Herbert Y Meltzer

  • 68391 Citations
1961 …2022
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Research Output 1961 2019

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Letter
2014
15 Citations (Scopus)

Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis

Tiwari, A. K., Need, A. C., Lohoff, F. W., Zai, C. C., Chowdhury, N. I., Müller, D. J., Putkonen, A., Repo-Tiihonen, E., Hallikainen, T., Anil Yaǧcoǧlu, A. E., Tiihonen, J., Kennedy, J. L. & Meltzer, H. Y., Jan 1 2014, In : Molecular Psychiatry. 19, 4, p. 403-405 3 p.

Research output: Contribution to journalLetter

HLA-DQ beta-Chains
Exome
Agranulocytosis
Clozapine
Finland
2011
6 Citations (Scopus)

Association of FAS, a TNF-α receptor gene, with treatment resistant schizophrenia

Jia, P., Jayathilake, K., Zhao, Z. & Meltzer, H. Y., Jul 1 2011, In : Schizophrenia Research. 129, 2-3, p. 211-212 2 p.

Research output: Contribution to journalLetter

CD95 Antigens
Tumor Necrosis Factor Receptors
Drug Resistance
Gene Frequency
Antipsychotic Agents
2010
34 Citations (Scopus)

Variants in the oxytocin gene and risk for schizophrenia

Souza, R. P., Ismail, P., Meltzer, H. Y. & Kennedy, J. L., Aug 1 2010, In : Schizophrenia Research. 121, 1-3, p. 279-280 2 p.

Research output: Contribution to journalLetter

Oxytocin Receptors
Genome-Wide Association Study
Linkage Disequilibrium
Oxytocin
Chi-Square Distribution
2009
6 Citations (Scopus)

Atypical antipsychotic drugs have their merits

Meltzer, H. Y., Mar 20 2009, In : The Lancet. 373, 9668, 1 p.

Research output: Contribution to journalLetter

Serotonin Antagonists
Clozapine
Psychotic Disorders
Antipsychotic Agents
6 Citations (Scopus)

MDR1 gene in tardive dyskinesia scale scores: Comparison of strategies for quantitative trait haplotype analysis

De Luca, V., Souza, R. P., Viggiano, E., Zai, C. C., Shinkai, T., Lieberman, J. A., Potkin, S. G., Meltzer, H. Y., Remington, G. & Kennedy, J. L., May 1 2009, In : Schizophrenia Research. 110, 1-3, p. 200-201 2 p.

Research output: Contribution to journalLetter

Severity of Illness Index
Drug-Induced Dyskinesia
Antidiarrheals
Linkage Disequilibrium
P-Glycoprotein
2008

Drs. Meltzer and Jayathilake reply

Meltzer, H. Y. & Jayathilake, K., Jan 1 2008, In : Journal of Clinical Psychiatry. 69, 10, p. 1660-1661 2 p.

Research output: Contribution to journalLetter

olanzapine
Clozapine
Schizophrenia
Therapeutics
Antipsychotic Agents
2007

Dr. Kane and colleagues reply [4]

Kane, J. M., Meltzer, H. Y., Carson, W. H., McQuade, R. D., Marcus, R. N. & Sanchez, R., Nov 1 2007, In : Journal of Clinical Psychiatry. 68, 11, p. 1813-1814 2 p.

Research output: Contribution to journalLetter

20 Citations (Scopus)

Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and quality of life in schizophrenia

Sumiyoshi, T., Higuchi, Y., Matsui, M., Arai, H., Takamiya, C., Meltzer, H. Y. & Kurachi, M., May 9 2007, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31, 4, p. 965-967 3 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Piperazines
Verbal Behavior
Indoles
Thiazoles
16 Citations (Scopus)

Multiple variants of the DRD3, but not BDNF gene, influence age-at-onset of schizophrenia [1]

Renou, J., De Luca, V., Zai, C. C., Bulgin, N., Remington, G., Meltzer, H. Y., Lieberman, J. A., Le Foll, B. & Kennedy, J. L., Dec 1 2007, In : Molecular Psychiatry. 12, 12, p. 1058-1060 3 p.

Research output: Contribution to journalLetter

Dopamine D3 Receptors
Brain-Derived Neurotrophic Factor
Age of Onset
Glycine
Serine
2006
1 Citation (Scopus)

To the editor [2]

Meltzer, H. Y., Yaǧcioǧlu, E. A. & Akdede, B. B. K., Apr 27 2006, In : New England Journal of Medicine. 354, 17, p. 1846-1847 2 p.

