Guifa Xi

  • 272 Citations

Research output per year

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Personal profile

Research Interests

Pediatric gliomas are among the most formidable and devastating cancers in children. Surgery followed by radio- and/or chemotherapy is often ineffective due to chemo- and/or radio-resistance. Our research is focusing on the role of posttranslational histone protein modifications in therapeutic resistance.

Education/Academic qualification

PhD, Huazhong University of Science and Technology

… → 2007

MD, Tongji Medical University, China

… → 2004

Research interests

  • Epigenetics
  • Genetics
  • Nanotechnology
  • Neuro-Oncology
  • Neurosurgery
  • Translational Research

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Research Output

  • 272 Citations
  • 17 Article
  • 2 Review article

Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

Research output: Contribution to journalReview article

Open Access
  • A Phenotypic Switch of Differentiated Glial Cells to Dedifferentiated Cells Is Regulated by Folate Receptor α

    Monick, S., Mohanty, V., Khan, M., Yerneni, G., Kumar, R., Cantu, J., Ichi, S., Xi, G., Singh, B. R., Tomita, T. & Mayanil, C. S., Nov 1 2019, In : Stem Cells. 37, 11, p. 1441-1454 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

    Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

    Xi, G., Li, Y. D., Grahovac, G., Rajaram, V., Wadhwani, N., Pundy, T., Mania-Farnell, B., James, C. D. & Tomita, T., Jan 31 2017, In : Molecular Cancer. 16, 1, 21.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma

    Xi, G., Best, B., Mania-Farnell, B., James, C. D. & Tomita, T., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 261-270 10 p.

    Research output: Contribution to journalReview article

  • 9 Scopus citations