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Personal profile

Research Interests

My research focuses predominantly on understanding physiological processes mediated by glutamate receptors, which are signaling proteins that respond to glutamate, the predominant excitatory neurotransmitter in the vertebrate central nervous system. Aberrant glutamate receptor signaling has been implicated in a number of pathological conditions, including epilepsy, schizophrenia and neuropathic pain; because these proteins are critical to brain function, they also are involved in most neurological diseases to varying degrees. Furthermore, modulation of glutamate receptors underlies models of learning and memory such as long-term potentiation and depression. The critical roles played by glutamate receptors in neurophysiological and neuropathological processes provide a strong impetus for understanding these fascinating molecules at many levels of study.

Training Experience

1995Postdoctoral Fellowship, University College, England
1998Postdoctoral Fellowship, The Salk Institute

Education/Academic qualification

PhD, University of California-Los Angeles

… → 1993

Keywords

  • Cellular Electrophysiology
  • Drug Discovery
  • Epilepsy
  • Nervous System Diseases
  • Neurobiology
  • Neuroscience
  • Pain
  • Pharmacology

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Grants 2002 2023

Kainic Acid Receptors
Intellectual Disability
Missense Mutation
Phenotype
Haploinsufficiency
Serotonin Antagonists
Serotonin Receptors
Biological Products
Pharmacology
Serotonin
Astrocytes
Nervous System
Neurotransmitter Agents
Exocytosis
Neurons

Research Output 1994 2018

4 Citations (Scopus)

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

Xu, D., Robinson, A. P., Ishii, T., Duncan, DA. S., Alden, T. D., Goings, G. E., Ifergan, I., Podojil, J. R., Penaloza-MacMaster, P., Kearney, J. A., Swanson, G. T., Miller, S. D. & Koh, S., Apr 1 2018, In : Journal of Experimental Medicine. 215, 4, p. 1169-1186 18 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-17
Granulocyte-Macrophage Colony-Stimulating Factor
Pediatrics
T-Lymphocytes
4 Citations (Scopus)

Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins

Smith, K. R., Jones, K. A., Kopeikina, K. J., Burette, A. C., Copits, B. A., Yoon, S., Forrest, M. P., Fawcett-Patel, J. M., Hanley, J. G., Weinberg, R. J., Swanson, G. T. & Penzes, P., Nov 15 2017, In : Journal of Neuroscience. 37, 46, p. 11127-11139 13 p.

Research output: Contribution to journalArticle

Cadherins
Synapses
Autistic Disorder
Proteins
Electrophysiology
4 Citations (Scopus)

Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice

Xu, J., Marshall, J. J., Fernandes, H. B., Nomura, T., Copits, B. A., Procissi, D., Mori, S., Wang, L., Zhu, Y., Swanson, G. T. & Contractor, A., Feb 21 2017, In : Cell Reports. 18, 8, p. 1848-1857 10 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Corpus Striatum
Genes
Neurons
Grooming
1 Citation (Scopus)

Excitatory synaptic input to hilar mossy cells under basal and hyperexcitable conditions

Hedrick, T. P., Nobis, W. P., Foote, K. M., Ishii, T., Chetkovich, D. M. & Swanson, G. T., Nov 1 2017, In : eNeuro. 4, 6, e0364-17.2017.

Research output: Contribution to journalArticle

Synapses
Pyramidal Cells
Kainic Acid Receptors
AMPA Receptors
Kainic Acid
5 Citations (Scopus)

Neto2 assembles with kainate receptors in DRG neurons during development and modulates neurite outgrowth in adult sensory neurons

Vernon, C. G. & Swanson, G. T., Mar 22 2017, In : Journal of Neuroscience. 37, 12, p. 3352-3363 12 p.

Research output: Contribution to journalArticle

Neuropilins
Kainic Acid Receptors
Spinal Ganglia
Sensory Receptor Cells
Neurons