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Hengfu Bu

  • 446 Citations
1990 …2020

Research output per year

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Personal profile

Research Interests

My research mainly focuses on mucosal immunology, pathogenesis of intestinal injury, intestinal epithelial biology, probiotics and immunity. We are now working on the identification of some novel targets for protection against tissue injury. MFG-E8, a macrophage-derived protein, is necessary for maintenance of the intestinal epithelial homeostasis and mediates the protection against intestinal mucosa injury. LZMPC, lysozyme-modified probiotic components, benefits the protection against CLP induced sepsis. The luminal propria peptidoglycan transcytosis through intestinal barrier mechanism is also addressed in our research.

Education/Academic qualification

PhD, Beijing Institute of Radiation Medicine

… → 1995

DVM, Jilin University, Changchun, China

… → 1986

Research interests

  • Gut Immunology
  • Microbial Pathogenesis

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Grants

Surgical studies of gut epithelial apoptosis-initiated critical illness

Bu, H., De Plaen, I., Tan, X. & Wang, X.

National Institute of General Medical Sciences

9/1/16 → 8/31/20

Project: Research project

Mechanisms underlying disruption of intestinal epithelial barrier in critical illness

Bu, H. & Tan, X.

National Institute of General Medical Sciences

9/15/17 → 8/31/19

Project: Research project

Preservation of mucosal barrier in surgical diseases

Bu, H., Tan, X. & Wang, X.

National Institute of Diabetes & Digestive & Kidney

7/1/13 → 6/30/17

Project: Research project

Research Output

  • 446 Citations
  • 32 Article
  • 1 Chapter

In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration

Geng, H., Bu, H. F., Liu, F., Wu, L., Pfeifer, K., Chou, P. M., Wang, X., Sun, J., Lu, L., Pandey, A., Bartolomei, M. S., De Plaen, I. G., Wang, P., Yu, J., Qian, J. & Tan, X. D., Jul 2018, In : Gastroenterology. 155, 1, p. 144-155 12 p.

Research output: Contribution to journal › Article

    • 25 Scopus citations

    Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice

    Liu, F., Bu, H. F., Geng, H., De Plaen, I. G., Gao, C., Wang, P., Wang, X., Kurowski, J. A., Yang, H., Qian, J. & Tan, X. D., Jan 1 2017, In : Molecular Medicine. 23, p. 272-284 13 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice

    Wang, X., Hao, L., Bu, H. F., Scott, A. W., Tian, K., Liu, F., De Plaen, I. G., Liu, Y., Mirkin, C. A. & Tan, X. D., Aug 19 2016, In : Scientific reports. 6, 31687.

    Research output: Contribution to journal › Article

    • 11 Scopus citations

    Molecular Mechanisms Underlying the Regulation of the MFG-E8 Gene Promoter Activity in Physiological and Inflammatory Conditions

    Wang, X., Bu, H. F., Liu, S. X., De Plaen, I. G. & Tan, X. D., Sep 1 2015, In : Journal of Cellular Biochemistry. 116, 9, p. 1867-1879 13 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice

    Asai, A., Chou, P. M., Bu, H. F., Wang, X., Sambasiva Rao, M., Jiang, A., DiDonato, C. J. & Tan, X. D., Mar 15 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 6, p. G496-G504

    Research output: Contribution to journal › Article

    • 18 Scopus citations