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Guang-Yu Yang

  • 8823 Citations
19952020

Research output per year

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Personal profile

Research Interests

Surgical Pathology

The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.

Certifications and Licenses

Anatomic Pathology & Clinical Pathology

Training Experience

2004Residency, New York University Medical Center
2005Fellowship, Johns Hopkins Hospital

Education/Academic qualification

PhD, China Medical University

… → 1992

MD, China Medical University

… → 1983

Research interests

  • Cancer Biology
  • Inflammatory Bowel Disease
  • Liver Disease / Pathobiology
  • Pancreatic Disorders
  • Pathology
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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Grants

Critical role of p53 gene mutation in ulcerative colitis-driving carcinogenesis.

Yang, G.

Digestive Health Foundation

7/1/20 → 6/30/21

Project: Research project

    • Consortium of Eosinophilic Gastrointestinal Disease Researchers

    Yang, G.

    Cincinnati Children's Hospital Medical Center, National Institute of Allergy and Infectious Diseases

    9/17/19 → 8/31/24

    Project: Research project

    • Disordered Tissue Biomechanics as a Driver of Esophageal Disease

    Budinger, G. S., Carlson, D. A., Ciolino, J. D., Espinosa, H. D., Gonsalves, N. P., Hinchcliff, M. E., Hirano, I., Kahrilas, P. J., Pandolfino, J. E., Passman, R. S., Patankar, N. A., Taft, T. N., Tetreault, M. & Yang, G.

    National Institute of Diabetes and Digestive and Kidney Diseases

    7/15/18 → 6/30/23

    Project: Research project

    • MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer

    Kim, D., Larson, A. C., Yang, G. & Zhang, Z.

    National Cancer Institute

    8/1/16 → 7/31/21

    Project: Research project

    • Omega-3 derived epoxy fatty acids and sEH in pancreatitis-induced carcinogenesis

    Jiang, H., Liao, J. & Yang, G.

    National Institute of Diabetes and Digestive and Kidney Diseases

    4/5/16 → 3/31/21

    Project: Research project

    • Research Output

    Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 28-37 10 p.

    Research output: Contribution to journal › Article

    • A phase I trial of berberine in Chinese with ulcerative colitis

    Xu, L., Zhang, Y., Xue, X., Liu, J., Li, Z. S., Yang, G. Y., Song, Y., Pan, Y., Ma, Y., Hu, S., Wen, A., Jia, Y., Rodriguez, L. M., Tull, M. B., Benante, K., Khan, S. A., Cao, Y., Jovanovic, B., Richmond, E., Umar, A. & 2 others, Bergan, R. & Wu, K., Jan 1 2020, In : Cancer Prevention Research. 13, 1, p. 117-126 10 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jun 2020, In : Journal of Allergy and Clinical Immunology. 145, 6, p. 1629-1640.e4

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study

    Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 255-269 15 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Pathology in Patients with Chronic Liver Disease: A Practical Approach to Liver Biopsy Interpretation in Patients with Acute and Chronic Liver Diseases

    Deeken-Draisey, A., Rao, S. M. & Yang, G. Y., 2020, (Accepted/In press) In : Clinics in liver disease.

    Research output: Contribution to journal › Review article