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Personal profile

Research Interests

Our laboratory studies the neuroinvasive herpesviruses with a focus on the molecular mechanisms by which these pathogens propagate and disseminate within the nervous system. The outcome of infection is closely tied to the route the viruses spread within the nervous system, and can range from no overt disease to blindness or lethal encephalitis. We use a combination of live-cell fluorescence microscopy, molecular genetics and neuronal cell biology to examine the dynamics of viral particle assembly and intracellular axon transport. These molecular mechanisms are then examined in the larger context of neuroinvasion and pathogenesis. Two long-term goals of our research are to identify novel targets in the viral infectious cycle for development of antivirals, and engineering recombinant viral particles as effective gene delivery vehicles. (Keywords: neuroinvasion, neuron, axon, microtubule, cytoskeleton, dynein, kinesin, transport, virus, virion, herpesvirus, herpes, capsid, tegument, egress, nucleus, GFP, BAC, bacmid, recombination, GS1783)

Training Experience

2001Postdoctoral Fellowship, Princeton University

Education/Academic qualification

PhD, University of Pennsylvania

… → 1996

Research interests

  • Cell Biology
  • Microbiology
  • Microscopy
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience
  • Viral Pathogenesis
  • Virology

Fingerprint Dive into the research topics where Greg A Smith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Herpesviridae Medicine & Life Sciences
Capsid Medicine & Life Sciences
Suid Herpesvirus 1 Medicine & Life Sciences
capsid Agriculture & Biology
Viruses Medicine & Life Sciences
Virion Medicine & Life Sciences
Axons Medicine & Life Sciences
Human Herpesvirus 1 Medicine & Life Sciences

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Grants 2004 2025

Research Output 1992 2019

  • 3993 Citations
  • 47 Article
  • 6 Review article
  • 2 Chapter
  • 2 Short survey
2 Citations (Scopus)

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

Lafaille, F. G., Harschnitz, O., Lee, Y. S., Zhang, P., Hasek, M. L., Kerner, G., Itan, Y., Ewaleifoh, O., Rapaport, F., Carlile, T. M., Carter-Timofte, M. E., Paquet, D., Dobbs, K., Zimmer, B., Gao, D., Rojas-Duran, M. F., Kwart, D., Rattina, V., Ciancanelli, M. J., McAlpine, J. L. & 23 others, Lorenzo, L., Boucherit, S., Rozenberg, F., Halwani, R., Henry, B., Amenzoui, N., Alsum, Z., Marques, L., Church, J. A., Al-Muhsen, S., Tardieu, M., Bousfiha, A. A., Paludan, S. R., Mogensen, T. H., Quintana-Murci, L., Tessier-Lavigne, M., Smith, G. A., Notarangelo, L. D., Studer, L., Gilbert, W., Abel, L., Casanova, J. L. & Zhang, S. Y., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1873-1884 12 p.

Research output: Contribution to journalArticle

Herpes Simplex Encephalitis
Human Herpesvirus 1
1 Citation (Scopus)
Human herpesvirus 1
Axonal Transport
Human Herpesvirus 1
nervous system
Nervous System
2 Citations (Scopus)

Dissecting the herpesvirus architecture by targeted proteolysis

Daniel, G. R., Pegg, C. E. & Smith, G. A., Sep 1 2018, In : Journal of virology. 92, 17, e00738-18.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

Zimmer, B., Ewaleifoh, O., Harschnitz, O., Lee, Y. S., Peneau, C., McAlpine, J. L., Liu, B., Tchieu, J., Steinbeck, J. A., Lafaille, F., Volpi, S., Notarangelo, L. D., Casanova, J. L., Zhang, S. Y., Smith, G. A. & Studer, L., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8775-E8782

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Induced Pluripotent Stem Cells
Human Herpesvirus 1
Virus Diseases
Trigeminal Ganglion
14 Citations (Scopus)

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

Zhang, S. Y., Clark, N. E., Freije, C. A., Pauwels, E., Taggart, A. J., Okada, S., Mandel, H., Garcia, P., Ciancanelli, M. J., Biran, A., Lafaille, F. G., Tsumura, M., Cobat, A., Luo, J., Volpi, S., Zimmer, B., Sakata, S., Dinis, A., Ohara, O., Garcia Reino, E. J. & 29 others, Dobbs, K., Hasek, M., Holloway, S. P., McCammon, K., Hussong, S. A., DeRosa, N., Van Skike, C. E., Katolik, A., Lorenzo, L., Hyodo, M., Faria, E., Halwani, R., Fukuhara, R., Smith, G. A., Galvan, V., Damha, M. J., Al-Muhsen, S., Itan, Y., Boeke, J. D., Notarangelo, L. D., Studer, L., Kobayashi, M., Diogo, L., Fairbrother, W. G., Abel, L., Rosenberg, B. R., Hart, P. J., Etzioni, A. & Casanova, J. L., Feb 22 2018, In : Cell. 172, 5, p. 952-965.e18

Research output: Contribution to journalArticle

Virus Diseases
Brain Stem