Grants per year
Personal profile
Research Interests
Surgical Pathology
The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.
Certifications and Licenses
| Anatomic Pathology & Clinical Pathology |
Training Experience
| 2004 | Residency, New York University Medical Center |
| 2005 | Fellowship, Johns Hopkins Hospital |
Education/Academic qualification
PhD, China Medical University
… → 1992
MD, China Medical University
… → 1983
Research interests
- Cancer Biology
- Inflammatory Bowel Disease
- Liver Disease / Pathobiology
- Pancreatic Disorders
- Pathology
- Digestive Cancer (esophagus, stomach, colon, rectum)
Fingerprint Dive into the research topics where Guang-Yu Yang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 8 Similar Profiles
Carcinogenesis
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Tea
Medicine & Life Sciences
Epoxide Hydrolases
Medicine & Life Sciences
Adenocarcinoma
Medicine & Life Sciences
Eosinophilic Esophagitis
Medicine & Life Sciences
Polyphenols
Medicine & Life Sciences
Ulcerative Colitis
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2005 2023
Disordered Tissue Biomechanics as a Driver of Esophageal Disease
Budinger, G. S., Carlson, D. A., Ciolino, J. D., Espinosa, H. D., Gonsalves, N. P., Hinchcliff, M. E., Hirano, I., Kahrilas, P. J., Pandolfino, J. E., Passman, R. S., Patankar, N. A., Taft, T. N., Tetreault, M. & Yang, G.
National Institute of Diabetes, Digestive and Kidney Diseases
7/15/18 → 6/30/23
Project: Research project
Esophageal Diseases
Deglutition Disorders
Biomechanical Phenomena
Esophagus
Mechanical Phenomena
Profiling unique eosinophile-generated eicosanoid metabolites in eosinophilic esophagitis using a liquid chromatography tandem mass spectrometry (LC-MS/MS)-based metabolomics approach
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/18 → 6/30/20
Project: Research project
Eicosanoids
Liquid chromatography
Metabolites
Unsaturated Fatty Acids
Mass spectrometry
MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer
Kim, D., Larson, A. C., Yang, G. & Zhang, Z.
8/1/16 → 7/31/21
Project: Research project
Pancreatic Neoplasms
Immunotherapy
Dendritic Cells
Vaccines
Magnetic Resonance Imaging
Omega-3 derived epoxy fatty acids and sEH in pancreatitis-induced carcinogenesis
Jiang, H., Liao, J. & Yang, G.
National Institute of Diabetes, Digestive and Kidney Diseases
4/5/16 → 3/31/20
Project: Research project
Epoxide Hydrolases
Epoxy Compounds
Pancreatitis
Unsaturated Fatty Acids
Carcinogenesis
Consortium of Eosinophilic Gastrointestinal Disease Researchers
Cincinnati Children's Hospital Medical Center, National Institute of Allergy and Infectious Diseases
8/1/18 → 7/31/19
Project: Research project
Gastrointestinal Diseases
Research Personnel
Pathology
Pediatrics
Biopsy
Research Output 1995 2019
7
Citations
(Scopus)
Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration
Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Mar 2019, In : Gastroenterology. 156, 4, p. 838-842 5 p.Research output: Contribution to journal › Editorial
Gastrointestinal Diseases
Research Personnel
Epoxy-oxylipins and soluble epoxide hydrolase metabolic pathway as targets for NSAID-induced gastroenteropathy and inflammation-associated carcinogenesis
Jones, R. D., Liao, J., Tong, X., Xu, D., Sun, L., Li, H. & Yang, G. Y., Jan 1 2019, In : Frontiers in Pharmacology. 10, JUN, 731.Research output: Contribution to journal › Review article
Open Access
Oxylipins
Epoxide Hydrolases
Metabolic Networks and Pathways
Epoxy Compounds
Carcinogenesis
Inhibition of mutant Kras and p53-driven pancreatic carcinogenesis by atorvastatin: Mainly via targeting of the farnesylated DNAJA1 in chaperoning mutant p53
Xu, D., Tong, X., Sun, L., Li, H., Jones, R. D., Liao, J. & Yang, G. Y., Nov 1 2019, In : Molecular Carcinogenesis. 58, 11, p. 2052-2064 13 p.Research output: Contribution to journal › Article
Carcinogenesis
Farnesyltranstransferase
tipifarnib
Protein Prenylation
Gene Knockdown Techniques
Inhibition of pancreatic carcinoma growth through enhancing ω-3 epoxy polyunsaturated fatty acid profile by inhibition of soluble epoxide hydrolase
Xia, R., Sun, L., Liao, J., Li, H., You, X., Xu, D., Yang, J., Hwang, S. H., Jones, R. D., Hammock, B. & Yang, G-Y., Jan 1 2019, In : Anticancer research. 39, 7, p. 3651-3660 10 p.Research output: Contribution to journal › Article
Epoxide Hydrolases
Unsaturated Fatty Acids
Growth
Epoxy Compounds
Fats
Uncommon intraluminal tumors of the gallbladder and biliary tract: Spectrum of imaging appearances
Chatterjee, A., Vendrami, C. L., Nikolaidis, P., Mittal, P. K., Bandy, A. J., Menias, C. O., Hammond, N. A., Yaghmai, V., Yang, G. Y. & Miller, F. H., Mar 1 2019, In : Radiographics. 39, 2, p. 388-412 25 p.Research output: Contribution to journal › Article
Biliary Tract
Gallbladder
Neoplasms
Bile Duct Neoplasms
Adenocarcinoma