Grants per year
Personal profile
Research Interests
Neisseria gonorrhoeae, gonorrhea, Neisseria meningitidis, pilus, antigenic variation, recombination, DNA transformation, DNA replication, DNA repair, antioxidant functions, reactive oxygen species (ROS), neutrophil interactions. epithelium interactions
Education/Academic qualification
PhD, Molecular Biology, Pennsylvania State University
… → 1983
Research interests keywords
- DNA Recombination
- DNA Repair
- Genetics: Microbial
- Genomics
- Infectious Diseases: Bacteria
- Inflammation
- Microbial Pathogenesis
- Microbiology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating Neisseria gonorrhoeae double-stranded bacteriophage
Seifert, H. S. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/26/24 → 8/31/26
Project: Research project
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A CRISPRi screen of essential genes of Neisseria gonorrhoeae
Seifert, H. S. (PD/PI) & Seifert, H. S. (PD/PI)
National Institute of Allergy and Infectious Diseases
7/21/23 → 6/30/25
Project: Research project
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Mechanisms of Gonococcal Pilin Antigenic and Phase Variation
Seifert, H. S. (PD/PI) & Ozer, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
6/15/23 → 5/31/28
Project: Research project
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Ordered gene knockout libraries for Neisseria gonorrhoeae
Seifert, H. S. (PD/PI), Seifert, H. S. (PD/PI), Seifert, H. S. (PD/PI), Ozer, E. A. (Co-Investigator), Ozer, E. A. (Co-Investigator) & Ozer, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/1/21 → 6/30/25
Project: Research project
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Targeting the functions of the gonococcal Type lV pilus
Seifert, H. S. (PD/PI), Seifert, H. S. (PD/PI), Seifert, H. S. (PD/PI), Ozer, E. A. (Co-Investigator), Ozer, E. A. (Co-Investigator), Ozer, E. A. (Co-Investigator), Hu, L.I.-L. (Other), Hu, L.I.-L. (Other) & Hu, L.I.-L. (Other)
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains
Rosas-Lemus, M., Minasov, G., Brunzelle, J. S., Taha, T. Y., Lemak, S., Yin, S., Shuvalova, L., Rosecrans, J., Khanna, K., Seifert, H. S., Savchenko, A., Stogios, P. J., Ott, M. & Satchell, K. J. F., Mar 2025, In: Protein Science. 34, 3, e70050.Research output: Contribution to journal › Article › peer-review
Open Access -
The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron
Hu, L. I., Stohl, E. A. & Seifert, H. S., Jun 2022, In: PLoS pathogens. 18, 6, e1010561.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Challenges and controversies concerning neisseria gonorrhoeae-neutrophil interactions in pathogenesis
Criss, A. K., Genco, C. A., Gray-Owen, S. D., Jerse, A. E. & Seifert, H. S., 2021, In: mBio. 12, 3, e00721-21.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Altering the Neisseria gonorrhoeae pilE Guanine Quadruplex Loop Bases Affects Pilin Antigenic Variation
Prister, L. L., Yin, S., Cahoon, L. A. & Seifert, H. S., Mar 17 2020, In: Biochemistry. 59, 10, p. 1104-1112 9 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Discovery of a new neisseria gonorrhoeae type iv pilus assembly factor, tfpc
Hu, L. I., Yin, S., Ozer, E. A., Sewell, L., Rehman, S., Garnett, J. A. & Seifert, H. S., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e02528-20.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
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Dimeric pil-e g-quadruplex dna from neisseria gonorrhoeae, NMR 11 structures
Kuryavyi, V. (Contributor), Cahoon, L. A. (Contributor), Seifert, H. S. (Contributor) & Patel, D. J. (Contributor), Protein Data Bank (PDB), Nov 28 2012
DOI: 10.2210/pdb2LXV/pdb, https://www.wwpdb.org/pdb?id=pdb_00002lxv
Dataset
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Monomeric PilE G-Quadruplex DNA from Neisseria Gonorrhoeae
Kuryavyi, V. (Contributor), Cahoon, L. A. (Contributor), Seifert, H. S. (Contributor) & Patel, D. J. (Contributor), Protein Data Bank (PDB), Nov 28 2012
DOI: 10.2210/pdb2LXQ/pdb, https://www.wwpdb.org/pdb?id=pdb_00002lxq
Dataset