• 5232 Citations
1989 …2023
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Personal profile

Research Interests

Local synaptic circuits in motor-frontal cortex engage in neural operations underlying many aspects of cognition and behavior – motor control, executive functions, working memory, and more – yet circuit organization at the synaptic, cellular, and molecular levels remains poorly understood in this agranular cortex. What is the functional organization of these synaptic pathways? What cellular and circuit-level operations do neurons in these perform? How do these local circuits communicate with each other and how do they interact with subcortical systems in the basal ganglia and thalamus? The focus of our laboratory is to apply multiple tools of quantitative synaptic circuit analysis to elucidate the functional ‘wiring diagrams’ of neocortical neurons in motor-frontal cortex. We use laser scanning photostimulation (LSPS) microscopy, based on glutamate uncaging and channelrhodopsin-2 excitation, for rapid functional mapping of synaptic pathways onto single neurons in brain slices of motor-frontal cortex. We are also applying a variety of circuit analysis tools in efforts to identify circuit-level mechanisms in mouse models of disease, including autism, Rett syndrome, epilepsy, and motor neuron diseases. Our lab is also involved in the development and maintenance of software tools for imaging and electrophysiology applications: www.scanimage.org, www.ephus.org.

Education/Academic qualification

MD, PhD, Harvard University

… → 1995

Keywords

  • Cellular Electrophysiology
  • Developmental Neurobiology
  • Ion Channels
  • Microscopy
  • Movement Control
  • Nervous System Diseases
  • Neurology
  • Neuroscience

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Grants 2005 2023

Forelimb
Motor Cortex
Organizations
Neurons
Neocortex
Hippocampus
Learning
Neurons
Proteins
CREB-Binding Protein
Leptin
Respiration
Obesity Hypoventilation Syndrome
Neurons
Peptides

Research Output 1989 2019

1 Citation (Scopus)

Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons

Yamawaki, N., Li, X., Lambot, L., Ren, L. Y., Radulovic, J. & Shepherd, G. M. G., Apr 1 2019, In : Nature Neuroscience. 22, 4, p. 618-626 9 p.

Research output: Contribution to journalArticle

Anterior Thalamic Nuclei
GABAergic Neurons
Dendrites
Neurons
Axons

Nongenetic optical neuromodulation with silicon-based materials

Jiang, Y., Parameswaran, R., Li, X., Carvalho-de-Souza, J. L., Gao, X., Meng, L., Bezanilla, F., Shepherd, G. M. G. & Tian, B., May 1 2019, In : Nature Protocols. 14, 5, p. 1339-1376 38 p.

Research output: Contribution to journalArticle

Silicon
Brain
Light
Aptitude
Nervous System Diseases
1 Citation (Scopus)
Pyramidal Tracts
Pyramidal Cells
Motor Cortex
Dendrites
Thalamus
Neurosciences
corrigendum
13 Citations (Scopus)

Rational design of silicon structures for optically controlled multiscale biointerfaces

Jiang, Y., Li, X., Liu, B., Yi, J., Fang, Y., Shi, F., Gao, X., Sudzilovsky, E., Parameswaran, R., Koehler, K., Nair, V., Yue, J., Guo, K. H., Fang, Y., Tsai, H. M., Freyermuth, G., Wong, R. C. S., Kao, C. M., Chen, C. T., Nicholls, A. W. & 3 othersWu, X., Shepherd, G. M. G. & Tian, B., Jul 1 2018, In : Nature Biomedical Engineering. 2, 7, p. 508-521 14 p.

Research output: Contribution to journalArticle

Silicon
Brain
Chemical Phenomena
Light
Cellular Structures