Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests keywords
- Neurology
- Neuroscience
- Neurosurgery
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Dive into the research topics where Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigate Munc13 levels and function in the brain and spinal cord of TDP-43A315T mice
Ozdinler, H. (PD/PI)
11/22/24 → 11/22/25
Project: Research project
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Investigations of the protein aggregation inhibitor NU-9 and its derivatives: mode of action and impact on Alzheimer’s disease and related dementias
Klein, W. L. (PD/PI), Ozdinler, H. (PD/PI) & Silverman, R. B. (PD/PI)
9/30/24 → 7/31/29
Project: Research project
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Revealing ultrastructural defects in the motor cortex of PLS patients with and without TDP-43 pathology.
Gautam, M. (PD/PI) & Ozdinler, H. (Co-Investigator)
Spastic Paraplegia Foundation, Inc.
7/1/23 → 6/30/25
Project: Research project
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Investigation of NU-9 and its impact on upper motor neurons diseased by spatin mutations in HSP
Ozdinler, H. (PD/PI) & Ozdinler, H. (PD/PI)
Spastic Paraplegia Foundation, Inc.
1/1/23 → 3/31/26
Project: Research project
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Preclinical Investigation of RNS60 Discovery Compounds in TDP-43A315T mouse model of ALS
Gautam, M. (PD/PI), Gautam, M. (PD/PI), Ozdinler, H. (Co-PD/PI) & Ozdinler, H. (Co-PD/PI)
10/19/22 → 4/25/26
Project: Research project
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High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons
Quintanilla, C. A., Fitzgerald, Z., Kashow, O., Radojicic, M. S., Ulupinar, E., Bitlis, D., Genc, B., Andjus, P., van Drongelen, W. & Ozdinler, P. H., Dec 2025, In: Scientific reports. 15, 1, 732.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum to “TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43” [Neurobiology of disease Volume 193, April 2024, 106437] (Neurobiology of Disease (2024) 193, (S0969996124000366), (10.1016/j.nbd.2024.106437))
Godoy-Corchuelo, J. M., Ali, Z., Brito Armas, J. M., Martins-Bach, A. B., García-Toledo, I., Fernandez-Beltrán, L. C., Lopez-Carbonero, J. I., Bascunana, P., Spring, S., Jimenez-Coca, I., Muñozde Bustillo Alfaro, R. A., Sanchez-Barrena, M. J., Nair, R. R., Nieman, B. J., Lerch, J. P., Miller, K. L., Ozdinler, H. P., Fisher, E. M. C., Cunningham, T. J. & Acevedo-Arozena, A. & 1 others, , Nov 2024, In: Neurobiology of Disease. 202, 106708.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Sleep Apnea and Amyotrophic Lateral Sclerosis: Cause, Correlation, Any Relation?
Ozdinler, P. H., Oct 2024, In: Brain Sciences. 14, 10, 978.Research output: Contribution to journal › Review article › peer-review
Open Access -
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
Godoy-Corchuelo, J. M., Ali, Z., Brito Armas, J. M., Martins-Bach, A. B., García-Toledo, I., Fernández-Beltrán, L. C., López-Carbonero, J. I., Bascuñana, P., Spring, S., Jimenez-Coca, I., Muñoz de Bustillo Alfaro, R. A., Sánchez-Barrena, M. J., Nair, R. R., Nieman, B. J., Lerch, J. P., Miller, K. L., Ozdinler, H. P., Fisher, E. M. C., Cunningham, T. J. & Acevedo-Arozena, A. & 1 others, , Apr 2024, In: Neurobiology of Disease. 193, 106437.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology
Genç, B., Nho, B., Seung, H., Helmold, B., Park, H., Gözütok, Ö., Kim, S., Park, J., Ye, S., Lee, H., Lee, N., Yu, S. S., Kim, S., Lee, J. & Özdinler, H., Aug 2023, In: Gene therapy. 30, 7-8, p. 560-574 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator) & Özdinler, P. H. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497
Dataset