Grants per year
Personal profile
Research Interests
Surgical Pathology
The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.
Certifications and Licenses
Anatomic Pathology & Clinical Pathology |
Training Experience
2004 | Residency, New York University Medical Center |
2005 | Fellowship, Johns Hopkins Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Molecular Pathology, China Medical University
… → 1992
MD, Medicine, China Medical University
… → 1983
Research interests keywords
- Cancer Biology
- Inflammatory Bowel Disease
- Liver Disease / Pathobiology
- Pancreatic Disorders
- Pathology
- Digestive Cancer (esophagus, stomach, colon, rectum)
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Collaborations and top research areas from the last five years
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Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial
Bonner, L. B., Dulai, P. S., Hanauer, S. B., Hirano, I., Scholtens, D. M., Sumagin, R. & Yang, G.
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/23 → 2/29/28
Project: Research project
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Consortium of Eosinophilic Gastrointestinal Disease Researchers
Cincinnati Children's Hospital Medical Center, National Institute of Allergy and Infectious Diseases
9/17/19 → 8/31/24
Project: Research project
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Neutrophils modulate DNA Damage Repair to promote survival/progression of colorectal cancer
Sumagin, R., Sumagin, R. & Yang, G.
U.S. Army Medical Research and Materiel Command
9/1/20 → 5/31/22
Project: Research project
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Clinical and histopathologic characterization of SETD2-mutated colorectal cancer
Bushara, O., Wester, J. R., Jacobsen, D., Sun, L., Weinberg, S., Gao, J., Jennings, L. J., Wang, L., Lauberth, S. M., Yue, F., Liao, J. & Yang, G. Y., Jan 2023, In: Human pathology. 131, p. 9-16 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis
Hiremath, G., Sun, L., Collins, M. H., Bonis, P. A., Arva, N. C., Capocelli, K. E., Chehade, M., Davis, C. M., Falk, G. W., Gonsalves, N., Gupta, S. K., Hirano, I., Leung, J., Khoury, P., Mukkada, V. A., Martin, L. J., Spergel, J. M., Wechsler, J. B., Yang, G. Y., Aceves, S. S., & 4 others , 2023, (Accepted/In press) In: Clinical Gastroenterology and Hepatology.Research output: Contribution to journal › Article › peer-review
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High-Density IgG4+ Plasma Cells Infiltration Is Associated With Fibroplasia in Fibrostenotic Crohn's Disease
Escobar, D., Bushara, O., Sun, L., Liao, J. & Yang, G. Y., Sep 2023, In: International Journal of Surgical Pathology. 31, 6, p. 1085-1092 8 p.Research output: Contribution to journal › Article › peer-review
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MRI features associated with HCC histologic subtypes: a western American and European bicenter study
Mulé, S., Serhal, A., Pregliasco, A. G., Nguyen, J., Vendrami, C. L., Reizine, E., Yang, G. Y., Calderaro, J., Amaddeo, G., Luciani, A. & Miller, F. H., Feb 2023, In: European Radiology. 33, 2, p. 1342-1352 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Novel histologic score predicts recurrent intestinal metaplasia after successful endoscopic eradication therapy
Triggs, J. R., Krogh, K., Simon, V., Krause, A., Kaplan, J. B., Yang, G. Y., Wani, S., Kahrilas, P. J., Pandolfino, J. & Komanduri, S., Apr 29 2023, In: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 36, 5Research output: Contribution to journal › Article › peer-review