Use molecular/genetic approaches with Drosophila to investigate two areas: 1) Understanding how individual cells control their shapes and coordinate with other cells to create the complex epithelial tubular networks found in multicellular organisms. 2) Understanding how non-neuronal cells sense and respond to elevated levels of CO₂ (hypercapnia) such as those present in patients with obstructive disease.  Our work has identified conserved genes that mediate hypercapnic suppression of innate immune responses in flies and mammals.