• 5880 Citations
1989 …2020

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Article
2020

Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops

Guo, K. H., Yamawaki, N., Barrett, J. M., Tapies, M. & Shepherd, G. M. G., Apr 1 2020, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 14, p. 2849-2858 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements

Barrett, J. M., Raineri Tapies, M. G. & Shepherd, G. M. G., Jan 2020, In : PloS one. 15, 1, e0226774.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Differential Contributions of Glutamatergic Hippocampal→Retrosplenial Cortical Projections to the Formation and Persistence of Context Memories

Yamawaki, N., Corcoran, K., Guedea, A. L., Shepherd, G. M. G. & Radulovic, J., Jun 1 2019, In : Cerebral Cortex. 29, 6, p. 2728-2736 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons

Yamawaki, N., Li, X., Lambot, L., Ren, L. Y., Radulovic, J. & Shepherd, G. M. G., Apr 1 2019, In : Nature Neuroscience. 22, 4, p. 618-626 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

NetpyNE, a tool for data-driven multiscale modeling of brain circuits

Dura-Bernal, S., Suter, B. A., Gleeson, P., Cantarelli, M., Quintana, A., Rodriguez, F., Kedziora, D. J., Chadderdon, G. L., Kerr, C. C., Neymotin, S. A., McDougal, R. A., Hines, M., Shepherd, G. M. G. & Lytton, W. W., Apr 2019, In : eLife. 8, e44494.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Nongenetic optical neuromodulation with silicon-based materials

Jiang, Y., Parameswaran, R., Li, X., Carvalho-de-Souza, J. L., Gao, X., Meng, L., Bezanilla, F., Shepherd, G. M. G. & Tian, B., May 1 2019, In : Nature Protocols. 14, 5, p. 1339-1376 38 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018
5 Scopus citations

Rational design of silicon structures for optically controlled multiscale biointerfaces

Jiang, Y., Li, X., Liu, B., Yi, J., Fang, Y., Shi, F., Gao, X., Sudzilovsky, E., Parameswaran, R., Koehler, K., Nair, V., Yue, J., Guo, K. H., Fang, Y., Tsai, H. M., Freyermuth, G., Wong, R. C. S., Kao, C. M., Chen, C. T., Nicholls, A. W. & 3 others, Wu, X., Shepherd, G. M. G. & Tian, B., Jul 1 2018, In : Nature Biomedical Engineering. 2, 7, p. 508-521 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Scaling of optogenetically evoked signaling in a higher-order corticocortical pathway in the anesthetized mouse

Li, X., Yamawaki, N., Barrett, J. M., Kording, K. P. & Shepherd, G. M. G., May 15 2018, In : Frontiers in Systems Neuroscience. 12, 16.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Optimizing computer models of corticospinal neurons to replicate in vitro dynamics

Neymotin, S. A., Suter, B. A., Dura-Bernal, S., Shepherd, G. M. G., Migliore, M. & Lytton, W. W., Jan 2017, In : Journal of neurophysiology. 117, 1, p. 148-162 15 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A corticocortical circuit directly links retrosplenial cortex to M2 in the mouse

Yamawaki, N., Radulovic, J. & Shepherd, G. M. G., Sep 7 2016, In : Journal of Neuroscience. 36, 36, p. 9365-9374 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Combining optogenetics and electrophysiology to analyze projection neuron circuits

Yamawaki, N., Suter, B. A., Wickersham, I. R. & Shepherd, G. M. G., Oct 2016, In : Cold Spring Harbor Protocols. 2016, 10, p. 840-847 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy

Heuermann, R. J., Jaramillo, T. C., Ying, S. W., Suter, B. A., Lyman, K. A., Han, Y., Lewis, A. S., Hampton, T. G., Shepherd, G. M. G., Goldstein, P. A. & Chetkovich, D. M., Jan 1 2016, In : Neurobiology of Disease. 85, p. 81-92 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Cell-specific activity-dependent fractionation of layer 2/3→5B excitatory signaling in mouse auditory cortex

Joshi, A., Middleton, J. W., Anderson, C. T., Borges, K., Suter, B. A., Shepherd, G. M. G. & Tzounopoulos, T., Feb 18 2015, In : Journal of Neuroscience. 35, 7, p. 3112-3123 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

GABAergic mechanisms regulated by MIR-33 encode state-dependent fear

Jovasevic, V., Corcoran, K. A., Leaderbrand, K., Yamawaki, N., Guedea, A. L., Chen, H. J., Shepherd, G. M. G. & Radulovic, J., Aug 26 2015, In : Nature Neuroscience. 18, 9, p. 1265-1271 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Reciprocal interareal connections to corticospinal neurons in mouse Ml and S2

Suter, B. A. & Shepherd, G. M. G., Feb 18 2015, In : Journal of Neuroscience. 35, 7, p. 2959-2974 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Synaptic circuit organization of motor corticothalamic neurons

Yamawaki, N. & Shepherd, G. M. G., 2015, In : Journal of Neuroscience. 35, 5, p. 2293-2307 15 p.

