Grants per year
Personal profile
Research Interests
The Pinkett Lab is interested in how nutrients, antibiotics and chemotherapeutics are transported into or out of the cell. We focus on ABC transporters, proteins that use ATP hydrolysis to shuttle substrates across cellular membranes. Current projects include 1) deciphering how individual components of a transporter coordinate to allow for substrate uptake and 2) determining the mechanism in which transporters recognize a wide variety of compounds with implications for understanding viability, host-pathogen interactions and multidrug resistance.
Education/Academic qualification
PhD, University of Pennsylvania
… → 2004
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Collaborations and top research areas from the last five years
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Molecular Biophysics Training Program at Northwestern University
Pinkett, H. W. (PD/PI), Pinkett, H. W. (PD/PI) & Radhakrishnan, I. (PD/PI)
National Institute of General Medical Sciences
7/1/21 → 6/30/26
Project: Research project
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Regulation mechanisms of ABC transporters
Pinkett, H. W. (PD/PI) & Pinkett, H. W. (PD/PI)
National Institute of General Medical Sciences
9/15/20 → 8/31/25
Project: Research project
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Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Mondragon, A. (PD/PI), O'Halloran, T. V. (Other), Pinkett, H. W. (Other), Rosenzweig, A. C. (Other) & Satchell, K. J. (Other)
Office of the Director, National Institutes of Health
8/26/20 → 8/25/22
Project: Research project
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Acquisition of an Eiger2 X 16M pixel array detector for macromolecular crystallography
Mondragon, A. (PD/PI), O'Halloran, T. V. (Other), Pinkett, H. W. (Other), Rosenzweig, A. C. (Other) & Satchell, K. J. (Other)
Office of the Director, National Institutes of Health
8/15/20 → 8/14/22
Project: Research project
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A novel multifunctional role of diverse substrate binding and import by the Haemophilus Sap transporter
Pinkett, H. W. (PD/PI) & Pinkett, H. W. (PD/PI)
Research Institute at Nationwide Children's Hospital, National Institute of Allergy and Infectious Diseases
3/1/19 → 2/29/24
Project: Research project
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Activity of the pleiotropic drug resistance transcription factors Pdr1p and Pdr3p is modulated by binding site flanking sequences
Buechel, E. R. & Pinkett, H. W., Jan 2024, In: FEBS Letters. 598, 2, p. 169-186 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Antimicrobial Peptide Recognition Motif of the Substrate Binding Protein SapA from Nontypeable Haemophilus influenzae
Rivera, K. G., Tanaka, K. J., Buechel, E. R., Origel, O., Harrison, A., Mason, K. M. & Pinkett, H. W., Feb 6 2024, In: Biochemistry. 63, 3, p. 294-311 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Detergent Alternatives: Membrane Protein Purification Using Synthetic Nanodisc Polymers
Dimitrova, V. S., Song, S., Karagiaridi, A., Marand, A. & Pinkett, H. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 375-387 13 p. (Methods in Molecular Biology; vol. 2507).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access4 Scopus citations -
Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M. & Lee, Y. & 23 others, , Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.Research output: Contribution to journal › Article › peer-review
Open Access163 Scopus citations -
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast
Buechel, E. R. & Pinkett, H. W., Dec 2020, In: FEBS Letters. 594, 23, p. 3943-3964 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access33 Scopus citations
Datasets
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Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to tungstate)
Tirado-Lee, L. (Contributor), Lee, A. (Contributor), Rees, D. C. (Contributor) & Pinkett, H. W. (Contributor), Protein Data Bank (PDB), Nov 30 2011
DOI: 10.2210/pdb3PSA, https://www.wwpdb.org/pdb?id=pdb_00003psa
Dataset
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Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to Molybdate)
Tirado-Lee, L. (Contributor), Lee, A. (Contributor), Rees, D. C. (Contributor) & Pinkett, H. W. (Contributor), Protein Data Bank (PDB), Nov 30 2011
DOI: 10.2210/pdb3PSH, https://www.wwpdb.org/pdb?id=pdb_00003psh
Dataset
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2NQ2 : An inward-facing conformation of a putative metal-chelate type ABC transporter.
Pinkett, H. W. (Contributor), Lee, A. T. (Contributor), Lum, P. (Contributor), Locher, K. P. (Contributor) & Rees, D. C. (Contributor), RCSB-PDB, 2007
DOI: 10.2210/pdb2nq2/pdb, https://www.rcsb.org/structure/2NQ2
Dataset
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Crystal structure of Haemophilus influenzae OppA complex with LGG
Tanaka, K. J. (Contributor) & Pinkett, H. W. (Contributor), Protein Data Bank (PDB), Nov 28 2018
DOI: 10.2210/pdb6DQT, https://www.wwpdb.org/pdb?id=pdb_00006dqt
Dataset
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Crystal structure of Haemophilus influenzae OppA complex with GIINTL
Tanaka, K. J. (Contributor) & Pinkett, H. W. (Contributor), Protein Data Bank (PDB), Nov 28 2018
DOI: 10.2210/pdb6DQU, https://www.wwpdb.org/pdb?id=pdb_00006dqu
Dataset