Grants per year
Personal profile
Research Interests
Local synaptic circuits in motor-frontal cortex engage in neural operations underlying many aspects of cognition and behavior – motor control, executive functions, working memory, and more – yet circuit organization at the synaptic, cellular, and molecular levels remains poorly understood in this agranular cortex. What is the functional organization of these synaptic pathways? What cellular and circuit-level operations do neurons in these perform? How do these local circuits communicate with each other and how do they interact with subcortical systems in the basal ganglia and thalamus? The focus of our laboratory is to apply multiple tools of quantitative synaptic circuit analysis to elucidate the functional ‘wiring diagrams’ of neocortical neurons in motor-frontal cortex. We use laser scanning photostimulation (LSPS) microscopy, based on glutamate uncaging and channelrhodopsin-2 excitation, for rapid functional mapping of synaptic pathways onto single neurons in brain slices of motor-frontal cortex. We are also applying a variety of circuit analysis tools in efforts to identify circuit-level mechanisms in mouse models of disease, including autism, Rett syndrome, epilepsy, and motor neuron diseases. Our lab is also involved in the development and maintenance of software tools for imaging and electrophysiology applications: www.scanimage.org, www.ephus.org.
Education/Academic qualification
MD, PhD, Harvard University
… → 1995
Research interests
- Cellular Electrophysiology
- Developmental Neurobiology
- Ion Channels
- Microscopy
- Movement Control
- Nervous System Diseases
- Neurology
- Neuroscience
Fingerprint
- 4 Similar Profiles
Network
Grants
-
Brainstem circuits of corticospinal neurons
National Institute of Neurological Disorders and Stroke
7/1/20 → 6/30/22
Project: Research project
-
Towards elucidation of circuit mechanisms for feeding-related manual dexterity
National Institute of Neurological Disorders and Stroke
4/1/20 → 9/30/21
Project: Research project
-
Synaptic Circuit Organization of Motor Cortex
National Institute of Neurological Disorders and Stroke
8/1/18 → 7/31/23
Project: Research project
-
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
Research Output
-
Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops
Guo, K. H., Yamawaki, N., Barrett, J. M., Tapies, M. & Shepherd, G. M. G., Apr 1 2020, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 14, p. 2849-2858 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements
Barrett, J. M., Raineri Tapies, M. G. & Shepherd, G. M. G., Jan 2020, In: PloS one. 15, 1, e0226774.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Differential Contributions of Glutamatergic Hippocampal→Retrosplenial Cortical Projections to the Formation and Persistence of Context Memories
Yamawaki, N., Corcoran, K. A., Guedea, A. L., Shepherd, G. M. G. & Radulovic, J., Jun 1 2019, In: Cerebral Cortex. 29, 6, p. 2728-2736 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons
Yamawaki, N., Li, X., Lambot, L., Ren, L. Y., Radulovic, J. & Shepherd, G. M. G., Apr 1 2019, In: Nature neuroscience. 22, 4, p. 618-626 9 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
NetpyNE, a tool for data-driven multiscale modeling of brain circuits
Dura-Bernal, S., Suter, B. A., Gleeson, P., Cantarelli, M., Quintana, A., Rodriguez, F., Kedziora, D. J., Chadderdon, G. L., Kerr, C. C., Neymotin, S. A., McDougal, R. A., Hines, M., Shepherd, G. M. G. & Lytton, W. W., Apr 2019, In: eLife. 8, e44494.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations