Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests keywords
- Neurology
- Neuroscience
- Neurosurgery
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Dive into the research topics where Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigation of NU-9 and its impact on upper motor neurons diseased by spatin mutations in HSP
Spastic Paraplegia Foundation, Inc.
12/22/22 → 12/21/24
Project: Research project
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Preclinical Investigation of RNS60 Discovery Compounds in TDP-43A315T mouse model of ALS
10/19/22 → 10/18/24
Project: Research project
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Profiles of Common and Unique aspects of Upper Motor Neuron degeneration in HSP and ALS
National Institute of Neurological Disorders and Stroke
9/1/22 → 8/31/24
Project: Research project
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Identification and Utilization of Upper Motor Neuron Biomarkers for ALS
Ozdinler, H., Kelleher, N. L. & Patrie, S. M.
U.S. Army Medical Research and Materiel Command
9/1/22 → 8/31/24
Project: Research project
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Developing Cell-Based and Mechanism-Focused Preclinical Platforms with Diseased Upper Motor Neurons
U.S. Army Medical Research and Materiel Command
5/1/22 → 4/30/24
Project: Research project
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SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function
Gautam, M., Genç, B., Helmold, B., Ahrens, A., Kuka, J., Makrecka-Kuka, M., Günay, A., Koçak, N., Aguilar-Wickings, I. R., Keefe, D., Zheng, G., Swaminathan, S., Redmon, M., Zariwala, H. A. & Özdinler, P. H., Mar 2023, In: Neurobiology of Disease. 178, 106022.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis
Elmansy, M. F., Reidl, C. T., Rahaman, M., Özdinler, P. H. & Silverman, R. B., 2023, (Accepted/In press) In: Medicinal Research Reviews.Research output: Contribution to journal › Review article › peer-review
Open Access -
2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma
Gautam, M., Carratore, R. D., Helmold, B., Tessa, A., Gozutok, O., Chandel, N., Idrisoglu, H., Bongioanni, P., Battini, R. & Ozdinler, P. H., Feb 2022, In: Metabolites. 12, 2, 174.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy
Gautam, M., Gunay, A., Chandel, N. S. & Ozdinler, P. H., Dec 2022, In: Scientific reports. 12, 1, 4287.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro
Kirsanov, O., Johnson, T., Malachowski, T., Niedenberger, B. A., Gilbert, E. A., Bhowmick, D., Ozdinler, P. H., Gray, D. A., Fisher-Wellman, K., Hermann, B. P. & Geyer, C. B., Nov 2022, In: Development (Cambridge). 149, 22, dev200713.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator), Ozdinler, H. (Contributor) & Weintraub, S. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497.v1, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497/1
Dataset