Grants per year
Personal profile
Research Interests
My research mainly focuses on mucosal immunology, pathogenesis of intestinal injury, intestinal epithelial biology, probiotics and immunity. We are now working on the identification of some novel targets for protection against tissue injury. MFG-E8, a macrophage-derived protein, is necessary for maintenance of the intestinal epithelial homeostasis and mediates the protection against intestinal mucosa injury. LZMPC, lysozyme-modified probiotic components, benefits the protection against CLP induced sepsis. The luminal propria peptidoglycan transcytosis through intestinal barrier mechanism is also addressed in our research.
Education/Academic qualification
PhD, Beijing Institute of Radiation Medicine
… → 1995
DVM, Jilin University
… → 1986
Research interests
- Gut Immunology
- Microbial Pathogenesis
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Grants
Surgical studies of gut epithelial apoptosis-initiated critical illness
Bu, H., De Plaen, I., Tan, X. & Wang, X.
National Institute of General Medical Sciences
9/1/16 → 8/31/20
Project: Research project
Mechanisms underlying disruption of intestinal epithelial barrier in critical illness
Bu, H. & Tan, X.
National Institute of General Medical Sciences
9/15/17 → 8/31/19
Project: Research project
Preservation of mucosal barrier in surgical diseases
National Institute of Diabetes & Digestive & Kidney
7/1/13 → 6/30/17
Project: Research project
Research Output
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X., Apr 2020, In : American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739Research output: Contribution to journal › Article
Open Access
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration
Geng, H., Bu, H. F., Liu, F., Wu, L., Pfeifer, K., Chou, P. M., Wang, X., Sun, J., Lu, L., Pandey, A., Bartolomei, M. S., De Plaen, I. G., Wang, P., Yu, J., Qian, J. & Tan, X. D., Jul 2018, In : Gastroenterology. 155, 1, p. 144-155 12 p.Research output: Contribution to journal › Article
32
Scopus
citations
Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice
Liu, F., Bu, H. F., Geng, H., De Plaen, I. G., Gao, C., Wang, P., Wang, X., Kurowski, J. A., Yang, H., Qian, J. & Tan, X. D., Jan 1 2017, In : Molecular Medicine. 23, p. 272-284 13 p.Research output: Contribution to journal › Article
4
Scopus
citations
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice
Wang, X., Hao, L., Bu, H. F., Scott, A. W., Tian, K., Liu, F., De Plaen, I. G., Liu, Y., Mirkin, C. A. & Tan, X. D., Aug 19 2016, In : Scientific reports. 6, 31687.Research output: Contribution to journal › Article
12
Scopus
citations
Molecular Mechanisms Underlying the Regulation of the MFG-E8 Gene Promoter Activity in Physiological and Inflammatory Conditions
Wang, X., Bu, H. F., Liu, S. X., De Plaen, I. G. & Tan, X. D., Sep 1 2015, In : Journal of Cellular Biochemistry. 116, 9, p. 1867-1879 13 p.Research output: Contribution to journal › Article
7
Scopus
citations