Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests
- Neurology
- Neuroscience
- Neurosurgery
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Dive into the research topics where Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing Cell-Based and Mechanism-Focused Preclinical Platforms with Diseased Upper Motor Neurons
U.S. Army Medical Research and Materiel Command
5/1/22 → 4/30/24
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Weintraub, S., Allada, R., Bevan, M. D., Caraveo Piso, G., Carvill, G. L., Chan, S., Contractor, A., Disterhoft, J. F., Dombeck, D. A., Dong, H., Ferreira, A. B., Flanagan, M. E., Gefen, T. D., Geula, C., Gratton, C., He, C., Kahnt, T., Kalb, R. G., Kennedy, A., Kessler, J., Kiskinis, E., Klein, W. L., Kozorovitskiy, Y., Krainc, D., Li, L., Mazzulli, J., Mesulam, M., Miller, R. J., Morimoto, R. I., Opal, P., Ozdinler, H., Paller, K., Parisiadou, L., Penzes, P., Pinto, L., Prakriya, M., Reber, P. J., Roberts, A. L., Rogalski, E., Savas, J. N., Surmeier Jr, D. J., Swanson, G. T., Voss, J. L., Zee, P. C. & Zelano, C.
National Institute on Aging, National Institutes of Health
5/1/22 → 4/30/27
Project: Research project
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Directed Gene Delivery to Upper Motor Neurons
Spastic Paraplegia Foundation, Inc.
7/16/20 → 7/15/22
Project: Research project
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SRA: Preclinical Investigation of SBT Discovery Compounds in Upper Motor Neuron Cell Based Model of ALS
8/1/19 → 7/31/23
Project: Research project
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2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma
Gautam, M., Carratore, R. D., Helmold, B., Tessa, A., Gozutok, O., Chandel, N., Idrisoglu, H., Bongioanni, P., Battini, R. & Ozdinler, P. H., Feb 2022, In: Metabolites. 12, 2, 174.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy
Gautam, M., Gunay, A., Chandel, N. S. & Ozdinler, P. H., Dec 2022, In: Scientific reports. 12, 1, 4287.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
Genç, B., Gautam, M., Helmold, B. R., Koçak, N., Günay, A., Goshu, G. M., Silverman, R. B. & Hande Ozdinler, P., Dec 2022, In: Scientific reports. 12, 1, 5383.Research output: Contribution to journal › Article › peer-review
Open Access -
Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons
Genç, B., Jara, J. H., Sanchez, S. S., Lagrimas, A. K. B., Gözütok, Ö., Koçak, N., Zhu, Y. & Hande Özdinler, P., Apr 2022, In: Gene therapy. 29, 3-4, p. 178-192 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Expanded access: opening doors to personalized medicine for rare disease patients and patients with neurodegenerative diseases
Özdinler, P. H., Mar 2021, In: FEBS Journal. 288, 5, p. 1457-1461 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations