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Research Output 1994 2019

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2019
30 Citations (Scopus)

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Jan 1 2019, In : Nature Immunology.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Joints
RNA Sequence Analysis
HLA-DR alpha-Chains
Monocytes
1 Citation (Scopus)

Influenza A virus infection induces muscle wasting via IL-6 regulation of the E3 ubiquitin ligase atrogin-1

Radigan, K. A., Nicholson, T. T., Welch, L. C., Chi, M., Amarelle, L., Angulo, M., Shigemura, M., Shigemura, A., Runyan, C. E., Morales-Nebreda, L., Perlman, H., Ceco, E., Lecuona, E., Dada, L. A., Misharin, A. V., Mutlu, G. M., Sznajder, J. I. & Scott Budinger, G. R., Jan 15 2019, In : Journal of Immunology. 202, 2, p. 484-493 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Influenza A virus
Virus Diseases
Interleukin-6
Human Influenza
Open Access
Choroidal Neovascularization
Receptors, Adrenergic, beta
Propranolol
Macrophages
Lasers

Oligoclonal immunoglobulin repertoire in biliary remnants of biliary atresia

Taylor, S. A., Malladi, P., Pan, X., Wechsler, J. B., Hulse, K. E., Perlman, H. R. & Whitington, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 4508.

Research output: Contribution to journalArticle

Open Access
Oligoclonal Bands
Biliary Atresia
Immunoglobulins
Liver Diseases
B-Lymphocytes
35 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
2018
11 Citations (Scopus)

Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus

Chalmers, S. A., Wen, J., Doerner, J., Stock, A., Cuda, C. M., Makinde, H. M., Perlman, H. R., Bosanac, T., Webb, D., Nabozny, G., Fine, J. S., Klein, E., Ramanujam, M. & Putterman, C., Jan 25 2018, In : Arthritis Research and Therapy. 20, 1, 10.

Research output: Contribution to journalArticle

Brain Diseases
Skin Diseases
Systemic Lupus Erythematosus
Skin
B-Lymphocytes
13 Citations (Scopus)

Inflammatory monocytes drive influenza A virus-mediated lung injury in juvenile mice

Coates, B. M., Staricha, K. L., Koch, C. M., Cheng, Y., Shumaker, D. K., Budinger, G. R. S., Perlman, H., Misharin, A. V. & Ridge, K. M., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2391-2404 14 p.

Research output: Contribution to journalArticle

Influenza A virus
Lung Injury
Human Influenza
Monocytes
Inflammasomes
5 Citations (Scopus)

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

Metformin
Air Pollution
Electron Transport
Particulate Matter
Alveolar Macrophages
17 Citations (Scopus)

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

Accelerating Medicines Partnership RA/SLE Network, Jul 11 2018, In : Arthritis Research and Therapy. 20, 1, 139.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Transcriptome
Phenotype
Rheumatoid Arthritis
Synovial Membrane
15 Citations (Scopus)

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

Mandelin, A. M., Homan, P. J., Shaffer, A. M., Cuda, C. M., Dominguez, S. T., Bacalao, E., Carns, M., Hinchcliff, M., Lee, J., Aren, K., Thakrar, A., Montgomery, A. B., Bridges, S. L., Bathon, J. M., Atkinson, J. P., Fox, D. A., Matteson, E. L., Buckley, C. D., Pitzalis, C., Parks, D. & 16 others, Hughes, L. B., Geraldino-Pardilla, L., Ike, R., Phillips, K., Wright, K., Filer, A., Kelly, S., Ruderman, E. M., Morgan, V., Abdala-Valencia, H., Misharin, A. V., Budinger, G. S., Bartom, E. T., Pope, R. M., Perlman, H. & Winter, D. R., Jun 2018, In : Arthritis and Rheumatology. 70, 6, p. 841-854 14 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Macrophages
Biopsy
RNA Sequence Analysis
Osteoarthritis
2017
2 Citations (Scopus)

Association of Increased F4/80high Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells

Huang, Q. Q., Birkett, R., Doyle, R. E., Haines, G. K., Perlman, H., Shi, B., Homan, P., Xing, L. & Pope, R. M., Sep 2017, In : Arthritis and Rheumatology. 69, 9, p. 1762-1771 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Arthritis
Macrophages
Serum
Rheumatoid Arthritis
3 Citations (Scopus)

Bim suppresses the development of SLE by limiting myeloid inflammatory responses

Tsai, F. N., Homan, P. J., Agrawal, H., Misharin, A. V., Abdala-Valencia, H., Haines, G. K., Dominguez, S., Bloomfield, C. L., Saber, R., Chang, A., Mohan, C., Hutcheson, J., Davidson, A., Scott Budinger, G. R., Bouillet, P., Dorfleutner, A., Stehlik, C., Winter, D. R., Cuda, C. M. & Perlman, H., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3753-3773 21 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Macrophages
Glomerulonephritis
Kidney
Interferon Type I
15 Citations (Scopus)

Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction

Zheng, Z., Chiu, S., Akbarpour, M., Sun, H., Reyfman, P. A., Anekalla, K. R., Abdala-Valencia, H., Edgren, D., Li, W., Kreisel, D., Korobova, F. V., Fernandez, R., Mcquattie-Pimentel, A., Zhang, Z. J., Perlman, H., Misharin, A. V., Budinger, G. R. S. & Bharat, A., Jun 14 2017, In : Science translational medicine. 9, 394, 4508.

Research output: Contribution to journalArticle

Allografts
Monocytes
Neutrophils
Lung
Primary Graft Dysfunction
14 Citations (Scopus)

Effect of Granulocyte-Macrophage Colony-Stimulating Factor with or Without Supervised Exercise on Walking Performance in Patients with Peripheral Artery Disease: The PROPEL Randomized Clinical Trial

McDermott, M. M., Ferrucci, L., Tian, L., Guralnik, J. M., Lloyd-Jones, D., Kibbe, M. R., Polonsky, T. S., Domanchuk, K., Stein, J. H., Zhao, L., Taylor, D., Skelly, C., Pearce, W., Perlman, H., McCarthy, W., Li, L., Gao, Y., Sufit, R., Bloomfield, C. L. & Criqui, M. H., Dec 5 2017, In : JAMA - Journal of the American Medical Association. 318, 21, p. 2089-2098 10 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Granulocyte-Macrophage Colony-Stimulating Factor
Walking
Randomized Controlled Trials
Exercise
7 Citations (Scopus)

FXYD5 is an essential mediator of the inflammatory response during lung injury

Brazee, P. L., Soni, P. N., Tokhtaeva, E., Magnani, N., Yemelyanov, A., Perlman, H. R., Ridge, K. M., Sznajder, J. I., Vagin, O. & Dada, L., Jun 1 2017, In : Frontiers in immunology. 8, JUN, 623.

Research output: Contribution to journalArticle

Lung Injury
Lipopolysaccharides
CC Chemokines
Cytokines
Ligands
9 Citations (Scopus)

Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

MacLauchlan, S., Zuriaga, M. A., Fuster, J. J., Cuda, C. M., Jonason, J., Behzadi, F., Duffen, J. P., Haines, G. K., Aprahamian, T., Perlman, H. & Walsh, K., Jul 19 2017, In : Arthritis Research and Therapy. 19, 1, 166.

Research output: Contribution to journalArticle

Arthritis
Osteoclasts
Rheumatoid Arthritis
Knockout Mice
Joints
148 Citations (Scopus)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Fibrosis
Macrophages
Lung
Monocytes
24 Citations (Scopus)

Nonclassical monocytes mediate secondary injury, neurocognitive outcome, and neutrophil infiltration after traumatic brain injury

Makinde, H. M., Cuda, C. M., Just, T. B., Perlman, H. R. & Schwulst, S. J., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3583-3591 9 p.

Research output: Contribution to journalArticle

Neutrophil Infiltration
Monocytes
Wounds and Injuries
Brain
Traumatic Brain Injury
9 Citations (Scopus)

Temporal expression of Bim limits the development of agonist-selected thymocytes and skews their TCRβ repertoire

Li, K. P., Fähnrich, A., Roy, E., Cuda, C. M., Grimes, H. L., Perlman, H. R., Kalies, K. & Hildeman, D. A., Jan 1 2017, In : Journal of Immunology. 198, 1, p. 257-269 13 p.

Research output: Contribution to journalArticle

Thymocytes
Interleukin-15
Homeostasis
Lymphocytes
Adoptive Transfer
3 Citations (Scopus)

The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis

Tsai, F. N., Perlman, H. R. & Cuda, C. M., Dec 1 2017, In : Clinical Immunology. 185, p. 74-85 12 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Systemic Lupus Erythematosus
Cell Death
Dendritic Cells
Macrophages
12 Citations (Scopus)

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

Ratsimandresy, R. A., Chu, L. H., Khare, S., De Almeida, L., Gangopadhyay, A., Indramohan, M., Misharin, A. V., Greaves, D. R., Perlman, H., Dorfleutner, A. & Stehlik, C., Jun 5 2017, In : Nature communications. 8, 15556.