Research output: Contribution to journalArticle

46 Scopus citations
2014

A genuine layer 4 in motor cortex with prototypical synaptic circuit connectivity

Yamawaki, N., Borges, K., Suter, B. A., Harris, K. D. & Shepherd, G. M. G., 2014, In : eLife. 3, p. e05422 e05422.

Research output: Contribution to journalArticle

45 Scopus citations

Motor cortex microcircuit simulation based on brain activity mapping

Chadderdon, G. L., Mohan, A., Suter, B. A., Neymotin, S. A., Kerr, C. C., Francis, J. T., Shepherd, G. M. G. & Lytton, W. W., 2014, In : Neural Computation. 26, 7, p. 1239-1262 24 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Convergent cortical innervation of striatal projection neurons

Kress, G. J., Yamawaki, N., Wokosin, D. L., Wickersham, I. R., Shepherd, G. M. G. & Surmeier, D. J., Jun 1 2013, In : Nature Neuroscience. 16, 6, p. 665-667 3 p.

Research output: Contribution to journalArticle

86 Scopus citations

eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model

Yasvoina, M. V., Genç, B., Jara, J. H., Sheets, P. L., Quinlan, K. A., Milosevic, A., Shepherd, G. M. G., Heckman, C. J. & Özdinler, P. H., May 10 2013, In : Journal of Neuroscience. 33, 18, p. 7890-7904 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Intrinsic electrophysiology of mouse corticospinal neurons: A class-specific triad of spike-related properties

Suter, B. A., Migliore, M. & Shepherd, G. M. G., Aug 2013, In : Cerebral Cortex. 23, 8, p. 1965-1977 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex

Hooks, B. M., Mao, T., Gutnisky, D. A., Yamawaki, N., Svoboda, K. & Shepherd, G. M. G., Jan 9 2013, In : Journal of Neuroscience. 33, 2, p. 748-760 13 p.

Research output: Contribution to journalArticle

138 Scopus citations
2012

An autism-associated variant of epac2 reveals a role for ras/epac2 signaling in controlling basal dendrite maintenance in mice

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Ozdinler, P. H., Shepherd, G. M. G. & Penzes, P., Jun 2012, In : PLoS biology. 10, 6, e1001350.

Research output: Contribution to journalArticle

50 Scopus citations

Circuit mapping by ultraviolet uncaging of glutamate

Shepherd, G. M. G., Sep 1 2012, In : Cold Spring Harbor Protocols. 7, 9, p. 998-1004 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Hierarchical connectivity and connection-specific dynamics in the corticospinal-corticostriatal microcircuit in mouse motor cortex

Kiritani, T., Wickersham, I. R., Seung, H. S. & Shepherd, G. M. G., Apr 4 2012, In : Journal of Neuroscience. 32, 14, p. 4992-5001 10 p.

Research output: Contribution to journalArticle

98 Scopus citations

Laminarly orthogonal excitation of fast-spiking and low-threshold-spiking interneurons in mouse motor cortex

Apicella, A. J., Wickersham, I. R., Sebastian Seung, H. & Shepherd, G. M. G., May 16 2012, In : Journal of Neuroscience. 32, 20, p. 7021-7033 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase

Qiu, S., Anderson, C. T., Levitt, P. & Shepherd, G. M. G., Apr 13 2011, In : Journal of Neuroscience. 31, 15, p. 5855-5864 10 p.

Research output: Contribution to journalArticle

75 Scopus citations
72 Scopus citations

Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas

Hooks, B. M., Hires, S. A., Zhang, Y. X., Huber, D., Petreanu, L., Svoboda, K. & Shepherd, G. M. G., 2011, In : PLoS biology. 9, 1, e1000572.

Research output: Contribution to journalArticle

126 Scopus citations

Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition

Middleton, J. W., Kiritani, T., Pedersen, C., Turner, J. G., Shepherd, G. M. G. & Tzounopoulos, T., May 3 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7601-7606 6 p.

