Grants per year
Personal profile
Research Interests
The Pinkett Lab is interested in how nutrients, antibiotics and chemotherapeutics are transported into or out of the cell. We focus on ABC transporters, proteins that use ATP hydrolysis to shuttle substrates across cellular membranes. Current projects include 1) deciphering how individual components of a transporter coordinate to allow for substrate uptake and 2) determining the mechanism in which transporters recognize a wide variety of compounds with implications for understanding viability, host-pathogen interactions and multidrug resistance.
Education/Academic qualification
PhD, University of Pennsylvania
… → 2004
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Regulation mechanisms of ABC transporters
National Institute of General Medical Sciences
9/15/20 → 8/31/25
Project: Research project
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Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C. & Satchell, K. J. F.
Office of the Director, National Institutes of Health
8/26/20 → 8/25/22
Project: Research project
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Acquisition of an Eiger2 X 16M pixel array detector for macromolecular crystallography
Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C. & Satchell, K. J. F.
Office of the Director, National Institutes of Health
8/15/20 → 8/14/22
Project: Research project
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Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y. & 23 others, , Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast
Buechel, E. R. & Pinkett, H. W., Dec 2020, In: FEBS Letters. 594, 23, p. 3943-3964 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
Oligopeptide-binding protein from nontypeable Haemophilus influenzae has ligand-specific sites to accommodate peptides and heme in the binding pocket
Tanaka, K. J. & Pinkett, H. W., Jan 18 2019, In: Journal of Biological Chemistry. 294, 3, p. 1070-1082 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence
Hardison, R. L., Harrison, A., Wallace, R. M., Heimlich, D. R., O’Bryan, M. E., Sebra, R. P., Pinkett, H. W., Justice, S. S. & Mason, K. M., Oct 2018, In: PLoS pathogens. 14, 10, e1007355.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis
Tanaka, K. J., Song, S., Mason, K. & Pinkett, H. W., Apr 2018, In: Biochimica et Biophysica Acta - Biomembranes. 1860, 4, p. 868-877 10 p.Research output: Contribution to journal › Review article › peer-review
71 Scopus citations