Research output: Contribution to journalArticle

Inflammasomes
priming
Caspase 1
Chemical activation
activation
27 Citations (Scopus)

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

Ross, E. A., Naylor, A. J., O'Neil, J. D., Crowley, T., Ridley, M. L., Crowe, J., Smallie, T., Tang, T. J., Turner, J. D., Norling, L. V., Dominguez, S., Perlman, H. R., Verrills, N. M., Kollias, G., Vitek, M. P., Filer, A., Buckley, C. D., Dean, J. L. & Clark, A. R., Mar 1 2017, In : Annals of the Rheumatic Diseases. 76, 3, p. 612-619 8 p.

Research output: Contribution to journalArticle

Tristetraprolin
Gene expression
Arthritis
Gene Expression
Phosphorylation
2016
4 Citations (Scopus)

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Archer, A. M., Saber, R., Rose, S., Shaffer, A., Misharin, A. V., Tsai, F. N., Haines, G. K., Dominguez, S., Eren, M., Vaughan, D. E., Cuda, C. M. & Perlman, H., Jun 10 2016, In : Journal of Translational Medicine. 14, 1, 170.

Research output: Contribution to journalArticle

Apolipoproteins E
Arthritis
Macrophages
Serum
Atherosclerosis
10 Citations (Scopus)

Humoral Human Lung Allograft Rejection by Tissue-Restricted Non-HLA Antibodies

Fernandez, R., Chiu, S., Raparia, K., Garcha, P., Farver, C., Budev, M., Tambur, A. R., DeCamp, M. M., Budinger, S., Perlman, H., Mohanakumar, T. & Bharat, A., Oct 1 2016, In : Annals of Thoracic Surgery. 102, 4, p. e339-e341

Research output: Contribution to journalArticle

Allografts
Lung
Antibodies
Transplantation
Autoantigens
13 Citations (Scopus)

Lung injury combined with loss of regulatory T cells leads to de novo lung-restricted autoimmunity

Chiu, S., Fernandez, R., Subramanian, V., Sun, H., DeCamp, M. M., Kreisel, D., Perlman, H., Budinger, G. R. S., Mohanakumar, T. & Bharat, A., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Collagen Type V
Lung Injury
Virus Diseases
Regulatory T-Lymphocytes
Tubulin
12 Citations (Scopus)

Lung-restricted antibodies mediate primary graft dysfunction and prevent allotolerance after murine lung transplantation

Bharat, A., Chiu, S., Zheng, Z., Sun, H., Yeldandi, A. V., DeCamp Jr, M. M., Perlman, H. R., Budinger, GR. S. & Mohanakumar, T., Oct 1 2016, In : American journal of respiratory cell and molecular biology. 55, 4, p. 532-541 10 p.

Research output: Contribution to journalArticle

Primary Graft Dysfunction
Transplantation (surgical)
Lung Transplantation
Grafts
Lung
2 Citations (Scopus)

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

Zheng, F., Perlman, H., Matthys, P., Wen, Y., Lahoutte, T., Muyldermans, S., Lu, S., De Baetselier, P., Schoonooghe, S., Devoogdt, N. & Raes, G., Oct 25 2016, In : Scientific reports. 6, 35966.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Complement Receptors
Arthritis
Experimental Arthritis
Joints
2015
13 Citations (Scopus)

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q-Q., Perlman, H. R., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S. K., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature communications. 6, 7086.

Research output: Contribution to journalArticle

arthritis
deletion
Dendritic Cells
Arthritis
T-cells
20 Citations (Scopus)

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

Cuda, C. M., Misharin, A. V., Khare, S., Saber, R., Tsai, F. N., Archer, A. M., Homan, P. J., Haines, G. K., Hutcheson, J., Dorfleutner, A., Budinger, G. R. S., Stehlik, C. & Perlman, H., Oct 16 2015, In : Arthritis Research and Therapy. 17, 1, 291.

Research output: Contribution to journalArticle

Macrophage Activation
Caspase 8
Toll-Like Receptors
Macrophages
Cell Culture Techniques
54 Citations (Scopus)

Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis

Xia, Y., Herlitz, L. C., Gindea, S., Wen, J., Pawar, R. D., Misharin, A., Perlman, H., Wu, L., Wu, P., Michaelson, J. S., Burkly, L. C. & Putterman, C., May 1 2015, In : Journal of the American Society of Nephrology. 26, 5, p. 1053-1070 18 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Knockout Mice
Kidney
Podocytes
Age Factors
17 Citations (Scopus)

Differential activation of infiltrating monocyte-derived cells after mild and severe traumatic brain injury

