Hengfu Bu

  • 463 Citations
1990 …2020

Research output per year

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Personal profile

Research Interests

My research mainly focuses on mucosal immunology, pathogenesis of intestinal injury, intestinal epithelial biology, probiotics and immunity. We are now working on the identification of some novel targets for protection against tissue injury. MFG-E8, a macrophage-derived protein, is necessary for maintenance of the intestinal epithelial homeostasis and mediates the protection against intestinal mucosa injury. LZMPC, lysozyme-modified probiotic components, benefits the protection against CLP induced sepsis. The luminal propria peptidoglycan transcytosis through intestinal barrier mechanism is also addressed in our research.

Education/Academic qualification

PhD, Beijing Institute of Radiation Medicine

… → 1995

DVM, Jilin University

… → 1986

Research interests

  • Gut Immunology
  • Microbial Pathogenesis

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Research Output

  • 463 Citations
  • 33 Article
  • 1 Chapter

Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism

Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X., Apr 2020, In : American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739

Research output: Contribution to journalArticle

Open Access
  • In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration

    Geng, H., Bu, H. F., Liu, F., Wu, L., Pfeifer, K., Chou, P. M., Wang, X., Sun, J., Lu, L., Pandey, A., Bartolomei, M. S., De Plaen, I. G., Wang, P., Yu, J., Qian, J. & Tan, X. D., Jul 2018, In : Gastroenterology. 155, 1, p. 144-155 12 p.

    Research output: Contribution to journalArticle

  • 32 Scopus citations

    Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice

    Liu, F., Bu, H. F., Geng, H., De Plaen, I. G., Gao, C., Wang, P., Wang, X., Kurowski, J. A., Yang, H., Qian, J. & Tan, X. D., Jan 1 2017, In : Molecular Medicine. 23, p. 272-284 13 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice

    Wang, X., Hao, L., Bu, H. F., Scott, A. W., Tian, K., Liu, F., De Plaen, I. G., Liu, Y., Mirkin, C. A. & Tan, X. D., Aug 19 2016, In : Scientific reports. 6, 31687.

    Research output: Contribution to journalArticle

  • 12 Scopus citations
  • 7 Scopus citations