Herbert Y Meltzer

  • 68420 Citations
1961 …2022
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Research Output 1961 2019

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Review article
2017
11 Citations (Scopus)

New trends in the treatment of schizophrenia

Meltzer, H. Y., Oct 1 2017, In : CNS and Neurological Disorders - Drug Targets. 16, 8, p. 900-906 7 p.

Research output: Contribution to journalReview article

Schizophrenia
Antipsychotic Agents
pamidronate
Pharmacogenetics
Psychotic Disorders
10 Citations (Scopus)

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia–a short version for primary care

WFSBP Task Force on Treatment Guidelines for Schizophrenia, Apr 3 2017, In : International Journal of Psychiatry in Clinical Practice. 21, 2, p. 82-90 9 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Primary Health Care
Guidelines
Schizophrenia
Pharmacology
2015
9 Citations (Scopus)

Attention must be paid: The association of plasma clozapine/NDMC ratio With working memory

Meltzer, H. Y., Jun 1 2015, In : American Journal of Psychiatry. 172, 6, p. 502-504 3 p.

Research output: Contribution to journalReview article

Clozapine
Short-Term Memory
Psychotic Disorders
Schizophrenia
6 Citations (Scopus)

Attention must be paid: The association of plasma clozapine/NDMC ratio With working memory

Meltzer, H. Y., Jun 1 2015, In : American Journal of Psychiatry. 172, 6, p. 502-504 3 p.

Research output: Contribution to journalReview article

Clozapine
Short-Term Memory
15 Citations (Scopus)

Pharmacotherapy of cognition in schizophrenia

Meltzer, H. Y., Aug 1 2015, In : Current Opinion in Behavioral Sciences. 4, p. 115-121 7 p.

Research output: Contribution to journalReview article

Cognition
Antipsychotic Agents
Schizophrenia
pamidronate
Drug Therapy
2014
12 Citations (Scopus)

Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: Systematic review and meta-analysis

Kishi, T., Meltzer, H. Y., Matsuda, Y. & Iwata, N., Jan 1 2014, In : Psychological Medicine. 44, 11, p. 2255-2269 15 p.

Research output: Contribution to journalReview article

Serotonin 5-HT1 Receptor Agonists
Receptor, Serotonin, 5-HT1A
Major Depressive Disorder
Meta-Analysis
Placebos
1 Citation (Scopus)

Schizophrenia and Suicide: Treatment Optimization

Agarwal, G., Pirigyi, M. & Meltzer, H. Y., Jun 1 2014, In : Current Treatment Options in Psychiatry. 1, 2, p. 149-162 14 p.

Research output: Contribution to journalReview article

Open Access
Clozapine
Suicide
Schizophrenia
Antipsychotic Agents
Therapeutics
2013
20 Citations (Scopus)

Augmentation of antipsychotic drug action by azapirone 5-HT1A receptor partial agonists: A meta-analysis

Kishi, T., Meltzer, H. Y. & Iwata, N., Jul 1 2013, In : International Journal of Neuropsychopharmacology. 16, 6, p. 1259-1266 8 p.

Research output: Contribution to journalReview article

Receptor, Serotonin, 5-HT1A
Antipsychotic Agents
Serotonin 5-HT1 Receptor Agonists
Meta-Analysis
Confidence Intervals
54 Citations (Scopus)

Lorcaserin and pimavanserin: Emerging selectivity of serotonin receptor subtype-targeted drugs

Meltzer, H. Y. & Roth, B. L., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 4986-4991 6 p.

Research output: Contribution to journalReview article

Serotonin Receptors
Serotonin
Pharmaceutical Preparations
Physiological Phenomena
Psychotic Disorders
188 Citations (Scopus)

Update on typical and atypical antipsychotic drugs

Meltzer, H. Y., Jan 14 2013, In : Annual Review of Medicine. 64, p. 393-406 14 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Aptitude
Clozapine
Cholinergic Antagonists
2012
108 Citations (Scopus)

Clozapine: Balancing safety with superior antipsychotic efficacy

Meltzer, H. Y., Oct 1 2012, In : Clinical Schizophrenia and Related Psychoses. 6, 3, p. 134-144 11 p.