Research output: Contribution to journalArticle

150 Scopus citations
2010

AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality

Christie, L. A., Russell, T. A., Xu, J., Wood, L., Shepherd, G. M. G. & Contractor, A., May 18 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9412-9417 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ephus: Multipurpose data acquisition software for neuroscience experiments

Suter, B. A., O'Connor, T., Iyer, V., Petreanu, L. T., Hooks, B. M., Kiritani, T., Svoboda, K. & Shepherd, G. M. G., Aug 26 2010, In : Frontiers in Neural Circuits. 4, AUG, 100.

Research output: Contribution to journalArticle

130 Scopus citations

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

Anderson, C. T., Sheets, P. L., Kiritani, T. & Shepherd, G. M. G., Jun 1 2010, In : Nature Neuroscience. 13, 6, p. 739-744 6 p.

Research output: Contribution to journalArticle

146 Scopus citations
36 Scopus citations
2009

Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency

Wood, L., Gray, N. W., Zhou, Z., Greenberg, M. E. & Shepherd, G. M. G., Oct 7 2009, In : Journal of Neuroscience. 29, 40, p. 12440-12448 9 p.

Research output: Contribution to journalArticle

70 Scopus citations
2008

Circuit and plasticity defects in the developing somatosensory cortex of Fmr1 knock-out mice

Bureau, I., Shepherd, G. M. G. & Svoboda, K., May 14 2008, In : Journal of Neuroscience. 28, 20, p. 5178-5188 11 p.

Research output: Contribution to journalArticle

126 Scopus citations

Local-circuit phenotypes of layer 5 neurons in motor-frontal cortex of YFP-H mice

Yu, J., Anderson, C. T., Kiritani, T., Sheets, P. L., Wokosin, D. L., Wood, L. & Shepherd, G. M. G., Dec 24 2008, In : Frontiers in Neural Circuits. 2, DEC, 6.

Research output: Contribution to journalArticle

43 Scopus citations

Top-down laminar organization of the excitatory network in motor cortex

Weiler, N., Wood, L., Yu, J., Solla, S. A. & Shepherd, G. M. G., Mar 1 2008, In : Nature Neuroscience. 11, 3, p. 360-366 7 p.

Research output: Contribution to journalArticle

179 Scopus citations
2005

Geometric and functional organization of cortical circuits

Shepherd, G. M. G., Stepanyants, A., Bureau, I., Chklovskii, D. & Svoboda, K., Jun 1 2005, In : Nature Neuroscience. 8, 6, p. 782-790 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex

Shepherd, G. M. G. & Svoboda, K., Jun 15 2005, In : Journal of Neuroscience. 25, 24, p. 5670-5679 10 p.

Research output: Contribution to journalArticle

158 Scopus citations

Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting

Sternson, S. M., Shepherd, G. M. G. & Friedman, J. M., Oct 1 2005, In : Nature Neuroscience. 8, 10, p. 1356-1363 8 p.

Research output: Contribution to journalArticle

207 Scopus citations

Transient and persistent dendritic spines in the neocortex in vivo

Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W. & Svoboda, K., Jan 20 2005, In : Neuron. 45, 2, p. 279-291 13 p.

Research output: Contribution to journalArticle

730 Scopus citations
2004

Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton

Zito, K., Knott, G., Shepherd, G. M. G., Shenolikar, S. & Svoboda, K., Oct 14 2004, In : Neuron. 44, 2, p. 321-334 14 p.

Research output: Contribution to journalArticle

150 Scopus citations

Precise development of functional and anatomical columns in the neocortex

Bureau, I., Shepherd, G. M. G. & Svoboda, K., Jun 10 2004, In : Neuron. 42, 5, p. 789-801 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
2003

Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex

Shepherd, G. M. G., Pologruto, T. A. & Svoboda, K., Apr 24 2003, In : Neuron. 38, 2, p. 277-289 13 p.

Research output: Contribution to journalArticle

246 Scopus citations
2002
73 Scopus citations
1998
Open Access
360 Scopus citations
1997

Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage

Shepherd, G. M. G., Tauböll, E., Bakke, S. J. & Nyberg-Hansen, R., Jun 3 1997, In : Movement Disorders. 12, 3, p. 432-437 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Streptococcus anginosus spondylodiskitis

Balsam, L. B., Shepherd, G. M. G. & Ruoff, K. L., Jan 1 1997, In : Clinical Infectious Diseases. 24, 1, p. 93-94 2 p.

Research output: Contribution to journalArticle

9 Scopus citations