Grants per year
Personal profile
Research Interests
My research focuses predominantly on understanding physiological processes mediated by glutamate receptors, which are signaling proteins that respond to glutamate, the predominant excitatory neurotransmitter in the vertebrate central nervous system. Aberrant glutamate receptor signaling has been implicated in a number of pathological conditions, including epilepsy, schizophrenia and neuropathic pain; because these proteins are critical to brain function, they also are involved in most neurological diseases to varying degrees. Furthermore, modulation of glutamate receptors underlies models of learning and memory such as long-term potentiation and depression. The critical roles played by glutamate receptors in neurophysiological and neuropathological processes provide a strong impetus for understanding these fascinating molecules at many levels of study.
Training Experience
| 1995 | Postdoctoral Fellowship, University College, England |
| 1998 | Postdoctoral Fellowship, The Salk Institute |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Pharmacology, PhD, University of California at Los Angeles
… → 1993
Research interests keywords
- Cellular Electrophysiology
- Drug Discovery
- Epilepsy
- Nervous System Diseases
- Neurobiology
- Neuroscience
- Pain
- Pharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The Physiology of Store-Operated Channels in the Nervous System
Prakriya, M. (PD/PI), Swanson, G. T. (Co-Investigator) & Yamashita, M. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
5/1/23 → 4/30/31
Project: Research project
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Regulation of kainate receptor expression in cone bipolar cells
Contractor, A. (PD/PI), Contractor, A. (PD/PI), DeVries, S. H. (PD/PI), DeVries, S. H. (PD/PI), Swanson, G. T. (PD/PI), Swanson, G. T. (PD/PI), Zhu, Y. (PD/PI), Zhu, Y. (PD/PI), Xu, J. (Co-Investigator) & Xu, J. (Co-Investigator)
9/30/22 → 5/31/26
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Subproject for Dr. Swanson
Swanson, G. T. (PD/PI) & Swanson, G. T. (PD/PI)
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/26
Project: Research project
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Targeting IDH mutations to improve seizure control in glioma patients
Horbinski, C. M. (PD/PI), Horbinski, C. M. (PD/PI), Horbinski, C. M. (PD/PI), Swanson, G. T. (Co-PD/PI), Swanson, G. T. (Co-PD/PI), Swanson, G. T. (Co-PD/PI), Templer, J. W. (Co-Investigator), Templer, J. W. (Co-Investigator), Templer, J. W. (Co-Investigator), Xi, G. (Co-Investigator), Xi, G. (Co-Investigator) & Xi, G. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/26
Project: Research project
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Bridging the gap: insights into sensorimotor deficits in NMDA receptor antibody encephalitis
Opal, P. & Swanson, G. T., Mar 3 2025, In: Journal of Clinical Investigation. 135, 5, e188251.Research output: Contribution to journal › Review article › peer-review
Open Access -
A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels
Nomura, T., Taniguchi, S., Wang, Y. Z., Yeh, N. H., Wilen, A. P., Castillon, C. C. M., Foote, K. M., Xu, J., Armstrong, J. N., Savas, J. N., Swanson, G. T. & Contractor, A., Nov 22 2023, In: Journal of Neuroscience. 43, 47, p. 7913-7928 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Postoperative risk of IDH-mutant glioma–associated seizures and their potential management with IDH-mutant inhibitors
Drumm, M. R., Wang, W., Sears, T. K., Bell-Burdett, K., Javier, R., Cotton, K. Y., Webb, B., Byrne, K., Unruh, D., Thirunavu, V., Walshon, J., Steffens, A., McCortney, K., Lukas, R. V., Phillips, J. J., Mohamed, E., Finan, J. D., Santana-Santos, L., Heimberger, A. B. & Franz, C. K. & 4 others, , Jun 15 2023, In: Journal of Clinical Investigation. 133, 12, e168035.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
The Antiseizure Drug Perampanel Is a Subunit-Selective Negative Allosteric Modulator of Kainate Receptors
Taniguchi, S., Stolz, J. R. & Swanson, G. T., Jul 13 2022, In: Journal of Neuroscience. 42, 28, p. 5499-5509 11 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome
Govind, A. P., Jeyifous, O., Russell, T. A., Yi, Z., Weigel, A. V., Ramaprasad, A., Newell, L., Ramos, W., Valbuena, F. M., Casler, J. C., Yan, J. Z., Glick, B. S., Swanson, G. T., Lippincott-Schwartz, J. & Green, W. N., Sep 2021, In: eLife. 10, e68910.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations
Datasets
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Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Nakamura, Y. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), Protein Data Bank (PDB), Aug 29 2012
DOI: 10.2210/pdb4AGR/pdb, https://www.wwpdb.org/pdb?id=pdb_00004agr
Dataset
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X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution
Naur, P. (Contributor), Vestergaard, B. (Contributor), Skov, L. K. (Contributor), Egebjerg, J. (Contributor), Gajhede, M. (Contributor), Kastrup, J. S. (Contributor), Frydenvang, K. (Contributor), Lash, L. L. (Contributor), Postila, P. A. (Contributor), Pickering, D. S. (Contributor), Smith, C. M. (Contributor), Sasaki, M. (Contributor), Sakai, R. (Contributor), Pentikänen, O. T. (Contributor) & Swanson, G. T. (Contributor), Protein Data Bank (PDB), Mar 17 2009
DOI: 10.2210/pdb3GBB/pdb, https://www.wwpdb.org/pdb?id=pdb_00003gbb
Dataset
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CCDC 900962: Experimental Crystal Structure Determination
Juknaitě, L. (Contributor), Sugamata, Y. (Contributor), Tokiwa, K. (Contributor), Ishikawa, Y. (Contributor), Takamizawa, S. (Contributor), Eng, A. (Contributor), Sakai, R. (Contributor), Pickering, D. S. (Contributor), Frydenvang, K. (Contributor), Swanson, G. T. (Contributor), Kastrup, J. S. (Contributor) & Oikawa, M. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.ccz7j90, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.ccz7j90&sid=DataCite
Dataset
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4AGR : Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4agr/pdb, https://www.rcsb.org/structure/4AGR
Dataset
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4AGG : Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge)
Freymann, D. M. (Contributor), Focia, P. J. (Contributor), Sakai, R. (Contributor) & Swanson, G. T. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4agg/pdb, https://www.rcsb.org/structure/4AGG
Dataset