Trahanas, D. M., Cuda, C. M., Perlman, H. & Schwulst, S. J., Mar 1 2015, In : Shock. 43, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

Brain Concussion
Monocytes
Microglia
Leukocytes
Wounds and Injuries
9 Citations (Scopus)

Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF-1

Belmadani, A., Ren, D., Bhattacharyya, B. J., Rothwangl, K. B., Hope, T. J., Perlman, H. R. & Miller, R. J., Nov 1 2015, In : Hippocampus. 25, 11, p. 1224-1241 18 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Chemokines
Hippocampus
Neural Stem Cells
CXCR4 Receptors
5 Citations (Scopus)

Ischemia-related changes in circulating stem and progenitor cells and associated clinical characteristics in peripheral artery disease

Saber, R., Liu, K., Ferrucci, L., Criqui, M. H., Zhao, L., Tian, L., Guralnik, J. M., Liao, Y., Domanchuk, K., Kibbe, M. R., Green, D., Perlman, H. & McDermott, M. M., Dec 1 2015, In : Vascular Medicine (United Kingdom). 20, 6, p. 534-543 10 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Stem Cells
Ischemia
Exercise Test
Lower Extremity
10 Citations (Scopus)

Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis

Morales-Nebreda, L. I., Rogel, M. R., Eisenberg, J. L., Hamill, K. J., Soberanes, S., Nigdelioglu, R., Chi, M., Cho, T., Radigan, K. A., Ridge, K. M., Misharin, A. V., Woychek, A., Hopkinson, S., Perlman, H., Mutlu, G. M., Pardo, A., Selman, M., Jones, J. C. R. & Scott Budinger, G. R., Apr 1 2015, In : American journal of respiratory cell and molecular biology. 52, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Bleomycin
Laminin
Lung
Fibrosis
16 Citations (Scopus)

Promotion of inflammatory arthritis by interferon regulatory factor 5 in a mouse model

Duffau, P., Menn-Josephy, H., Cuda, C. M., Dominguez, S., Aprahamian, T. R., Watkins, A. A., Yasuda, K., Monach, P., Lafyatis, R., Rice, L. M., Kenneth Haines, G., Gravallese, E. M., Baum, R., Richez, C., Perlman, H. R., Bonegio, R. G. & Rifkin, I. R., Dec 1 2015, In : Arthritis and Rheumatology. 67, 12, p. 3146-3157 12 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Arthritis
Rheumatoid Arthritis
Joints
RNA
35 Citations (Scopus)

The heterogeneity of lung macrophages in the susceptibility to disease

Morales-Nebreda, L., Misharin, A. V., Perlman, H. & Scott Budinger, G. R., Sep 1 2015, In : European Respiratory Review. 24, 137, p. 505-509 5 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Alveolar Macrophages
Macrophages
Lung
Transcriptome
42 Citations (Scopus)

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

de Almeida, L., Khare, S., Misharin, A. V., Patel, R., Ratsimandresy, R. A., Wallin, M. C., Perlman, H., Greaves, D. R., Hoffman, H. M., Dorfleutner, A. & Stehlik, C., Aug 18 2015, In : Immunity. 43, 2, p. 264-276 13 p., 3145.

Research output: Contribution to journalArticle

Inflammasomes
Caspase 1
Interleukin-18
Interleukin-1
Inflammation
2014
28 Citations (Scopus)

Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation

Cuda, C. M., Misharin, A. V., Gierut, A. K., Saber, R., Haines, G. K., Hutcheson, J., Hedrick, S. M., Mohan, C., Budinger, G. S., Stehlik, C. & Perlman, H., Jun 15 2014, In : Journal of Immunology. 192, 12, p. 5548-5560 13 p.

Research output: Contribution to journalArticle

Caspase 8
Dendritic Cells
Autoimmunity
Autoimmune Lymphoproliferative Syndrome
Death Domain Receptors
10 Citations (Scopus)

Fas signaling in macrophages promotes chronicity in K/BxN serum-induced arthritis

Huang, Q. Q., Birkett, R., Koessler, R. E., Cuda, C. M., Haines, G. K., Jin, J. P., Perlman, H. & Pope, R. M., Jan 2014, In : Arthritis and Rheumatology. 66, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Interleukin-10
Arthritis
Macrophages
Interleukin-1
Serum
18 Citations (Scopus)

Impaired clearance of influenza a virus in obese, Leptin receptor deficient mice is independent of Leptin signaling in the Lung Epithelium and Macrophages

Radigan, K. A., Morales-Nebreda, L., Soberanes, S., Nicholson, T., Nigdelioglu, R., Cho, T., Chi, M., Hamanaka, R. B., Misharin, A. V., Perlman, H., Scott Budinger, G. R. & Mutlu, G. M., Sep 18 2014, In : PloS one. 9, 9, A1351.