Research output: Contribution to journalLetter

2005
5 Citations (Scopus)

Neurotensin receptor agonists and antagonists for schizophrenia [13] (multiple letters)

Richelson, E., Fredrickson, P. A., Boules, M. M., Robertson, V. B., Wilson, M. S., Meltzer, H. Y. & Arvanitis, L., Mar 1 2005, In : American Journal of Psychiatry. 162, 3, p. 633-635 3 p.

Research output: Contribution to journalLetter

Neurotensin Receptors
Pyrazoles
Quinolines
Investigational Drugs
Neurotensin
2004
21 Citations (Scopus)

A comparison of incidence of diabetes mellitus between atypical antipsychotic drugs: A survey of clozapine, risperidone, olanzapine, and quetiapine [3]

Sumiyoshi, T., Roy, A., Anil, A. E., Jayathilake, K., Ertugrul, A. & Meltzer, H. Y., Jun 1 2004, In : Journal of clinical psychopharmacology. 24, 3, p. 345-348 4 p.

Research output: Contribution to journalLetter

olanzapine
Dibenzothiazepines
Risperidone
Clozapine
Benzodiazepines
23 Citations (Scopus)

Serotonin 1A receptors in memory function [11] (multiple letters)

Sumiyoshi, T., Meltzer, H. Y., Yasuno, F., Suhara, T., Nakayama, T., Ichimiya, T., Takano, A., Ando, T., Inoue, M., Maeda, J., Suzuki, K. & Okubo, Y., Aug 1 2004, In : American Journal of Psychiatry. 161, 8, p. 1505-1506 2 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Drug Dose Response Relationship
Drug Administration Schedule
Piperazines
Cognition Disorders
11 Citations (Scopus)

The effect of hypertension and obesity on the development of diabetes mellitus in patients treated with atypical antipsychotic drugs [4]

Sumiyoshi, T., Roy, A., Jayathilake, K. & Meltzer, H. Y., Aug 1 2004, In : Journal of Clinical Psychopharmacology. 24, 4, p. 452-454 3 p.

Research output: Contribution to journalLetter

Diabetes Complications
Chi-Square Distribution
Antipsychotic Agents
Diabetes Mellitus
Retrospective Studies
2003
29 Citations (Scopus)

Atypical antipsychotic drugs improve cognition in schizophrenia [1] (multiple letters)

Meltzer, H. Y., Sumiyoshi, T., Carpenter, W. T. & Gold, J. M., Feb 1 2003, In : Biological Psychiatry. 53, 3, p. 265-267 3 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Cognition Disorders
Risperidone
Neuropsychological Tests
Haloperidol
26 Citations (Scopus)

H1-histamine Receptor Affinity Predicts Short-term Weight Gain for Typical and Atypical Antipsychotic Drugs [1]

Goudie, A. J., Halford, J. C. G., Dovey, T. M., Cooper, G. D., Neill, J. C., Kroeze, W. K., Hufeisen, S. J., Popadak, B. A., Renock, S. M., Steinberg, S., Ernsberger, P., Jayathilake, K., Meltzer, H. Y. & Roth, B. L., Dec 1 2003, In : Neuropsychopharmacology. 28, 12, p. 2209-2211 3 p.

Research output: Contribution to journalLetter

Histamine H1 Receptors
Preclinical Drug Evaluations
Random Allocation
Antipsychotic Agents
Weight Gain
2002
137 Citations (Scopus)

-759C/T genetic variation of 5HT 2C receptor and clozapine-induced weight gain [8] (multiple letters)

Tsai, S. J., Hong, C. J., Yu, Y. W. Y., Lin, C. H., Basile, V. S., Masellis, M., De Luca, V., Meltzer, H. Y. & Kennedy, J. L., Nov 30 2002, In : Lancet. 360, 9347, p. 1790-1791 2 p.

Research output: Contribution to journalLetter

Clozapine
Weight Gain
Weights and Measures
Serotonin Receptors
Genotype
13 Citations (Scopus)

Clozapine and suicide [13]

Ertugrul, A., Meltzer, H., Sernyak, M. J., Desai, R. & Rosenheck, R., Jan 1 2002, In : American Journal of Psychiatry. 159, 2, p. 323-324 2 p.

