Guifa Xi

  • 252 Citations
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Personal profile

Research Interests

Pediatric gliomas are among the most formidable and devastating cancers in children. Surgery followed by radio- and/or chemotherapy is often ineffective due to chemo- and/or radio-resistance. Our research is focusing on the role of posttranslational histone protein modifications in therapeutic resistance.

Education/Academic qualification

PhD, Huazhong University of Science and Technology

… → 2007

MD, Tongji Medical University, China

… → 2004

Research interests

  • Epigenetics
  • Genetics
  • Nanotechnology
  • Neuro-Oncology
  • Neurosurgery
  • Translational Research

Fingerprint Dive into the research topics where Guifa Xi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Glioma Medicine & Life Sciences
Folic Acid Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Convection Medicine & Life Sciences
Vincristine Medicine & Life Sciences
Rodentia Medicine & Life Sciences
Pediatrics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2019

  • 252 Citations
  • 17 Article
  • 1 Review article

A Phenotypic Switch of Differentiated Glial Cells to Dedifferentiated Cells Is Regulated by Folate Receptor α

Monick, S., Mohanty, V., Khan, M., Yerneni, G., Kumar, R., Cantu, J., Ichi, S., Xi, G., Singh, B. R., Tomita, T. & Mayanil, C. S., Nov 1 2019, In : Stem Cells. 37, 11, p. 1441-1454 14 p.

Research output: Contribution to journalArticle

Open Access
Folic Acid
Chromatin Assembly Factor-1
Small Interfering RNA

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

Open Access
Histone Code
Post Translational Protein Processing
3 Citations (Scopus)

Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

Xi, G., Li, Y. D., Grahovac, G., Rajaram, V., Wadhwani, N., Pundy, T., Mania-Farnell, B., James, C. D. & Tomita, T., Jan 31 2017, In : Molecular Cancer. 16, 1, 21.

Research output: Contribution to journalArticle

Drug Therapy
Phosphatidylinositol 3-Kinases
7 Citations (Scopus)

Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma

Xi, G., Best, B., Mania-Farnell, B., James, C. D. & Tomita, T., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 261-270 10 p.

Research output: Contribution to journalReview article

Bone Morphogenetic Protein 4
Neoplastic Stem Cells
human BMP4 protein
38 Citations (Scopus)

CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro

Xi, G., Hayes, E., Lewis, R., Ichi, S., Mania-Farnell, B., Shim, K., Takao, T., Allender, E., Mayanil, C. S. K. & Tomita, T., Jan 14 2016, In : Oncogene. 35, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Phosphatidylinositol 3-Kinase
Neoplastic Stem Cells