Research output: Contribution to journalArticle

Leptin Receptors
Macrophages
Orthomyxoviridae
Leptin
leptin
111 Citations (Scopus)

Nonclassical Ly6C- monocytes drive the development of inflammatory arthritis in mice

Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Kenneth Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Scott Budinger, G. R. & Perlman, H., Jan 1 2014, In : Cell reports. 9, 2, p. 591-604 14 p.

Research output: Contribution to journalArticle

Macrophages
Arthritis
Monocytes
Joints
Inflammation
77 Citations (Scopus)

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

Khare, S., Ratsimandresy, R. A., De Almeida, L., Cuda, C. M., Rellick, S. L., Misharin, A. V., Wallin, M. C., Gangopadhyay, A., Forte, E., Gottwein, E., Perlman, H., Reed, J. C., Greaves, D. R., Dorfleutner, A. & Stehlik, C., Apr 2014, In : Nature Immunology. 15, 4, p. 343-353 11 p.

Research output: Contribution to journalArticle

DNA Virus Infections
Inflammasomes
Macrophages
Virus Activation
Caspase 1
50 Citations (Scopus)

β2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis

Chiarella, S. E., Soberanes, S., Urich, D., Morales-Nebreda, L., Nigdelioglu, R., Green, D., Young, J. B., Gonzalez, A., Rosario, C., Misharin, A. V., Ghio, A. J., Wunderink, R. G., Donnelly, H. K., Radigan, K. A., Perlman, H., Chandel, N. S., Budinger, G. R. S. & Mutlu, G. M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2935-2946 12 p.

Research output: Contribution to journalArticle

Adrenergic Agonists
Particulate Matter
Air Pollution
Alveolar Macrophages
Interleukin-6
2013
18 Citations (Scopus)

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis

Rose, S., Eren, M., Murphy, S., Zhang, H., Thaxton, C. S., Chowaniec, J., Waters, E. A., Meade, T. J., Vaughan, D. E. & Perlman, H., Jan 1 2013, In : Annals of the Rheumatic Diseases. 72, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Arthritis
Atherosclerosis
Animals
Rheumatoid Arthritis
Assays
1108 Citations (Scopus)

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K. W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., Hume, D. A., Perlman, H., Malissen, B., Zelzer, E. & Jung, S., Jan 24 2013, In : Immunity. 38, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

Monocytes
Homeostasis
Macrophages
Kupffer Cells
Alveolar Macrophages
262 Citations (Scopus)

Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

Misharin, A. V., Morales-Nebreda, L., Mutlu, G. M., Budinger, G. R. S. & Perlman, H., Oct 1 2013, In : American journal of respiratory cell and molecular biology. 49, 4, p. 503-510 8 p.

Research output: Contribution to journalArticle

Macrophages
Dendritic Cells
Bleomycin
Lung
Pathology
8 Citations (Scopus)
Osteitis
Ankle Joint
Arthritis
Magnetic Resonance Imaging
Bone and Bones
398 Citations (Scopus)

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C-R., Schumacker, P. T., Licht, J. D., Perlman, H. R., Bryce, P. J. & Chandel, N., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

CD27 Antigens
Reactive Oxygen Species
Mitochondria
T-Lymphocytes
Interleukin-2
15 Citations (Scopus)

Progenitor cell release plus exercise to improve functional performance in peripheral artery disease: The PROPEL Study

Domanchuk, K., Ferrucci, L., Guralnik, J. M., Criqui, M. H., Tian, L., Liu, K., Losordo, D., Stein, J., Green, D., Kibbe, M., Zhao, L., Annex, B., Perlman, H., Lloyd-Jones, D., Pearce, W., Taylor, D. & McDermott, M. M., Nov 1 2013, In : Contemporary Clinical Trials. 36, 2, p. 502-509 8 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Granulocyte-Macrophage Colony-Stimulating Factor
Stem Cells
Walking
Exercise
9 Citations (Scopus)

TLR2 deletion promotes arthritis through reduction of IL-10

Huang, Q-Q., Koessler, R. E., Birkett, R., Perlman, H. R., Xing, L. & Pope, R. M., Apr 1 2013, In : Journal of Leukocyte Biology. 93, 5, p. 751-759 9 p.

Research output: Contribution to journalArticle

Interleukin-10
Arthritis
Macrophages
Cytokines
Interleukin 1 Receptor Antagonist Protein