Grants per year
Personal profile
Research Interests
Local synaptic circuits in motor-frontal cortex engage in neural operations underlying many aspects of cognition and behavior – motor control, executive functions, working memory, and more – yet circuit organization at the synaptic, cellular, and molecular levels remains poorly understood in this agranular cortex. What is the functional organization of these synaptic pathways? What cellular and circuit-level operations do neurons in these perform? How do these local circuits communicate with each other and how do they interact with subcortical systems in the basal ganglia and thalamus? The focus of our laboratory is to apply multiple tools of quantitative synaptic circuit analysis to elucidate the functional ‘wiring diagrams’ of neocortical neurons in motor-frontal cortex. We use laser scanning photostimulation (LSPS) microscopy, based on glutamate uncaging and channelrhodopsin-2 excitation, for rapid functional mapping of synaptic pathways onto single neurons in brain slices of motor-frontal cortex. We are also applying a variety of circuit analysis tools in efforts to identify circuit-level mechanisms in mouse models of disease, including autism, Rett syndrome, epilepsy, and motor neuron diseases. Our lab is also involved in the development and maintenance of software tools for imaging and electrophysiology applications: www.scanimage.org, www.ephus.org.
Education/Academic qualification
MD, PhD, Neurobiology, Harvard University
… → 1995
Research interests keywords
- Cellular Electrophysiology
- Developmental Neurobiology
- Ion Channels
- Microscopy
- Movement Control
- Nervous System Diseases
- Neurology
- Neuroscience
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Collaborations and top research areas from the last five years
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Bidirectional circuits of locus ceruleus and motor cortex neurons
National Institute of Neurological Disorders and Stroke
6/1/22 → 5/31/24
Project: Research project
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Developing new paradigms for mouse forelimb sensorimotor circuit analysis
National Institute of Neurological Disorders and Stroke
9/29/21 → 3/1/24
Project: Research project
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Synaptic Circuit Organization of Motor Cortex
National Institute of Neurological Disorders and Stroke
8/1/18 → 7/31/24
Project: Research project
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Brainstem circuits of corticospinal neurons
National Institute of Neurological Disorders and Stroke
7/1/20 → 6/30/23
Project: Research project
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Axonal Barcode Analysis of Pyramidal Tract Projections from Mouse Forelimb M1 and M2
Hausmann, F. S., Barrett, J. M., Martin, M. E., Zhan, H. & Shepherd, G. M. G., Oct 12 2022, In: Journal of Neuroscience. 42, 41, p. 7733-7743 11 p.Research output: Contribution to journal › Article › peer-review
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Manipulation-specific cortical activity as mice handle food
Barrett, J. M., Martin, M. E. & Shepherd, G. M. G., Nov 21 2022, In: Current Biology. 32, 22, p. 4842-4853.e6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Circuit organization of the excitatory sensorimotor loop through hand/forelimb s1 and m1
Yamawaki, N., Tapies, M. G. R., Stults, A., Smith, G. A. & Shepherd, G. M. G., 2021, In: eLife. 10, e66836.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle
Shepherd, G. M. G. & Yamawaki, N., Jul 2021, In: Nature Reviews Neuroscience. 22, 7, p. 389-406 18 p.Research output: Contribution to journal › Review article › peer-review
56 Scopus citations -
Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops
Guo, K. H., Yamawaki, N., Barrett, J. M., Tapies, M. & Shepherd, G. M. G., Apr 1 2020, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 14, p. 2849-2858 10 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations
Datasets
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Data and code for Barrett, Martin, and Shepherd (2022) "Manipulation-specific cortical activity as mice handle food"
Barrett, J. M. (Contributor), Martin, M. E. (Contributor) & Shepherd, G. M. G. (Contributor), ZENODO, 2022
DOI: 10.5281/zenodo.6588397, https://zenodo.org/record/6588397
Dataset
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Data and code for Barrett, Martin, and Shepherd (2022) "Manipulation-specific cortical activity as mice handle food"
Barrett, J. M. (Contributor), Martin, M. E. (Contributor) & Shepherd, G. M. G. (Contributor), ZENODO, May 27 2022
DOI: 10.5281/zenodo.7083395, https://zenodo.org/record/7083395
Dataset