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Personal profile

Research Interests

Our laboratory studies the neuroinvasive herpesviruses with a focus on the molecular mechanisms by which these pathogens propagate and disseminate within the nervous system. The outcome of infection is closely tied to the route the viruses spread within the nervous system, and can range from no overt disease to blindness or lethal encephalitis. We use a combination of live-cell fluorescence microscopy, molecular genetics and neuronal cell biology to examine the dynamics of viral particle assembly and intracellular axon transport. These molecular mechanisms are then examined in the larger context of neuroinvasion and pathogenesis. Two long-term goals of our research are to identify novel targets in the viral infectious cycle for development of antivirals, and engineering recombinant viral particles as effective gene delivery vehicles. (Keywords: neuroinvasion, neuron, axon, microtubule, cytoskeleton, dynein, kinesin, transport, virus, virion, herpesvirus, herpes, capsid, tegument, egress, nucleus, GFP, BAC, bacmid, recombination, GS1783)

Training Experience

2001Postdoctoral Fellowship, Princeton University

Education/Academic qualification

PhD, University of Pennsylvania

… → 1996

Research interests

  • Cell Biology
  • Microbiology
  • Microscopy
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience
  • Viral Pathogenesis
  • Virology

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Research Output

  • 4086 Citations
  • 48 Article
  • 6 Review article
  • 2 Chapter
  • 2 Short survey

The pseudorabies virus R2 non-neuroinvasive vaccine: A proof-of-concept study in pigs

Pickard, G. E., Brodersen, B., Sollars, P. J. & Smith, G. A., Jun 15 2020, In : Vaccine. 38, 29, p. 4524-4528 5 p.

Research output: Contribution to journalArticle

Open Access
  • Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

    Lafaille, F. G., Harschnitz, O., Lee, Y. S., Zhang, P., Hasek, M. L., Kerner, G., Itan, Y., Ewaleifoh, O., Rapaport, F., Carlile, T. M., Carter-Timofte, M. E., Paquet, D., Dobbs, K., Zimmer, B., Gao, D., Rojas-Duran, M. F., Kwart, D., Rattina, V., Ciancanelli, M. J., McAlpine, J. L. & 23 others, Lorenzo, L., Boucherit, S., Rozenberg, F., Halwani, R., Henry, B., Amenzoui, N., Alsum, Z., Marques, L., Church, J. A., Al-Muhsen, S., Tardieu, M., Bousfiha, A. A., Paludan, S. R., Mogensen, T. H., Quintana-Murci, L., Tessier-Lavigne, M., Smith, G. A., Notarangelo, L. D., Studer, L., Gilbert, W., Abel, L., Casanova, J. L. & Zhang, S. Y., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1873-1884 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations
  • 1 Scopus citations

    Dissecting the herpesvirus architecture by targeted proteolysis

    Daniel, G. R., Pegg, C. E. & Smith, G. A., Sep 1 2018, In : Journal of virology. 92, 17, e00738-18.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

    Zimmer, B., Ewaleifoh, O., Harschnitz, O., Lee, Y. S., Peneau, C., McAlpine, J. L., Liu, B., Tchieu, J., Steinbeck, J. A., Lafaille, F., Volpi, S., Notarangelo, L. D., Casanova, J. L., Zhang, S. Y., Smith, G. A. & Studer, L., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8775-E8782

    Research output: Contribution to journalArticle

  • 15 Scopus citations