Heather W Pinkett

Associate Professor, Molecular Biosciences
Irving M. Klotz Research Professor, Molecular Biosciences
Interdisciplinary Biological Sciences PhD Program
Member, CLP - Chemistry of Life Processes Institute

Phone+1 847 467 4048
Emailh-pinkett@northwestern.edu

Source: Scopus

Research activity per year

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Personal profile

Research Interests

The Pinkett Lab is interested in how nutrients, antibiotics and chemotherapeutics are transported into or out of the cell. We focus on ABC transporters, proteins that use ATP hydrolysis to shuttle substrates across cellular membranes. Current projects include 1) deciphering how individual components of a transporter coordinate to allow for substrate uptake and 2) determining the mechanism in which transporters recognize a wide variety of compounds with implications for understanding viability, host-pathogen interactions and multidrug resistance.

Education/Academic qualification

PhD, University of Pennsylvania

… → 2004

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4 Active
7 Finished

Regulation mechanisms of ABC transporters
Pinkett, H. W.
National Institute of General Medical Sciences
9/15/20 → 8/31/25
Project: Research project
Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C. & Satchell, K. J. F.
Office of the Director, National Institutes of Health
8/26/20 → 8/25/21
Project: Research project
Acquisition of an Eiger2 X 16M pixel array detector for macromolecular crystallography
Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C. & Satchell, K. J. F.
Office of the Director, National Institutes of Health
8/15/20 → 8/14/21
Project: Research project
A novel multifunctional role of diverse substrate binding and import by the Haemophilus Sap transporter
Pinkett, H. W.
Research Institute at Nationwide Children's Hospital, National Institute of Allergy and Infectious Diseases
3/1/19 → 2/29/24
Project: Research project
Blocking the Antimicrobial Transport Pathway to Eradicate Multidrug-Resistant Bacteria in Otitis Media
Pinkett, H. W.
Hartwell Foundation
4/1/17 → 3/31/21
Project: Research project

806 Citations
16 Article
3 Review article

Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y. & 23 others, Lewinson, O., Lill, R., Martinoia, E., Murakami, S., Pinkett, H. W., Poolman, B., Rosenbaum, D., Sarkadi, B., Schmitt, L., Schneider, E., Shi, Y., Shyng, S. L., Slotboom, D. J., Tajkhorshid, E., Tieleman, D. P., Ueda, K., Váradi, A., Wen, P. C., Yan, N., Zhang, P., Zheng, H., Zimmer, J. & Tampé, R., Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
16 Scopus citations
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast
Buechel, E. R. & Pinkett, H. W., Dec 2020, In: FEBS Letters. 594, 23, p. 3943-3964 22 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
1 Scopus citations
Oligopeptide-binding protein from nontypeable Haemophilus influenzae has ligand-specific sites to accommodate peptides and heme in the binding pocket
Tanaka, K. J. & Pinkett, H. W., Jan 18 2019, In: Journal of Biological Chemistry. 294, 3, p. 1070-1082 13 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence
Hardison, R. L., Harrison, A., Wallace, R. M., Heimlich, D. R., O’Bryan, M. E., Sebra, R. P., Pinkett, H. W., Justice, S. S. & Mason, K. M., Oct 2018, In: PLoS pathogens. 14, 10, e1007355.
Research output: Contribution to journal › Article › peer-review
8 Scopus citations
Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis
Tanaka, K. J., Song, S., Mason, K. & Pinkett, H. W., Apr 2018, In: Biochimica et Biophysica Acta - Biomembranes. 1860, 4, p. 868-877 10 p.
Research output: Contribution to journal › Review article › peer-review
50 Scopus citations