Grants per year
Personal profile
Research Interests
Brain functions are the result of the coordinated activity of large networks of neurons, which are composed by many different cell types. As a consequence, the specific properties of synaptic communication between different types of neurons play a pivotal role in shaping the computational power and network activity of specific brain regions. Research in my laboratory is focused on the hippocampus, which is an area of the brain involved in higher cognitive functions, such as learning and memory, and is often affected by important neurological illnesses like epilepsy, schizophrenia and Alzheimer’s disease. In particular, we are interested in the synaptic properties of GABAergic inhibitory interneurons, which are a very heterogeneous cellular population, with wide anatomical and functional diversity. Additionally we are trying to unravel the network properties of Cajal-Retzius cells, which are a neuronal population involved in guiding cortical development, whose computational functions remain poorly understood. Methodologically, we use state-of-the-art electrophysiological techniques in vitro such as paired recordings from anatomically identified connected neurons and optogenetic control of specific cellular populations. We hope that relating different neuronal types to clear network functions may lead to a better understanding of the cellular and molecular basis of hippocampal activity, and generate important insight into the organizing principles of cortical networks in the normal brain and during disease.
Education/Academic qualification
PhD, University of Milan
… → 1993
MD, University of Milan
… → 1989
Research interests
- Biophysics
- Cellular Electrophysiology
- Computational Neuroscience
- Developmental Neurobiology
- Nervous System Diseases
- Neurobiology
- Neuroscience
- Pharmacology
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Grants
Cajal-Retzius cells and neuronal signaling in postnatal cortical networks
Kearney, J. A. & Maccaferri, G.
National Institute of Neurological Disorders and Stroke
4/15/19 → 3/31/24
Project: Research project
Microcircuits of the Subiculum and Epilepsy
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
Mechanisms of Stress-Enhanced Aversive Conditioning
Maccaferri, G. & Radulovic, J.
National Institute of Mental Health
4/1/16 → 3/31/21
Project: Research project
Hippocampal microcircuits regulating neurogenesis
National Institute of Neurological Disorders and Stroke
5/1/17 → 4/30/20
Project: Research project
Research Output
A toolbox of criteria for distinguishing cajal–retzius cells from other neuronal types in the postnatal mouse hippocampus
Anstötz, M. & Maccaferri, G., Jan 1 2020, In : eNeuro. 7, 1, ENEURO.0516-19.2019.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
The intrinsic cell type-specific excitatory connectivity of the developing mouse subiculum is sufficient to generate synchronous epileptiform activity
Fiske, M. P., Anstötz, M., Welty, L. J. & Maccaferri, G., May 1 2020, In : Journal of Physiology. 598, 10, p. 1965-1985 21 p.Research output: Contribution to journal › Article
Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind
Anstötz, M., Quattrocolo, G. & Maccaferri, G., Oct 15 2018, In : Brain research. 1697, p. 124-133 10 p.Research output: Contribution to journal › Review article
2
Scopus
citations
Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus
Anstötz, M., Lee, S. K., Neblett, T. I., Rune, G. M. & Maccaferri, G., Feb 1 2018, In : Cerebral Cortex. 28, 2, p. 672-687 16 p.Research output: Contribution to journal › Article
8
Scopus
citations
Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus
Anstötz, M., Lee, S. K. & Maccaferri, G., Aug 15 2018, In : Journal of Physiology. 596, 16, p. 3739-3758 20 p.Research output: Contribution to journal › Article
7
Scopus
citations