Grants per year
Personal profile
Research Interests
The Pinkett Lab is interested in how nutrients, antibiotics and chemotherapeutics are transported into or out of the cell. We focus on ABC transporters, proteins that use ATP hydrolysis to shuttle substrates across cellular membranes. Current projects include 1) deciphering how individual components of a transporter coordinate to allow for substrate uptake and 2) determining the mechanism in which transporters recognize a wide variety of compounds with implications for understanding viability, host-pathogen interactions and multidrug resistance.
Education/Academic qualification
PhD, University of Pennsylvania
… → 2004
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Dive into the research topics where Heather W Pinkett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Molecular Biophysics Training Program at Northwestern University
National Institute of General Medical Sciences
7/1/21 → 6/30/26
Project: Research project
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Regulation mechanisms of ABC transporters
National Institute of General Medical Sciences
9/15/20 → 8/31/25
Project: Research project
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Blocking the Antimicrobial Transport Pathway to Eradicate Multidrug-Resistant Bacteria in Otitis Media
4/1/17 → 3/31/21
Project: Research project
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Participant Support Costs for Understanding the Mechanism of Import for Bacterial Transporters
9/15/11 → 8/31/17
Project: Research project
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The role of lipid bilayer composition in cell-free expressed ABC transporter folding
Villaseñor, C. G., Dimitrova, V., Karagiaridi, A., Rivera, K., Pinkett, H. & Kamat, N. P., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 342a-343aResearch output: Contribution to journal › Article › peer-review
1 Scopus citations -
Detergent Alternatives: Membrane Protein Purification Using Synthetic Nanodisc Polymers
Dimitrova, V. S., Song, S., Karagiaridi, A., Marand, A. & Pinkett, H. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 375-387 13 p. (Methods in Molecular Biology; vol. 2507).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y., & 23 others, Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.Research output: Contribution to journal › Article › peer-review
Open Access124 Scopus citations -
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast
Buechel, E. R. & Pinkett, H. W., Dec 2020, In: FEBS Letters. 594, 23, p. 3943-3964 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access21 Scopus citations -
Oligopeptide-binding protein from nontypeable Haemophilus influenzae has ligand-specific sites to accommodate peptides and heme in the binding pocket
Tanaka, K. J. & Pinkett, H. W., Jan 18 2019, In: Journal of Biological Chemistry. 294, 3, p. 1070-1082 13 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Datasets
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3PSH : Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to Molybdate)
Tirado-Lee, L. (Contributor), Lee, A. (Contributor), Rees, D. C. (Contributor) & Pinkett, H. W. (Contributor), RCSB-PDB, 2011
DOI: 10.2210/pdb3psh/pdb, https://www.rcsb.org/structure/3PSH
Dataset
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3PSA : Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to tungstate)
Tirado-Lee, L. (Contributor), Lee, A. (Contributor), Rees, D. C. (Contributor) & Pinkett, H. W. (Contributor), RCSB-PDB, 2011
DOI: 10.2210/pdb3psa/pdb, https://www.rcsb.org/structure/3PSA
Dataset
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2NQ2 : An inward-facing conformation of a putative metal-chelate type ABC transporter.
Pinkett, H. W. (Contributor), Lee, A. T. (Contributor), Lum, P. (Contributor), Locher, K. P. (Contributor) & Rees, D. C. (Contributor), RCSB-PDB, 2007
DOI: 10.2210/pdb2nq2/pdb, https://www.rcsb.org/structure/2NQ2
Dataset