Guang-Yu Yang

  • 8076 Citations
1995 …2023
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Personal profile

Research Interests

Surgical Pathology

The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.

Certifications and Licenses

Anatomic Pathology & Clinical Pathology

Training Experience

2004Residency, New York University Medical Center
2005Fellowship, Johns Hopkins Hospital

Education/Academic qualification

PhD, China Medical University

… → 1992

MD, China Medical University

… → 1983

Keywords

  • Cancer Biology
  • Inflammatory Bowel Disease
  • Liver Disease / Pathobiology
  • Pancreatic Disorders
  • Pathology
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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  • 9 Similar Profiles
Carcinogenesis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Tea Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Eosinophilic Esophagitis Medicine & Life Sciences
Epoxide Hydrolases Medicine & Life Sciences
Ulcerative Colitis Medicine & Life Sciences
Liver Medicine & Life Sciences

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Grants 2005 2023

Pancreatic Neoplasms
Immunotherapy
Dendritic Cells
Vaccines
Magnetic Resonance Imaging
Epoxide Hydrolases
Epoxy Compounds
Pancreatitis
Unsaturated Fatty Acids
Carcinogenesis

Research Output 1995 2019

1 Citation (Scopus)

Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration

Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Mar 1 2019, In : Gastroenterology. 156, 4, p. 838-842 5 p.

Research output: Contribution to journalEditorial

Gastrointestinal Diseases
Research Personnel

Uncommon Intraluminal Tumors of the Gallbladder and Biliary Tract: Spectrum of Imaging Appearances

Chatterjee, A., Lopes Vendrami, C., Nikolaidis, P., Mittal, P. K., Bandy, A. J., Menias, C. O., Hammond, N. A., Yaghmai, V., Yang, G-Y. & Miller, F. H., Mar 1 2019, In : Radiographics : a review publication of the Radiological Society of North America, Inc. 39, 2, p. 388-412 25 p.

Research output: Contribution to journalArticle

Biliary Tract
Gallbladder
Neoplasms
Bile Duct Neoplasms
Adenocarcinoma
9 Citations (Scopus)

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Yang, H., Wang, W., Romano, K. A., Gu, M., Sanidad, K. Z., Kim, D., Yang, J., Schmidt, B., Panigrahy, D., Pei, R., Martin, D. A., Ilker Ozay, E., Wang, Y., Song, M., Bolling, B. W., Xiao, H., Minter, L. M., Yang, G-Y., Liu, Z., Rey, F. E. & 1 othersZhang, G., May 30 2018, In : Science translational medicine. 10, 443, eaan4116.

Research output: Contribution to journalArticle

Triclosan
Colitis
Colon
Carcinogenesis
Inflammation
2 Citations (Scopus)

Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Jul 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 1, p. 130-138.e1

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Histology
Quality of Life
Parents
Pediatrics
2 Citations (Scopus)

Anaplastic thyroid carcinoma: an epidemiologic, histologic, immunohistochemical, and molecular single-institution study

Deeken-Draisey, A., Yang, G-Y., Gao, J. & Alexiev, B. A., Dec 1 2018, In : Human Pathology. 82, p. 140-148 9 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Mutation
Anaplastic Large-Cell Lymphoma
Neoplasms
Small Cell Carcinoma