Grants per year
Personal profile
Research Interests
Use molecular/genetic approaches with Drosophila to investigate two areas: 1) Understanding how individual cells control their shapes and coordinate with other cells to create the complex epithelial tubular networks found in multicellular organisms. 2) Understanding how non-neuronal cells sense and respond to elevated levels of CO2 (hypercapnia) such as those present in patients with obstructive disease. Our work has identified conserved genes that mediate hypercapnic suppression of innate immune responses in flies and mammals.
Education/Academic qualification
PhD, Massachusetts Institute of Technology
… → 1994
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Grants
- 24 Finished
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Tube size control by Src and Yorkie/YAP
National Institute of General Medical Sciences
2/1/14 → 1/31/19
Project: Research project
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Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
National Heart, Lung, and Blood Institute
12/15/11 → 11/30/16
Project: Research project
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Research Output
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Hypercapnia suppresses macrophage antiviral activity and increases mortality of influenza a infection via akt1
Casalino-Matsuda, S. M., Chen, F., Gonzalez-Gonzalez, F. J., Nair, A., Dib, S., Yemelyanov, A., Gates, K. L., Budinger, G. R. S., Beitel, G. J. & Sporn, P. H. S., Jul 15 2020, In: Journal of Immunology. 205, 2, p. 489-501 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, , Dec 1 2019, In: Scientific reports. 9, 1, 18251.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
QuBiT: A quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in the Drosophila trachea
Yang, R., Li, E., Kwon, Y. J., Mani, M. & Beitel, G. J., Jun 2019, In: Development (Cambridge). 146, 12, dev172759.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis
McSharry, S. S. & Beitel, G. J., Dec 1 2019, In: Nature communications. 10, 1, 1031.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Design, implementation, and evaluation of a multi-disciplinary professional development program for research mentors
Brace, J. L., Baiduc, R. R., Drane, D. L., Flores, L. C., Beitel, G. J. & Lo, S. M., Aug 8 2018, In: Mentoring and Tutoring: Partnership in Learning. 26, 4, p. 377-399 23 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations