcett-Patel, J. M., Hanley, J. G., Weinberg, R. J., Swanson, G. T. & Penzes, P., Nov 15 2017, In : Journal of Neuroscience. 37, 46, p. 11127-11139 13 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice

    Xu, J., Marshall, J. J., Fernandes, H. B., Nomura, T., Copits, B. A., Procissi, D., Mori, S., Wang, L., Zhu, Y., Swanson, G. T. & Contractor, A., Feb 21 2017, In : Cell reports. 18, 8, p. 1848-1857 10 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations