Han-Xiang Deng

  • 13781 Citations
1989 …2021
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Personal profile

Research Interests

Understanding the mechanism of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis.

Education/Academic qualification

MD, PhD, Hunan Medical University, China

… → 1983

Keywords

  • Amyotrophic Lateral Sclerosis
  • Cell Biology
  • Genetics
  • Neurogenetics
  • Neuromuscular Disorders

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  • 12 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Mutation Medicine & Life Sciences
Genes Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Human Chromosomes Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Microdissection Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences

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Grants 2002 2021

Secretory Vesicles
Dementia
Motor Neurons
Carisoprodol
Therapeutics
Parkinson Disease
Chromosomes, Human, Pair 20
Genetic Loci
Neurodegenerative Diseases
Genes
Amyotrophic Lateral Sclerosis
Motor Neurons
Oxidation-Reduction
Clustered Regularly Interspaced Short Palindromic Repeats
Pathology
Chromosomes, Human, Pair 15
Nerve Degeneration
Motor Neuron Disease
Molecular Models
Motor Neurons

Research Output 1989 2019

Parkinsonian Disorders
Parkinson Disease
Genes
8 Citations (Scopus)

A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

Edens, B. M., Yan, J., Miller, N., Deng, H-X., Siddique, T. & Ma, Y., May 2 2017, In : eLife. 6, e25453.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Morphogenesis
Axons
beta Catenin
Wnt Signaling Pathway
4 Citations (Scopus)

Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Zhong, Y., Wang, J., Henderson, M. J., Yang, P., Hagen, B. M., Siddique, T., Vogel, B. E., Deng, H-X. & Fang, S., May 2 2017, In : eLife. 6, e23759.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Cytotoxicity
Protein Sorting Signals
Gene encoding
15 Citations (Scopus)

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

Shi, H., Deng, H-X., Gius, D. R., Schumacker, P. T., Surmeier Jr, D. J. & Ma, Y., May 15 2017, In : Human molecular genetics. 26, 10, p. 1915-1926 12 p.

Research output: Contribution to journalArticle

Sirtuin 3
Dopaminergic Neurons
Oxidative Stress
Superoxide Dismutase
Acetylation
15 Citations (Scopus)
Secretory Vesicles
Parkinson Disease
Autophagy
Proteins
Genes