Hariharan Subramanian

  • 1084 Citations
20052019

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2019

Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm

Gladstein, S., Almassalha, L. M., Cherkezyan, L., Chandler, J. E., Eshein, A., Eid, A., Zhang, D., Wu, W., Bauer, G. M., Stephens, A. D., Morochnik, S., Subramanian, H., Marko, J. F., Ameer, G. A., Szleifer, I. & Backman, V., Dec 1 2019, In : Nature communications. 10, 1, 1652.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology

Zhou, X., Gladstein, S., Almassalha, L. M., Li, Y., Eshein, A., Cherkezyan, L., Viswanathan, P., Subramanian, H., Szleifer, I. & Backman, V., Jan 1 2019, In : PloS one. 14, 7, e0219006.

Research output: Contribution to journalArticle

Open Access
2018

Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study

Kalman, R., Stawarz, A., Nunes, D., Zhang, D., Dela Cruz, M. A., Mohanty, A., Subramanian, H., Backman, V. & Roy, H. K., May 2018, In : PloS one. 13, 5, e0197427.

Research output: Contribution to journalArticle

Correlating colorectal cancer risk with field carcinogenesis progression using partial wave spectroscopic microscopy

Gladstein, S., Damania, D., Almassalha, L. M., Smith, L. T., Gupta, V., Subramanian, H., Rex, D. K., Roy, H. K. & Backman, V., May 2018, In : Cancer medicine. 7, 5, p. 2109-2120 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Label free localization of nanoparticles in live cancer cells using spectroscopic microscopy

Spicer, G. L. C., Almassalha, L., Martinez, I. A., Ellis, R., Chandler, J. E., Gladstein, S., Zhang, D., Nguyen, T. Q., Feder, S., Subramanian, H., De La Rica, R., Thompson, S. A. & Backman, V., Oct 28 2018, In : Nanoscale. 10, 40, p. 19125-19130 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Colocalization of cellular nanostructure using confocal fluorescence and partial wave spectroscopy

Chandler, J. E., Stypula-Cyrus, Y., Almassalha, L., Bauer, G., Bowen, L., Subramanian, H., Szleifer, I. & Backman, V., Mar 1 2017, In : Journal of Biophotonics. 10, 3, p. 377-384 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Measuring the Autocorrelation Function of Nanoscale Three-Dimensional Density Distribution in Individual Cells Using Scanning Transmission Electron Microscopy, Atomic Force Microscopy, and a New Deconvolution Algorithm

Li, Y., Zhang, D., Capoglu, I., Hujsak, K. A., Damania, D., Cherkezyan, L., Roth, E., Bleher, R., Wu, J. S., Subramanian, H., Dravid, V. P. & Backman, V., Jun 1 2017, In : Microscopy and Microanalysis. 23, 3, p. 661-667 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Reflection statistics of weakly disordered optical medium when its mean refractive index is different from an outside medium

Pradhan, P., John Park, D., Capoglu, I., Subramanian, H., Damania, D., Cherkezyan, L., Taflove, A. & Backman, V., Jun 15 2017, In : Optics Communications. 393, p. 185-190 6 p.

Research output: Contribution to journalArticle

The effects of chemical fixation on the cellular nanostructure

Li, Y., Almassalha, L. M., Chandler, J. E., Zhou, X., Stypula-Cyrus, Y. E., Hujsak, K. A., Roth, E. W., Bleher, R., Subramanian, H., Szleifer, I., Dravid, V. P. & Backman, V., Sep 15 2017, In : Experimental Cell Research. 358, 2, p. 253-259 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The global relationship between chromatin physical topology, fractal structure, and gene expression

Almassalha, L. M., Tiwari, A., Ruhoff, P. T., Stypula-Cyrus, Y., Cherkezyan, L., Matsuda, H., Dela Cruz, M. A., Chandler, J. E., White, C., Maneval, C., Subramanian, H., Szleifer, I., Roy, H. K. & Backman, V., Jan 24 2017, In : Scientific reports. 7, 41061.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Automated Cell Selection Using Support Vector Machine for Application to Spectral Nanocytology

Miao, Q., Derbas, J., Eid, A., Subramanian, H. & Backman, V., Jan 1 2016, In : BioMed Research International. 2016, 6090912.

Research output: Contribution to journalArticle

3 Scopus citations

Finite-difference time-domain-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques

Zhang, D., Capoglu, I., Li, Y., Cherkezyan, L., Chandler, J., Spicer, G., Subramanian, H., Taflove, A. & Backman, V., Jun 1 2016, In : Journal of Biomedical Optics. 21, 6, 065004.

Research output: Contribution to journalArticle

5 Scopus citations

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy

Almassalha, L. M., Bauer, G. M., Chandler, J. E., Gladstein, S., Cherkezyan, L., Stypula-Cyrus, Y., Weinberg, S., Zhang, D., Ruhoff, P. T., Roy, H. K., Subramanian, H., Chandel, N. S., Szleifer, I. & Backman, V., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6372-E6381

Research output: Contribution to journalArticle

30 Scopus citations

Nanoscale refractive index fluctuations detected via sparse spectral microscopy

Chandler, J. E., Cherkezyan, L., Subramanian, H. & Backman, V., Feb 19 2016, In : Biomedical Optics Express. 7, 3, p. 883-893 11 p., 252091.

