Guang-Yu Yang

  • 8454 Citations
1995 …2023
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Personal profile

Research Interests

Surgical Pathology

The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.

Certifications and Licenses

Anatomic Pathology & Clinical Pathology

Training Experience

2004Residency, New York University Medical Center
2005Fellowship, Johns Hopkins Hospital

Education/Academic qualification

PhD, China Medical University

… → 1992

MD, China Medical University

… → 1983

Research interests

  • Cancer Biology
  • Inflammatory Bowel Disease
  • Liver Disease / Pathobiology
  • Pancreatic Disorders
  • Pathology
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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  • 8 Similar Profiles
Carcinogenesis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Tea Medicine & Life Sciences
Epoxide Hydrolases Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Eosinophilic Esophagitis Medicine & Life Sciences
Polyphenols Medicine & Life Sciences
Ulcerative Colitis Medicine & Life Sciences

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Grants 2005 2023

Pancreatic Neoplasms
Dendritic Cells
Magnetic Resonance Imaging
Epoxide Hydrolases
Epoxy Compounds
Unsaturated Fatty Acids
Gastrointestinal Diseases
Research Personnel

Research Output 1995 2019

7 Citations (Scopus)

Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration

Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), Mar 2019, In : Gastroenterology. 156, 4, p. 838-842 5 p.

Research output: Contribution to journalEditorial

Gastrointestinal Diseases
Research Personnel
Open Access
Epoxide Hydrolases
Metabolic Networks and Pathways
Epoxy Compounds

Inhibition of mutant Kras and p53-driven pancreatic carcinogenesis by atorvastatin: Mainly via targeting of the farnesylated DNAJA1 in chaperoning mutant p53

Xu, D., Tong, X., Sun, L., Li, H., Jones, R. D., Liao, J. & Yang, G. Y., Nov 1 2019, In : Molecular Carcinogenesis. 58, 11, p. 2052-2064 13 p.

Research output: Contribution to journalArticle

Protein Prenylation
Gene Knockdown Techniques

Inhibition of pancreatic carcinoma growth through enhancing ω-3 epoxy polyunsaturated fatty acid profile by inhibition of soluble epoxide hydrolase

Xia, R., Sun, L., Liao, J., Li, H., You, X., Xu, D., Yang, J., Hwang, S. H., Jones, R. D., Hammock, B. & Yang, G-Y., Jan 1 2019, In : Anticancer research. 39, 7, p. 3651-3660 10 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Unsaturated Fatty Acids
Epoxy Compounds

Uncommon intraluminal tumors of the gallbladder and biliary tract: Spectrum of imaging appearances

Chatterjee, A., Vendrami, C. L., Nikolaidis, P., Mittal, P. K., Bandy, A. J., Menias, C. O., Hammond, N. A., Yaghmai, V., Yang, G. Y. & Miller, F. H., Mar 1 2019, In : Radiographics. 39, 2, p. 388-412 25 p.

Research output: Contribution to journalArticle

Biliary Tract
Bile Duct Neoplasms