Gordon M G Shepherd

Personal profile

Research Interests

Local synaptic circuits in motor-frontal cortex engage in neural operations underlying many aspects of cognition and behavior – motor control, executive functions, working memory, and more – yet circuit organization at the synaptic, cellular, and molecular levels remains poorly understood in this agranular cortex. What is the functional organization of these synaptic pathways? What cellular and circuit-level operations do neurons in these perform? How do these local circuits communicate with each other and how do they interact with subcortical systems in the basal ganglia and thalamus? The focus of our laboratory is to apply multiple tools of quantitative synaptic circuit analysis to elucidate the functional ‘wiring diagrams’ of neocortical neurons in motor-frontal cortex. We use laser scanning photostimulation (LSPS) microscopy, based on glutamate uncaging and channelrhodopsin-2 excitation, for rapid functional mapping of synaptic pathways onto single neurons in brain slices of motor-frontal cortex. We are also applying a variety of circuit analysis tools in efforts to identify circuit-level mechanisms in mouse models of disease, including autism, Rett syndrome, epilepsy, and motor neuron diseases. Our lab is also involved in the development and maintenance of software tools for imaging and electrophysiology applications: www.scanimage.org, www.ephus.org.

Education/Academic qualification

MD, PhD, Harvard University

… → 1995

Research interests

Cellular Electrophysiology
Developmental Neurobiology
Ion Channels
Microscopy
Movement Control
Nervous System Diseases
Neurology
Neuroscience

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Grants

1 Not started
3 Active
19 Finished

Synaptic Circuit Organization of Motor Cortex

Shepherd, G. M. G.

National Institute of Neurological Disorders and Stroke

8/1/18 → 7/31/23

Project: Research project

Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program

Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.

National Institute of General Medical Sciences

5/1/17 → 4/30/22

Project: Research project

Slow Outward Currents and Learning In Aging Hippocampus

Disterhoft, J. F., Oh, M. M. & Shepherd, G. M. G.

National Institute on Aging

2/1/15 → 1/31/21

Project: Research project

Towards elucidation of circuit mechanisms for feeding-related manual dexterity

Shepherd, G. M. G.

National Institute of Neurological Disorders and Stroke

4/1/20 → 9/30/21

Project: Research project

Synaptic Circuit Organization of Motor Cortex

Shepherd, G. M. G.

National Institute of Neurological Disorders and Stroke

8/1/16 → 7/31/18

Project: Research project

Research Output

5660 Citations
56 Article
7 Review article
3 Chapter
1 Comment/debate
2 More
- 1 Letter
- 1 Short survey

Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements

Barrett, J. M., Raineri Tapies, M. G. & Shepherd, G. M. G., Jan 2020, In : PloS one. 15, 1, e0226774.