Research output: Contribution to journalArticle

6 Scopus citations

Procedures for risk-stratification of lung cancer using Buccal Nanocytology

Subramanian, H., Viswanathan, P., Cherkezyan, L., Iyengar, R., Rozhok, S., Verleye, M., Derbas, J., Czarnecki, J., Roy, H. K. & Backman, V., Sep 1 2016, In : Biomedical Optics Express. 7, 9, p. 3795-3810 16 p., #268778.

Research output: Contribution to journalArticle

4 Scopus citations

Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy

Cherkezyan, L., Zhang, D., Subramanian, H., Taflove, A. & Backman, V., Feb 1 2016, In : Journal of Biomedical Optics. 21, 2, 025007.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Nanocytological field carcinogenesis detection to mitigate overdiagnosis of prostate cancer: A proof of concept study

Roy, H. K., Brendler, C. B., Subramanian, H., Zhang, D., Maneval, C., Chandler, J., Bowen, L., Kaul, K. L., Helfand, B. T., Wang, C. H., Quinn, M., Petkewicz, J., Paterakos, M. & Backman, V., Feb 23 2015, In : PloS one. 10, 2, e0115999.

Research output: Contribution to journalArticle

20 Scopus citations

Spectroscopic microscopy can quantify the statistics of subdiffractional refractive-index fluctuations in media with random rough surfaces

Zhang, D., Cherkezyan, L., Capoglu, I., Subramanian, H., Chandler, J., Thompson, S., Taflove, A. & Backman, V., Nov 1 2015, In : Optics Letters. 40, 21, p. 4931-4934 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: A transmission electron microscopy study

Cherkezyan, L., Stypula-Cyrus, Y., Subramanian, H., White, C., Dela Cruz, M., Wali, R. K., Goldberg, M. J., Bianchi, L. K., Roy, H. K. & Backman, V., Mar 14 2014, In : BMC cancer. 14, 1, 189.

Research output: Contribution to journalArticle

51 Scopus citations

Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer

Damania, D., Subramanian, H., Backman, V., Anderson, E. C., Wong, M. H., McCarty, O. J. T. & Phillips, K. G., Jan 1 2014, In : Journal of Biomedical Optics. 19, 1, 016016.

Research output: Contribution to journalArticle

15 Scopus citations

What structural length scales can be detected by the spectral variance of a microscope image?

Cherkezyan, L., Subramanian, H. & Backman, V., Aug 1 2014, In : Optics Letters. 39, 15, p. 4290-4293 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

93 Scopus citations

HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin Structure

Stypula-Cyrus, Y., Damania, D., Kunte, D. P., Cruz, M. D., Subramanian, H., Roy, H. K. & Backman, V., May 28 2013, In : PloS one. 8, 5, e64600.

Research output: Contribution to journalArticle

75 Scopus citations

High-speed spectral nanocytology for early cancer screening

Chandler, J. E., Subramanian, H., Maneval, C. D., White, C. A., Levenson, R. M. & Backman, V., Nov 1 2013, In : Journal of Biomedical Optics. 18, 11, 117002.

Research output: Contribution to journalArticle

12 Scopus citations

Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells

Damania, D., Roy, H. K., Kunte, D., Hurteau, J. A., Subramanian, H., Cherkezyan, L., Krosnjar, N., Shah, M. & Backman, V., Sep 1 2013, In : International Journal of Cancer. 133, 5, p. 1143-1152 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Interferometric spectroscopy of scattered light can quantify the statistics of subdiffractional refractive-index fluctuations

Cherkezyan, L., Capoglu, I., Subramanian, H., Rogers, J. D., Damania, D., Taflove, A. & Backman, V., Jul 19 2013, In : Physical review letters. 111, 3, 033903.

Research output: Contribution to journalArticle

44 Scopus citations

Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: Potential for screening

Roy, H. K., Damania, D. P., DelaCruz, M., Kunte, D. P., Subramanian, H., Crawford, S. E., Tiwari, A. K., Wali, R. K. & Backman, V., Oct 1 2013, In : Cancer Prevention Research. 6, 10, p. 1111-1119 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nanoscale markers of esophageal field carcinogenesis: Potential implications for esophageal cancer screening

Konda, V. J. A., Cherkezyan, L., Subramanian, H., Wroblewski, K., Damania, D., Becker, V., Gonzalez, M. H. R., Koons, A., Goldberg, M., Ferguson, M. K., Waxman, I., Roy, H. K. & Backman, V., Dec 9 2013, In : Endoscopy. 45, 12, p. 983-988 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization

Damania, D., Roy, H. K., Subramanian, H., Weinberg, D. S., Rex, D. K., Goldberg, M. J., Muldoon, J., Cherkezyan, L., Zhu, Y., Bianchi, L. K., Shah, D., Pradhan, P., Borkar, M., Lynch, H. & Backman, V., Jun 1 2012, In : Cancer Research. 72, 11, p. 2720-2727 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Targeted alteration of real and imaginary refractive index of biological cells by histological staining

