• 2475 Citations
1989 …2024
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Personal profile

Research Interests

Brain functions are the result of the coordinated activity of large networks of neurons, which are composed by many different cell types. As a consequence, the specific properties of synaptic communication between different types of neurons play a pivotal role in shaping the computational power and network activity of specific brain regions. Research in my laboratory is focused on the hippocampus, which is an area of the brain involved in higher cognitive functions, such as learning and memory, and is often affected by important neurological illnesses like epilepsy, schizophrenia and Alzheimer’s disease. In particular, we are interested in the synaptic properties of GABAergic inhibitory interneurons, which are a very heterogeneous cellular population, with wide anatomical and functional diversity. Additionally we are trying to unravel the network properties of Cajal-Retzius cells, which are a neuronal population involved in guiding cortical development, whose computational functions remain poorly understood. Methodologically, we use state-of-the-art electrophysiological techniques in vitro such as paired recordings from anatomically identified connected neurons and optogenetic control of specific cellular populations. We hope that relating different neuronal types to clear network functions may lead to a better understanding of the cellular and molecular basis of hippocampal activity, and generate important insight into the organizing principles of cortical networks in the normal brain and during disease.

Education/Academic qualification

PhD, University of Milan

… → 1993

MD, University of Milan

… → 1989

Keywords

  • Biophysics
  • Cellular Electrophysiology
  • Computational Neuroscience
  • Developmental Neurobiology
  • Nervous System Diseases
  • Neurobiology
  • Neuroscience
  • Pharmacology

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2002 2024

Febrile Seizures
Hippocampus
Vesicular Glutamate Transport Proteins
Physiological Phenomena
Temperature
Epilepsy
Hippocampus
Seizures
Temporal Lobe Epilepsy
Optogenetics
Neurogenesis
Hippocampus
Neurons
Aptitude
Organized Financing
Oxytocin Receptors
Fear
Amnesia
Social Behavior
GABA-A Receptors

Research Output 1989 2018

1 Citation (Scopus)

Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind

Anstötz, M., Quattrocolo, G. & Maccaferri, G., Oct 15 2018, In : Brain research. 1697, p. 124-133 10 p.

Research output: Contribution to journalReview article

Interneurons
Hippocampus
Temporal Lobe Epilepsy
Pyramidal Cells
Electrophysiology
6 Citations (Scopus)

Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus

Anstötz, M., Lee, S. K., Neblett, T. I., Rune, G. M. & Maccaferri, G., Feb 1 2018, In : Cerebral Cortex. 28, 2, p. 672-687 16 p.

Research output: Contribution to journalArticle

Hippocampus
Neurogenesis
Interneurons
Parvalbumins
Neocortex
3 Citations (Scopus)

Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus

Anstötz, M., Lee, S. K. & Maccaferri, G., Aug 15 2018, In : Journal of Physiology. 596, 16, p. 3739-3758 20 p.

Research output: Contribution to journalArticle

Capsaicin
Synaptic Transmission
Hippocampus
Calcium
Interneurons
13 Citations (Scopus)

Developmental Profile, Morphology, and Synaptic Connectivity of Cajal-Retzius Cells in the Postnatal Mouse Hippocampus

Anstötz, M., Huang, H., Marchionni, I., Haumann, I., Maccaferri, G. & Lübke, J. H. R., Feb 1 2016, In : Cerebral Cortex. 26, 2, p. 855-872 18 p.

Research output: Contribution to journalArticle

Hippocampus
Entorhinal Cortex
Aminobutyrates
Synaptic Potentials
Brain
22 Citations (Scopus)

Morphology, input–output relations and synaptic connectivity of Cajal–Retzius cells in layer 1 of the developing neocortex of CXCR4-EGFP mice

Anstötz, M., Cosgrove, K. E., Hack, I., Mugnaini, E., Maccaferri, G. & Lübke, J. H. R., Nov 1 2014, In : Brain Structure and Function. 219, 6, p. 2119-2139 21 p.

Research output: Contribution to journalArticle

Neocortex
Presynaptic Terminals
Neurons
Pyramidal Cells
Interneurons