Research output: Contribution to journalReview article

Clozapine
Antipsychotic Agents
Safety
Schizophrenia
Agranulocytosis
2 Citations (Scopus)
Comparative Effectiveness Research
Antipsychotic Agents
Decision Making
Research Design
National Institute of Mental Health (U.S.)
2011
44 Citations (Scopus)

Pathway-based analysis of GWAS datasets: Effective but caution required

Jia, P., Wang, L., Meltzer, H. Y. & Zhao, Z., May 1 2011, In : International Journal of Neuropsychopharmacology. 14, 4, p. 567-572 6 p.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Psychiatry
Genes
Single Nucleotide Polymorphism
Datasets
88 Citations (Scopus)
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Psychotic Disorders
Serotonin
Antipsychotic Agents
88 Citations (Scopus)

The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment

Meltzer, H. Y., Horiguchi, M. & Massey, B. W., Feb 1 2011, In : Psychopharmacology. 213, 2-3, p. 289-305 17 p.

Research output: Contribution to journalReview article

N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Psychotic Disorders
Serotonin
Antipsychotic Agents
2008
160 Citations (Scopus)

Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

Lieberman, J. A., Bymaster, F. P., Meltzer, H. Y., Deutch, A. Y., Duncan, G. E., Marx, C. E., Aprille, J. R., Dwyer, D. S., Li, X. M., Mahadik, S. P., Duman, R. S., Porter, J. H., Modica-Napolitano, J. S., Newton, S. S. & Csernansky, J. G., Sep 1 2008, In : Pharmacological Reviews. 60, 3, p. 358-403 46 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Neurotransmitter Agents
Animal Models
Schizophrenia
Aptitude
119 Citations (Scopus)

Does stimulation of 5-HT1A receptors improve cognition in schizophrenia?

Meltzer, H. Y. & Sumiyoshi, T., Dec 16 2008, In : Behavioural Brain Research. 195, 1, p. 98-102 5 p.

Research output: Contribution to journalReview article

Receptor, Serotonin, 5-HT1A
Cognition
Schizophrenia
Serotonin 5-HT1 Receptor Agonists
Antipsychotic Agents
2007
48 Citations (Scopus)

Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment

Carlo Altamura, A., Bobo, W. V. & Meltzer, H. Y., Sep 1 2007, In : International Clinical Psychopharmacology. 22, 5, p. 249-267 19 p.

Research output: Contribution to journalReview article

Schizophrenia
Psychopathology
Antipsychotic Agents
Mortality
Psychotic Disorders
195 Citations (Scopus)

Suicide risk in schizophrenia: Learning from the past to change the future

Pompili, M., Amador, X. F., Girardi, P., Harkavy-Friedman, J., Harrow, M., Kaplan, K., Krausz, M., Lester, D., Meltzer, H. Y., Modestin, J., Montross, L. P., Bo Mortensen, P., Munk-Jørgensen, P., Nielsen, J., Nordentoft, M., Saarinen, P. I., Zisook, S., Wilson, S. T. & Tatarelli, R., Mar 16 2007, In : Annals of General Psychiatry. 6, 10.

Research output: Contribution to journalReview article

Suicide
Schizophrenia
Learning
Consensus
Research Personnel
2006
112 Citations (Scopus)

ACNP task force report on SSRIs and suicidal behavior in youth

Mann, J. J., Emslie, G., Baldessarini, R. J., Beardslee, W., Fawcett, J. A., Goodwin, F. K., Leon, A. C., Meltzer, H. Y., Ryan, N. D., Shaffer, D. & Wagner, K. D., Mar 1 2006, In : Neuropsychopharmacology. 31, 3, p. 473-492 20 p.

Research output: Contribution to journalReview article

Serotonin Uptake Inhibitors
Advisory Committees
Suicide
Antidepressive Agents
Depression
5 Citations (Scopus)

Diretrizes da Federação Mundial das Sociedades de Psiquiatria Biológica para o tratamento biológico da esquizofrenia parte 1: Tratamento agudo

Falkai, P., Wobrock, T., Lieberman, J., Glenthoj, B., Gattaz, W. F., Möller, H. J., Altamura, A. C., Andreasen, N., Barnes, T. R. E., Beckmann, H., Ciprian-Ollivier, J., Crow, T., David, A., Davidson, M., Deakin, B., Elkis, H., Farde, L., Gaebel, W., Gallhofer, B., Gerlach, J. & 17 others, Hirsch, S. R., Hojaij, C. R., Jablensky, A., Kane, J., Kojima, T., Von Knorring, L., McGorry, P., Meltzer, H., Moussaoui, D., Müller-Spahn, F., Olie, J. P., Palha, A. P., Sato, M., Sauer, H., Schooler, N., Weinberger, D. & Yamawaki, S., Dec 1 2006, In : Revista de Psiquiatria Clinica. 33, SUPPL. 1, p. 7-64 58 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Schizophrenia
Guidelines
Therapeutics
Pharmacology
4 Citations (Scopus)

