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Personal profile

Research Interests

Brain functions are the result of the coordinated activity of large networks of neurons, which are composed by many different cell types. As a consequence, the specific properties of synaptic communication between different types of neurons play a pivotal role in shaping the computational power and network activity of specific brain regions. Research in my laboratory is focused on the hippocampus, which is an area of the brain involved in higher cognitive functions, such as learning and memory, and is often affected by important neurological illnesses like epilepsy, schizophrenia and Alzheimer’s disease. In particular, we are interested in the synaptic properties of GABAergic inhibitory interneurons, which are a very heterogeneous cellular population, with wide anatomical and functional diversity. Additionally we are trying to unravel the network properties of Cajal-Retzius cells, which are a neuronal population involved in guiding cortical development, whose computational functions remain poorly understood. Methodologically, we use state-of-the-art electrophysiological techniques in vitro such as paired recordings from anatomically identified connected neurons and optogenetic control of specific cellular populations. We hope that relating different neuronal types to clear network functions may lead to a better understanding of the cellular and molecular basis of hippocampal activity, and generate important insight into the organizing principles of cortical networks in the normal brain and during disease.

Education/Academic qualification

PhD, University of Milan

… → 1993

MD, University of Milan

… → 1989

Research interests

  • Biophysics
  • Cellular Electrophysiology
  • Computational Neuroscience
  • Developmental Neurobiology
  • Nervous System Diseases
  • Neurobiology
  • Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics where Gianmaria Maccaferri is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 29 Similar Profiles
Interneurons Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
Pyramidal Cells Medicine & Life Sciences
Neurons Medicine & Life Sciences
GABA-A Receptors Medicine & Life Sciences
Hippocampal CA1 Region Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
CXCR4 Receptors Medicine & Life Sciences

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Grants 2002 2024

Febrile Seizures
Vesicular Glutamate Transport Proteins
Physiological Phenomena
Temporal Lobe Epilepsy
Organized Financing
Oxytocin Receptors
Social Behavior
GABA-A Receptors

Research Output 1989 2018

1 Citation (Scopus)

Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind

Anstotz, M., Quattrocolo, G. & Maccaferri, G., Oct 15 2018, In : Brain research. 1697, p. 124-133 10 p.

Research output: Contribution to journalReview article

Temporal Lobe Epilepsy
Pyramidal Cells
7 Citations (Scopus)

Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus

Anstötz, M., Lee, S. K., Neblett, T. I., Rune, G. M. & Maccaferri, G., Feb 1 2018, In : Cerebral Cortex. 28, 2, p. 672-687 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Synaptic Transmission
16 Citations (Scopus)

Developmental Profile, Morphology, and Synaptic Connectivity of Cajal-Retzius Cells in the Postnatal Mouse Hippocampus

Anstötz, M., Huang, H., Marchionni, I., Haumann, I., MacCaferri, G. & Lübke, J. H. R., Feb 1 2016, In : Cerebral Cortex. 26, 2, p. 855-872 18 p.

Research output: Contribution to journalArticle

Entorhinal Cortex
Synaptic Potentials
25 Citations (Scopus)

Morphology, input–output relations and synaptic connectivity of Cajal–Retzius cells in layer 1 of the developing neocortex of CXCR4-EGFP mice

Anstotz, M., Cosgrove, K. E., Hack, I., Mugnaini, E., Maccaferri, G. & Lübke, J. H. R., Nov 1 2014, In : Brain Structure and Function. 219, 6, p. 2119-2139 21 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Pyramidal Cells