Grants per year
Personal profile
Research Interests
Herbert Y. Meltzer, MD, is Professor of Psychiatry and Behavioral Sciences, Pharmacology and Physiology and Director of the Translational Neuropharmacology Program at Northwestern University in Chicago, IL. He received his BA from Cornell University, an MA in Chemistry from Harvard, and his MD from Yale University. Dr. Meltzer has been President of the American College of Neuropsychopharmacology (ACNP) and the Collegium International Neuro-psychopharmacologicum (CINP). He was co-editor of the ACNP journal, Neuropsychopharmacology. Current research interests include: 1) development of novel drugs for treatment and prevention of psychosis, depression, opioid abuse, and age associated cognitive impairment; 2) behavioral and neurochemical studies of antipsychotic, antidepressant, cognitive improving, and antisuicide drugs; and 3) genetic biomarkers. Dr. Meltzer is the recipient of the Efron and Paul Hoch Awards of the ACNP, the Lieber Prize for Schizophrenia Research from NARSAD/Brain Behavior Research Foundation, the Dean Award for Research in Schizophrenia of the American College of Psychiatry, the Gold Medal Award of the Society of Biological Psychiatry, the Sutherland Prize for Research and Grant Liddle Award for Clinical Research of Vanderbilt University, the Research Prize of the American Psychiatric Association, and the Lifetime Achievement awards from the Schizophrenia International Research Society (SIRS).
Training Experience
1964 | Internship, Saint Luke's Hospital |
1966 | Residency, Massachusetts Mental Health Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Yale University
… → 1963
Research interests keywords
- Clinical Research
- Depression
- Mental Health
- Neuropsychology
- Pharmacology
- Physiology
- Psychiatry
- Schizophrenia
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Collaborations and top research areas from the last five years
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Prot #CT‐155‐R‐001: A Multicenter, Randomized, Double‐Blind, Parallel‐Group, Controlled, 16‐week Study to Evaluate the Efficacy and Safety of a Digital Therapeutic (CT‐155) as an Adjunct to Standard‐of‐Care Antipsychotic Therapy in Adult and Late Adolesc
Meltzer, H. Y. (PD/PI) & Rado, J. T. (PD/PI)
Novella Clinical, LLC, Click Therapeutics, Inc.
6/27/23 → 6/27/26
Project: Research project
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Prot #CT-155-C-002: A Multi-center, Exploratory, Single-Arm, 7-week Study to Evaluate the Feasibility and Acceptability of Treatment with CT-155 in People with Schizophrenia Experiencing Negative Symptoms
Meltzer, H. Y. (PD/PI)
ICON Clinical Research, LLC, Click Therapeutics, Inc.
7/14/22 → 7/14/25
Project: Research project
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Analysis of Apoaequorin as a Therapeutic Agent for Schizoprenia, Depression, and Cognitive Decline
Meltzer, H. Y. (PD/PI), Meltzer, H. Y. (PD/PI), Huang, M. (Other), Huang, M. (Other), Rajagopal, L. (Other) & Rajagopal, L. (Other)
8/7/20 → 8/6/25
Project: Research project
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Evaluate Pimavanserin, Risperidone or a combination of Pimavanserin and Risperidone in a treatment-resistant model of negative symptoms of schizophrenia
Meltzer, H. Y. (PD/PI), Meltzer, H. Y. (PD/PI), Rajagopal, L. (Co-Investigator) & Rajagopal, L. (Co-Investigator)
2/10/17 → 8/31/25
Project: Research project
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Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia
Wang, R., Lu, J. Y., Herbert, D., Lieberman, J. A., Meltzer, H. Y., Tiwari, A. K., Remington, G., Kennedy, J. L. & Zai, C. C., Jul 2024, In: Human Psychopharmacology. 39, 4, e2898.Research output: Contribution to journal › Article › peer-review
Open Access -
Lack of Efficacy of JNJ-18038683 on Cognitive Impairment in Patients with Stable Bipolar Disorder
