Grants per year
Personal profile
Research Interests
Understanding the mechanism of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, PhD, Hunan Medical University, China
… → 1983
Research interests keywords
- Amyotrophic Lateral Sclerosis
- Cell Biology
- Genetics
- Neurogenetics
- Neuromuscular Disorders
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mechanisms of Neurodegeneration in KIF5A ALS/FTD
Brent, J. R. (PD/PI) & Deng, H.-X. (Other)
7/1/23 → 6/30/26
Project: Research project
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Mouse model studies of TMEM230-linked Parkinson's disease
Deng, H.-X. (PD/PI), Deng, H.-X. (PD/PI), Siddique, T. (Co-Investigator) & Siddique, T. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
12/1/21 → 11/30/26
Project: Research project
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CRISPR-Cas9 Gene Therapy for ALS Enhanced by TJ-Targeted Barrier Modulation
Kiskinis, E. (PD/PI) & Deng, H.-X. (Co-Investigator)
University of Texas at Dallas, U.S. Army Medical Research and Materiel Command
6/1/21 → 5/31/23
Project: Research project
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Development of a novel therapeutic strategy for treatment of SOD1-linked ALS by CRISPR/Cas9-mediated SOD1 promoter editing
Deng, H.-X. (PD/PI) & Siddique, T. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
7/1/20 → 6/30/24
Project: Research project
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Development of CHCHD2-linked PD mouse models
Deng, H.-X. (PD/PI) & Siddique, T. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
12/1/19 → 11/30/21
Project: Research project
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Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson’s disease models
Gao, G., Shi, Y., Deng, H. X. & Krainc, D., Dec 2025, In: Nature communications. 16, 1, 1982.Research output: Contribution to journal › Article › peer-review
Open Access -
Paving a way to treat spastic paraplegia 50
Brent, J. R. & Deng, H. X., May 1 2023, In: Journal of Clinical Investigation. 133, 10, e170226.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Does Somatic Mosaicism Account for Some Sporadic ALS?
Ryan, É. B. & Deng, H. X., Feb 12 2021, In: Neurology: Genetics. 7, 1, e555.Research output: Contribution to journal › Editorial › peer-review
Open Access2 Scopus citations -
Early death of ALS-linked CHCHD10-R15L transgenic mice with central nervous system, skeletal muscle, and cardiac pathology
Ryan, É. B., Yan, J., Miller, N., Dayanidhi, S., Ma, Y. C., Deng, H. X. & Siddique, T., Feb 19 2021, In: iScience. 24, 2, 102061.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS
Deng, H. X., Zhai, H., Shi, Y., Liu, G., Lowry, J., Liu, B., Ryan, É. B., Yan, J., Yang, Y., Zhang, N., Yang, Z., Liu, E., Ma, Y. C. & Siddique, T., Dec 2021, In: Communications Biology. 4, 1, 396.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations