Han-Xiang Deng

  • 13926 Citations
1989 …2021
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Personal profile

Research Interests

Understanding the mechanism of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis.

Education/Academic qualification

MD, PhD, Hunan Medical University, China

… → 1983

Research interests

  • Amyotrophic Lateral Sclerosis
  • Cell Biology
  • Genetics
  • Neurogenetics
  • Neuromuscular Disorders

Fingerprint Dive into the research topics where Han-Xiang Deng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Mutation Medicine & Life Sciences
Genes Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Human Chromosomes Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Microdissection Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences

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Grants 2002 2021

Secretory Vesicles
Motor Neurons
Parkinson Disease
Chromosomes, Human, Pair 20
Genetic Loci
Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
Chromosomes, Human, Pair 15
Nerve Degeneration
Motor Neuron Disease
Molecular Models
Motor Neurons

Research Output 1989 2019

4 Citations (Scopus)

Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans

Tan, Y. Q., Tu, C., Meng, L., Yuan, S., Sjaarda, C., Luo, A., Du, J., Li, W., Gong, F., Zhong, C., Deng, H-X., Lu, G., Liang, P. & Lin, G., May 1 2019, In : Genetics in Medicine. 21, 5, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Parkinsonian Disorders
Parkinson Disease
9 Citations (Scopus)

A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

Edens, B. M., Yan, J., Miller, N., Deng, H-X., Siddique, T. & Ma, Y., May 2 2017, In : eLife. 6, e25453.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
beta Catenin
Wnt Signaling Pathway
7 Citations (Scopus)

Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Zhong, Y., Wang, J., Henderson, M. J., Yang, P., Hagen, B. M., Siddique, T., Vogel, B. E., Deng, H-X. & Fang, S., May 2 2017, In : eLife. 6, e23759.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Protein Sorting Signals
Gene encoding
17 Citations (Scopus)

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

Shi, H., Deng, H-X., Gius, D. R., Schumacker, P. T., Surmeier Jr, D. J. & Ma, Y., May 15 2017, In : Human molecular genetics. 26, 10, p. 1915-1926 12 p.

Research output: Contribution to journalArticle

Sirtuin 3
Dopaminergic Neurons
Oxidative Stress
Superoxide Dismutase