Grants per year
Personal profile
Research Interests
Our laboratory studies the neuroinvasive herpesviruses with a focus on the molecular mechanisms by which these pathogens propagate and disseminate within the nervous system. The outcome of infection is closely tied to the route the viruses spread within the nervous system, and can range from no overt disease to blindness or lethal encephalitis. We use a combination of live-cell fluorescence microscopy, molecular genetics and neuronal cell biology to examine the dynamics of viral particle assembly and intracellular axon transport. These molecular mechanisms are then examined in the larger context of neuroinvasion and pathogenesis. Two long-term goals of our research are to identify novel targets in the viral infectious cycle for development of antivirals, and engineering recombinant viral particles as effective gene delivery vehicles. (Keywords: neuroinvasion, neuron, axon, microtubule, cytoskeleton, dynein, kinesin, transport, virus, virion, herpesvirus, herpes, capsid, tegument, egress, nucleus, GFP, BAC, bacmid, recombination, GS1783)
Training Experience
2001 | Postdoctoral Fellowship, Princeton University |
Education/Academic qualification
PhD, Microbiology, University of Pennsylvania
… → 1996
Research interests keywords
- Cell Biology
- Microbiology
- Microscopy
- Molecular Biology
- Molecular Genetics
- Neuroscience
- Viral Pathogenesis
- Virology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Production and assessment of a UL37R2 attenuated Marek’s Disease Virus
6/12/23 → 12/11/23
Project: Research project
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An R2 non-neuroinvasive herpes simplex virus type 2 vaccine
Antinone, S. E. & Smith, G. A.
Thyreos, Inc., National Institute of Allergy and Infectious Diseases
5/1/23 → 4/30/24
Project: Research project
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Neurotropic herpesvirus envelopment and microtubule-mediated transport
Albert Einstein College of Medicine, National Institute of Allergy and Infectious Diseases
12/1/22 → 11/30/27
Project: Research project
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Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency
Liu, Z., Reino, E. J. G., Harschnitz, O., Guo, H., Chan, Y. H., Khobrekar, N. V., Hasek, M. L., Dobbs, K., Rinchai, D., Materna, M., Matuozzo, D., Lee, D., Bastard, P., Chen, J., Lee, Y. S., Kim, S. K., Zhao, S., Amin, P., Lorenzo, L., Seeleuthner, Y., & 21 others , Apr 2023, In: Science Immunology. 8, 82, eade2860.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Virology under the Microscope-a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Jan 2023, In: mBio. 14, 1Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Virology under the Microscope-a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Apr 20 2023, In: mSphere. 8, 2, p. e0003423Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Virology under the Microscope—a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Feb 2023, In: Journal of virology. 97, 2Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Bovine Herpesvirus 1 Invasion of Sensory Neurons by Retrograde Axonal Transport Is Dependent on the pUL37 Region 2 Effector
Stults, A. M., Sollars, P. J., Heath, K. D., Sillman, S. J., Pickard, G. E. & Smith, G. A., May 2022, In: Journal of virology. 96, 9Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Additional file 2: of New tools to convert bacterial artificial chromosomes to a self-excising design and their application to a herpes simplex virus type 1 infectious clone
Richards, A. L. (Contributor), Sollars, P. J. (Creator) & Smith, G. A. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3639116_d2, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_New_tools_to_convert_bacterial_artificial_chromosomes_to_a_self-excising_design_and_their_application_to_a_herpes_simplex_virus_type_1_infectious_clone/4451186
Dataset
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New tools to convert bacterial artificial chromosomes to a self-excising design and their application to a herpes simplex virus type 1 infectious clone
Richards, A. L. (Contributor), Sollars, P. J. (Creator) & Smith, G. A. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3639116.v1, https://figshare.com/collections/New_tools_to_convert_bacterial_artificial_chromosomes_to_a_self-excising_design_and_their_application_to_a_herpes_simplex_virus_type_1_infectious_clone/3639116/1
Dataset