Arshadi, M., Elmaadawi, A. Z., Nasr, S., Jayathilake, K., Rassnick, S., Ford, L., Drevets, W. C. & Meltzer, H. Y., Sep 1 2024, In: Journal of clinical psychopharmacology. 44, 5, p. 481-491 11 p.Research output: Contribution to journal › Article › peer-review
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Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., Hoshino, M., Nakao, A., Mori, Y., Okabe, S., Matsushita, M., Urbach, A., Katayama, Y., Matsumoto, A., Nakayama, K. I. & Katori, S. & 111 others, , Mar 26 2024, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The dopamine D1 receptor positive allosteric modulator, DETQ, improves cognition and social interaction in aged mice and enhances cortical and hippocampal acetylcholine efflux
Rajagopal, L., Huang, M., Mahjour, S., Ryan, C., Elzokaky, A., Svensson, K. A. & Meltzer, H. Y., Feb 29 2024, In: Behavioural Brain Research. 459, 114766.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Long-Term Outcome of Clozapine in Treatment-Resistant Schizophrenia
Lee, M. A., Cola, P., Jayathilake, K. & Meltzer, H. Y., May 1 2023, In: Journal of clinical psychopharmacology. 43, 3, p. 211-219 9 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations
Datasets
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CCDC 1040072: Experimental Crystal Structure Determination
Younai, A. (Contributor), Zeng, B.-S. (Contributor), Meltzer, H. Y. (Contributor) & Scheidt, K. A. (Contributor), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc13x8q0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13x8q0&sid=DataCite
Dataset
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Supplementary Material for: Fat Mass- and Obesity-Associated (FTO) Gene and Antipsychotic-Induced Weight Gain: An Association Study
Shing, E. C. (Creator), Tiwari, A. K. (Creator), Brandl, E. J. (Creator), Zai, C. C. (Creator), Lieberman, J. A. (Creator), Meltzer, H. Y. (Creator), Kennedy, J. L. (Creator), Müller, D. J. (Creator), Tiwari, A. K. (Creator), Zai, C. C. (Creator) & Meltzer, H. Y. (Creator), Karger Publishers, 2014
DOI: 10.6084/m9.figshare.5125795.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Fat_Mass-_and_Obesity-Associated_FTO_Gene_and_Antipsychotic-Induced_Weight_Gain_An_Association_Study/5125795/1
Dataset
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Awareness of illness moderates self-assessment of psychotic symptoms
Martinez Agulleiro, L. (Creator), de Filippis, R. (Creator), Rosson, S. (Creator), Patil, B. (Creator), Prizgint, L. (Creator), Talasazan, N. (Creator), Meltzer, H. Y. (Creator), Kane, J. M. (Creator), Gibbons, R. D. (Creator) & Guinart, D. (Creator), SAGE Journals, 2021
DOI: 10.25384/sage.c.5713265, https://sage.figshare.com/collections/Awareness_of_illness_moderates_self-assessment_of_psychotic_symptoms/5713265
Dataset
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Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain
Tiwari, A. K. (Contributor), Zhang, D. (Creator), Pouget, J. G. (Creator), Zai, C. C. (Contributor), Chowdhury, N. I. (Contributor), Brandl, E. J. (Contributor), Qin, L. (Creator), Freeman, N. (Creator), Lieberman, J. A. (Contributor), Meltzer, H. Y. (Contributor), Kennedy, J. L. (Contributor) & Müller, D. J. (Contributor), Taylor & Francis, 2016
DOI: 10.6084/m9.figshare.4239230, https://tandf.figshare.com/articles/figure/Impact_of_Histamine_Receptors_H1_and_H3_Polymorphisms_on_Antipsychotic-Induced_Weight_Gain/4239230
Dataset
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CCDC 1030168: Experimental Crystal Structure Determination
Younai, A. (Contributor), Zeng, B.-S. (Contributor), Meltzer, H. Y. (Contributor) & Scheidt, K. A. (Contributor), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc13kz7w, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13kz7w&sid=DataCite
Dataset