Grants per year
Personal profile
Research Interests
My research mainly focuses on mucosal immunology, pathogenesis of intestinal injury, intestinal epithelial biology, probiotics and immunity. We are now working on the identification of some novel targets for protection against tissue injury. MFG-E8, a macrophage-derived protein, is necessary for maintenance of the intestinal epithelial homeostasis and mediates the protection against intestinal mucosa injury. LZMPC, lysozyme-modified probiotic components, benefits the protection against CLP induced sepsis. The luminal propria peptidoglycan transcytosis through intestinal barrier mechanism is also addressed in our research.
Education/Academic qualification
PhD, Beijing Institute of Radiation Medicine
… → 1995
Veterinary Medicine, DVM, Jilin University
… → 1986
Research interests
- Gut Immunology
- Microbial Pathogenesis
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Grants
- 3 Finished
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Mechanisms underlying disruption of intestinal epithelial barrier in critical illness
Tan, X., Bu, H., Chou, P. M. & Wang, X.
National Institute of General Medical Sciences
9/15/17 → 8/31/20
Project: Research project
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Surgical studies of gut epithelial apoptosis-initiated critical illness
Tan, X., Bu, H., De Plaen, I. & Wang, X.
National Institute of General Medical Sciences
9/1/16 → 8/31/20
Project: Research project
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Preservation of mucosal barrier in surgical diseases
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/13 → 6/30/17
Project: Research project
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Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice
Subramanian, S., Geng, H., Du, C., Chou, P. M., Bu, H., Wang, X., Swaminathan, S., Tan, S. C., Ridlon, J. M., De Plaen, I. G. & Tan, X., Sep 1 2022, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 323, 3, p. G205-G218Research output: Contribution to journal › Article › peer-review
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MFG-E8 plays an important role in attenuating cerulein-induced acute pancreatitis in mice
Bu, H. F., Subramanian, S., Geng, H., Wang, X., Liu, F., Chou, P. M., Du, C., De Plaen, I. G. & Tan, X. D., Apr 2021, In: Cells. 10, 4, 728.Research output: Contribution to journal › Article › peer-review
Open Access -
SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells
Geng, H., Subramanian, S., Wu, L., Bu, H. F., Wang, X., Du, C., De Plaen, I. G. & Tan, X. D., 2021, In: Frontiers in immunology. 12, p. 679482 1 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X. D., Apr 2020, In: American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration
Geng, H., Bu, H. F., Liu, F., Wu, L., Pfeifer, K., Chou, P. M., Wang, X., Sun, J., Lu, L., Pandey, A., Bartolomei, M. S., De Plaen, I. G., Wang, P., Yu, J., Qian, J. & Tan, X. D., Jul 2018, In: Gastroenterology. 155, 1, p. 144-155 12 p.Research output: Contribution to journal › Article › peer-review
90 Scopus citations