• 6256 Citations
1969 …2024
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Personal profile

Research Interests

William Schnaper received a B.A. in Philosophy from Yale University and his M.D. from University of Maryland, then served as Resident and Chief Resident in Pediatrics at the Mount Sinai Hospital in New York. After two years in the National Health Service Corps he was a Fellow in Pediatric Nephrology at St. Louis Children's Hospital/Washington University, then joined the Faculty there. After 4 years in the extracellular matrix laboratory of Hynda Kleinman at the NIDR, NIH, he joined the Faculty in Pediatrics at Northwestern in 1994.

We study fibrogenic mechanisms of progressive kidney disease. The Hayashida-Schnaper lab group examines cell phenotype control of fibrogenic responses. Structural, metabolic and environmental factors influence whether renal cells respond to specific stimuli with scar generation. In particular, we study how the molecule, Smad Anchor for Receptor Activation (SARA), maintains epithelial phenotype in a way that makes cells resistant to fibrotic stimuli. For more information on the laboratory's activities, see the lab URL at http://www.pediatrics.northwestern.edu/research/labs/schnaper/index.html. My second interest is career development. As Associate Chair, Faculty Development, I support the growth of academic faculty in various activities including Co-director of the Department of Pediatrics Office of Faculty Development, Program Director for the NUCATS Postdoctoral Training Program in Engineering and Pediatrics, and Director of Enrichment Programs for the FSM O'Brien Kidney Research Center.

Dr. Schnaper has studied the clinical manifestations of glomerular disease and the mechanisms by which kidney disease progresses to chronicity and ultimately the need for dialysis and transplantation. A series of events occurs by which (1) the renal response to injury is either inadequate or excessive; (2) a compensatory response by the kidney causes stress to renal structures; (3) adaptive/maladaptive responses occur, altering renal metabolism to cause further stress; and (4) the resulting cycle of injury and misdirected repair leads inexorably to renal failure. For information regarding clinical pediatric nephrology at Lurie Children's Hospital, please see the URL at: https://www.luriechildrens.org/en-us/care-services/specialties-services/kidney-diseases/specialists/Pages/index.aspx

Certifications and Licenses

Pediatric Nephrology

Training Experience

1978Residency, Mt. Sinai Hospital-NY
1982Fellowship, Saint Louis Children's Hospital

Education/Academic qualification

MD, University of Maryland

… → 1975

Research interests

  • Extracellular Matrix
  • Fibrosis
  • Kidney
  • Signal Transduction
  • TGF-beta

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Grants 2002 2024

Research Output 1969 2018

Focal Segmental Glomerulosclerosis

Kopp, JB., Rosenberg, AZ., Weiner, DE. & Schnaper, HW., 2018, Primer on Kidney Diseases. Gilbert, SJ. (ed.). Philadelphia, PA: Elsevier, p. 181-187

Research output: Chapter in Book/Report/Conference proceedingChapter

Clinical Pediatric Nephrology

Kher, KK., Schnaper, HW. & Greenbaum, L., 2017, London: Taylor and Francis Medical Publishers. 1 p.

Research output: Book/ReportBook

1 Citation (Scopus)

Enhancing clinical trial development for pediatric kidney diseases

Schnaper, H. W., Flynn, J. T., Gross, C., Cropp, A. B., Dehmel, B., Patel, L. B., Greenbaum, L. A., Houtsmuller, E., Kaskel, F., Moxey-Mims, M., Nowak, K., Silverstein, D., Thompson, A., Yao, L., Darsey, E. & Smoyer, W. E., Nov 1 2017, In : Pediatric research. 82, 5, p. 727-732 6 p.

Research output: Contribution to journalReview article

Kidney Diseases
Pharmacy and Therapeutics Committee
Clinical Trials
4 Citations (Scopus)

Keeping the customers stratified: moving toward genetics-based treatment options in childhood NS

Roy-Puckelwartz, M. J. & Schnaper, H. W., Apr 1 2017, In : Kidney International. 91, 4, p. 781-783 3 p.

Research output: Contribution to journalComment/debate

Nephrotic Syndrome
Clinical Studies

Physiology of glomerular filtration

Schnaper, HW., 2017, Clinical Pediatric Nephrology. Kher, KK., Schnaper, HW. & Greenbaum, L. (eds.). London: Taylor and Francis, p. 153-163

Research output: Chapter in Book/Report/Conference proceedingChapter