Research output: Contribution to journalLetter

Attempted Suicide
Clozapine
Survival Analysis
Suicide
Antipsychotic Agents
9 Citations (Scopus)

Regional selectivity in Clozapine treatment? [5]

Kessler, R. M. & Meltzer, H. Y., Jun 13 2002, In : American Journal of Psychiatry. 159, 6, p. 1064-1065 2 p.

Research output: Contribution to journalLetter

Carbon Radioisotopes
Salicylamides
Pyrrolidines
Emission-Computed Tomography
Corpus Striatum

The role of endogenous cortisol in neuroendocrine studies [1] (multiple letters)

Watson, S., Young, A. M., Meltzer, H. & Lee, M., Feb 28 2002, In : Neuropsychopharmacology. 26, 3, p. 408-409 2 p.

Research output: Contribution to journalLetter

Neurosecretory Systems
Apomorphine
Dopamine Agonists
Hydrocortisone
Schizophrenia
2000
61 Citations (Scopus)

Effect of adjunctive treatment with serotonin-1A agonist tandospirone on memory functions in schizophrenia [3]

Sumiyoshi, T., Matsui, M., Yamashita, I., Nohara, S., Uehara, T., Kurachi, M. & Meltzer, H. Y., Jun 6 2000, In : Journal of Clinical Psychopharmacology. 20, 3, p. 386-388 3 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Psychiatric Status Rating Scales
Piperazines
Serotonin 5-HT1 Receptors
Wechsler Scales
1999
5 Citations (Scopus)

Dopamine receptor occupancy and the action of clozapine: Does it make a difference to add a neuroleptic? (multiple letters)

Meltzer, H. Y., Carpenter W.T., J., Zito, J. M. & Volavka, J., Jan 1 1999, In : Biological Psychiatry. 46, 1, p. 144-147 4 p.

Research output: Contribution to journalLetter

Severity of Illness Index
Brief Psychiatric Rating Scale
Dopamine D2 Receptors
Clozapine
Dopamine Receptors
8 Citations (Scopus)

Risperidone and clozapine for treatment-resistant schizophrenia [21] (multiple letters)

Meltzer, H. Y., Rubin, E., Dunayevich, E., Chatterjee, A., Bondolfi, G. & Baumann, P., Jul 10 1999, In : American Journal of Psychiatry. 156, 7, p. 1126-1128 3 p.

Research output: Contribution to journalLetter

Drug Administration Schedule
Risperidone
Clozapine
Antipsychotic Agents
Schizophrenia
1998
8 Citations (Scopus)

Do loxapine plus cyproheptadine make an atypical antipsychotic? PET analysis of their dopamine D2 and serotonin2 receptor occupancy [3] (multiple letters)

Kapur, S., Zipursky, R. B., Remington, G. & Meltzer, H., Aug 3 1998, In : Archives of general psychiatry. 55, 7, p. 666-668 3 p.

Research output: Contribution to journalLetter

Schizophrenia
Letters
Dopamine
1997
9 Citations (Scopus)

Clozapine in treatment of bromocriptine-induced psychosis [6]

Al-Semaan, Y. M., Clay, H. A. & Meltzer, H. Y., Apr 16 1997, In : Journal of Clinical Psychopharmacology. 17, 2, p. 126-128 3 p.

Research output: Contribution to journalLetter

Substance-Induced Psychoses
Hormone Antagonists
Bromocriptine
Clozapine
Psychotic Disorders
10 Citations (Scopus)

Clozapine withdrawal: Serotonergic or dopaminergic mechanisms? [1] (multiple letters)

Meltzer, H. Y., Baldessarini, R. J., Tarazi, F. I., Kula, N. S., Gardner, D. M. & Seeman, P., Jan 1 1997, In : Archives of General Psychiatry. 54, 8, p. 760-763 4 p.

Research output: Contribution to journalLetter

31 Citations (Scopus)

Risperidone in treatment of choreoathetosis of Huntington's disease [13]

Parsa, M. A., Szigethy, E., Voci, J. M. & Meltzer, H. Y., Apr 16 1997, In : Journal of Clinical Psychopharmacology. 17, 2, p. 134-135 2 p.

Research output: Contribution to journalLetter

Serotonin Antagonists
Risperidone
Dopamine Antagonists
Clozapine
Huntington Disease
1996
1 Citation (Scopus)

Studies of Ventricular Enlargement-Reply

Friedman, L., Jesberger, J. A. & Meltzer, H. Y., Jan 1 1996, In : Archives of general psychiatry. 53, 12, p. 1166-1167 2 p.

