Guang-Yu Yang

  • 8584 Citations
1995 …2023

Research output per year

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Personal profile

Research Interests

Surgical Pathology

The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.

Certifications and Licenses

Anatomic Pathology & Clinical Pathology

Training Experience

2004Residency, New York University Medical Center
2005Fellowship, Johns Hopkins Hospital

Education/Academic qualification

PhD, China Medical University

… → 1992

MD, China Medical University

… → 1983

Research interests

  • Cancer Biology
  • Inflammatory Bowel Disease
  • Liver Disease / Pathobiology
  • Pancreatic Disorders
  • Pathology
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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Grants

  • Research Output

    Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 28-37 10 p.

    Research output: Contribution to journalArticle

  • Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 255-269 15 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Mar 2019, In : Gastroenterology. 156, 4, p. 838-842 5 p.

    Research output: Contribution to journalEditorial

    7 Scopus citations
    Open Access
  • Inhibition of mutant Kras and p53-driven pancreatic carcinogenesis by atorvastatin: Mainly via targeting of the farnesylated DNAJA1 in chaperoning mutant p53

    Xu, D., Tong, X., Sun, L., Li, H., Jones, R. D., Liao, J. & Yang, G. Y., Nov 1 2019, In : Molecular Carcinogenesis. 58, 11, p. 2052-2064 13 p.

    Research output: Contribution to journalArticle