Grants per year
Personal profile
Research Interests
Use molecular/genetic approaches with Drosophila to investigate two areas: 1) Understanding how individual cells control their shapes and coordinate with other cells to create the complex epithelial tubular networks found in multicellular organisms. 2) Understanding how non-neuronal cells sense and respond to elevated levels of CO2 (hypercapnia) such as those present in patients with obstructive disease. Our work has identified conserved genes that mediate hypercapnic suppression of innate immune responses in flies and mammals.
Education/Academic qualification
PhD, Massachusetts Institute of Technology
… → 1994
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Drosophila
Medicine & Life Sciences
Hypercapnia
Medicine & Life Sciences
Morphogenesis
Medicine & Life Sciences
Caenorhabditis elegans
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Cell Shape
Medicine & Life Sciences
Intercellular Junctions
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2019
- 24 Finished
Tube size control by Src and Yorkie/YAP
National Institute of General Medical Sciences
2/1/14 → 1/31/19
Project: Research project
Drosophila
Apoptosis
Blood Vessels
Growth
Trachea
Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
National Heart, Lung, and Blood Institute
12/15/11 → 11/30/16
Project: Research project
Hypercapnia
Diptera
Mammals
Drosophila
Genes
Research Output 1986 2019
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, , Dec 1 2019, In : Scientific reports. 9, 1, 18251.Research output: Contribution to journal › Article
Open Access
Wnt Signaling Pathway
Hypercapnia
Caenorhabditis elegans
Drosophila melanogaster
Mammals
1
Citation
(Scopus)
QuBiT: A quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in the Drosophila trachea
Yang, R., Li, E., Kwon, Y. J., Mani, M. & Beitel, G. J., Jun 2019, In : Development (Cambridge). 146, 12, dev172759.Research output: Contribution to journal › Article
Open Access
Trachea
Drosophila
Morphogenesis
Cell Shape
Periodicity
1
Citation
(Scopus)
The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis
McSharry, S. S. & Beitel, G. J., Dec 1 2019, In : Nature communications. 10, 1, 1031.Research output: Contribution to journal › Article
Drosophila
Caspases
Morphogenesis
Caspase 3
apoptosis
1
Citation
(Scopus)
Design, implementation, and evaluation of a multi-disciplinary professional development program for research mentors
Brace, J. L., Baiduc, R. R., Drane, D. L., Flores, L. C., Beitel, G. J. & Lo, S. M., Aug 8 2018, In : Mentoring and Tutoring: Partnership in Learning. 26, 4, p. 377-399 23 p.Research output: Contribution to journal › Article
evaluation
mentoring
student
graduate
mathematics
5
Citations
(Scopus)
Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells
Casalino-Matsuda, S. M., Wang, N., Ruhoff, P. T., Matsuda, H., Nlend, M. C., Nair, A., Szleifer, I., Beitel, G. J., Sznajder, J. I. & Sporn, P. H. S., Dec 1 2018, In : Scientific reports. 8, 1, 13508.Research output: Contribution to journal › Article
Hypercapnia
Nucleosomes
Lipid Metabolism
Epithelial Cells
Genes