• 1621 Citations
1986 …2019
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Personal profile

Research Interests

After my PhD studies at the University of Freiburg, Germany, and postdoctoral training at Harvard I gained research experiences in academic and industrial settings. As a developmental biologist, at Northwestern, I investigate the reactivation of developmental programs as a mechanism to restore damaged or missing tissues and/or organs. At the Stanley Manne Children’s Research Institute I have built the Pre- and Postdoctoral Research Training Program to inspire and educate the next generation scientists.

Building And Re-Building Of Limbs And Hearts. The Simon laboratory has identified regulatory genes that play key roles in limb development in virtually all vertebrates, including humans. Surprisingly, these genes are also critical for the shaping of the heart during embryogenesis and when mutated in humans, they lead to birth defects of the arms and heart. Using zebrafish, chicken, and mouse models, the lab tries to gain a deeper understanding of common genetic pathways in limb and heart development and disease. In addition to these developmental studies, the lab is interested in discovering the genes that are involved in regenerative processes. As models for these investigations, zebrafish and newts are employed, which can regenerate limbs and heart ventricles throughout their life times. The identification of genetic pathways that are operational in these regenerating species, but not in mammals, provides new insights how to restore regenerative abilities in non-regenerating species including humans.

Education/Academic qualification

PhD, University of Freiburg

… → 1988

Research interests

  • Cell Biology
  • Congenital Heart Disease
  • Cytoskeleton
  • Developmental Biology
  • Extracellular Matrix
  • Regenerative Medicine
  • Stem Cells
  • Blood and Bleeding Disorders (anemia, clotting, etc.)

Fingerprint Dive into the research topics where Hans-Georg Simon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Salamandridae Medicine & Life Sciences
Regeneration Medicine & Life Sciences
Extremities Medicine & Life Sciences
Serine Proteases Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Amphibians Medicine & Life Sciences
Forelimb Medicine & Life Sciences
Genes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2006 2016

Research Output 1986 2019

Afadin cooperates with claudin-2 to promote breast cancer metastasis

Tabariès, S., McNulty, A., Ouellet, V., Annis, M. G., Dessureault, M., Vinette, M., Hachem, Y., Lavoie, B., Omeroglu, A., Simon, H-G., Walsh, L. A., Kimbung, S., Hedenfalk, I. & Siegel, P. M., Feb 1 2019, In : Genes and Development. 33, 3-4, p. 180-193 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Liver Neoplasms
2 Citations (Scopus)

Proteomic characterization of epicardialmyocardial signaling reveals novel regulatory networks including a role for NF-κB in epicardial EMT

Li, Y., Urban, A., Midura, D., Simon, H-G. & Wang, Q. T., Mar 1 2017, In : PLoS One. 12, 3, e0174563.

Research output: Contribution to journalArticle

Computational Biology

Putting cells into context

Stricker, S., Knaus, P. & Simon, H-G., Apr 5 2017, In : Frontiers in Cell and Developmental Biology. 5, APR, 38.

Research output: Contribution to journalComment/debate

Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation

Dettman, RW. & Simon, HG., Aug 8 2017, In : Dev Dyn. doi: 10.1002/dvdy.24560., Epub ahead of print

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
4 Citations (Scopus)

Pdlim7 regulates Arf6-dependent actin dynamics and is required for platelet-mediated thrombosis in mice

Urban, A. E., Quick, E. O., Miller, K. P., Krcmery, J. & Simon, H-G., Oct 1 2016, In : PloS one. 11, 10, e0164042.

Research output: Contribution to journalArticle