Research output: Contribution to journalLetter

Cerebral Ventricles
Mood Disorders
Meta-Analysis
Schizophrenia
Research Design
1995
13 Citations (Scopus)

Clozapine's cost effectiveness [6]

Schiller, M., Hargreaves, W. A., Essock, S. M., Rosenheck, R., Charney, D. S., Frisman, L. K., Cramer, J., Meltzer, H. Y. & Cola, P., Jan 1 1995, In : American Journal of Psychiatry. 152, 1, p. 151-154 4 p.

Research output: Contribution to journalLetter

Drug Costs
Clozapine
Mental Health Services
Cost-Benefit Analysis
Schizophrenia
70 Citations (Scopus)

Genetic variation of 5-HT2A receptor and response to clozapine

Masellis, M., Paterson, A. D., Badri, F., Lieberman, J. A., Meltzer, H. Y., Cavazzoni, P. & Kennedy, J. L., Oct 21 1995, In : The Lancet. 346, 8982, 1 p.

Research output: Contribution to journalLetter

Receptor, Serotonin, 5-HT2A
Clozapine
Serotonin Receptors
Antipsychotic Agents
Schizophrenia
11 Citations (Scopus)

Neuroleptic Withdrawal in Schizophrenic Patients: An Idea Whose Time Has Come

Meltzer, H. Y., Jan 1 1995, In : Archives of General Psychiatry. 52, 3, p. 200-202 3 p.

Research output: Contribution to journalLetter

Drug Administration Schedule
Substance Withdrawal Syndrome
Antipsychotic Agents
Meta-Analysis
Schizophrenia
1994

Our goals, our challenges

Ciaranello, R. & Meltzer, H. Y., Jan 1 1994, In : Neuropsychopharmacology. 10, 1, 1 p.

Research output: Contribution to journalLetter

5 Citations (Scopus)

Serotonin2A Receptors in Schizophrenia: Relation to Suicide

Meltzer, H. Y., Jan 1 1994, In : Archives of general psychiatry. 51, 12, 1 p.

Research output: Contribution to journalLetter

Spiperone
Serotonin Receptors
Frontal Lobe
Suicide
Cause of Death
22 Citations (Scopus)

Treatment of delusional disorders with clozapine [3]

Buckley, P. F., Sajatovic, M. & Meltzer, H. Y., Jan 1 1994, In : American Journal of Psychiatry. 151, 9, p. 1394-1395 2 p.

Research output: Contribution to journalLetter

Psychiatric Status Rating Scales
Paranoid Schizophrenia
Delusions
Clozapine
Antipsychotic Agents
19 Citations (Scopus)

Valproic acid treatment of clozapine-induced myoclonus [2]

Meltzer, H. Y. & Ranjan, R., Jan 1 1994, In : American Journal of Psychiatry. 151, 8, p. 1246-1247 2 p.

Research output: Contribution to journalLetter

Drug Administration Schedule
Myoclonus
Clozapine
Serotonin Receptors
Valproic Acid
1993
2 Citations (Scopus)

Clozapine and NMS [3]

Buckley, P. F. & Meltzer, H. Y., Jan 1 1993, In : British Journal of Psychiatry. 162, APR., 1 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Neuroleptic Malignant Syndrome
Clozapine
Schizophrenia
Differential Diagnosis
32 Citations (Scopus)

Prolonged psychotic relapse after abrupt clozapine withdrawal

Parsa, M. A., Al-Lahham, Y. H., Ramirez, L. F. & Meltzer, H. Y., Jan 1 1993, In : Journal of Clinical Psychopharmacology. 13, 2, p. 154-155 2 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Psychiatric Status Rating Scales
Substance-Induced Psychoses
Substance Withdrawal Syndrome
Agranulocytosis
1992
28 Citations (Scopus)

Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation

Meltzer, H. Y., Hong, S. L. & Nash, J. F., Jan 1 1992, In : Archives of General Psychiatry. 49, 2, 1 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Buspirone
Pindolol
Receptor, Serotonin, 5-HT1A
Serotonin Receptors
10 Citations (Scopus)

In Vivo Occupancy of Dopamine Receptors by Antipsychotic Drugs

Meltzer, H. Y. & Stockmeier, C. A., Jan 1 1992, In : Archives of General Psychiatry. 49, 7, p. 588-589 2 p.

