Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests keywords
- Neurology
- Neuroscience
- Neurosurgery
Fingerprint
Dive into the research topics where Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Revealing ultrastructural defects in the motor cortex of PLS patients with and without TDP-43 pathology.
Gautam, M. (PD/PI) & Ozdinler, H. (Co-Investigator)
Spastic Paraplegia Foundation, Inc.
7/1/23 → 6/30/25
Project: Research project
-
Investigation of NU-9 and its impact on upper motor neurons diseased by spatin mutations in HSP
Ozdinler, H. (PD/PI)
Spastic Paraplegia Foundation, Inc.
1/1/23 → 12/31/24
Project: Research project
-
Preclinical Investigation of RNS60 Discovery Compounds in TDP-43A315T mouse model of ALS
Gautam, M. (PD/PI) & Ozdinler, H. (Co-PD/PI)
10/19/22 → 10/18/24
Project: Research project
-
Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
-
Developing Cell-Based and Mechanism-Focused Preclinical Platforms with Diseased Upper Motor Neurons
Ozdinler, H. (PD/PI), Ozdinler, H. (PD/PI), Luan, C.-H. (Co-Investigator) & Luan, C.-H. (Co-Investigator)
U.S. Army Medical Research and Materiel Command
5/1/22 → 4/30/25
Project: Research project
-
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
Godoy-Corchuelo, J. M., Ali, Z., Brito Armas, J. M., Martins-Bach, A. B., García-Toledo, I., Fernández-Beltrán, L. C., López-Carbonero, J. I., Bascuñana, P., Spring, S., Jimenez-Coca, I., Muñoz de Bustillo Alfaro, R. A., Sánchez-Barrena, M. J., Nair, R. R., Nieman, B. J., Lerch, J. P., Miller, K. L., Ozdinler, H. P., Fisher, E. M. C., Cunningham, T. J. & Acevedo-Arozena, A. & 1 others, , Apr 2024, In: Neurobiology of Disease. 193, 106437.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology
Genç, B., Nho, B., Seung, H., Helmold, B., Park, H., Gözütok, Ö., Kim, S., Park, J., Ye, S., Lee, H., Lee, N., Yu, S. S., Kim, S., Lee, J. & Özdinler, H., Aug 2023, In: Gene therapy. 30, 7-8, p. 560-574 15 p.Research output: Contribution to journal › Article › peer-review
-
SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function
Gautam, M., Genç, B., Helmold, B., Ahrens, A., Kuka, J., Makrecka-Kuka, M., Günay, A., Koçak, N., Aguilar-Wickings, I. R., Keefe, D., Zheng, G., Swaminathan, S., Redmon, M., Zariwala, H. A. & Özdinler, P. H., Mar 2023, In: Neurobiology of Disease. 178, 106022.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis
Elmansy, M. F., Reidl, C. T., Rahaman, M., Özdinler, P. H. & Silverman, R. B., Nov 2023, In: Medicinal Research Reviews. 43, 6, p. 2260-2302 43 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
TDP-43 protein interactome informs about perturbed canonical pathways and may help develop personalized medicine approaches for patients with TDP-43 pathology
Helmold, B. R., Pauss, K. E. & Ozdinler, P. H., Nov 2023, In: Drug Discovery Today. 28, 11, 103769.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Datasets
-
-
Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator), Özdinler, P. H. (Contributor) & Roos, R. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497
Dataset