Diretrizes da Federação Mundial das Sociedades de Psiquiatria Biológica para o tratamento biológico da esquizofrenia parte 2: Tratamento de longo prazo

Falkai, P., Wobrock, T., Lieberman, J., Glenthoj, B., Gattaz, W. F., Möller, H. J., Altamura, A. C., Andreasen, N., Barnes, T. R. E., Beckmann, H., Ciprian-Ollivier, J., Crow, T., David, A., Davidson, M., Deakin, B., Elkis, H., Farde, L., Gaebel, W., Gallhofer, B., Gerlach, J. & 17 others, Hirsch, S. R., Hojaij, C. R., Jablensky, A., Kane, J., Kojima, T., Von Knorring, L., McGorry, P., Meltzer, H., Moussaoui, D., Müller-Spahn, F., Olie, J. P., Palha, A. P., Sato, M., Sauer, H., Schooler, N., Weinberger, D. & Yamawaki, S., Dec 1 2006, In : Revista de Psiquiatria Clinica. 33, SUPPL. 1, p. 65-100 36 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Schizophrenia
Guidelines
Therapeutics
Pharmacology
28 Citations (Scopus)

NK3 receptor antagonists for the treatment of schizophrenia

Meltzer, H. & Prus, A., Jun 1 2006, In : Drug Discovery Today: Therapeutic Strategies. 3, 4, p. 555-560 6 p.

Research output: Contribution to journalReview article

Schizophrenia
Limbic System
Aptitude
Cholinergic Agents
Antipsychotic Agents
1 Citation (Scopus)

Serotonergic mechanisms in schizophrenia: Evolution and current concepts

Meltzer, H. Y., Li, Z., Huang, M. & Prus, A., Mar 1 2006, In : Current Psychosis and Therapeutics Reports. 4, 1, p. 12-19 8 p.

Research output: Contribution to journalReview article

Receptor, Serotonin, 5-HT1A
Serotonin
Schizophrenia
Psychotic Disorders
Receptor, Serotonin, 5-HT2C
114 Citations (Scopus)

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: Long-term treatment of schizophrenia

Falkai, P., Wobrock, T., Lieberman, J., Glenthoj, B., Gattaz, W. F., Möller, H. J., Altamura, A. C., Andreasen, N., Barnes, T. R. E., Beckmann, H., Ciprian-Ollivier, J., Crow, T., David, A., Davidson, M., Deakin, B., Elkis, H., Farde, L., Gaebel, W., Gallhofer, B., Gerlach, J. & 17 others, Hirsch, S. R., Hojaij, C. R., Jablensky, A., Kane, J., Kojima, T., von Knorring, L., McGorry, P., Meltzer, H., Moussaoui, D., Müller-Spahn, F., Olie, J. P., Pacheco Palha, A., Sato, M., Sauer, H., Schooler, N., Weinberger, D. & Yamawaki, S., Mar 1 2006, In : World Journal of Biological Psychiatry. 7, 1, p. 5-40 36 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Schizophrenia
Guidelines
Therapeutics
Pharmacology
2005
430 Citations (Scopus)

A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia

Woodward, N. D., Purdon, S. E., Meltzer, H. Y. & Zald, D. H., Sep 1 2005, In : International Journal of Neuropsychopharmacology. 8, 3, p. 457-472 16 p.