Research output: Contribution to journalLetter

Spiperone
Clozapine
Serotonin Receptors
Dopamine Receptors
Haloperidol

Reply to Dr. Verghese and associates

Lee, H. S., Kwon, K. Y., Meltzer, H. Y. & Alphs, L. D., Jan 1 1992, In : Journal of clinical psychopharmacology. 12, 3, 1 p.

Research output: Contribution to journalLetter

1991
74 Citations (Scopus)

Clozapine prophylaxis in rapid cycling bipolar disorder

Calabrese, J. R., Meltzer, H. Y. & Markovitz, P. J., Jan 1 1991, In : Journal of Clinical Psychopharmacology. 11, 6, p. 396-397 2 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Psychiatric Status Rating Scales
Clozapine
Bipolar Disorder
39 Citations (Scopus)

Effect of clozapine on psychogenic polydipsia in chronic schizophrenia

Lee, H. S., Kwon, K. Y., Alphs, L. D. & Meltzer, H. Y., Jan 1 1991, In : Journal of clinical psychopharmacology. 11, 3, p. 222-223 2 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Psychiatric Status Rating Scales
Psychogenic Polydipsia
Loxapine
Thirst
33 Citations (Scopus)

Effect of clozapine on psychotic depression and parkinsonism

Parsa, M. A., Ramirez, L. F., Loula, E. C. & Meltzer, H. Y., Jan 1 1991, In : Journal of Clinical Psychopharmacology. 11, 5, p. 330-331 2 p.

Research output: Contribution to journalLetter

Clozapine
Parkinsonian Disorders
Depressive Disorder
Parkinson Disease
Neurocognitive Disorders
42 Citations (Scopus)

Polypharmacy in fatal clozapine-associated agranulocytosis

Gerson, S. L., Lieberman, J. A., Friedenberg, W. R., Lee, D., Marx, J. J. & Meltzer, H., Jul 27 1991, In : The Lancet. 338, 8761, p. 262-263 2 p.

Research output: Contribution to journalLetter

Polypharmacy
Agranulocytosis
Clozapine
Carbamazepine
Physiologic Monitoring
1990
3 Citations (Scopus)

Clozapine and Electroconvulsive Therapy

Meltzer, H. Y., Jan 1 1990, In : Archives of General Psychiatry. 47, 3, 1 p.

Research output: Contribution to journalLetter

Electroconvulsive Therapy
Clozapine
Therapy
12 Citations (Scopus)

Is Clozapine Response Different in Neuroleptic Nonresponders vs Partial Responders?-Reply

Kane, J. M., Honigfeld, G., Singer, J. & Meltzer, H. Y., Jan 1 1990, In : Archives of general psychiatry. 47, 2, p. 189-190 2 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Dibenzazepines
Psychiatric Status Rating Scales
Clozapine
Antipsychotic Agents
6 Citations (Scopus)

Letters to the editors

Parsa, M. A., Rohr, T., Ramirez, L. F. & Meltzer, H. Y., Jan 1 1990, In : Journal of Clinical Psychopharmacology. 10, 6, p. 437-438 2 p.

Research output: Contribution to journalLetter

Tranylcypromine
Carbidopa
Neuroleptic Malignant Syndrome
Antiparkinson Agents
Substance Withdrawal Syndrome
3 Citations (Scopus)

Monitoring clozapine

Meltzer, H. Y., Jan 1 1990, In : Hospital and Community Psychiatry. 41, 12, 1 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
Agranulocytosis
Clozapine
Physiologic Monitoring
Cost-Benefit Analysis
1989
17 Citations (Scopus)

Choreoathetosis induced by verapamil and lithium treatment

Helmuth, D., Ljaljevic, Z., Ramirez, L. & Meltzer, H. Y., Jan 1 1989, In : Journal of clinical psychopharmacology. 9, 6, p. 63-69 7 p.

Research output: Contribution to journalLetter

Verapamil
Lithium

Choreoathetosis induced by verapamil and lithium treatment

Helmuth, D., Ljaljevic, Z., Ramirez, L. & Meltzer, H. Y., Dec 1 1989, In : Journal of Clinical Psychopharmacology. 9, 6, p. 454-455 2 p.

Research output: Contribution to journalLetter

Athetosis
Lithium Carbonate
Chorea
Verapamil
Combination Drug Therapy