Cherkezyan, L., Subramanian, H., Stoyneva, V., Rogers, J. D., Yang, S., Damania, D., Taflove, A. & Backman, V., May 15 2012, In : Optics Letters. 37, 10, p. 1601-1603 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Visualizing Native Cell Nano-architecture During Early Carcinogenesis Using Scanning Transmission Electron Microscopy

Damania, D., Bleher, R., Wu, J., Rogers, J. D., Subramanian, H., Dravid, V., Backman, V. & Roy, H. K., Jan 1 2012, In : Microscopy and Microanalysis. 18, p. 1642-1643 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011

Numerical simulation of partially coherent broadband optical imaging using the finite-difference time-domain method

Çapoglu, I. R., White, C. A., Rogers, J. D., Subramanian, H., Taflove, A. & Backman, V., May 1 2011, In : Optics Letters. 36, 9, p. 1596-1598 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantification of nanoscale density fluctuations by electron microscopy: Probing cellular alterations in early carcinogenesis

Pradhan, P., Damania, D., Joshi, H. M., Turzhitsky, V., Subramanian, H., Roy, H. K., Taflove, A., Dravid, V. P. & Backman, V., Apr 2011, In : Physical Biology. 8, 2, 026012.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: Implications for screening

Roy, H. K., Subramanian, H., Damania, D., Hensing, T. A., Rom, W. N., Pass, H. I., Ray, D., Rogers, J. D., Bogojevic, A., Shah, M., Kuzniar, T., Pradhan, P. & Backman, V., Oct 15 2010, In : Cancer Research. 70, 20, p. 7748-7754 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells

Pradhan, P., Damania, D., Joshi, H. M., Turzhitsky, V., Subramanian, H., Roy, H. K., Taflove, A., Dravid, V. P. & Backman, V., Dec 13 2010, In : Applied Physics Letters. 97, 24, 243704.

Research output: Contribution to journalArticle

12 Scopus citations

Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture

Damania, D., Subramanian, H., Tiwari, A. K., Stypula, Y., Kunte, D., Pradhan, P., Roy, H. K. & Backman, V., Aug 4 2010, In : Biophysical Journal. 99, 3, p. 989-996 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2009

Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy

Subramanian, H., Roy, H. K., Pradhan, P., Goldberg, M. J., Muldoon, J., Brand, R. E., Sturgis, C., Hensing, T., Ray, D., Bogojevic, A., Mohammed, J., Chang, J. S. & Backman, V., Jul 1 2009, In : Cancer Research. 69, 13, p. 5357-5363 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: An application to cancer diagnosis

Subramanian, H., Pradhan, P., Liu, Y., Capoglu, I. R., Rogers, J. D., Roy, H. K., Brand, R. E. & Backman, V., Feb 15 2009, In : Optics Letters. 34, 4, p. 518-520 3 p.

Research output: Contribution to journalArticle

71 Scopus citations
2008

Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells

Subramanian, H., Pradhan, P., Liu, Y., Capoglu, I. R., Li, X., Rogers, J. D., Heifetz, A., Kunte, D., Roy, H. K., Taflove, A. & Backman, V., Dec 23 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 51, p. 20118-20123 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
2007
12 Scopus citations
2006

Low-coherence enhanced backscattering: Review of principles and applications for colon cancer screening

Kim, Y. L., Turzhitsky, V. M., Liu, Y., Roy, H. K., Wali, R. K., Subramanian, H., Pradhan, P. & Backman, V., Jul 1 2006, In : Journal of Biomedical Optics. 11, 4, 041125.

Research output: Contribution to journalArticle

39 Scopus citations

Modeling low-coherence enhanced backscattering using Monte Carlo simulation

Subramanian, H., Pradhan, P., Kim, Y. L., Liu, Y., Li, X. & Backman, V., Aug 20 2006, In : Applied optics. 45, 24, p. 6292-6300 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Origin of low-coherence enhanced backscattering

Kim, Y. L., Pradhan, P., Subramanian, H., Liu, Y., Kim, M. H. & Backman, V., May 15 2006, In : Optics Letters. 31, 10, p. 1459-1461 3 p.

Research output: Contribution to journalArticle

18 Scopus citations
2005

An autocorrelation-based time domain analysis technique for monitoring perfusion and oxygenation in transplanted organs

Subramanian, H., Ibey, B. L., Xu, W., Wilson, M. A., Ericson, M. N. & Coté, G. L., Jul 1 2005, In : IEEE Transactions on Biomedical Engineering. 52, 7, p. 1355-1358 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Real-time separation of perfusion and oxygenation signals for an implantable sensor using adaptive filtering

Subramanian, H., Ibey, B. L., Xu, W., Wilson, M. A., Ericson, M. N. & Coté, G. L., Dec 1 2005, In : IEEE Transactions on Biomedical Engineering. 52, 12, p. 2016-2023 8 p.

Research output: Contribution to journalArticle

12 Scopus citations