Research output: Contribution to journalReview article

olanzapine
Risperidone
Clozapine
Antipsychotic Agents
Meta-Analysis
27 Citations (Scopus)
olanzapine
Dibenzothiazepines
Risperidone
Long-Term Care
Benzodiazepines
232 Citations (Scopus)

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: Acute treatment of schizophrenia

Falkai, P., Wobrock, T., Lieberman, J., Glenthoj, B., Gattaz, W. F., Möller, H. J., Altamura, A. C., Andreasen, N., Barnes, T. R. E., Beckmann, H., Ciprian-Ollivier, J., Crow, T., David, A., Davidson, M., Deakin, B., Elkis, H., Farde, L., Gaebel, W., Gallhofer, B., Gerlach, J. & 17 others, Hirsch, S. R., Hojaij, C. R., Jablensky, A., Kane, J., Kojima, T., von Knorring, L., McGorry, P., Meltzer, H., Moussaoui, D., Müller-Spahn, F., Olie, J. P., Palha, A. P., Sato, M., Sauer, H., Schooler, N., Weinberger, D. & Yamawaki, S., Aug 1 2005, In : World Journal of Biological Psychiatry. 6, 3, p. 132-191 60 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Schizophrenia
Guidelines
Therapeutics
Pharmacology
2004
31 Citations (Scopus)

The International Suicide Prevention Trial (InterSePT): Rationale and design of a trial comparing the relative ability of clozapine and olanzapine to reduce suicidal behavior in schizophrenia and schizoaffective patients

Alphs, L., Anand, R., Islam, M. Z., Meltzer, H. Y., Kane, J. M., Krishnan, R., Green, A. I., Potkin, S., Chouinard, G., Lindenmayer, J. P. & Kerwin, R., Jan 1 2004, In : Schizophrenia bulletin. 30, 3, p. 577-586 10 p.

Research output: Contribution to journalReview article

olanzapine
Aptitude
Clozapine
Suicide
Schizophrenia
120 Citations (Scopus)

What's atypical about atypical antipsychotic drugs?

Meltzer, H. Y., Jan 1 2004, In : Current Opinion in Pharmacology. 4, 1, p. 53-57 5 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Neuronal Plasticity
Delusions
Clozapine
Hallucinations
2003
31 Citations (Scopus)

Antipsychotic drugs in bipolar disorder

Ertugrul, A. & Meltzer, H. Y., Sep 1 2003, In : International Journal of Neuropsychopharmacology. 6, 3, p. 277-284 8 p.

Research output: Contribution to journalReview article

Bipolar Disorder
Antipsychotic Agents
olanzapine
Risperidone
Clozapine
89 Citations (Scopus)

Neurocognitive assessment in the clinical antipsychotic trials of intervention effectiveness (CATIE) project schizophrenia trial: Development, methodology, and rationale

Keefe, R. S. E., Mohs, R. C., Bilder, R. M., Harvey, P. D., Green, M. F., Meltzer, H. Y., Gold, J. M. & Sano, M., Jan 1 2003, In : Schizophrenia bulletin. 29, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Clinical Trials
Pharmaceutical Preparations
17 Citations (Scopus)

Psychosis of Parkinson's disease: Serotonin 2A receptor inverse agonists as potential therapeutics

Weiner, D. M., Vanover, K. E., Brann, M. R., Meltzer, H. Y. & Davis, R. E., Jul 1 2003, In : Current Opinion in Investigational Drugs. 4, 7, p. 815-819 5 p.

Research output: Contribution to journalReview article

Receptor, Serotonin, 5-HT2A
Psychotic Disorders
Parkinson Disease
Therapeutics
Movement Disorders
2002
45 Citations (Scopus)

Assessing cardiovascular risks versus clinical benefits of atypical antipsychotic drug treatment.

Meltzer, H. Y., Davidson, M., Glassman, A. H. & Vieweg, W. V. R., Jan 1 2002, In : The Journal of clinical psychiatry. 63 Suppl 9, p. 25-29 5 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Torsades de Pointes
Therapeutics
Sudden Death
Hypoglycemia
88 Citations (Scopus)

Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options.

Meltzer, H. Y., Jan 1 2002, In : Current Psychiatry Reports. 4, 4, p. 279-283 5 p.

Research output: Contribution to journalReview article

Suicide
Schizophrenia
Clozapine
olanzapine
Therapeutics
2001
201 Citations (Scopus)

Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle

Basile, V. S., Masellis, M., McIntyre, R. S., Meltzer, H. Y., Lieberman, J. A. & Kennedy, J. L., Oct 22 2001, In : Journal of Clinical Psychiatry. 62, SUPPL. 23, p. 45-66 22 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Clozapine
Antipsychotic Agents
Weight Gain
Dissection
43 Citations (Scopus)

Putting metabolic side effects into perspective: Risks versus benefits of atypical antipsychotics

Meltzer, H. Y., Dec 1 2001, In : Journal of Clinical Psychiatry. 62, SUPPL. 27, p. 35-39 5 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Hyperglycemia
Psychotic Disorders
Cognition
Caregivers
2000
69 Citations (Scopus)

Adverse events related to olanzapine

Conley, R. R. & Meltzer, H. Y., May 22 2000, In : Journal of Clinical Psychiatry. 61, SUPPL. 8, p. 26-30 5 p.

Research output: Contribution to journalReview article

olanzapine
Antipsychotic Agents
Schizophrenia
Psychomotor Agitation
Serotonin Antagonists
78 Citations (Scopus)

Pharmacogenetics of antipsychotic treatment: Lessons learned from clozapine

Masellis, M., Basile, V. S., Özdemir, V., Meltzer, H. Y., Macciardi, F. M. & Kennedy, J. L., Feb 1 2000, In : Biological psychiatry. 47, 3, p. 252-266 15 p.

Research output: Contribution to journalReview article

Clozapine
Pharmacogenetics
Antipsychotic Agents
Therapeutics
Schizophrenia
36 Citations (Scopus)

Psychological and behavioural effects of interferons

Bonaccorso, S., Meltzer, H. & Maes, M., Nov 25 2000, In : Current Opinion in Psychiatry. 13, 6, p. 673-677 5 p.

Research output: Contribution to journalReview article

Interferons
Immunotherapy
Psychology
Depression
Tryptophan
24 Citations (Scopus)

Reducing suicide risk in schizophrenia: Focus on the role of clozapine

Meltzer, H. Y., Anand, R. & Alphs, L., Jan 1 2000, In : CNS Drugs. 14, 5, p. 355-365 11 p.

Research output: Contribution to journalReview article

Clozapine
Suicide
Schizophrenia
olanzapine
Cohort Effect
1999

Pharmacoeconomic factors related to the treatment of schizophrenia

Meltzer, H., Awad, A. G., Manning W.G., J., Shon, S. P., Diamond, R., Mahmoud, R. & Weisburd, D. E., Mar 10 1999, In : Journal of Clinical Psychiatry. 60, SUPPL. 3, p. 59-60 2 p.

Research output: Contribution to journalReview article

77 Citations (Scopus)

Suicide and schizophrenia: Clozapine and the InterSePT study

Meltzer, H. Y., Jun 30 1999, In : Journal of Clinical Psychiatry. 60, SUPPL. 12, p. 47-50 4 p.

Research output: Contribution to journalReview article

Clozapine
Suicide
Schizophrenia
Antipsychotic Agents
olanzapine
885 Citations (Scopus)

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

Meltzer, H. Y. & McGurk, S. R., Jan 1 1999, In : Schizophrenia bulletin. 25, 2, p. 233-255 23 p.

Research output: Contribution to journalReview article

olanzapine
Risperidone
Clozapine
Cognition
Schizophrenia
20 Citations (Scopus)

Variability in response to clozapine: Potential role of cytochrome P450 1A2 and the dopamine D4 receptor gene

Ozdemir, V., Masellis, M., Basile, V. S., Kalow, W., Meltzer, H. Y., Lieberman, J. A. & Kennedy, J. L., Jun 30 1999, In : CNS spectrums. 4, 6, p. 30-56 27 p.

Research output: Contribution to journalReview article

Dopamine D4 Receptors
Cytochrome P-450 CYP1A2
Clozapine
Antipsychotic Agents
Genes
1998
102 Citations (Scopus)

Adverse effects of the atypical antipsychotics

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 17-22 6 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Clozapine
Cholinergic Antagonists
Weight Gain
Orthostatic Hypotension
40 Citations (Scopus)

Assessing the effects of atypical antipsychotics on negative symptoms

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 28-34 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Depression
36 Citations (Scopus)

Assessment of EPS and tardive dyskinesia in clinical trials

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 23-27 5 p.

Research output: Contribution to journalReview article

Symptom Assessment
Antipsychotic Agents
Clinical Trials
Psychomotor Agitation
Dystonia
50 Citations (Scopus)

Atypical antipsychotics for treatment of depression in schizophrenia and affective disorders

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 41-45 5 p.

Research output: Contribution to journalReview article

Mood Disorders
Antipsychotic Agents
Schizophrenia
Depression
Suicide
20 Citations (Scopus)

Clinical development of atypical antipsychotics: Research design and evaluation

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 10-16 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Research Design
Clinical Trials
Investigational New Drug Application
Product Labeling